Trifexis Heartworm for Dogs | On Sale | EntirelyPets Rx
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Trifexis Heartworm for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Trifexis for Dogs protects petite dogs from fleas, heartworms, hookworms, roundworms, and whipworms. This FDA-Approved, chewable tablet features a scrumptious beef flavor that makes it easy to administer your pet's monthly dose. By combining spinosad and milbemycin oxide, this treatment combats parasites for a full month and begins working within 30 minutes of administering the first dose.

Triflexis is a prescription medication that is safe for dogs that are at least 8 weeks of age. There are also five different formulations of Triflexis to give the proper dosage based on your dog's weight: 5-10 lbs (Pink), 11-20 lbs (Orange), 21-40 lbs (Green), 41-60 lbs (Blue), and 61-120 lbs (Brown).

Key Features:

  • Begins killing fleas 30 minutes after application and kills 100% of biting fleas after 4 hours
  • Prevents heartworm disease
  • Treats and controls roundworms, hookworms, and whipworms
  • Palatable beef flavor and real pork liver makes tablet easy to administer

How It Works

Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

Prescription Required

NADA 141-321

NDC 58198-4332-6 (Pink)

NDC 58198-4333-6 (Orange)

NDC 58198-4334-6 (Green)

NDC 58198-4335-6 (Blue)

NDC 58198-4336-6 (Brown)


Active IngredientTrifexis PinkTrifexis OrangeTrifexis GreenTrifexis BlueTrifexis Brown
Spinosad140 mg270 mg560 mg810 mg1620 mg
Milbemycin Oxime2.3 mg4.5 mg9.3 mg13.5 mg27 mg


Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications.

View Trifexis Drug Facts Sheet.

Quick Tips

  • Give Trifexis chewable tablets with food.
  • Give Trifexis chewable tablets once a month.
  • Please view the chart below for the correct dosage of Trifexis for your dog.
  • Trifexis does not protect against ticks.
  • If vomiting occurs within 1 hour of administration, redose the pet with another full dose.
  • Consult your veterinarian for pregnant or lactating dogs.

Dosage Table

Dog WeightDosage
5 - 10 lbsGive one tablet (Pink)
0.1 - 20 lbsGive one tablet (Orange)
20.1 - 40 lbsGive one tablet (Green)
40.1 - 60 lbsGive one tablet (Blue)
60.1 - 120 lbsGive one tablet (Brown)
Over 120 lbsAdminister the appropriate combination of tablets

Storage Directions

Store Trifexis at room temperature (68° - 77° F). Keep away from pets and children.


Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

Possible Side effects

Vomiting and diarrhea, coughing, increased thirst and/or appetite, redness of skin, anorexia, lethargy or hyperactivity, vocalization, excessive salivation.


What happens if I miss giving a dose? Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose the pet? Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Trifexis? Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

What are the possible side effects of Trifexis? Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Trifexis? Talk to your veterinarian before giving any prescription or over the counter medications.

What should I discuss with my veterinarian before giving Trifexis? Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).


Review Summary
56 Reviews
93% (52)
4% (2)
2% (1)
2% (1)
0% (0)
98% Recommend this product (55 of 56 responses)
By Matthew
Best for Texas Dogs
February 12, 2020
I've used several different meds for my dog and this one works great for Texas. The only negative is that my dog hates the smell, but if you let it sit out for about 24 hours after removing the pill from the package you can probably sneak it by them in a pill pocket or slathered in peanut butter.
ProsPerfect 1-pill combo for Texas dogs.
By Yana
No issues
January 8, 2020
Being concerned about some negative reviews I was reluctant ordering from here. This is my first time ordering on this site and I had no issues with this company. The product arrived fast and as described. The pharmacy sent out emails about the progress of the prescription validation, sending out the product, etc. Price was great compared to other companies. Will try this Pharmacy again.
By Jose F.
Miami, FL
One and done
January 4, 2020
This is exactly what i need for protection of multiple threats for my pet.
ProsOne pill a month
ConsI believe taste & texture could be better
Orlando, FL
December 29, 2019
This product works great for keeping fleas off my dog. However, it has become overpriced.
ProsProduct works. (Although a lot of flea, tick and heartworm meds work too.)
ConsIt is becoming too expensive. The mfg should work on keeping the price more affordable. I know a lot of pet owners that are discontinuing flea and heartworm products because the cost of these items are becoming unaffordable for pet owners. At least Entirely Pets gives a discount on this item.
By Lisa C.
October 6, 2019
We bought flea and heart worm treatment for much less that Vet prices, strongly recommended by our vet. Quickly delivered and boxed perfectly. Very pleased with our first purchase and will keep ordering whatever we need for our dog Rogue. She loves toys but chews up everything , hoping we can buy her toys she can play with but not destroy or eat
By Annalise M.
It works
May 23, 2019
Great product. I have a standard poodle and a mixed dog. My mom has a German Shepard my sister a standard poodle my other sister a German Shepard. They're all on this medicine and once they get their medicine for the month they become in better spirits. They play more, they run more and they’re happier. Happier because they don't have fleas or worms. 10/10
By Gail
Portland, Ore
Great service and accommodation for my 2 dogs
January 1, 2019
I have 2 dogs of different weight, and needed Trifexis for both. By ordering from Entirely Pets Pharmacy, I was able to split and order and get 3 tablets for each without having buy 6 for each dog at one time.
ProsI was able to split and order 3 tablets for each dog.
By John
Brandon, Mississippi
December 19, 2018
I have absolutely fallen in love with ur company! This was my first order/purchase, I normally get my Trifexis (for 1 dog: 40- 60lbs). from my vet for a little less then $40 but this place I was able to get one try FacSys for eight 40–60 LP ass dog for not even $13! Have never seen it that low for just 1 pill, that’s another amazing aspect of this website is you don’t have to buy a six-month supply! I also decided to look at some of their deals and I found this spray mate you can use for cuts, wings, birds, pretty much anything and everything and has no alcohol in it so it will not stink them and I bought some for my dog, she was being treated by a vet for two or three months and it has only gotten worse BUT since finding the spray, it has gone down and she seems to be feeling better! I don’t know it’s going to completely fix her, as a matter fact we’re trying to decide if we should put her down
Pros She will take it with or without food, she has had no side effects, easiest alarm and easy to keep organized!
Cons Man, that we have found so far!
By Pam
Wet and wild Oregon for
Good product, great price
December 13, 2018
I've used Trifexis for our dog for 3 years. Works well and takes care of all issues with one monthly pill. This was a very good price and glad I ordered.
By LInda
Dallas TX
My top choice
December 2, 2018
I have used Trifexis for many years now. It is a winner. My pets are free of heartworms, fleas and ticks....which can be a major scourge in the south.
Pros In the long run, this is more economical than buying separate treatments and I have not seen a tick or a flea on my dogs in years. I wish I wish I had this for Happy who contracted heartworms in 1975. She was finally cured but it was excruciating.
By Carole
Morgan Hill, CA
November 22, 2018
They contact my vet for prescription. Then send product. Simple process.
By Sandra D.
Ormond Beach
October 10, 2018
Our dog gets this everymonth for fleas and ticks-- she has never had them.
By Connie
Summerville, SC
Great Buy
September 28, 2018
Paid half the price of what I would have paid at the vet. Delivery was easy. Had it in a couple of days.
Merchant Response:We get that a lot Connie. Happy to have you as a customer.
By Carlos
Your service and prompt delivery sets Entirely Pets at a higher level of efficiency.
September 21, 2018
Outstanding products and prompt delivery are provided.
Merchant Response:Carlos, that's high praise, we do our best.
By Zute
Silicon Valley, CA
September 17, 2018
If a dog doesn’t mind eating a pill, this is the treatment I trust. I need to cut it in half and mix it in with his supper to get my dog to eat it. I couldn’t get my previous dog to eat this pill no matter what I tried.
By Ruger
Orlando, FL
Excellent product, Highly recommended by my Vet - Great Pricing
September 4, 2018
We used this product for the first time just over 3 yrs ago when we adopted our German Shepard and he was on it already. He loves it and we love the easy one pill a month dosage. Our Vet says this is an excellent product with great results. Excellent pricing here at Entirely pets
Merchant Response:Ruger, Glad to hear your German Shepard does well with Trifexis.
By Meg
San Diego
Good product
August 29, 2018
Good product, Good service, fast shipping
By Debra S.
Cape Coral, FL
No regrets
August 5, 2018
I was pleased with the customer service and the product I received. I will purchase from them again if they continue to offer great prices.
Merchant Response:Debra, We work directly with the drug manufacturing companies to bring you the best pricing possible. We also do our best with our customer service. Thank you for the kind words. Wishing you and your dog the best!
ProsThey deal directly with my vet to obtain the script.
By Tamara B.
Saint Petersburg
Great Value!!
August 3, 2018
Great value and I will continue to purchase from them....much lower prices than our local vet.
By Lou
orlando, fl
great buy
June 2, 2018
We have been using trifexis for quite a while and Entirely Pets offered the best price and the service was exceptional! In the past other services had long delays contacting our Vet and gave slow delivery.NOT HERE. Hope Entirely Pets gets the accreditation my vet likes to see to assure them that EP is totally trustworthy.
By Eliza
Customer Service A1+
May 27, 2018
Love this product. Very capable, professional customer service helped me through this transaction. Will buy from them again. Don't experience customer service like this must, especially online stores!
Merchant Response:Eliza, we are happy to hear about your positive experience with us! Every day we try to be better than the last. Enjoy the Trifexis and take care!
By C M.
Great Pricees
May 25, 2018
Good product, service an quick delivery.
By Randall
Land O Lakes, Florida
Best bang for your buck
April 29, 2018
I was really amazed and pleased at the discounted price for the trifexis.
By Maureen K.
St.Pete, Florida
5 star rating
April 29, 2018
Thank you for the wonderful service that you provide. My rescue dog Ci Ci and I are extremely happy with Trifexis caused no adverse reactions to Ci Ci the product is perfect for her. And you made it so easy ordering. Thank you, Maureen Kirby & Ci Ci
ProsMaureen, glad to hear Trifexis is working well for your rescue, Ci Ci. You both take care :)
By Marillyn
Covers it all
April 13, 2018
Trifexis covers 3 parasites in one tablet. My Saint Bernard doesn't care for the whole tablet so I just crush it up on top of her food. Easy once a month dose.
ProsOnce a month dosing. Easy to give.
By Marilyn
Easy to give
April 13, 2018
Love Trifexis. It covers 3 parasites in one tablet and you only have to give it once a month. My beagle eats it like it's a treat. No mess. Entirely Pets has the lowest price for this product.
ProsEasy to give, no mess, monthly
By Rhonda R.
Vero Beach FL
Great value!
March 28, 2018
Happy to find a less expensive way to treat my animals.
ProsPrice Fast shipping Accredited pharmacy Variety of choices
ConsNew customer so none yet. Hopefully never!
By Nancy P.
Washington, Tx
Great Service!!
March 1, 2018
Recently purchased Trifexis from EntirelyPets. Very pleased with the service received.
Kept informed of order process and received phone calls to update when needed. I will definitely be ordering again from EntirelyPets.
ProsVery friendly and helpful service.
By ehumama
Great prices
February 6, 2018
Prices were good, but just took a little longer than normal to get the fax request to the vet. But overall the service was good.
By margaret a.
San Antonio, TX
January 3, 2018
Great product at a great price. Enjoyed the savings compared to the vets price.
Fast service without any hassles.
Merchant Response:Glad we're able to help save you some money Margaret while still providing the same great Trifexis you would get from your veterinarian's office!

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