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Revolution for Dogs

Revolution for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Revolution for dogs is a safe and simple, FDA-Approved, monthly topical medication used to protect your pet from heartworms, fleas, and ear mites. It also protects dogs from ticks and sarcoptic mange. Revolution requires a prescription from your veterinarian. (Example: 3 Pack=3 doses which lasts 3 months.)


Revolution is recommended for use in dogs six weeks of age or older.

Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Key Benefits

  • Protects your pet from heartworms, fleas, and ear mites, among other foreign invaders
  • Fights both internal and surface parasitic infections
  • Treats mange
  • Only administered once a month
  • Safe and easy to use

How It Works

Revolution works by penetrating the skin and entering your pet's bloodstream. Concentrations of selamectin, the active ingredient, in the tissue and bloodstream prevent heartworm disease. Selamectin also redistributes into the skin from the bloodstream and kills adult fleas, American dog ticks, and ear mites, and prevents flea eggs from hatching. It is also an anthelmintic, which means it fights to expel parasitic worms. Parasites ingest the drug when they feed on the animal's blood.

Prescription Required

NADA 141-152


Active Ingredient


Package ColorSelamactin Amount
Mauve15 mg
Purple30 mg
Brown60 mg
Red120 mg
Teal240 mg
Plum360 mg


View Revolution product insert.


The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Dosage Table

Dogs (lb) Package Color mg per tube Potency (mg/ml) Administered volume(mL)
Up to 5Mauve15 mg600.25
5.1-15Purple30 mg1200.25
10.1-20Brown60 mg1200.5
20.1-40Red120 mg1201.0
40.1-85Teal240 mg1202.0
85.1-130Plum360 mg1203.0
For dogs over 130 lbs use the appropriate combination of tubes


  1. Remove the Revolution tube from its protective package.
  2. Holding the tube upright, firmly press the cap down until you hear a ‘click’ sound, which signals that the cap has punctured the applicator seal. Remove the cap and check to be sure that the tip of the tube is open.
  3. Part the hair on the back of the animal at the base of the neck, in front of the shoulder blades, until the skin is visible.
  4. Apply the tip of the Revolution tube directly to the skin. Squeeze the tube firmly 3–4 times in one spot until empty. Keep tube compressed on the final squeeze to avoid drawing liquid back into tube. Avoid contact between Revolution and your fingers.
  5. While keeping tube squeezed, drag it away from liquid and lift up to remove.
  6. Ensure tube is empty.

Quick Tips

  • Do not massage Revolution into the skin.
  • Do not apply when the haircoat is wet.
  • Do not apply to broken skin – Revolution contains alcohol.

Storage Directions

Revolution is flammable – Keep away from heat, sparks, open flames or other sources of ignition. Store below 30°C (86°F). After application, empty tubes can be placed in your normal household refuse for disposal.

Possible Side Effects

Like all medicines, Revolution has some side effects. The most common is hair loss at the site of application with or without inflammation (redness, flaking) in cats. Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death. There have also been rare reports of seizures in dogs.

If you have additional questions about possible side effects, talk to your veterinarian


Revolution is a prescription medication applied topically once a month. Do not use Revolution on puppies under 6 weeks of age or kittens under 8 weeks of age. According to the product literature, Revolution is safe for use on pregnant or lactating dogs and cats.

Revolution is a topical parasiticide applied once a month for the prevention of heartworm disease in dogs and cats. Revolution is also used on dogs for the treatment or prevention of fleas, the American Dog Tick, ear mites, and canine sarcoptic mange. When used on cats it is also used to treat or prevent fleas, ear mites, hookworms, and roundworms. It is recommended that heartworm prevention be used year-round. Revolution may also be used for purposes other than those listed in this guide.

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

Apply Revolution exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Revolution is available as unit of use applicator tubes containing the specific amount of medication based on the weight of your pet. Revolution is available as a 15mg/0.25ml puppy/kitten dose for puppies older than 6 weeks and kittens older than 8 weeks weighing up to 5 lbs. Revolution is also available for cats 5.1-15 lbs (45mg/0.75ml), 15.1-22 lbs (60mg/1ml), and for dogs 5.1-10 lbs (30mg/0.25ml), dogs 10.1-20 lbs (60mg/0.5ml), 20.1-40 lbs (120mg/1 ml), 40-1-85 lbs (240mg/2 ml) and 85.1-130 lbs (360mg/3ml). For dogs over 130 lbs use the appropriate combination of tubes. The entire contents of the tube should be used. Do not split the contents as the accuracy of the dose and effectiveness of the medication cannot be assured. Bathing or shampooing your pet 2 or more hours after treatment will not reduce the effectiveness of Revolution. Keep this medication away from children and pets.

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

Seek emergency veterinary medical treatment. Symptoms of overdose, while rare, may include salivation and lack of coordination, as well as symptoms listed below as side effects.

Because humans can contract hookworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the house and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended. Do not use on sick, weak, or underweight animals. Do not apply to wet hair. Dogs should be tested for heartworms prior to using Revolution. In humans, Revolution may be irritating to skin and eyes. Wash hands thoroughly after applying Revolution to your pet.

Side effects of Revolution that may occur include temporary hair loss at the site of application, loss of appetite, drooling, vomiting, diarrhea, drowsiness, rapid breathing, increased heart rate, and muscle tremors.

Do not apply Revolution to your pet if already giving an alternate heartworm medication. When switching from another heartworm medication, begin Revolution when the next dose of the heartworm medication is due.

Your pharmacist has additional information about Revolution written for health professionals that you may read.

Revolution kills adult fleas and prevents flea eggs from hatching. You may occasionally see a few fleas on dogs or cats treated with Revolution but more than 98% of adult fleas are killed within 36 hours.

Immature stages of the flea called pupae may be present in your pets’ environment (yard, flooring, carpet, bedding, etc.). These pupae are not killed by parasiticides (including Revolution) and as such may emerge as adult fleas. These adult fleas may hop onto your pet at anytime. They must be exposed to Revolution on your dog or cat before being killed. It can take from 3–5 weeks (or longer depending on environmental conditions) for most fleas to complete their 4-stage life cycle (egg, larvae, pupae, and adult) and reach the adult stage before being seen on your pet. Due to the presence of immature flea stages in infested environments it can take up to 2 to 3 monthly applications for Revolution to maximally control the infestation of fleas in the environment. Once the flea population is controlled you will be less likely to see fleas.

Revolution controls tick infestations only due to the American Dog Tick (Dermacentor variabilis), a tick commonly found on dogs. There are other common species of ticks that are not killed or controlled by Revolution. Your veterinarian can recommend appropriate products to control or kill ticks common to your area. For the control of the American Dog Tick, Revolution should be applied once a month; however, your veterinarian may recommend a second administration applied 14 days after the first dose if your dog has a heavy tick infestation and/or recommend additional tick control methods. It may take up to 5 days to kill the majority of ticks on your dog.

In well-controlled clinical studies, Revolution was used safely in dogs and cats receiving other veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolution. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog’s or cat’s medicines can be given together.


Review Summary
30 Reviews
97% (29)
3% (1)
0% (0)
0% (0)
0% (0)
100% Recommend this product (30 of 30 responses)
By Fairy M.
San Diego
July 5, 2018
My dog is allergic to beef products and many heartworm meds contain beef. This topical is an excellent value because it is a heartworm med as well as a flea product. My sheltie tolerates it well. I also haven't seen or heard of any horror stories regarding this full spectrum product as I've heard and seen with others.
Merchant Response:You are quite the pet parent! We are happy to help and too glad to fill your pet scripts Fairy Dog Mother.
ProsNo bovine source as with edible heartworm med Flea and heartworm preventative
By Dogman
Wasington D.C. & Utal
SBD K-9 Unit
January 30, 2020
So far so good. This product covers heart worm, fleas and ticks.
ConsI guess the only way to tell if it works is that there are no problems -- right?
By Barbara
super easy
January 30, 2020
Very easy to apply and effective.
By Anita
Sheffield, VT
November 3, 2019
Purchased the 6 pack version as a new customer. Supplied my vet information so they could obtain a prescription and I only had to wait for my shipment to be delivered. Very pleased with the purchase and I would purchase from these folks again.
Merchant Response:Hi Anita, I am so glad to hear that we were able to provide you with good customer service. I would like to thank you for shopping with our Pharmacy.
By Marge
Tucson, AZ
September 25, 2019
Excellent product. Candy has been hear worm free and also tick, flea free since applying revolution monthly.
By dDanz
austin, texas
Great prices and efficent shipping
February 3, 2019
great prices, discount coupons sent via email and efficient, fast shipping
Prosgreat prices, discount coupons sent via email and efficient & fast shipping
Consnone that I can think of
By Jan
Macomb, MI
Great Job!
December 6, 2018
Ordering through Entirely Pets is always so quick and easy. Revolution is a great product. It is two medications in one. Our dog has allergies and our vet put him on Revolution to help. Not only is it for heart worm, flea and tick prevention, but also helps with his allergies. I like the two in one (heart worm AND flea/tick). Just one medication to give our dog. And it is cheaper not having to buy two prevention products. I highly recommend Revolution.
ProsGiving pet only one medication every month. Cheaper than buying heat worm and flea and tick prevention meds separately.
By Dave
Hamilton, Ohio
Great Product
November 10, 2018
We've used Revolution for quite a few years and haven't been disappointed in the results. It's a once a month product for fleas as well as a heartworm medication.
By Adrienne U.
Lake worth fl
Great price
October 26, 2018
Very easy to order and received in less than a week
ProsGreat price
By Linda P.
Great Product
October 21, 2018
Been using Revolution for many years on all my dogs and cats.
ProsProtects against fleas, heartworms, ear mites, some types of ticks and one intestinal parasite (don't recall which one).
Consexpensive but you must keep in mind that in addition to flea prevention it also provides heartworm protection so no need to purchase heartworm preventive meds.
By Beatrix
Petaluma, CA
Excellent Product
August 30, 2018
Gets the job done with protecting for hear worm and fleas. Doesn't make my dog sick.
By Mary B.
Costa Mesa, CA
August 29, 2018
Received product on time.
Always a pleasure to shop here.
Merchant Response:Mary, it's our pleasure. =)
By Moni
Austin, Tx
Good price
April 26, 2018
Received it quickly and exactly what ordered for a very good price.
ProsCovers everything in one application
ConsIt is a liquid you put on the back.
By Margaret C.
Tucson, Arizona
March 15, 2018
Ordered online and received product fairly quickly as I had a prescription on file. Product well labeled and instructions clear. Great company
By Susan
Great price
February 21, 2018
You have the best prices and fast shipping. Thank you...I know I will buy from you again
Hayward, CA
Fast, easy, and pricing is good!
January 20, 2017
Now, I do not have to spend my time on the weekend with my dog at Pet Expres to purchase this item. Also, the cost is cheaper!
ProsGreat service!
By Carol K.
Sublette, ILimois
Love the price
November 25, 2016
Exactly the same as the expense ones from our vet
What a bargain!
November 13, 2016
When the sale started I bought 12 months! I have used this for years and have no fleas, ticks, or internal pests on my dogs. It's a great product at a great price.
By Judy
Las Cruces, NM
Very nice
September 30, 2016
Fast shippers and the price is always fair
By Ashley
Just what I wanted
July 25, 2016
Great price
By Carol K.
Great price for a great product
July 6, 2016
Saved almost $40 over the vet price no
By Margaret B.
Tucson, AZ
Revolution for dogs
April 22, 2016
Excellent product. Protects my dog from heartworm as well as fleas and ticks. Easy to administer. Entirely pets offers a great price and service.
ProsEffective against heartworm and fleas and ticks.
By Joan D.
Easy to apply, does the job
April 1, 2016
I have returned housing Revolution after trying other products, and applying this small amount of liquid on our dog's skin is working the best for her and for me. She didn't like the oral meds - spit them out after the first two treatments, and the other options were "too icky" when it came to cleaning her coat after application. She is a 47# Australian Shepherd.
November 13, 2015
No problems on ordering, delivery, and great pricing!
By Christine
La Mesa, CA
What a deal!
October 23, 2015
Just like what I get from the vet, only better. Being a pet parent to 3 fur babies any time I can score a super great price on something I use what's not to like?!? I ran into some complications, on my end, but the people at Entirely Pets Pharmacy worked with me and I was able to get what I needed at the sale price! They were so helpful and understanding I can't see why I'd ever shop anywhere else. Thank you for a job well done.
ProsGreat service, great prices, friendly and caring people.
Pittsburgh, PA
great product
October 23, 2015
This is an easy all in one product. We have not used more than a year yet, but so far it seems to work well.
Proseasy all in one
By Diana
Stockton, California
Great product for dogs and cats...
September 27, 2015
Works really great, seemingly safe and does not leave a greasy film on the fur. Not only does it take care of fleas, but also Sarcoptic mange mites and the tiny red spiders in plants.
ProsEasy to apply and with the clear vial you can see that you are putting ALL of the product on the furkids.
ConsNone so far.
By Bob
San Antonio
September 27, 2015
Have used it for years and it works.
Prosit works
By Tom
Olympia, WA
Great price & service
September 18, 2015
We've used Revoltion for years with solid results. Found the best price here and their service was attentive and kept us informed about the order status until it arrived in our mailbox.
By Cindy K.
Dallas, TX
Love this product..
July 18, 2015
My dog won't eat or take pills well, so this is the best way for me to guard her against fleas and heartworms. I would recommend this product for all pet lovers..
ProsEasy to apply with no mess...

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