What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
Itrafungol (Itraconazole Oral Solution) is used to treat ringworm in cats caused by a fungus infection. Cats with ringworm typically have patches of hair loss, scaling, crusting, and redness, with or without itchiness. Most skin lesions are found around the ears and face or on the legs. The disease is most commonly seen in kittens.
Itrafungol oral solution is used for treating dermatophytosis caused by Microsporum in cats.
Itrafungol is a cherry caramel-flavored liquid that is easy to dose and easy to administer. It requires a short course of pulse therapy oral dosing on alternate weeks for three treatment cycles.
View Itrafungol package insert for more information
The solution should be administered orally using the graduated dosing syringe.
The daily dosage is 5 mg/kg body weight administered once daily on alternating weeks for 3 treatment cycles. Cats are treated during weeks 1, 3, and 5, and left untreated during weeks 2 and 4.
For cats weighing more than 13.0 lbs, the total dose will need to be calculated and given over two doses as the dosing syringe only holds 3.0 mL of solution.
After dosing, the syringe should be removed from the bottle, rinsed and dried and the bottle cap should be screwed back on tightly.
Store at 68-77°F (20-25°C). Excursions permitted between 59-86°F (15-30°C). Keep away from children and pets.
Do not administer to cats with hypersensitivity to itraconazole.
Itrafungol (itraconazole oral solution) has not been shown to be safe in pregnant cats (see Animal Safety section). Itrafungol should only be used in pregnant or lactating cats when the benefits outweigh the potential risks.
Not for use in humans. Keep this and all medications out of reach of children. Wash hands and exposed skin after use. In case of accidental contact with eyes, rinse thoroughly with water. In case of pain or irritation, seek medical advice. In case of accidental ingestion, rinse mouth with water and seek medical advice.
Special precautions for person administering the veterinary product to the animal:
Microsporum canis dermatophytosis is a zoonotic disease (a disease that can be transmitted from animals to humans); therefore consult a physician if a suspected lesion occurs on a human. Wear protective gloves when handling the animal during treatment or when cleaning the syringe. Wash hands and exposed skin after handling the animal.
Itrafungol has not been shown to be sporicidal; therefore in order to reduce zoonotic potential, environmental contamination, and to decrease course of the disease, topical and environmental treatment should also be utilized.
Itrafungol has been associated with renal changes found on histopathology that were not noted after an eight week recovery period (see Animal Safety). Use with caution in cats with renal dysfunction.
Itrafungol is metabolized by the liver (mainly CYP3A) and can cause elevated liver enzymes (see Animal Safety section). Use with caution in cats with impaired liver function. If clinical signs suggestive of liver dysfunction develop, treatment should be discontinued.
Itrafungol is a cytochrome p-450 inhibitor and may increase or prolong plasma concentrations of other drugs metabolized by this pathway, such as amitriptyline, amlodipine, benzodiazepines, buspirone, cisapride, corticosteroids, cyclosporine, ivermectin, and macrolide antibiotics.
Negative effects have been reported in literature when itraconazole was administered intravenously to dogs and healthy human volunteers. Cats suffering from heart disease should be carefully monitored during treatment.