Piroxicam (Manufacturer may vary)

Piroxicam in veterinary medicine is most often prescribed to treat certain types of cancers, such as colon, prostate, and bladder cancer. This drug is used off label and discussions with your veterinarian are highly recommended. It can also be combined with opioid analgesics to reduce discomfort in oncology patients, while reducing the drowsiness commonly associated with those drugs.

For: Dogs and cats

Key Benefits

• Demonstrates effectiveness against fevers
• Helps treat chronic rhinitis in dogs and cats.
• Can be used as an anti-inflammatory and pain medication in cats.
• Combined with other drugs to treat transitional cell carcinoma, a bladder cancer, in dogs.

How It Works

Piroxicam belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). Piroxicam is a nonselective cyclooxygenase (COX) inhibitor with inhibitory effects on both COX-1 and COX-2. COX-1 produces prostaglandins that regulate homeostasis, allowing the kidney to respond to hypotension and protect the GI tract. COX-2 produces the prostaglandins that are increased in the presence of inflammation. COX-2 is upregulated in many types of tumors, including nasal epithelial tumors, mammary tumors, colorectal tumorsoral squamous cell carcinomaoral melanoma, prostatic carcinoma, transitional cell carcinoma (TCC) of the urinary bladder and osteosarcoma.

Carefully consider the potential benefits and risks of Piroxicam Capsules, USP and other treatment options before decidign to use Piroxicam Capsules, USP. Use the lowest effective dose for shortest duration consistent with individual patient treatment goals.

After observing the response to initial therapy with Piroxicam Capsules, USP, the dose and frequency should be adjusted to suit an individual patient's needs.

For the relief of rheumatoid arthritis and osteoarthritis, the recommended dose is 20 mg given orally once per day. If desired, the daily dose may be divided. Because of the logn half-life of Piroxicam Capsules, USP, steady-state blood levels are not reached for 7-12 days. Therefore, although the therapeutic effects of Piroxicam Capsules, USp are evident early in treatment, there is a progressive increase in response over several weeks and the effect of therapy should not be assessed for two weeks.

Indications and Usage:

Carefully consider the potential benefits and risks of Piroxicam Capsules, USP and other treatmetn options before decidign to use Piroxicam Capsules, USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

Piroxicam Capsules, USP is indicated

• For relief of the signs and symptoms of osteoarthritis.
• For relief of the signs and symptomms of rheumatoid arthritis.

Contraindications

Piroxicam Capsules, USP is containdicated in patients with known hypersensitivity to piroxicam. Piroxicam Capsules, USP should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients (see Warnings: Anaphylactoid Reactions and Precautions: Preexisting Asthma).

Piroxicam Capsules, USP is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see Warnings).