Interceptor Plus for Dogs | All Sizes | EntirelyPets Rx
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Interceptor Plus for Dogs

Interceptor Plus for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews

Description

Interceptor Plus is a monthly, broad spectrum parasiticide used to prevent heartworm disease, as well as treat and control common intestinal parasites including roundworms, hookworms, whipworms and tapeworms. Interceptor Plus offers long-lasting protection in the convenience of a tasty, easy-to-administer chewable. The chewable tablets are chicken flavored, which is an added benefit for dogs suffering from beef allergies. Most dogs love the taste, and you can rest assured that your best friend will be protected against heartworms for a full month. Interceptor Plus requires a prescription from your veterinarian. It is available as a 6-pack, which provides six months of heartworm protection or as a 12-pack which provides 12 months of protection.

Key Benefits

  • Each tablet provides a full month of protection against heartworms, roundworms, hookworms, whipworms and tapeworms
  • Tasty, chicken-flavored chewable is easy to administer
  • Chewables can be given directly to your dog or broken up and mixed with food
  • Available in four weight categories: 2-8 lbs, 8.1-25 lbs, 25.1-50 lbs, and 50.1-100 lbs
  • Package includes calendar reminder stickers to help make sure you never miss a dose

Indication:

Interceptor Plus is indicated for the prevention of heartworm disease caused by Dirofilaria immitis; and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis, Echinococcus granulosus, and Dipylidium caninum) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Prescription Required

Ingredients

Interceptor Plus for Dogs 2-8 lbs (Orange):
Active Ingredients (per flavor tab) Amount
Milbemycin Oxime 2.3 mg
Praziquantel 22.5 mg
Interceptor Plus for Dogs 8.1-25 lbs (Green):
Active Ingredients (per flavor tab) Amount
Milbemycin Oxime 5.75 mg
Praziquantel 57 mg
Interceptor Plus for Dogs 25.1-50 lbs (Yellow):
Active Ingredients (per flavor tab) Amount
Milbemycin Oxime 11.5 mg
Praziquantel 114 mg
Interceptor Plus for Dogs 50.1-100 lbs (Blue):
Active Ingredients (per flavor tab) Amount
Milbemycin Oxime 23 mg
Praziquantel 228 mg

Directions

View Interceptor Plus Drug Facts Sheet

Interceptor Plus should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, and 2.28 mg/lb (5 mg/kg) praziquantel. For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes (see Effectiveness).

Dosage Schedule
Body Weight Milbemycin Oxime per chewable Praziquantel per chewable Number of chewables
2 to 8 lbs. 2.3 mg 22.8 mg 1
8.1 to 25 lbs. 5.75 mg 57 mg 1
25.1 to 50 lbs. 11.5 mg 114 mg 1
50.1 to 100 lbs. 23 mg 228 mg 1
Over 100 lbs. Administer the appropriate combination of chewables.

Interceptor Plus may be offered to the dog by hand or added to a small amount of dog food. The chewables should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Heartworm Prevention:

Interceptor Plus should be administered at monthly intervals beginning within 1 month of the dog's first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog's last seasonal exposure (see Effectiveness). Interceptor Plus may be administered year-round without interruption. When switching from another heartworm preventative product to Interceptor Plus, the first dose of Interceptor Plus should be given within a month of the last dose of the former product.

Intestinal Nematode and Cestode Treatment and Control:

Dogs may be exposed to and can become infected with roundworms, whipworms, hookworms, and tapeworms throughout the year, regardless of season or climate. Clients should be advised of appropriate measures to prevent reinfection of their dog with intestinal parasites. Because the prepatent period for E. multilocularis may be as short as 26 days, dogs treated at the labeled monthly intervals may become reinfected and shed eggs between treatments.

Contraindications:

There are no known contraindications to the use of Interceptor Plus.

Warnings:

Not for use in humans. Keep this and all drugs out of the reach of children.

Precautions:

Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention (see Effectiveness).

Prior to administration of Interceptor Plus, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Interceptor Plus is not effective against adult D. immitis.

Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.

Do not use in puppies less than six weeks of age.

Do not use in dogs or puppies less than two pounds of body weight.

The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females. Studies have been performed with milbemycin oxime alone (see Animal Safety).

Information for Owner or Person Treating Animal:

Echinococcus multilocularis and Echinococcus granulosus are tapeworms found in wild canids and domestic dogs. E. multilocularis and E. granulosus can infect humans and cause serious disease (alveolar hydatid disease and hydatid disease, respectively). Owners of dogs living in areas where E. multilocularis or E. granulosus are endemic should be instructed on how to minimize their risk of exposure to these parasites, as well as their dog's risk of exposure. Although Interceptor Plus was 100% effective in laboratory studies in dogs against E. multilocularis and E. granulosus, no studies have been conducted to show that the use of this product will decrease the incidence of alveolar hydatid disease or hydatid disease in humans. Because the prepatent period for E. multilocularis may be as short as 26 days, dogs treated at the labeled monthly intervals may become reinfected and shed eggs between treatments.

Effectiveness:

Heartworm Prevention:

In a well-controlled laboratory study, Interceptor Plus was 100% effective against induced heartworm infections when administered once monthly for 6 consecutive months. In well-controlled laboratory studies, neither one dose nor two consecutive doses of Interceptor Plus provided 100% effectiveness against induced heartworm infections.

Intestinal Nematodes and Cestodes Treatment and Control:

Elimination of the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxocara canis, Toxascaris leonina), whipworm (Trichuris vulpis) and tapeworm (Echinococcus multilocularis, Echinococcus granulosus, Taenia pisiformis and Dipylidium caninum) infections in dogs was demonstrated in well-controlled laboratory studies.

Palatability:

In a field study of 115 dogs offered Interceptor Plus, 108 dogs (94.0%) accepted the product when offered from the hand as if a treat, 1 dog (0.9%) accepted it from the bowl with food, 2 dogs (1.7%) accepted it when it was placed in the dog's mouth, and 4 dogs (3.5%) refused it.

Animal Safety:

Interceptor Plus:

In a repeated dose safety study, 40 ten-week-old puppies (10 per group) were dosed with either a sham dose (0X) or 1, 3, or 5X the maximum label exposure of Interceptor Plus every 14 days for a total of seven treatments. Ataxia, lethargy, and salivation were seen in the 3X and 5X treated dogs following each of the seven doses. Vomiting was seen in all treatment groups but had a higher incidence in the 3X and 5X treatment groups.

In a repeated dose safety study, 64 six-week-old puppies (16 per group) were dosed with either a sham dose (0X) or 1, 3, or 5X the maximum label exposure of Interceptor Plus every 14 days for a total of four treatments. Lethargy was observed in all groups. Ataxia was observed in the three treated groups, including one dog in the 1X treated group. For both lethargy and ataxia the incidence and duration increased in the 3X and 5X groups. These signs were observed during the first 24 hours following treatment. Salivation and tremors were observed in the 3X and 5X treated dogs beginning immediately after dosing and up to six hours post dose. Vomiting was only observed in the 5X treatment group on most, but not all, treatment days.

For Interceptor Plus the maximum exposure based on product dosing is 2.5 mg/kg for milbemycin oxime and 25.1 mg/kg for praziquantel, which is higher than the minimum effective dose used in the safety studies for milbemycin oxime (see below).

Milbemycin Oxime:

Two studies were conducted in heartworm-infected dogs treated with milbemycin oxime. Mild, transient hypersensitivity reactions were observed in dogs with high microfilariae counts (see Precautions).

Safety studies in pregnant dogs demonstrated that doses of 0.6X the maximum exposure dose of Interceptor Plus, (1.5 mg/kg of milbemycin oxime), administered daily from mating through weaning, resulted in measurable concentrations of milbemycin oxime in milk. Puppies nursing these females demonstrated milbemycin oxime-related effects (depression, decreased activity, diarrhea, dehydration, nasal discharge). A subsequent study, which evaluated the daily administration of 0.6X the maximum exposure dose of Interceptor Plus, from mating until one week before weaning, demonstrated no effects on the pregnant females or their litters. A study, in which pregnant females were dosed once, at 0.6X the maximum exposure dose of Interceptor Plus before, on the day of, or shortly after whelping, resulted in no effects on the puppies.

Some nursing puppies, at 2, 4, and 6 weeks of age, administered oral doses of 9.6 mg/kg milbemycin oxime (3.8X the maximum exposure dose of Interceptor Plus) exhibited tremors, vocalization, and ataxia. These effects were all transient and puppies returned to normal within 24 to 48 hours. No effects were observed in puppies administered 0.5 mg/kg milbemycin oxime (minimum label dose).

A rising-dose safety study conducted in rough-coated Collies resulted in ataxia, pyrexia, and periodic recumbency in one of fourteen dogs administered milbemycin oxime at 12.5 mg/kg (5X the maximum exposure dose of Interceptor Plus). Prior to receiving the 12.5 mg/kg dose on day 56 of the study, all animals had undergone a dosing regimen consisting of 2.5 mg/kg milbemycin oxime on day 0, followed by 5.0 mg/kg on day 14, and 10.0 mg/kg on day 32. No adverse reactions were observed in any of the Collies treated with doses less than 12.5 mg/kg.

Storage:

Store at room temperature, between 59° and 77°F (15-25°C).

FAQ

Interceptor Plus is used for the prevention of heartworm disease caused by Dirofilaria immitis, and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis) and adult tapeworm (Taenia pisiformis, Dipylidium canium, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies over 6 weeks in age and weighing over 2 lbs. Prior to administration of Interceptor Plus (milbemycin oxime/praziquantel), dogs should be tested for existing heartworm infections.
Interceptor Plus should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, and 2.28 mg/lb (5 mg/kg) praziquantel. For heartworm prevention, give once monthly for at least 6 months after exposure. Dogs weighing 2-8 lbs should be given one Interceptor Plus chewable tablet (Orange Box) monthly. Dogs weighing 8.1-25 lbs should be given one Interceptor Plus chewable tablet (Green Box) monthly. Dogs weighing 25.1-50 lbs should be given one Interceptor Plus chewable tablet (Yellow Box) monthly. Dogs weighing 50.1-100 lbs should be given one Interceptor Plus chewable tablet (Blue Box) monthly.
The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/lethargy, ataxia, weight loss, convulsions, weakness, and salivation.
Give the missed dose as soon as you remember. Do not give a double dose of the medication.
Contact your veterinarian immediately.
Do not give Interceptor to your pet if your pet is already taking an alternate heartworm medication.
Interceptor Plus should be administered in a manner that encourages your dog to chew, rather than swallow whole. However, we do not expect a difference in the effectiveness of the product if your dog consumes it whole.
You may maintain normal activities and interactions with your dog.

Interceptor Plus is indicated to treat and control intestinal parasite infections of adult hookworms, roundworms, whipworms and tapeworms.* In occasional cases, it is possible that the action of Interceptor Plus in killing the intestinal worms will lead to the dog expelling them in stool. If you have questions, consult your veterinarian for measures you can take to prevent a reinfection of intestinal parasites.

Hookworm (A. caninum), roundworm (T. canis, T. leonina), whipworm (T. vulpis) and tapeworm (T. pisiformis, E. multilocularis, E. granulosus and D. caninum)

Reviews

Review Summary
4.9
25 Reviews
5
92% (23)
4
8% (2)
3
0% (0)
2
0% (0)
1
0% (0)
100% Recommend this product (25 of 25 responses)
By Sabrina
Buzzards Bay, MA
Amazing
March 14, 2020
I could not be happier with entirely pets pharmacy. I have tried other websites and ordered medications for our puppy dog, however this is by far the best. They are diligent on contacting the veterinary office and prompt on sending out the medications for your pet. I will only use this company.
By Deanie
Crossville, Tennessee
Heartworm treatment for new pup
February 9, 2020
Collie pup is starting heartworm prevention and is restricted to interceptor. Great product used on all my collides. Just need to purchase individual pills that coincide with her weight. Entirely Pets has been great. Good prices, great service.
By Maureen
Alsip, Il
Great price.
December 1, 2019
I compared prices for this product and Entirely Pets had the best, plus free shipping and timely delivery.
By Jesse
Sacramento, CA
You dont have to disguise it
October 23, 2019
This medicine is easy to administer. You don't typically need a pill pocket or anything like that, the dogs take it willingly.
By Mark D.
Vancouver Wa
Great service
October 6, 2019
There was a Hiccup with the prescription and the veterinary. They took care of it and got us our order
By Carolyn
Missouri
Interceptor Plus for Dogs 50-100 lbs
August 16, 2019
Have used for years, works well and dogs love the flavor
By Rayna
Prairie du chien, Wisconsin
Priced right and quick
March 22, 2019
Did research to find best price in bulk (12 month quantity), they had the best price for this exact product. The price did change and go up 2 months after ( this purchase) so just know your prices so you get the best deal.
Shipping was very fast. It was like- hello here i am, in your mailbox. This might depend on your vet and how quickly they approve the RX.
By Beth
Madison, CT
Great Product
February 1, 2019
I lobe Interceptor. My German Shepard loves taking his "treats". I've used this product for years with all my pets.
By Susan
Salem, MO
Good price, fast service
January 20, 2019
These chews are much cheaper through Entirely Pets than at my vet's office. I always receive them quickly ..... have never had a delay.
By Susan
Salem, MO
Fast service
January 20, 2019
My dog needed a prescription refill. Entirely Pets handled the transaction efficiently and I received my order quickly.
By Diana B.
Galt
Great Experience
November 22, 2018
You guys are great! This is the second order I have placed with you for heartworm medication. You took care of contacting the vet for a prescription and made the whole experience painless. Shipping was also fast and items arrived as ordered.
By Mindy b.
De Soto MO
Heart Worm Prevention
November 15, 2018
Feel safer knowing that my babies are all protected from heartworms by taking this medication every month!
ProsSame protection as from the more expensive brands at a better price
ConsNone
By Deb H.
Commerce city, co
Awesome
October 26, 2018
The protection for my fur babies is #1 priority. Service was fast,accurate and very affordable. Thank you!
By Lynn
Denver, CO
Would order again
September 23, 2018
Easy to order. Good experience
Merchant Response:We win one pet parent at a time Lynn. We appreciate your order and your time taken to review Interceptor Plus.
By Suzie
Thousand Oaks, CA
She eats them!
August 16, 2018
Although these chews, prescribed by our vet to guard against fleas and heartworm, are not her favorite thing to eat, Missy does eat them.
Merchant Response:Suzie, They say an ounce of prevention is worth a pound of cure. Glad to hear Missy takes her Interceptor Plus medicine. You both take care!
By Liza
Boston
Excellent price for well proven product
July 22, 2018
This is a mainstay product in our household for our dogs. I was very pleased to find it at an excellent price here. The delivery time was so speedy it felt like it was instantaneous!
Merchant Response:Thank you Liza! We will continue to do our be our best. Take care!
By Beedub
Napa, CA
Great service, arrived on time!
July 13, 2018
Everything was perfect except the packaging (not the product though) was somewhat crushed in the shipping process. Excellent pricing as well.
By Chris
Danville, Illinois
Works great
June 10, 2018
I have 2 small dogs and they both take this. We have no issues and both dogs chew it up and swallow it quickly. Never had any trouble with it bit staying down or the dogs acting like they don't feel well with this.
Merchant Response:Hi Chris, Great to hear that Interceptor Plus Green is working well for both your dogs. Hope all is well!
By Steve
IA
Saved Money!
April 27, 2018
Product is the same as from vet. Received when needed. Will order from Entirely Pets again.
ProsSaved money!
ConsNone
By Tammy
IL
Easy purchase
April 13, 2018
Great price and fast shipping!
By Rich
OH
Awesome
March 7, 2018
Great prices and awesome customer service
Cons?
By Dan
Milwaukee
Best product on market
February 21, 2018
1/2 the price of what my vet was charging me.
ConsPrescription paperwork takes time. Would rather be able to order without prescription since I can buy over the counter at my vet without a prescription
By Lee
Cambridge, MA
Wonderful service
December 14, 2017
Buying heart worm meds online was easy, cheaper than buying them from a veterinary practice, and quick. Communication from Entirely Pets Pharmacy was terrific.
ConsThank you for the great feedback Lee! Glad to hear the Interceptor works well for your dog and we were able to save you some money and the hassel at the same time!
By Dock's m.
Waconia, Mn
Great product
August 16, 2017
Entirely Pets Pharmacy was easy to order from and the prices were great. I will definitely order from them in the future.
By Paul
Nathrop CO
Fast Shipping
March 19, 2016
Product delivered quickly

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