Interceptor Plus for Dogs | All Sizes | EntirelyPets Rx
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Interceptor Plus for Dogs

Interceptor Plus for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Interceptor Plus is a prescribed chewable for your dog that prevents against heartworm disease. Unlike other medications, it also treats and protects against 4 other types of worms. Interceptor Plus is also administer with it's palatable chicken flavor and month-long protection.

Medical Use

Protection for your dog against 5 types of worms. Treatment against 4 types of worms.

Key Benefits

  • Prevents heartworm disease
  • Treats and controls hookworms, roundworms, whipworms, and tapeworms
  • No-hassle adminstration with 1 chew per month
  • Delicious chicken flavor


Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Do not use in puppies less than six weeks old. Do not use in dogs or puppies last than two pounds of body weight.

Prescription Required

NADA 141-338


Package Color Milbemycin Oxime Praziquantel
Orange 2.3 mg 22.8 mg
Green 5.75 mg 57 mg
Yellow 11.5 mg 114 mg
Blue 23 mg 228 mg



Interceptor Plus should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, and 2.28 mg/lb (5 mg/kg) praziquantel. For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes


  • The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing.
  • Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.
  • Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the doses have been lost, redosing is recommended.

Quick Tips

  • Interceptor Plus may be offered to the dog by hand or added to a small amount of dog food.
  • Interceptor Plus should be administered at monthly intervals beginning within 1 month of the dog's first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog's last seasonal exposure.
  • Interceptor Plus may be administered year-round without interruption.
  • When switching from another heartworm preventative product to Interceptor Plus, the first dose should be given within a month of the last dose of the former product.

View Interceptor Plus Drug Facts Sheet

Dosage Table

Body WeightNumber of chewables
2 to 8 lbsOne (Orange)
8.1 to 25 lbsOne (Green)
25.1 to 50 lbsOne (Yellow)
50.1 to 100 lbsOne (Blue)
Over 100 lbsAdminister the appropriate combination of chewables

Storage Directions

Store at room temperature, between 59° and 77° F (15-25° F)


Heartworm Prevention

In a well-controlled laboratory study, Interceptor Plus was 100% effective against induced heartworm infections when administered once monthly for 6 consecutive months. In well-controlled laboratory studies, neither one dose nor two consecutive doses of Interceptor Plus provided 100% effectiveness against induced heartworm infections.

Intestinal Nematodes and Cestodes Treatment and Control

Elimination of the adult state of hookworm (Ancylostoma caninum), roundworm (Toxocara canis, Toxascaris leonina), whipworm (Trichuris vulpis) and tapeworm (Echinococcus multilocularis, Echinococcus granulosus, Taenia pisiformis and Dipylidium caninum) infections in dogs was demonstrated in well-controlled laboratory studies.


In a field study of 115 dogs offered Interceptor Plus, 108 dogs (94.0%) accepted the product when offered from the hand as if a treat, 1 dog (0.9%) accepted if from the bowl with food, 2 dogs (1.7%) accepted it when it was placed in the dog's mouth, and 4 dogs (3.5%) refused it.


Not for use in humans. Keep this and all drugs outof the reach of children.


There are no known contraindications.

Possible Side Effects

Vomiting, diarrhea, depression/lethargy, ataxia, anorexia, convulsions, weakness, and salivation.


The Package reads "Chewable". What if my dog swallows the tablet whole?

Interceptor Plus should be administered in a manner that encourages your dog to chew, rather than swallow whole. However, we do not expect a difference in the effectiveness of the product if your dog consumes it whole.

What if I give more than the prescribed amount of Interceptor Plus to my dog?

Contact your veterinarian as soon as possible if you believe your dog has ingested more than the recommended dose of Interceptor Plus. In studies where dogs were dosed at one, three, or five times the maximum dosage, they exhibited signs consistent with avermectin toxicity that followed a dose-related pattern in respect to onset, incidence and duration. Clinical signs included ataxia, decreased activity, tremors, vomiting and salivation.

Should I restrict either my dog's activity or contact with my dog after the tablet is consumed?

You may maintain normal activities and interactions with your dog.

What if I see worms in my dog's stool during the month after administration?

Interceptor Plus is indicated to treat and control intestinal parasite infections of adult hookworms, roundworms, whipworms and tapeworms.* In occasional cases, it is possible that the action of Interceptor Plus in killing the intestinal worms will lead to the dog expelling them in stool. If you have questions, consult your veterinarian for measures you can take to prevent a reinfection of intestinal parasites.

Hookworm (A. caninum), roundworm (T. canis, T. leonina), whipworm (T. vulpis) and tapeworm (T. pisiformis, E. multilocularis, E. granulosus and D. caninum)


Review Summary
25 Reviews
92% (23)
8% (2)
0% (0)
0% (0)
0% (0)
100% Recommend this product (25 of 25 responses)
By Sabrina
Buzzards Bay, MA
March 14, 2020
I could not be happier with entirely pets pharmacy. I have tried other websites and ordered medications for our puppy dog, however this is by far the best. They are diligent on contacting the veterinary office and prompt on sending out the medications for your pet. I will only use this company.
By Deanie
Crossville, Tennessee
Heartworm treatment for new pup
February 9, 2020
Collie pup is starting heartworm prevention and is restricted to interceptor. Great product used on all my collides. Just need to purchase individual pills that coincide with her weight. Entirely Pets has been great. Good prices, great service.
By Maureen
Alsip, Il
Great price.
December 1, 2019
I compared prices for this product and Entirely Pets had the best, plus free shipping and timely delivery.
By Jesse
Sacramento, CA
You dont have to disguise it
October 23, 2019
This medicine is easy to administer. You don't typically need a pill pocket or anything like that, the dogs take it willingly.
By Mark D.
Vancouver Wa
Great service
October 6, 2019
There was a Hiccup with the prescription and the veterinary. They took care of it and got us our order
By Carolyn
Interceptor Plus for Dogs 50-100 lbs
August 16, 2019
Have used for years, works well and dogs love the flavor
By Rayna
Prairie du chien, Wisconsin
Priced right and quick
March 22, 2019
Did research to find best price in bulk (12 month quantity), they had the best price for this exact product. The price did change and go up 2 months after ( this purchase) so just know your prices so you get the best deal.
Shipping was very fast. It was like- hello here i am, in your mailbox. This might depend on your vet and how quickly they approve the RX.
By Beth
Madison, CT
Great Product
February 1, 2019
I lobe Interceptor. My German Shepard loves taking his "treats". I've used this product for years with all my pets.
By Susan
Salem, MO
Good price, fast service
January 20, 2019
These chews are much cheaper through Entirely Pets than at my vet's office. I always receive them quickly ..... have never had a delay.
By Susan
Salem, MO
Fast service
January 20, 2019
My dog needed a prescription refill. Entirely Pets handled the transaction efficiently and I received my order quickly.
By Diana B.
Great Experience
November 22, 2018
You guys are great! This is the second order I have placed with you for heartworm medication. You took care of contacting the vet for a prescription and made the whole experience painless. Shipping was also fast and items arrived as ordered.
By Mindy b.
De Soto MO
Heart Worm Prevention
November 15, 2018
Feel safer knowing that my babies are all protected from heartworms by taking this medication every month!
ProsSame protection as from the more expensive brands at a better price
By Deb H.
Commerce city, co
October 26, 2018
The protection for my fur babies is #1 priority. Service was fast,accurate and very affordable. Thank you!
By Lynn
Denver, CO
Would order again
September 23, 2018
Easy to order. Good experience
Merchant Response:We win one pet parent at a time Lynn. We appreciate your order and your time taken to review Interceptor Plus.
By Suzie
Thousand Oaks, CA
She eats them!
August 16, 2018
Although these chews, prescribed by our vet to guard against fleas and heartworm, are not her favorite thing to eat, Missy does eat them.
Merchant Response:Suzie, They say an ounce of prevention is worth a pound of cure. Glad to hear Missy takes her Interceptor Plus medicine. You both take care!
By Liza
Excellent price for well proven product
July 22, 2018
This is a mainstay product in our household for our dogs. I was very pleased to find it at an excellent price here. The delivery time was so speedy it felt like it was instantaneous!
Merchant Response:Thank you Liza! We will continue to do our be our best. Take care!
By Beedub
Napa, CA
Great service, arrived on time!
July 13, 2018
Everything was perfect except the packaging (not the product though) was somewhat crushed in the shipping process. Excellent pricing as well.
By Chris
Danville, Illinois
Works great
June 10, 2018
I have 2 small dogs and they both take this. We have no issues and both dogs chew it up and swallow it quickly. Never had any trouble with it bit staying down or the dogs acting like they don't feel well with this.
Merchant Response:Hi Chris, Great to hear that Interceptor Plus Green is working well for both your dogs. Hope all is well!
By Steve
Saved Money!
April 27, 2018
Product is the same as from vet. Received when needed. Will order from Entirely Pets again.
ProsSaved money!
By Tammy
Easy purchase
April 13, 2018
Great price and fast shipping!
By Rich
March 7, 2018
Great prices and awesome customer service
By Dan
Best product on market
February 21, 2018
1/2 the price of what my vet was charging me.
ConsPrescription paperwork takes time. Would rather be able to order without prescription since I can buy over the counter at my vet without a prescription
By Lee
Cambridge, MA
Wonderful service
December 14, 2017
Buying heart worm meds online was easy, cheaper than buying them from a veterinary practice, and quick. Communication from Entirely Pets Pharmacy was terrific.
ConsThank you for the great feedback Lee! Glad to hear the Interceptor works well for your dog and we were able to save you some money and the hassel at the same time!
By Dock's m.
Waconia, Mn
Great product
August 16, 2017
Entirely Pets Pharmacy was easy to order from and the prices were great. I will definitely order from them in the future.
By Paul
Nathrop CO
Fast Shipping
March 19, 2016
Product delivered quickly

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