What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
Bravecto Plus for Cats is the first spot-on treatment to give your cat effective defence against fleas, paralysis ticks and heartworm with intestinal worm and ear mite treatment all in one.
|It´s effective and long-lasting Bravecto works fast and provides your pet with long-lasting protection against fleas and paralysis ticks, so you can both be free to explore and life without interruption.|
|It offers peace of mind It's no secret fleas can be a major discomfort for your pet and cause severe irritation. More threatening still, paralysis ticks can be lethal, with just one tick capable of causing death. A single dose of Bravecto provides longer protection than standard monthly doses, so you can enjoy peace of mind with fewer chances to forget a treatment.|
|It's simple and convenient With Bravecto's range of chew and spot-on applications, you can treat your pet the way that suits them best. With just a few easy steps every 2, 3 or 6 months, your pets can continue doing what they love - exploring, playing and getting the most out of life.|
Fluralaner and moxidectin
Bravecto Plus is available in three sizes. The following table indicates the size of pipette to be used according to the body weight of the cat (equivalent to 40-94 mg fluralaner/kg body weight and 2-4.7 mg moxidectin/kg body weight).
Method of Administration:
Step 1: Immediately before use, open the sachet and remove the pipette. The pipette should be held by base or by the upper rigid portion below the cap in an upright position (tip up) for opening it. The twist-and-use cap should be rotated clockwise or counter clockwise one full turn. The cap will stay on the pipette; it is not possible to remove it. The pipette is open and ready for application when the breaking of the seal is felt.
Step 2: The cat should be standing or lying with its back horizontal for easy application. Part hair, place the pipette tip on the base of the skull of the cat.
Step 3: Squeeze the pipette gently at least twice, and apply the entire contents directly to the cat's skin. The product should be applied on cats up to 6.25 kg body weight in one spot at the base of the skull, or two spots in the middle line of the base of the skull on cats greater than 6.25 kg body weight. Ingestion may cause adverse reactions and will remove product from the coat. If multiple cats are treated and amy mutually groom, it is recommended that the cats are separated while product dries.
Not to be used for any purpose, or in any manner, contrary to this label unless authorised under appropriate legislation.
Bravecto Plus contains flualaner, a member of the antiparasitic class of isoxazoline-substituted benzamide derivatives. Fluralaner acts antagonistically on arthropods ligand-gated chloride channels (GABA-receptor and glutamate-receptor).
Bravecto Plus is effective against fipronil-resistant strains of fleas.
Bravecto Plus also contains moxidectin, a member of the milbemycin group of macrocyclic lactones. Milbemycins mode of action is based on the binding of ligand-gated chloride channels. This leads to an increased membrane per meability of nematode and arthropod nerve and/or muscle cells for chloride ions and results in hyperpolarization, paralysis and death of the parasites. Binding of glutamate-gated chloride channels, which are specific to invertebrates and do not exist in mammals, is considered the main mechanism for the anthelmintic and insecticidal activity.
Both fluralaner and moxidectin are readily systemically absorbed from the topical administration site.
Macrocyclic lactones including moxidectin have been shown to be substrates for p-glycoprotein. Therefore, during treatment with Bravecto Plus, other products that can inhibit p-glycoprotein (e.g. cyclosporine, ketoconazole, spinosad, verapamil) should only be used concomitantly according to the benefit/risk assessment of the responsible veterinarian.
Flea Treatment, Control and Prevention
The average flea life cycle lasts 3-8 weeks, and following treatment with Bravecto Plus spot-on the life cycle is broken due to the rapid onset of action and the long-lasting efficacy against adult fleas on the animal and the absence of viable egg production.
The product contributes towards the control of the environmental flea populations in areas to which treated cats have access, by killing newly emerged fleas on a cat before viable eggs are produced.
Bravecto Plus reduces the flea challenge experienced by the animal and aids in the treatment strategy for flea allergy dermatitis.
To obtain maximum flea control, it is recommended that all cats and dogs in the same environment are treated. Cats and dogs may be exposed to fleas when they go outside and they can carry these back into the home
Heartworm Disease Prevention
To ensure continuous prevention of hearworm disease a repetition of treatment is necessary at 2-month intervals. At the time of treatment Bravecto Plus is effective against D.immitis larvae (L2 and L4) which have developed in the previous 30 days and against incoming D.immitis larvae (L3 and L4) for the subsequent 60 days.
Prevention of heartworm disease in cats that are oly temporarily in endemic areas should start at the latest within 1 month after the first expected exposure to mosquitoes and should be continued at 2-month intervals untul return to an non-endemic area.
Fluralaner is part of the isoxazoline family of chemicals. Adverse reaction so this family of chemical are rarely observed but may include vomiting, diarrhea, lethargy, inappetence, itching and very rarely, seizures. Most adverse reactions are self-limiting and of short duration. If you have any concerns, please speak to your veterinarian.
SAFETY DIRECTIONS: Will irritate the eyes, Avoid cotnact with the eyes. If product in eyes, wash it out immediately with water. Wash hands after use.
FIRST AID: If poisoning occurs, contact a doctor or Poisons Information Centre. If skin contact occurs, remove contaminated clothing and wash skin thoroughly.
CONTRAINDICATIONS: Bravecto Plus must not be used in case of hypersensitivity to the active constituents or to any of the excipients.
PRECAUTIONS: Bravecto Plus should not be used on kittens less than 9 weeks of age or cats weighing less than 1.2 kg.
SIDE EFFECTS: Mild and transient skin reactions at the application site may be seen such as flaking skin, itching or har loss. Shortly after application, the following signs were observed in clinical trials, but were uncommon: breathing discomfort after licking the application site, vomiting, vomiting of blood, diarrhea, lethargy, hypersalivation, fever, rapid breathing, and dilated pupils.
Additional User Safety Information
Rehandling Statements Do not contact, or allow children to contact the application site until it is dry; it is therefore recommended to treat the animal in the evening. On the day of treatment, treated animals should not be permitted to sleep with their owner, especially children.
Disposal Dispose immediately of empty pipette, sachet and carton by wrapping in paper and putting in garbage.
Storage Store below 30°C (room temperature). The pipettes should be kept in the sachets to prevent solvent loss or moisture uptake. The sachets should only be opened immediately prior to use.
Bravecto's rapid and persistent protection agains fleas and paralysis ticks is due to its breakthrough molecule: fluralaner. This active ingredient is a unique member of the isoxazoline family, the first new insecticide class in over a decade, and it has no know flea or tick resistance. Once Bravecto Plus is administered, it is readily absorbed transdermally and systemically distributed to provide long-lasting nose-to-toes protection.
Rapid and long-lasting flea control
Bravecto Plus kills 100% of fleas within 12 hours of application.3
Protection against deadly paralysis ticks
Moxidextin is a proven and trusted endoparasiticide of the milbemycin group of macrocyclic lactones. Moxidectin is an agonist (stimulates activity) at ligand-gated chloride channels in the nematode nervous system leadign to hyperpolarisation, paralysis and death of the intestinal worms and heartworms.