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Tri-Heart Plus for Dogs

Tri-Heart Plus for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Tri-Heart Plus for dogs is a heartworm preventative that also controls roundworms and hookworms. Tri-Heart Plus is a generic equivalent to Heartgard Plus, and requires a prescription from your veterinarian. It has the same active ingredients and is the same strength. Tri-Heart Plus is considered to be the #1 generic heartworm preventative recommended by veterinarians.

Key Benefits

  • Tasty flavored chewable tablets
  • Easy to administer
  • Small, easy-to-chew tablet for smaller or finicky dogs
  • Given once a month


Tri-Heart Plus chewable tablets are indicated for use in prevention of canine heartworm caused by Dirofilaria immitis and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) in dogs and in puppies six weeks of age.

How It Works

Tri-Heart Plus is used in the prevention of heartworm infection and the control and treatment of various other worm infections. Tri-Heart Plus contains two active ingredients: ivermectin, which interferes with the parasite's nerve transmission, causing paralysis and death of the immature heartworms (larvae), and Pyrantel pamoate, which also interferes with the parasite's nerve transmission, causes paralysis and death of intestinal worms.

Prescription Required


Active Ingredient Tri-Heart Plus Blue Tri-Heart Plus Green Tri-Heart Plus Brown
Ivermectin 68 mcg 57 mg 136 mcg
Pyrantel 114 mg 272 mcg 227 mg


View Tri-Heart Plus Drug Facts Sheet.

Tri-Heart Plus ivermectin/pyrantel chewable tablets should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Dog Weight Chewable Tablets per Month Ivermectin Content Pyrantel Content Color Coding on Blister Card and Carton
Up to 25 lbs 1 68 mcg 7 mg Blue
26 t0 50 lbs 1 136 mcg 114 mg Green
51 to 100 lbs 1 272 mcg 227 mg Brown
Over 100 lbs Give combination of chewables based on weight

Tri-Heart Plus ivermectin/pyrantel cewable tablets are recommended for dogs 6 weeks of age and older. For dogs over 100 lbs. use the appropriate combination of these tablets.


Remove only one chewable tablet at a time from the blister card. Because most dogs find Tri-Heart Plus chewable tablets palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food or placed in the back of the dog's mouth for forced swallowing.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Tri-Heart Plus chewable tablets should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Tri-Heart Plus chewable tablets must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceed a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many immediate treatment with Tri-Heart Plus chewable tablets and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

Monthly treatment with Tri-Heart Plus Chewable tablets also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.


Tri-Heart Plus chewable tablets given orally sung the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult state. Tri-Heart Plus chewable tablets are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braciliense).


In acceptability trials, Tri-Heart Plus chewable tablets were shown to be a palatable oral dosage form that was consumed at first offering by the majority of dogs.


All dogs should be tested for existing heartworm infection before starting treatment with Tri-Heart Plus chewable tablets which are not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Tri-Heart Plus chewable tablets.

While some microfilariae may be killed by the ivermectin in Tri-Heart Plus chewable tablets at the recommended dose level, Tri-Heart Plus chewable tablets are not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advice concerning cases of ingestion by humans.


Store at controlled room temperature of 59-86° (15-30° C). Protect product from light.

Adverse Reactions:

In clinical field trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of ivermectin at the recommended dose: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level of 6 mcg/kg) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Ivermectin demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies support the safety of ivermectin products in dogs, including Collies, when used as recommended.

Ivermectin/pyrantel has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease preventive program.

In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.


Tri-Heart® Plus flavored chewable tablets are an FDA-licensed product, indicating they are safe and effective when used as recommended on the label. All dogs should be tested for existing heartworm infection before starting treatment with Tri-Heart® Plus.
In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics (deworming medications), antibiotics, vaccines and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease prevention program. For questions about specific medications, please consult your veterinarian.
Ivermectin/pyrantel, the active ingredients in Tri-Heart® Plus, have a wide margin of safety at the recommended dose level in dogs, including pregnant females, breeding males and females, and puppies 6 weeks or older, according to the package insert.
No. Tri-Heart® Plus is labeled for use in dogs to prevent heartworm disease and not for the treatment of heartworm infections. The package insert contains this precautionary statement: "Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Tri-Heart® Plus flavored chewable tablets."
No. Tri-Heart® Plus is not approved for use in cats.
Tri-Heart® Plus flavored chewable tablets can be obtained only by prescription and are available from your veterinarian.
The American Heartworm Society (AHS) is an excellent source of information for both pet owners and veterinarians. Please visit for further details.


Review Summary
24 Reviews
92% (22)
8% (2)
0% (0)
0% (0)
0% (0)
100% Recommend this product (24 of 24 responses)
By Gene I.
Roseville MN
Review for Tri-Heart Plus for Dogs Purchase
April 9, 2015
Your price was the lowest that I found on- line and the product was delivered in a prompt manner. Very satisfied with your on-line pharmacy! I would use your site again for ordering product for my dog. Thanks!
ProsGreat price prompt delivery of product got exactly what I ordered simple ordering process
By Kit
so easy
June 26, 2020
entirely pets made it so easy.
they called vet for prescription and mailed it directly to me!
Prosgood price delivered to your door efficient they keep you posted on order progress
Consplan ahead... it will be a few days to arrive by mail
By Adam L.
Boynton Beach, FL
Easy transaction
June 26, 2020
Good prices. Fast service & delivery. Company contacted vet for Rx. Been using product several years no problems.
By Linda
Good Deal
June 4, 2020
I've used tri heart plus for 5 yrs and like the product. Was a good deal.I like that they offer coupons and using Rakuten saved me even more money. I would shop with EntirelyPets again!
Prosdiscount prices
ConsCommunication between the pharmacy and the Vet needs to be worked on. I shouldn,t have to be the middle man calling the pharmacy looking for my script,
By TerriM
My dogs love it!
March 15, 2020
If you watched them, you might believe I had fed them a treat. They just gobble the pill up! No muss, no fuss!! Thanks.
By Jean
Chester, VT
Less cost than thru local clinic
February 6, 2020
Same product as have been using @ less cost.
By Cheryl
South Carolina
Tri-Heart Plus
January 27, 2020
Great Product
York, Pennsylvania
Great price! Fast shipping!
December 13, 2019
Best price I have found.
By Debi
Great Price
November 29, 2019
Great price. Easy ordering. Timely delivery
By Nicola
Great Price
November 13, 2019
Best price when compared to other online stores!
Merchant Response:Hi Nicola, I would like to personally thank you for ordering with EntirelyPets Pharmacy. We appreciate your business and the opportunity to service you.
By Linda
Wilton, CT
Reasonable Price
October 8, 2019
I had not heard of this brand before, but I hope the product is as effective as some of the more expensive ones.
Best price and service
September 29, 2019
Never have an issue with entirely pets rx program.
By Linda W.
Loved the price
April 5, 2019
Price was great and received so quickly
By Margo
Tri-Heart Plus for dogs
December 27, 2018
Ordering was convenient. They contacted the vet for prescription. delivery of the meds was on time and in good order. Have been doing this for a while now and am happy with the service.
By Brian V.
Tri-Heart Plus For Dogs 51-100#
May 25, 2018
Easy online ordering. Though it's not a normal soft chew medicated treat, my dog enjoyed the taste of the product.
ProsEasy open pkg. Easy to read directions. Dog loves the taste. No mess.
By Lasaandr
Triheart plus for dogs
November 8, 2017
I have been giving it to my dog ever since he had to start. He likes it and gives me no trouble when he takes it. Always good lab reports too.
By Jarred
Boston ma
Heartworm pills
September 27, 2017
Always order here prices are great
By Jo
Denver, Colorado
Great product! Great purchase!
August 23, 2017
Easy to order! EntirelyPets worked directly with my dogs vet to complete the order. My dogs like the product and enjoy with peanut butter! Works great!
By Jo
Denver, Colorado
March 9, 2017
Easy to use and dogs love taking it once a month! Price is right! So much better than the overpriced bigger name brands! Works great! Switched to tri heart years ago and have continued using since. Would highly recommend!
By Mary
Shawnee Mission. KS
Tri-Heart Plus just rightth
April 29, 2016
I've been using this for my 10 lb chihuahua for 5 years. Per a Vet's recommendation, I use a 6 month supply which lasts one year-by dividing each pill in half. It works great! Also, Entirely Pets Pharmacy was the best price on-line! Thanks so much.
By Joan
Sun City, AZ
great product that I trust
April 24, 2016
I have given Tri-Heart Plus to all my dogs for years. It is less expensive than the name brand and staff are great and so patient with the vet offices.
ProsLots of money saving when you treat 3 dogs a month.
By bcollyard
tri-heart plus
April 15, 2016
good price, good product. at least this isn't killing dogs like tri-flexis
By Brian
Fitchburg, MA
Quick and Easy
November 20, 2015
This Heartworm medicine was recommended by my vet and price is 1/3 less than at my Vet's office. The order process was very easy. I placed the order. The pharmacy contacted my Vet and I had the product in a week.
By Angela L.
Philadelphia, PA
September 13, 2015
I liked the fact that they checked with the doctor to make sure what I was ordering was correct, then informed me of suggested change. At that time I also received a reduction of the cost because of the promo E-mail I had received. Good deal!
ProsTaking care to be correct. Fast shipping. Patience over the phone because I am deaf and have a hearing dog.

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