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Tri-Heart Plus for Dogs

Tri-Heart Plus for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Tri-Heart Plus for dogs is a heartworm preventative that also controls roundworms and hookworms. Tri-Heart Plus is a generic equivalent to Heartgard Plus, and requires a prescription from your veterinarian. It has the same active ingredients and is the same strength. Tri-Heart Plus is considered to be the #1 generic heartworm preventative recommended by veterinarians.

Key Benefits

  • Tasty flavored chewable tablets
  • Easy to administer
  • Small, easy-to-chew tablet for smaller or finicky dogs
  • Given once a month


Tri-Heart Plus chewable tablets are indicated for use in prevention of canine heartworm caused by Dirofilaria immitis and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) in dogs and in puppies six weeks of age.

How It Works

Tri-Heart Plus is used in the prevention of heartworm infection and the control and treatment of various other worm infections. Tri-Heart Plus contains two active ingredients: ivermectin, which interferes with the parasite's nerve transmission, causing paralysis and death of the immature heartworms (larvae), and Pyrantel pamoate, which also interferes with the parasite's nerve transmission, causes paralysis and death of intestinal worms.


Active Ingredient Tri-Heart Plus Blue Tri-Heart Plus Green Tri-Heart Plus Brown
Ivermectin 68 mcg 57 mg 136 mcg
Pyrantel 114 mg 272 mcg 227 mg


View Tri-Heart Plus Drug Facts Sheet.

Tri-Heart Plus ivermectin/pyrantel chewable tablets should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Dog Weight Chewable Tablets per Month Ivermectin Content Pyrantel Content Color Coding on Blister Card and Carton
Up to 25 lbs 1 68 mcg 7 mg Blue
26 t0 50 lbs 1 136 mcg 114 mg Green
51 to 100 lbs 1 272 mcg 227 mg Brown
Over 100 lbs Give combination of chewables based on weight

Tri-Heart Plus ivermectin/pyrantel cewable tablets are recommended for dogs 6 weeks of age and older. For dogs over 100 lbs. use the appropriate combination of these tablets.


Remove only one chewable tablet at a time from the blister card. Because most dogs find Tri-Heart Plus chewable tablets palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food or placed in the back of the dog's mouth for forced swallowing.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Tri-Heart Plus chewable tablets should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Tri-Heart Plus chewable tablets must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceed a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many immediate treatment with Tri-Heart Plus chewable tablets and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

Monthly treatment with Tri-Heart Plus Chewable tablets also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.


Tri-Heart Plus chewable tablets given orally sung the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult state. Tri-Heart Plus chewable tablets are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braciliense).


In acceptability trials, Tri-Heart Plus chewable tablets were shown to be a palatable oral dosage form that was consumed at first offering by the majority of dogs.


All dogs should be tested for existing heartworm infection before starting treatment with Tri-Heart Plus chewable tablets which are not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Tri-Heart Plus chewable tablets.

While some microfilariae may be killed by the ivermectin in Tri-Heart Plus chewable tablets at the recommended dose level, Tri-Heart Plus chewable tablets are not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advice concerning cases of ingestion by humans.


Store at controlled room temperature of 59-86° (15-30° C). Protect product from light.

Adverse Reactions:

In clinical field trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of ivermectin at the recommended dose: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level of 6 mcg/kg) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Ivermectin demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies support the safety of ivermectin products in dogs, including Collies, when used as recommended.

Ivermectin/pyrantel has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease preventive program.

In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.


Tri-Heart® Plus flavored chewable tablets are an FDA-licensed product, indicating they are safe and effective when used as recommended on the label. All dogs should be tested for existing heartworm infection before starting treatment with Tri-Heart® Plus.
In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics (deworming medications), antibiotics, vaccines and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease prevention program. For questions about specific medications, please consult your veterinarian.
Ivermectin/pyrantel, the active ingredients in Tri-Heart® Plus, have a wide margin of safety at the recommended dose level in dogs, including pregnant females, breeding males and females, and puppies 6 weeks or older, according to the package insert.
No. Tri-Heart® Plus is labeled for use in dogs to prevent heartworm disease and not for the treatment of heartworm infections. The package insert contains this precautionary statement: "Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Tri-Heart® Plus flavored chewable tablets."
No. Tri-Heart® Plus is not approved for use in cats.
Tri-Heart® Plus flavored chewable tablets can be obtained only by prescription and are available from your veterinarian.
The American Heartworm Society (AHS) is an excellent source of information for both pet owners and veterinarians. Please visit for further details.


Review Summary
48 Reviews
81% (39)
15% (7)
4% (2)
0% (0)
0% (0)
98% Recommend this product (47 of 48 responses)
By Lisa
Willow Grove, PA
Fantastic Experience!
October 26, 2020
I have used several online pharmacies for my pets and, without a doubt, these folks are the best! Since we have several dogs and a cat, buying from the vet is definitely not feasible. I'm so happy I found Entirely Pets Pharmacy! They send a request to my vet and within a day or two (no supposed Covid delays like some places) they contacted me that my order was being processed and then shipped- easy as that! Not only are their prices the best I've found, but their customer support is excellent.

Merchant Response:Lisa, this review warms our hearts and is motivation for us to continue on! We have some big improvements coming in the near future to help get more orders out more quickly and an even better customer expereicne. Thanks for being a great customer. Thanks for sharing pictures of your fur babies, they are cute!
ProsLow Cost Easy Ordering Fast shipping
ConsHaven't found any yet and about to place my 3rd order!
By Gene I.
Roseville MN
Review for Tri-Heart Plus for Dogs Purchase
April 9, 2015
Your price was the lowest that I found on- line and the product was delivered in a prompt manner. Very satisfied with your on-line pharmacy! I would use your site again for ordering product for my dog. Thanks!
ProsGreat price prompt delivery of product got exactly what I ordered simple ordering process
By Yankey
Really good
April 19, 2021
My dog does really well on this product
By Brian R.
Marshallton, DE
Hard to navigate web site
March 23, 2021
Couldn’t get order processed through web site on numerous occasions, never got email customer service said I would get
Merchant Response:Brian, we are taking steps to improve our site navigation. Thank you for your feedback. At this time, our notification emails are nearly all online and working again. System upgrades have had some bugs. Your next order will be better-taken care of.
By Julie L.
Great product
March 6, 2021
Very nice people but they were updating their system & we were told it was coming on a weds.... they hadnt even sent it yet. one week later it shows up- they waited 1 week bbefore sending it to us .. so the communication is bad with entirely pets
Merchant Response:Hi Julie, Very true. We were having some growing pains. All new pharmacy and shipping software lead to some delays. The team here worked overtime to work through the bugs. Hope to have you back for your next order. Take care.
Prosgreat products --- comparable prices
Conswe have ordered 2 times from them... took more than 2 weeks because it wasnt sent for over a week each time...very slow in filling orders...
By Ange
Entirely Pleased
February 28, 2021
This is my first order with this company and my first trial of Tri-Heart Plus. I usually use Heartgard but my vet doesn't carry it anymore so he wanted me to try Interceptor. My chihuahua has had reactions to several medications so I'm cautious as to what I give her. After giving her the Interceptor for 2 months, each time she would be listless for a few days, just not her usual self.
So I found this med. I checked the ingredients (the same ingredients and same amount) as the Heartgard, it had good reviews and a great price. I consulted with my vet. He agreed to authorize the prescription for Tri-Heart Plus and I am "entirely pleased."
I will be reordering.
ProsSame medication as the Heartgard Great savings on the price
ConsMy dog wouldn't chew the pill. I had to break it in pieces and add to peanut butter. I would really prefer a chewable treat option, but at this price I'm not going to complain.
By john P.
great transaction by entirely pets
January 24, 2021
excellent transaction from start to finish
By Mari
December 23, 2020
This med did not come in a package altogether, rather in packs and parts of packs with different dates. One was labeled, Use First.
I don 't like this and in the future, want an entire pack with same dates on all tabs.
ProsMed itself seems OK.
By Joyce
Porter, Tx
Tri-Heart Plus for dogs
November 15, 2020
Great value. Very fast delivery, I ordered on Friday and received product on Monday.
By Diana
Lexington, KY
Good Product
November 11, 2020
I treat all my dogs with Tri-Heart Plus and every vet visit confirms, it works :)
By Ellen
Great finding this online pet supply
October 29, 2020
perfect for our dog and great delivery
By Eric
Central Fl
Works, our Yorkie eats it without problem
October 19, 2020
I'm a bit of a pragmatist... first, the product has to work, and while this product doesn't do flea's, it DOES do much more than the standard heartworm / flea combo chew at a much better price.

So, after years of buying the other, I switched to this and a separate flea treatment. Could be happier. Second biggie is will she eat it and does it have any adverse effects? Our Yorkie eats it without fuss, no side effects, and she is well protected.

Very happy with Tri-Heart and highly recommend.
ProsBroad spectrum protection Dog likes taste Price
ConsDoesn't have Flea/tick protection (but not really a con, when you work out the price)
By Dog l.
Chapel Hill, North Carolina
Excellent product
October 14, 2020
I have been using this product for years and have been very pleased with the protection it has given my dogs. The price was good and having it delivered is a plus.
By Kelly
DE Forest, Wi
Best price
August 20, 2020
The price is excellent!
Merchant Response:Hi Kelly, We are always finding ways to increase our shipping speed. Thanks for being a great customer.
ConsI think shipping could be a little faster
By Dog l.
Washoe Valley Nevada
Does the trick
August 19, 2020
I purchase Tri-heart plus for my dogs and it works well. Fast shipping and reasonable price.
By Marianne
Chino Hills,California
Fast delivery
August 19, 2020
Quick delivery
By Tammy D.
San Antonio, Texas
Fast ship & great price
August 12, 2020
They sent the prescription to my vet right away. I was very pleased with the speed of this and shipping. I always find the best prices on EntirelyPets, both the pharmacy items and regular product. Thank you!
By Shirley
Clarkesville, GA
A Big Thumbs Up
July 31, 2020
Fast efficient service and great prices
By Melody
Tri-Heart Plus
July 25, 2020
I've been giving my boy this for over 6 months now. He devours the "treat", so I guess it tastes good to him! I like the fact that the ingredients are identical to Heartgard plus, but this is more affordable for me. Shipping was reasonably quick after getting authorization from the vet. This is a great product.

Merchant Response:Melody, you have a very cute dog!
ProsAffordable, tasty
By Kit
so easy
June 26, 2020
entirely pets made it so easy.
they called vet for prescription and mailed it directly to me!
Prosgood price delivered to your door efficient they keep you posted on order progress
Consplan ahead... it will be a few days to arrive by mail
By Adam L.
Boynton Beach, FL
Easy transaction
June 26, 2020
Good prices. Fast service & delivery. Company contacted vet for Rx. Been using product several years no problems.
By Donna F.
Edison nj
June 21, 2020
Have been using for years great price
By Linda
Gatlinburg, TN
May 2020 Pet Meds Order
June 11, 2020
Given the negative reviews, I was worried about ordering from Entirely Pets Pharmacy. I'm glad I decided to give them a chance. The process was seamless, the expiration dates on ALL the meds was fantastic - over a year, my order was received in just a few days, and best of all, I got the price offered on the entire Internet. No one can ask for more.
Thanks - Entirely Pets !!!!!!!
By Linda
Gatlinburg, TN
May 2020 Order
June 11, 2020
Given the negative reviews, I was worried about ordering from Entirely Pets Pharmacy. I'm glad I decided to give them a chance. The process was seamless, my order was received in just a few days, and best of all, I got the price offered on the entire Internet. No one can ask for more. Thanks - Entirely Pets !!!!!!!
By Linda
Good Deal
June 4, 2020
I've used tri heart plus for 5 yrs and like the product. Was a good deal.I like that they offer coupons and using Rakuten saved me even more money. I would shop with EntirelyPets again!
Prosdiscount prices
ConsCommunication between the pharmacy and the Vet needs to be worked on. I shouldn,t have to be the middle man calling the pharmacy looking for my script,
By Richard
Cadillac, Michigan
Quality product at a reasonable price.
May 17, 2020
A simple, quality product to prevent heartworm at a reasonable price.
ProsSimple, reasonable price.
ConsWhile the price was reasonable, I still feel it is a bit too high.
By Lisa
Tri -Heart Plus for extra large dogs
May 7, 2020
This is a great product! The generic version is less expensive and hopefully will work as well as the Advantix product. Easy transaction and fast shipping.
By susan
Fallsington, PA
April 13, 2020
Same ingredients and less expensive than anywhere else! Dogs eat it just like it's a treat ! Won't buy any other brand !
By TerriM
My dogs love it!
March 15, 2020
If you watched them, you might believe I had fed them a treat. They just gobble the pill up! No muss, no fuss!! Thanks.
By Jean
Chester, VT
Less cost than thru local clinic
February 6, 2020
Same product as have been using @ less cost.

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