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Tri-Heart Plus for Dogs

Tri-Heart Plus for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Tri-Heart Plus Chewable Tablets for Dogs are a monthly heartworm preventive medication that also provides protection against certain intestinal parasites. These flavored chewable tablets are easy to administer, making them a convenient option for dog owners. Tri-Heart Plus contains two active ingredients, Ivermectin and Pyrantel, which work together to prevent heartworm disease and treat and control roundworm and hookworm infections in dogs. Tri-Heart Plus Chewable Tablets are available in different strengths for dogs of various sizes and should be given once a month, as directed by a veterinarian.

Key Features:

  • Heartworm Prevention: Tri-Heart Plus Chewable Tablets prevent heartworm disease in dogs.
  • Intestinal Parasite Control: Tri-Heart Plus also treats and controls roundworm and hookworm infections in dogs.
  • Flavored Chewable Tablets: The tablets are flavored, making them palatable and easy to administer.
  • Monthly Administration: Tri-Heart Plus Chewable Tablets are given once a month, which helps ensure continuous protection against heartworms and intestinal parasites.
  • Active Ingredients: Contains Ivermectin and Pyrantel, which work together to prevent heartworm disease and control intestinal parasites.


  • Prevention of heartworm disease: Tri-Heart Plus is primarily used to prevent heartworm disease in dogs. It kills the immature stages of heartworm larvae (Dirofilaria immitis) that are transmitted by mosquitoes. By preventing the development of adult heartworms, Tri-Heart Plus helps protect dogs from the potentially serious and life-threatening consequences of heartworm infection.
  • Control of roundworms: Tri-Heart Plus is effective in controlling and treating infections caused by the roundworm species Toxocara canis and Toxascaris leonina. Roundworms are common intestinal parasites that can be found in dogs, especially puppies. Tri-Heart Plus helps eliminate roundworms and prevents reinfestation.
  • Control of hookworms: Tri-Heart Plus also provides control and treatment for hookworm infections in dogs. The hookworm species Ancylostoma caninum and Uncinaria stenocephala can cause intestinal damage, anemia, and other health problems in dogs. Tri-Heart Plus helps eliminate hookworms and reduces the risk of infection.

It's important to note that Tri-Heart Plus is a prescription medication, and the specific indications and dosage may vary based on factors such as the dog's weight, age, and health status. Always consult with your veterinarian to determine the appropriate use of Tri-Heart Plus for your dog and to receive accurate dosing instructions.

How it works:

Tri-Heart Plus works by combining two active ingredients, ivermectin and pyrantel pamoate, to provide its preventive and therapeutic effects against heartworms, roundworms, and hookworms.

  1. Ivermectin: Ivermectin is a broad-spectrum antiparasitic agent that belongs to the class of drugs known as avermectins. It works by interfering with the nervous system of the parasites, leading to their paralysis and death. In the case of heartworms, ivermectin kills the immature stages (larvae) of the heartworms transmitted to dogs through mosquito bites. It prevents the larvae from maturing into adult worms that can cause serious health issues.
  2. Pyrantel pamoate: Pyrantel pamoate is an anthelmintic medication that specifically targets roundworms and hookworms. It works by paralyzing the worms' neuromuscular system, causing them to be expelled from the dog's body through normal bowel movements. Pyrantel pamoate is effective against both adult worms and the larval stages of these intestinal parasites.

By combining these two active ingredients, Tri-Heart Plus provides comprehensive protection against heartworms, roundworms, and hookworms. It eliminates existing parasite infections and prevents new infestations, reducing the risk of associated health problems in dogs.

It's important to note that Tri-Heart Plus is administered orally as a flavored chewable tablet. The active ingredients are absorbed into the dog's bloodstream and distributed throughout the body to target the parasites. Regular monthly administration of Tri-Heart Plus helps maintain continuous protection against these parasites and is an essential part of a comprehensive parasite prevention program recommended by veterinarians.


Active Ingredient Tri-Heart Plus Blue Tri-Heart Plus Green Tri-Heart Plus Brown
Ivermectin 68 mcg 57 mg 136 mcg
Pyrantel 114 mg 272 mcg 227 mg


View Tri-Heart Plus Drug Facts Sheet.

Tri-Heart Plus ivermectin/pyrantel chewable tablets should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Dog Weight Chewable Tablets per Month Ivermectin Content Pyrantel Content Color Coding on Blister Card and Carton
Up to 25 lbs 1 68 mcg 7 mg Blue
26 t0 50 lbs 1 136 mcg 114 mg Green
51 to 100 lbs 1 272 mcg 227 mg Brown
Over 100 lbs Give combination of chewables based on weight

Tri-Heart Plus ivermectin/pyrantel cewable tablets are recommended for dogs 6 weeks of age and older. For dogs over 100 lbs. use the appropriate combination of these tablets.


Remove only one chewable tablet at a time from the blister card. Because most dogs find Tri-Heart Plus chewable tablets palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food or placed in the back of the dog's mouth for forced swallowing.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Tri-Heart Plus chewable tablets should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Tri-Heart Plus chewable tablets must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceed a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many immediate treatment with Tri-Heart Plus chewable tablets and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

Monthly treatment with Tri-Heart Plus Chewable tablets also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.


Tri-Heart Plus chewable tablets given orally sung the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult state. Tri-Heart Plus chewable tablets are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braciliense).


In acceptability trials, Tri-Heart Plus chewable tablets were shown to be a palatable oral dosage form that was consumed at first offering by the majority of dogs.


All dogs should be tested for existing heartworm infection before starting treatment with Tri-Heart Plus chewable tablets which are not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Tri-Heart Plus chewable tablets.

While some microfilariae may be killed by the ivermectin in Tri-Heart Plus chewable tablets at the recommended dose level, Tri-Heart Plus chewable tablets are not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advice concerning cases of ingestion by humans.


Store at controlled room temperature of 59-86° (15-30° C). Protect product from light.

Adverse Reactions:

In clinical field trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of ivermectin at the recommended dose: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level of 6 mcg/kg) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Ivermectin demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies support the safety of ivermectin products in dogs, including Collies, when used as recommended.

Ivermectin/pyrantel has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease preventive program.

In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.


Tri-Heart® Plus flavored chewable tablets are an FDA-licensed product, indicating they are safe and effective when used as recommended on the label. All dogs should be tested for existing heartworm infection before starting treatment with Tri-Heart® Plus.
In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics (deworming medications), antibiotics, vaccines and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease prevention program. For questions about specific medications, please consult your veterinarian.
Ivermectin/pyrantel, the active ingredients in Tri-Heart® Plus, have a wide margin of safety at the recommended dose level in dogs, including pregnant females, breeding males and females, and puppies 6 weeks or older, according to the package insert.
No. Tri-Heart® Plus is labeled for use in dogs to prevent heartworm disease and not for the treatment of heartworm infections. The package insert contains this precautionary statement: "Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Tri-Heart® Plus flavored chewable tablets."
No. Tri-Heart® Plus is not approved for use in cats.
Tri-Heart® Plus flavored chewable tablets can be obtained only by prescription and are available from your veterinarian.
The American Heartworm Society (AHS) is an excellent source of information for both pet owners and veterinarians. Please visit for further details.


Review Summary
82 Reviews
82% (67)
13% (11)
2% (2)
0% (0)
2% (2)
96% Recommend this product (79 of 82 responses)
By Lisa
Willow Grove, PA
Fantastic Experience!
October 26, 2020
I have used several online pharmacies for my pets and, without a doubt, these folks are the best! Since we have several dogs and a cat, buying from the vet is definitely not feasible. I'm so happy I found Entirely Pets Pharmacy! They send a request to my vet and within a day or two (no supposed Covid delays like some places) they contacted me that my order was being processed and then shipped- easy as that! Not only are their prices the best I've found, but their customer support is excellent.

Merchant Response:Lisa, this review warms our hearts and is motivation for us to continue on! We have some big improvements coming in the near future to help get more orders out more quickly and an even better customer expereicne. Thanks for being a great customer. Thanks for sharing pictures of your fur babies, they are cute!
  • Low Cost
  • Easy Ordering
  • Fast shipping
  • Haven't found any yet and about to place my 3rd order!
By Gene I.
Roseville MN
Review for Tri-Heart Plus for Dogs Purchase
April 9, 2015
Your price was the lowest that I found on- line and the product was delivered in a prompt manner. Very satisfied with your on-line pharmacy! I would use your site again for ordering product for my dog. Thanks!
  • Great price
  • prompt delivery of product
  • got exactly what I ordered
  • simple ordering process
  • none
By Adam L.
Boynton Beach FL
Good Product Good Pharmacy
July 18, 2024
I have been using this facility for a few yrs now. They are professional, responsible, thorough and always reliable. Prices are good.

The product is my go to for what I use it for. Purchasing the generic brand has never given my puppy & I any issues, @ a fraction of the cost. I have been using it for many yrs now (my furbaby is 16) & wouldn’t consider anything else
By Buster
south FL
same stuff, much lower price !
June 19, 2024
Very Good
By Mark
June 16, 2024
Will be using someone else,
  • Thought being this close to Cal. we, in Az.,
  • would be a little more reasonable. Pet
  • gets 3.50 per pill. We ordered a 12 month
  • supply from them.
By Wendy A.
High Ridge, MO
Affordable & It Works!
June 1, 2024
My dog's 'name brand' heart worm medicine was getting way too expensive. It's great to know that you can purchase Tri-Heart Plus at a much lower price & with the confidence that it contains the same active ingredients as the name brand. My German Shepherd Dog loves the taste & chews them without hesitation.
By Gr33n T.
High Rockies, CO
Good medicine
May 28, 2024
Works great
By Louie
Coe Lake , Berea, OH
Timely Refill
May 23, 2024
Online service for ordering was easy to navigate.
  • -easy online procedure
  • - timely arrival w:in 1 week for regular shipping
By Michael O.
May 14, 2024
By BAtkinson
Peoria, IL
Excellent savings for heartworm protection
April 26, 2024
Finally an affordable product for heartworm prevention. I have 4 dogs so this is such a budget friendly option to protect my babies. I have only 1 dog who doesn't like the dry chewable tablet but grinding it up and putting it in wet food solves that issue.
Excellent Service
April 19, 2024
Easy to order, quick response.
By Michelle
Great product
April 18, 2024
Work as good as the other brand
By V R.
Happy customer!
April 2, 2024
Purchase processed very quickly and happy with contact updates!
By Melissa
Hebron, Kentucky
Good buy!
March 15, 2024
Better pricing than elsewhere; they took care of contacting my vet for the prescription; kept me updated on status of my order; received in timely manner; will definitely purchase from this company again.

Merchant Response:It's a lot of work to get all the proper Rx approvals, we are pleased to hear you like the pricing and our service.
By Theresa
DeLand, Florida
Great product
February 23, 2024
Love it! It's a small pill instead of a large chew my dog dislikes.
By Theresa
DeLand, Florida
Great product!
February 23, 2024
Love that it is a small pill! So much easier than the chews that my dog hates.
By Amy
Cincinnati, Ohio
Great Customer Service
January 23, 2024
The veterinarian office was difficult to get in touch due to the Holiday's. However, Entirely Pets kept reaching out until the prescription was filled. Appreciate their work in completing this order.
By Jaynie
St. Simons Island, GA
Effective economical product for my pups!
January 6, 2024
Tri-Heart is an effective and economical alternative to other heartworm prevention products. I break up the tablets into two or four pieces, put them in bread or cheese, and my Jack Russell/Dachshund mixes readily eat the medication. I've given the medication to them for 6 months, and they've tolerated it without any issue.
  • Effective, economical, no issues tolerating it.
  • None of which I am aware.
By Donna
East Rochester. N Y
Triheart plus
December 23, 2023
I use this monthly for my two small dogs.They seem to like the taste as they take it eagerly 🐾🐾The price is good and auto ship great as it arrives on time and I don’t have to keep track of when to order 😕win win situation 👍
By Gus's M.
Fast and easy ordering process.
December 13, 2023
My first experience ordering from EntirelyPets was very good. I switched vets recently and they were diligent in getting the authorization needed for the prescription. The price was good and the order came quickly. Will definitely use them again.
By Eileen F.
Tri-Heart Plus
October 12, 2023
Only 2 tablets? For price & shipping cost will NOT use this pet pharmacy again!
By Margarita
Miami, fl
Very good product
June 14, 2023
Very good product and price
By Deborah
North Carolina
Quality Product at Excellent Price
May 17, 2023
We've typically ordered products for our dog from one supplier; however, because of rising prices, I decided to compare prices across the internet before placing the last order. EntirelyPets Pharmacy, without a doubt, has the absolute best prices. Website is easy to navigate and shipping was quick.
By DoxieMom
March 8, 2023
Happy to find a product to fit our needs for a good price! With small dog going with us on a cross country road trip to the South East, we needed protection against heart worm for a month only. It was perfect to be able to purchase in smaller quantity! Also, customer service was great, shipping prompt!
Thank you!
  • Much less expensive than many other brands!
By Candice
Houston, TX
Give all my docs this product!
February 17, 2023
Great product. Great service. Very timely delivery.
By Helen
October 2, 2022
very nice and pleasant
By Carol
Very Happy
May 1, 2022
I have been very happy with this product in the past, with my 1st rescue dog. I have a new rescue so I ordered her some Tri-Heart. It was a good price and arrived in a short time.
Big pill can be broken into pieces
March 17, 2022
I like that the pill can be broken into smaller pieces so my dog won’t try to swallow a big pill and choke on it. And my dog takes it like a treat. I also like that the back of the box has a calendar to keep track monthly.
  • Pill can be broken into pieces
  • Calendar on the box to keep track monthly
By Yvonne
Great product
February 26, 2022
Price is good and my dogs are protected
By Stephie
Plant City, FL
Tri-Heart Plus for Dogs
February 18, 2022
Good Product, Good Price. Wish it came with softer tablet, but if did it would probably be more expensive like Heart Gard.

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