Tri-Heart Plus for Dogs | On Sale | EntirelyPets Rx
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Tri-Heart Plus for Dogs

Tri-Heart Plus for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Tri Heart Plus for dogs comes in chewable tablets. Each chewable tablet contains Tri Heart Plus for dogs comes in chewable tablets. Each chewable tablet contains 68 mcg ivermectin and 57 mg pyrantel as pamoate salt. Administer once a month to prevent heartworm disease and to treat and control ascarid and hookworm infections in dogs. as pamoate salt. Administer once a month to prevent heartworm disease and to treat and control ascarid and hookworm infections in dogs.

For: Dogs and puppies over 6 weeks of age. Safe for pregnant/breeding females.

Key Benefits

  • Tasty medicine used for both heartworm prevention and intestinal worming
  • Economical heartworm medication with the same active ingredients as Heartgard Plus
  • Give year round for complete protection

How It Works

Tri-Heart Plus is used in the prevention of heartworm infection and the control and treatment of various other worm infections. Tri-Heart Plus contains two active ingredients: ivermectin, which interferes with the parasite's nerve transmission, causing paralysis and death of the immature heartworms (larvae), and Pyrantel pamoate, which also interferes with the parasite's nerve transmission, causes paralysis and death of intestinal worms.

Prescription Required

ANADA 200-338


Active IngredientTri-Heart Plus BlueTri-Heart Plus GreenTri-Heart Plus Brown
Ivermectin 68 mcg136 mcg272 mcg
Pyrantel57 mg114 mg227 mg


Tri-Heart® Plus ivermectin/pyrantel chewable tablets should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg / lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg / lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

View Tri-Heart Plus Drug Facts Sheet.


Remove only one chewable tablet at a time from the blister card. Because most dogs find Tri-Heart® Plus chewable tablets palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food or placed in the back of the dog's mouth for forced swallowing.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the doses have been lost, redosing is recommended.

Dosage Table

Up to 25 lbsGive 1 chewable every month (Tri-Heart Plus Blue)
26-50 lbsGive 1 chewable every month (Tri-Heart Plus Green)
51-100 lbsGive 1 chewable every month (Tri-Heart Plus Brown)
Over 100 lbsGive combination of chewables based on weight

Additional Info

Tri-Heart® Plus chewable tablets should be given at monthly intervals during the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Tri-Heart® Plus chewable tablets must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Tri-Heart® Plus chewable tablets and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

Monthly treatment with Tri-Heart® Plus chewable tablets also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braxiliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.


What happens if I miss giving a dose?

If a dose is missed and over 30 days have gone by since the last dose, give Tri-Heart Plus immediately and resume a monthly dosing schedule. Tell your veterinarian that a dose was missed.

What happens if I overdose my pet?

If you know or suspect your pet has had an overdose, or if you observe diarrhea, vomiting, incoordination, convulsions or drooling, contact your veterinarian immediately.

What should I avoid while giving Tri-Heart Plus?

Although there are no known drug or food interactions with this medication, consult with your veterinarian before using Tri-Heart Plus with any other medications, including vitamins and supplements, since interactions may occur.

What are the possible side effects of Tri-Heart Plus?

Side effects of Tri-Heart Plus are very rare but may include vomiting and diarrhea. Even more uncommon are incoordination, convulsions, or drooling. Contact your veterinarian if you observe any of these side effects.


Review Summary
21 Reviews
95% (20)
5% (1)
0% (0)
0% (0)
0% (0)
100% Recommend this product (21 of 21 responses)
By Gene I.
Roseville MN
Review for Tri-Heart Plus for Dogs Purchase
April 9, 2015
Your price was the lowest that I found on- line and the product was delivered in a prompt manner. Very satisfied with your on-line pharmacy! I would use your site again for ordering product for my dog. Thanks!
ProsGreat price prompt delivery of product got exactly what I ordered simple ordering process
By TerriM
My dogs love it!
March 15, 2020
If you watched them, you might believe I had fed them a treat. They just gobble the pill up! No muss, no fuss!! Thanks.
By Jean
Chester, VT
Less cost than thru local clinic
February 6, 2020
Same product as have been using @ less cost.
By Cheryl
South Carolina
Tri-Heart Plus
January 27, 2020
Great Product
York, Pennsylvania
Great price! Fast shipping!
December 13, 2019
Best price I have found.
By Debi
Great Price
November 29, 2019
Great price. Easy ordering. Timely delivery
By Nicola
Great Price
November 13, 2019
Best price when compared to other online stores!
Merchant Response:Hi Nicola, I would like to personally thank you for ordering with EntirelyPets Pharmacy. We appreciate your business and the opportunity to service you.
By Linda
Wilton, CT
Reasonable Price
October 8, 2019
I had not heard of this brand before, but I hope the product is as effective as some of the more expensive ones.
Best price and service
September 29, 2019
Never have an issue with entirely pets rx program.
By Linda W.
Loved the price
April 5, 2019
Price was great and received so quickly
By Margo
Tri-Heart Plus for dogs
December 27, 2018
Ordering was convenient. They contacted the vet for prescription. delivery of the meds was on time and in good order. Have been doing this for a while now and am happy with the service.
By Brian V.
Tri-Heart Plus For Dogs 51-100#
May 25, 2018
Easy online ordering. Though it's not a normal soft chew medicated treat, my dog enjoyed the taste of the product.
ProsEasy open pkg. Easy to read directions. Dog loves the taste. No mess.
By Lasaandr
Triheart plus for dogs
November 8, 2017
I have been giving it to my dog ever since he had to start. He likes it and gives me no trouble when he takes it. Always good lab reports too.
By Jarred
Boston ma
Heartworm pills
September 27, 2017
Always order here prices are great
By Jo
Denver, Colorado
Great product! Great purchase!
August 23, 2017
Easy to order! EntirelyPets worked directly with my dogs vet to complete the order. My dogs like the product and enjoy with peanut butter! Works great!
By Jo
Denver, Colorado
March 9, 2017
Easy to use and dogs love taking it once a month! Price is right! So much better than the overpriced bigger name brands! Works great! Switched to tri heart years ago and have continued using since. Would highly recommend!
By Mary
Shawnee Mission. KS
Tri-Heart Plus just rightth
April 29, 2016
I've been using this for my 10 lb chihuahua for 5 years. Per a Vet's recommendation, I use a 6 month supply which lasts one year-by dividing each pill in half. It works great! Also, Entirely Pets Pharmacy was the best price on-line! Thanks so much.
By Joan
Sun City, AZ
great product that I trust
April 24, 2016
I have given Tri-Heart Plus to all my dogs for years. It is less expensive than the name brand and staff are great and so patient with the vet offices.
ProsLots of money saving when you treat 3 dogs a month.
By bcollyard
tri-heart plus
April 15, 2016
good price, good product. at least this isn't killing dogs like tri-flexis
By Brian
Fitchburg, MA
Quick and Easy
November 20, 2015
This Heartworm medicine was recommended by my vet and price is 1/3 less than at my Vet's office. The order process was very easy. I placed the order. The pharmacy contacted my Vet and I had the product in a week.
By Angela L.
Philadelphia, PA
September 13, 2015
I liked the fact that they checked with the doctor to make sure what I was ordering was correct, then informed me of suggested change. At that time I also received a reduction of the cost because of the promo E-mail I had received. Good deal!
ProsTaking care to be correct. Fast shipping. Patience over the phone because I am deaf and have a hearing dog.

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