Prascend Tablets for Horses | EntirelyPets Pharmacy
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Prascend Tablets for Horses

Prascend Tablets for Horses

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Prascend is the first and only medicine available in the US that is fully approved by the FDA to treat pituitary pars intermedia dysfunction (more commonly called PPID or equine Cushing's disease) in horses. As part of the FDA approval process, Prascend was rigorously tested to prove its safety and effectiveness in reducing signs of PPID in horses.

When you treat your horse with Prascend under guidance from your veterinarian, you can rest assured that you're giving your equine friend a medicine that is tested and trusted to work safely and consistently. These study results really mean that you can feel confident giving your horse Prascend to control signs of PPID! It may help get your horse back to his healthy, happy self again.


For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (equine Cushing’s Disease) in horses.

Prescription Required


Active Ingredient



View Prascend prescribing information.

Dosage & Administration

Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when Prascend Tablets are split or crushed. Prascend Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment.

Please follow veterinarian's directions.

Dosage Table

Body weight
2 mcg/kg dosage
4 mcg/kg dosage
136 - 340 kg
(300 - 749 lb)
0.5 tablet1 tablet
341 - 568 kg
(750 - 1,249 lb)
1 tablet2 tablets
569 - 795 kg
(1,250 - 1,749 lb)
1.5 tablets3 tablets
796 - 1,022 kg
(1,750 - 2,249 lb)
2 tablets4 tablets


Store at or below 25°C (77°F). Keep away from children and pets.


Do not use in horses intended for human consumption.

Human Warnings

Not for use in humans. Keep this and all medications out of the reach of children. Prascend should not be administered by persons who have had adverse reactions to ergotamine or other ergot derivatives. Pregnant or lactating women should wear gloves when administering this product. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when Prascend Tablets are split or crushed. Prascend Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. Consult a physician in case of accidental ingestion by humans.


Prascend is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives.


Treatment with Prascend may cause inappetance.

The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

Prascend is approximately 90% associated with plasma proteins. Use caution if administering Prascend with other drugs that affect protein binding. Dopamine antagonists, such as neuroleptics (phenothiazines, domperidone) or metoclopramide, ordinarily should not be administered concurrently with Prascend (a dopamine agonist) since these agents may diminish the effectiveness of Prascend.

Potential Side Effects

A total of 122 horses treated with Prascend Tablets for six months were included in a field study safety analysis.

The adverse reactions noted were decreased appetite, lameness, diarrhea/loose stool, colic, lethargy, abnormal weight loss, laminitis, heart murmur, death, tooth disorder, skin abscess, musculoskeletal pain, behavior change.


Treatment with Prascend improves the quality of life of PPID-affected horses by reducing common signs and decreasing the risk of other illnesses that may be associated with PPID.
Prascend has not been evaluated in breeding, pregnant, or lactating animals. As Prascend is a dopamine agonist, it may interfere with reproductive hormones involved in these groups of animals.

Horses with PPID will also benefit from an overall excellent general health care along with individual nutritionrecommendations from your veterinarian.

Regular care from hoof to teeth

  • Maintain proper hoof care, and communicate any abnormal observations to your veterinarian and farrier. Contact your veterinarian if any abnormal hoof wall growth or lameness issues are observed.
  • Regular dental exams (teeth floating as needed)

Body clipping, if needed

  • Many horses with PPID fail to shed out completely in the spring or, at the very least, shed later than herd or stablemates. The winter coat that “fails to shed” may include the entire hair coat (all over the horse’s body), or may just bea specific area of the horse’s body; for example, the side of the neck.

Deworm regularly

Following recommendations from your veterinarian

  • Horses with PPID also have been shown to have higher fecal strongyle egg counts, suggesting that they are moresusceptible to harboring internal parasites.

Properly vaccinate your horse

According to recommendations from your veterinarian

  • Horses with advanced PPID have been shown to have an insufficient immune response following vaccination for West NileVirus. Based on this information, it was recommended that horses with advanced PPID should be considered for twiceyearly vaccination for WNV.

Diet and exercise

  • Your veterinarian can advise you on a customized diet and exercise plan that will help your horse maintain the correctbody weight. Your horse’s overall body condition (lean or overweight) may determine the type of nutrition planrecommended by your veterinarian. Horses with PPID often do well on low-sugar, lowstarch diets, if considered prone tolaminitis.
Ask your veterinarian about the best way to transition your horse to Prascend.
Depending on the specific clinical sign, improvement may be observed beginning within 30 days and continue through 6 months of initial treatment.
Obtaining FDA approval is a strict and rigorous process. Prascend is manufactured according to the strict specifications set forth by the US Food & Drug Administration. Prascend is manufactured to provide a consistent, safe, and efficacious product.
Prascend is available only through licensed veterinarians. Your veterinarian will calculate the correct dosage based on the needs of your horse and provide you with all dosing and administration information.
Prascend tablets can be hidden in an apple or treat. The tablet may be administered orally by dissolving in a small amount of water, with or without sweetener. Administer the liquid with a syringe or as a top-dressing on feed. After dissolving, the tablet should be given immediately. Do not crush the tablet. See complete prescribing information and important safety information in product label.

Prascend comes in convenient packaging:

  • Pink rectangular-shaped tablets
  • Single scored tablets are easy for horse owners to divide
  • Each tablet contains 1 mg of pergolide, as pergolide mesylate
  • Packaged in convenient 10-tablet blister cards (plastic pockets sealed with aluminum foil)
  • Blister cards are packaged in cartons containing 60 or 160 tablets

Important Safety Information

  • Prascend is for use in Horses Only.
  • Treatment with Prascend may cause loss of appetite. Most cases are mild. Weight loss, lack of energy and behavioral changes maybe observed. If severe, dose reduction may be necesessary.
  • Do not use in horses intended for human consumption.
  • Prascend has not been evaluated in breeding, pregnant or lactating horses and may intefere with repreductive hormones in these horses.
  • Prascend tablets should not be crushed due to the potential for increased human exposure.

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