Treatment with Prascend improves the quality of life of PPID-affected horses by reducing common signs and decreasing the risk of other illnesses that may be associated with PPID.
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Prascend Tablets for Horses
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Description
Prascend tablets are a veterinary medication used for the management of symptoms related to Equine Cushing's Disease (pituitary pars intermedia dysfunction, or PPID) in horses. Each tablet contains pergolide mesylate, which helps regulate the excessive production of certain hormones associated with PPID. This medication is essential for hormonal regulation and effective symptom management, addressing issues such as increased thirst and urination, weight loss, and abnormal coat growth. Prascend tablets are available in a convenient tablet form, making them easy to administer orally. Please note that Prascend tablets are a prescription-only veterinary medication, and should only be used under the guidance of a licensed veterinarian.
Key Features
- Pergolide Mesylate: Active ingredient that helps manage symptoms of Equine Cushing's Disease.
- Hormonal Regulation: Helps regulate the excessive production of certain hormones.
- Symptom Management: Addresses symptoms such as increased thirst and urination, weight loss, and abnormal coat growth.
- Tablet Form: Convenient and easy to administer orally.
- Veterinary Prescription Required: Available only with a prescription from a licensed veterinarian.
How It Works
Prascend contains the active ingredient, pergolide mesylate, which is a potent dopamine receptor agonist. It inhibits the release of prolactin, a hormone released by the pituitary gland. In horses with Equine Cushing's Disease, pergolide is believed to exert its therapeutic effect by stimulating dopamine receptors.
Indications
For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (equine Cushing’s Disease) in horses.
Specifications:
- Active Ingredient: Pergolide mesylate
- Brand Name: Prascend
- Type: Oral tablet
- Available Strengths: 1 mg tablets
- Indicated for: Management of clinical signs associated with pituitary pars intermedia dysfunction (Cushing's disease) in horses
- Dosage Form: Tablet
- Administration: Administer orally once daily, preferably in the morning, with or without food
- Storage: Store at controlled room temperature (20-2°C, 68-77°F), excursions permitted between 15-30°C (59-86°F)
- Manufacturer: Boehringer Ingelheim Pharmaceuticals, Inc.
- Prescription Required: Yes, prescription-only medication. Must be prescribed by a veterinarian.
Ingredients
Active Ingredient
Peroglide
Directions
View Prascend prescribing information.
Dosage & Administration
Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when Prascend Tablets are split or crushed. Prascend Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment.
Please follow veterinarian's directions.
Dosage Table
| Body weight | 2 mcg/kg dosage | 4 mcg/kg dosage |
|---|---|---|
| 136 - 340 kg (300 - 749 lb) | 0.5 tablet | 1 tablet |
| 341 - 568 kg (750 - 1,249 lb) | 1 tablet | 2 tablets |
| 569 - 795 kg (1,250 - 1,749 lb) | 1.5 tablets | 3 tablets |
| 796 - 1,022 kg (1,750 - 2,249 lb) | 2 tablets | 4 tablets |
Storage
Store at or below 25°C (77°F). Keep away from children and pets.
Warnings
Do not use in horses intended for human consumption.
Human Warnings
Not for use in humans. Keep this and all medications out of the reach of children. Prascend should not be administered by persons who have had adverse reactions to ergotamine or other ergot derivatives. Pregnant or lactating women should wear gloves when administering this product. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when Prascend Tablets are split or crushed. Prascend Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. Consult a physician in case of accidental ingestion by humans.
Contraindications
Prascend is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives.
Precautions
Treatment with Prascend may cause inappetance.
The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.
Prascend is approximately 90% associated with plasma proteins. Use caution if administering Prascend with other drugs that affect protein binding. Dopamine antagonists, such as neuroleptics (phenothiazines, domperidone) or metoclopramide, ordinarily should not be administered concurrently with Prascend (a dopamine agonist) since these agents may diminish the effectiveness of Prascend.
Potential Side Effects
A total of 122 horses treated with Prascend Tablets for six months were included in a field study safety analysis.
The adverse reactions noted were decreased appetite, lameness, diarrhea/loose stool, colic, lethargy, abnormal weight loss, laminitis, heart murmur, death, tooth disorder, skin abscess, musculoskeletal pain, behavior change.
FAQ
Prascend has not been evaluated in breeding, pregnant, or lactating animals. As Prascend is a dopamine agonist, it may interfere with reproductive hormones involved in these groups of animals.
Horses with PPID will also benefit from an overall excellent general health care along with individual nutritionrecommendations from your veterinarian.
Regular care from hoof to teeth
- Maintain proper hoof care, and communicate any abnormal observations to your veterinarian and farrier. Contact your veterinarian if any abnormal hoof wall growth or lameness issues are observed.
- Regular dental exams (teeth floating as needed)
Body clipping, if needed
- Many horses with PPID fail to shed out completely in the spring or, at the very least, shed later than herd or stablemates. The winter coat that “fails to shed” may include the entire hair coat (all over the horse’s body), or may just bea specific area of the horse’s body; for example, the side of the neck.
Deworm regularly
Following recommendations from your veterinarian
- Horses with PPID also have been shown to have higher fecal strongyle egg counts, suggesting that they are moresusceptible to harboring internal parasites.
Properly vaccinate your horse
According to recommendations from your veterinarian
- Horses with advanced PPID have been shown to have an insufficient immune response following vaccination for West NileVirus. Based on this information, it was recommended that horses with advanced PPID should be considered for twiceyearly vaccination for WNV.
Diet and exercise
- Your veterinarian can advise you on a customized diet and exercise plan that will help your horse maintain the correctbody weight. Your horse’s overall body condition (lean or overweight) may determine the type of nutrition planrecommended by your veterinarian. Horses with PPID often do well on low-sugar, lowstarch diets, if considered prone tolaminitis.
Ask your veterinarian about the best way to transition your horse to Prascend.
Depending on the specific clinical sign, improvement may be observed beginning within 30 days and continue through 6 months of initial treatment.
Obtaining FDA approval is a strict and rigorous process. Prascend is manufactured according to the strict specifications set forth by the US Food & Drug Administration. Prascend is manufactured to provide a consistent, safe, and efficacious product.
Prascend is available only through licensed veterinarians. Your veterinarian will calculate the correct dosage based on the needs of your horse and provide you with all dosing and administration information.
Prascend tablets can be hidden in an apple or treat. The tablet may be administered orally by dissolving in a small amount of water, with or without sweetener. Administer the liquid with a syringe or as a top-dressing on feed. After dissolving, the tablet should be given immediately. Do not crush the tablet. See complete prescribing information and important safety information in product label.
Prascend comes in convenient packaging:
- Pink rectangular-shaped tablets
- Single scored tablets are easy for horse owners to divide
- Each tablet contains 1 mg of pergolide, as pergolide mesylate
- Packaged in convenient 10-tablet blister cards (plastic pockets sealed with aluminum foil)
- Blister cards are packaged in cartons containing 60 or 160 tablets
Important Safety Information
- Prascend is for use in Horses Only.
- Treatment with Prascend may cause loss of appetite. Most cases are mild. Weight loss, lack of energy and behavioral changes maybe observed. If severe, dose reduction may be necesessary.
- Do not use in horses intended for human consumption.
- Prascend has not been evaluated in breeding, pregnant or lactating horses and may intefere with repreductive hormones in these horses.
- Prascend tablets should not be crushed due to the potential for increased human exposure.