Treatment with Prascend improves the quality of life of PPID-affected horses by reducing common signs and decreasing the risk of other illnesses that may be associated with PPID.
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Prascend Tablets for Horses
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Description
Prascend tablets are a veterinary medication used for the management of symptoms related to Equine Cushing's Disease (pituitary pars intermedia dysfunction, or PPID) in horses. Each tablet contains pergolide mesylate, which helps regulate the excessive production of certain hormones associated with PPID. This medication is essential for hormonal regulation and effective symptom management, addressing issues such as increased thirst and urination, weight loss, and abnormal coat growth. Prascend tablets are available in a convenient tablet form, making them easy to administer orally. Please note that Prascend tablets are a prescription-only veterinary medication, and should only be used under the guidance of a licensed veterinarian.
Key Features
- Pergolide Mesylate: Active ingredient that helps manage symptoms of Equine Cushing's Disease.
- Hormonal Regulation: Helps regulate the excessive production of certain hormones.
- Symptom Management: Addresses symptoms such as increased thirst and urination, weight loss, and abnormal coat growth.
- Tablet Form: Convenient and easy to administer orally.
- Veterinary Prescription Required: Available only with a prescription from a licensed veterinarian.
How It Works
Prascend contains the active ingredient, pergolide mesylate, which is a potent dopamine receptor agonist. It inhibits the release of prolactin, a hormone released by the pituitary gland. In horses with Equine Cushing's Disease, pergolide is believed to exert its therapeutic effect by stimulating dopamine receptors.
Indications
For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (equine Cushing’s Disease) in horses.
Specifications:
- Active Ingredient: Pergolide mesylate
- Brand Name: Prascend
- Type: Oral tablet
- Available Strengths: 1 mg tablets
- Indicated for: Management of clinical signs associated with pituitary pars intermedia dysfunction (Cushing's disease) in horses
- Dosage Form: Tablet
- Administration: Administer orally once daily, preferably in the morning, with or without food
- Storage: Store at controlled room temperature (20-2°C, 68-77°F), excursions permitted between 15-30°C (59-86°F)
- Manufacturer: Boehringer Ingelheim Pharmaceuticals, Inc.
- Prescription Required: Yes, prescription-only medication. Must be prescribed by a veterinarian.
Ingredients
Active Ingredient
Peroglide
Directions
View Prascend prescribing information.
Dosage & Administration
Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when Prascend Tablets are split or crushed. Prascend Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment.
Please follow veterinarian's directions.
Dosage Table
| Body weight | 2 mcg/kg dosage | 4 mcg/kg dosage |
|---|---|---|
| 136 - 340 kg (300 - 749 lb) | 0.5 tablet | 1 tablet |
| 341 - 568 kg (750 - 1,249 lb) | 1 tablet | 2 tablets |
| 569 - 795 kg (1,250 - 1,749 lb) | 1.5 tablets | 3 tablets |
| 796 - 1,022 kg (1,750 - 2,249 lb) | 2 tablets | 4 tablets |
Storage
Store at or below 25°C (77°F). Keep away from children and pets.
Warnings
Do not use in horses intended for human consumption.
Human Warnings
Not for use in humans. Keep this and all medications out of the reach of children. Prascend should not be administered by persons who have had adverse reactions to ergotamine or other ergot derivatives. Pregnant or lactating women should wear gloves when administering this product. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when Prascend Tablets are split or crushed. Prascend Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. Consult a physician in case of accidental ingestion by humans.
Contraindications
Prascend is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives.
Precautions
Treatment with Prascend may cause inappetance.
The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.
Prascend is approximately 90% associated with plasma proteins. Use caution if administering Prascend with other drugs that affect protein binding. Dopamine antagonists, such as neuroleptics (phenothiazines, domperidone) or metoclopramide, ordinarily should not be administered concurrently with Prascend (a dopamine agonist) since these agents may diminish the effectiveness of Prascend.
Potential Side Effects
A total of 122 horses treated with Prascend Tablets for six months were included in a field study safety analysis.
The adverse reactions noted were decreased appetite, lameness, diarrhea/loose stool, colic, lethargy, abnormal weight loss, laminitis, heart murmur, death, tooth disorder, skin abscess, musculoskeletal pain, behavior change.
FAQ
Prascend has not been evaluated in breeding, pregnant, or lactating animals. As Prascend is a dopamine agonist, it may interfere with reproductive hormones involved in these groups of animals.
Horses with PPID will also benefit from an overall excellent general health care along with individual nutritionrecommendations from your veterinarian.
Regular care from hoof to teeth
- Maintain proper hoof care, and communicate any abnormal observations to your veterinarian and farrier. Contact your veterinarian if any abnormal hoof wall growth or lameness issues are observed.
- Regular dental exams (teeth floating as needed)
Body clipping, if needed
- Many horses with PPID fail to shed out completely in the spring or, at the very least, shed later than herd or stablemates. The winter coat that “fails to shed” may include the entire hair coat (all over the horse’s body), or may just bea specific area of the horse’s body; for example, the side of the neck.
Deworm regularly
Following recommendations from your veterinarian
- Horses with PPID also have been shown to have higher fecal strongyle egg counts, suggesting that they are moresusceptible to harboring internal parasites.
Properly vaccinate your horse
According to recommendations from your veterinarian
- Horses with advanced PPID have been shown to have an insufficient immune response following vaccination for West NileVirus. Based on this information, it was recommended that horses with advanced PPID should be considered for twiceyearly vaccination for WNV.
Diet and exercise
- Your veterinarian can advise you on a customized diet and exercise plan that will help your horse maintain the correctbody weight. Your horse’s overall body condition (lean or overweight) may determine the type of nutrition planrecommended by your veterinarian. Horses with PPID often do well on low-sugar, lowstarch diets, if considered prone tolaminitis.
Ask your veterinarian about the best way to transition your horse to Prascend.
Depending on the specific clinical sign, improvement may be observed beginning within 30 days and continue through 6 months of initial treatment.
Obtaining FDA approval is a strict and rigorous process. Prascend is manufactured according to the strict specifications set forth by the US Food & Drug Administration. Prascend is manufactured to provide a consistent, safe, and efficacious product.
Prascend is available only through licensed veterinarians. Your veterinarian will calculate the correct dosage based on the needs of your horse and provide you with all dosing and administration information.
Prascend tablets can be hidden in an apple or treat. The tablet may be administered orally by dissolving in a small amount of water, with or without sweetener. Administer the liquid with a syringe or as a top-dressing on feed. After dissolving, the tablet should be given immediately. Do not crush the tablet. See complete prescribing information and important safety information in product label.
Prascend comes in convenient packaging:
- Pink rectangular-shaped tablets
- Single scored tablets are easy for horse owners to divide
- Each tablet contains 1 mg of pergolide, as pergolide mesylate
- Packaged in convenient 10-tablet blister cards (plastic pockets sealed with aluminum foil)
- Blister cards are packaged in cartons containing 60 or 160 tablets
Important Safety Information
- Prascend is for use in Horses Only.
- Treatment with Prascend may cause loss of appetite. Most cases are mild. Weight loss, lack of energy and behavioral changes maybe observed. If severe, dose reduction may be necesessary.
- Do not use in horses intended for human consumption.
- Prascend has not been evaluated in breeding, pregnant or lactating horses and may intefere with repreductive hormones in these horses.
- Prascend tablets should not be crushed due to the potential for increased human exposure.
Reviews
Review Summary
4.6
31 Reviews
5
74% (23)
4
23% (7)
3
0% (0)
2
0% (0)
1
3% (1)
97% Recommend this product (30 of 31 responses)
By Connie
Ohio
Equine Prascend
April 19, 2025
Pills required for treatment of equine cushings disease. Expensive medication but this site has been the best price. Shipped quickly, great phone service!
By Abigail S.
Gettysburg, PA
Misleading!
January 9, 2025
The descriptions of your products are very misleading! It said that Prascend was "available in 60 and 160 tablets". I ordered "Prascend tablets 1 mg, 160 count, 1 count". That tells me that there are 160 tablets in 1 box and I ordered 20 boxes. I only received 20 tablets! When I called they agreed with me that it was misleading. I have talked to 3 different people and I was told someone would call me 2 days ago and no one has called me. I am VERY upset about this! It feels like I was scammed by a Pet pharmacy! Very sad! I attached pictures from YOUR website showing the information I was given. I am so glad I took pictures since you have now changed your website to reflect that you would only receive 1 tablet out of the box of 60 or 160 count! Interesting! It won't let me attach the pictures but I have emailed them to pablog@healthypets.com
By Caroline
Monroe, NY
Fast delivery easy ordering
November 5, 2024
Was easy to order and delivered quickly
By Judy
Boothbay, Maine
Easy, good pricing Efficient
July 22, 2024
Have always had an easy time of ordering from entirely pets. Their communications is great and always ship in a timely manner
By Elizabeth
Carmel
Prascend
November 30, 2023
This product has really helped my horse and my pony through cushions. The pill is easy to administer. I know they feel better when they have receive the pill.
Pros
- Small enough, you can drop it in their grain and they'll eat it.
Cons
- Sometimes my pony will not eat it. I wish it was in liquid form so that I could give it to her in her mouth.
By Jackie
Washington
Amazing price
September 13, 2023
Always happy with entirely pets! Awesome customer service, fast shipping, and a fantastic price on this product! Thank you!
By Linda
Woodbine, Maryland
It works & only approved drug 4 Cushings
August 9, 2023
EXPENSIVE & labs show need to INCREASE this drug to effect. Shouldn't touch w/ bare hands....headache city from ergot
Pros
- Works! Entirelypets makes it more affordable w/ their discounts & coupons
Cons
- EXPENSIVE & more drug needed if blood work indicates .
By Feather
Austin, TX
Prascend saved my horse
May 17, 2023
Upon his diagnosis with Cushing’s, my horse was mopey and stressed and was losing weight no matter what it how much we fed him. He changed almost overnight once he started taking Prascend.
By Donna
PA
Initial treatment for Cushings
November 1, 2020
Too soon to rate medication but no negative reaction after 1 week of 1/2 tablet. Will be increasing to full tablet.
Pros
- Easy to administer .
Cons
- Expensive medication since it needs to be given for the rest of the horses?s life.
By Laura C.
Rhode Island
effective for horses cushing's desease
November 1, 2020
over priced
Merchant Response:Hi Laura, we do our best to bring you the best price on Prascend anywhere the internet. We wish the price could be lower too. Take care.
Pros
- excellent product for horses
Cons
- over priced
By Girl1234
New York
Best price
October 23, 2020
Best price for an expensive product. Easy to order. They followed up with my vet and shipped my supply timely.
Pros
- Will definitely look to order from them again.
Cons
- No problems or issues.
By Valerie
Georgia
Best price!
September 25, 2020
Easy to order, they contact my vet. Prascend is the only choice available to treat PPID and its expensive! I appreciate the great prices here!
By DEBBIE
BORING, OREGON
PRASCEND TABLETS BEST PRICE
September 21, 2020
MY HORSE HAS BEEN ON PRASCEND TABLETS AND IT HAS DONE THEJOB OF BRINGING HER BLOOD COUNTS BACK IN LINE AND HELPS WITHTHE OTHER SYMPTOMS OF CUSHINGS DISEASE, AN ECONOMICAL MEDICATION OPTION
Cons
- A LITTLE DIFFICULT TO PORTION PILLS INTO SMALLER DOSES
By Delia
Hauppauge, NY
Great
September 17, 2020
Works great on my 27 year old gelding. He had a bad case of laminitis do to Cushings and he’s been good for two years now.
Merchant Response:He is handsome!
By Carol
New Hampshire
Prascend Tablets
July 31, 2020
Excellent product. This has improved the quality of life for my donkey immensely. No adverse effects. I have a healthy , happy donkey again.
Pros
- Easy to administer.
By Feather
Austin, TX
Great product for my horse
July 10, 2020
My horse was diagnosed with Cushings disease about 5 years ago. He gets one pill per day and he acts and looks like the horse he was 10 years ago. It’s been a lifesaver for him. I recently switched to entirelypetspharmacy.com as their prices were better than my previous online pharmacy. They filled the prescription quickly and shipped it out right away so a shout out to them as well. I’m hoping they continue to offer great service.
By Dora
Massachusetts (USA)
Best Price
July 4, 2020
The sheet of tabs were in a plastic bag, with a few of them close to be expired but I had enough time to use them, I was also missing a couple of the sheets and they sent them out to me after I called them. Not perfect but definitely worth the savings and I would use them again.
Pros
- Cost Savings!
By Lildudestk
Washington
Great price! Great discounts!
June 3, 2020
Quick shipping. Easy to get a hold of. Pleasant!
By Natalie
Virginia
Very fast shipping!
May 21, 2020
Product arrives quickly and my pony is doing great! Thank you!
By Kimberly W.
Little Chute , WI
Prascend meds
April 8, 2020
Meds seem to be working for her still too early to tell since cushing’s diagnosis
Cons
- Did not receive any type of shipping notice to know when it would arrive
By Anette P.
Boomer, Nc
Good service
March 14, 2020
Company was helpful in getting my prescription and the order came in a timely manner once it was received.
By Stacy
Central Oregon
STOPPED my horses laminitis
January 30, 2020
Helped my horse by stopping laminitis once he was diagnosed with Cushings and put on this medicine. Entirely Pets was very helpful in filling the Rx quickly and shipping it to me.
By Barbara
PA
best price
December 16, 2019
Most vendors offer the same price, but I found a coupon here that gave me an exceptional price.
By Judy
Columbia MO
great price
December 16, 2019
I was impressed with the great price for the really expensive prescription drug. Unfortunately my older horse has Cushings and needs a pill daily. I was really happy to find the 15% off. With something that expensive 15% really helps.
Pros
- Great price, nice people
Cons
- none
By Noelle
New Jersey
Prascend
December 15, 2019
Entirely pets had exactly what I needed and I received it in a timely manner and the best price too!
By Laurie
Texas
Great!
December 12, 2019
Quick and easy ordering. Entirely Pets contacted our vet and we received the medication for our horse within days!
By Andria
Rocky Point, New York
Great price!
November 21, 2019
I searched the web and found that Entirely Pets offered the best price for prascend with the coupon offered and my rakuten cash back. I also received another coupon with my order! I will definitely order from here for my horse all the time.
Merchant Response:Hi, I would like to personally thank you for ordering with our EntirelyPets Pharmacy. We appreciate your business and the opportunity to serve you.
Pros
- Price
- Shipping
- Coupons
- Fast
By CK
Massachusetts
Good Value
October 22, 2019
This is the exact same medicine that I got from the vet but this is a better value per pill.
By Marie L.
Denver Colorado
Miranda
August 22, 2019
This was prescribed by my vet foa a 21 year old Arabian with EMS and cushings. After 4 weeks on Precsend he is feeling good and acting like a 10 year old. The service was fast and pricing fair
Pros
- Quick and easy
By Barbara
CA
Prascend for cushings syndrome
April 14, 2018
Not shipped in the manufacturers box (the pink one in the picture). You get the pills, and since they are in blister packs it really isn't that big of a deal. I have had my horse on them for a year now and the prascend has really helped his cushings symptoms. This website seems to have the best prices on average for this medicine, and since it is prescription only it makes it easier to get your refills.