Advantage Multi for Cats

Advantage Multi for Cats is a popular veterinary medication used to protect cats from various parasites, including fleas, heartworms, ear mites, roundworms, and hookworms. Here are some advantages of using Advantage Multi for Cats:

Key Benefits:

• Broad-spectrum protection: Advantage Multi is a broad-spectrum parasite preventive, meaning it is effective against multiple types of parasites that commonly affect cats. It eliminates and prevents fleas, heartworm disease, and treats and controls ear mites, roundworms, and hookworms.
• Flea control: Advantage Multi kills fleas quickly upon contact, helping to eliminate infestations and prevent reinfestation. It not only kills adult fleas but also prevents the development of flea eggs and larvae, breaking the flea life cycle.
• Heartworm prevention: Heartworm disease is a serious and potentially fatal condition in cats. Advantage Multi provides monthly heartworm prevention, protecting your cat from heartworm larvae transmitted by mosquitoes.
• Ear mite treatment: Ear mites can cause irritation, itching, and discomfort in cats. Advantage Multi effectively treats ear mites, relieving your cat's symptoms and eliminating the infestation.
• Internal parasite control: Advantage Multi also controls and treats common intestinal parasites in cats, such as roundworms and hookworms. These parasites can cause digestive issues and other health problems in cats, and regular treatment helps to keep them under control.
• Convenient application: Advantage Multi comes in a topical solution that is easy to apply. You simply part the fur on the back of your cat's neck and apply the medication directly to the skin. It is absorbed into the bloodstream and provides protection for up to a month.

Indications:

• Flea infestations: Advantage Multi kills fleas on cats and prevents further flea infestations. It is effective against both adult fleas and flea larvae, helping to break the flea life cycle.
• Heartworm disease prevention: Advantage Multi provides monthly protection against heartworm disease in cats. It kills heartworm larvae that are transmitted by mosquitoes, preventing them from developing into adult worms that can cause serious health problems.
• Treatment and control of ear mites: Advantage Multi treats and controls ear mite infestations in cats. It helps relieve the symptoms of ear mites, such as itching, irritation, and inflammation.
• Treatment and control of intestinal parasites: Advantage Multi also treats and controls roundworms and hookworms in cats. These internal parasites can affect the digestive system and overall health of cats, and Advantage Multi helps eliminate and prevent their infestation.

It's important to note that Advantage Multi for Cats is specifically formulated for use in cats and should not be used on other animals or species. Always follow the dosage instructions provided by your veterinarian and read the product label carefully before applying the medication to your cat. If you have any questions or concerns about the indications or proper use of Advantage Multi, consult with your veterinarian.

How it works:

Advantage Multi for Cats contains two active ingredients: imidacloprid and moxidectin. Each of these ingredients works in different ways to provide a broad spectrum of protection against parasites.

1. Imidacloprid: Imidacloprid is an insecticide that targets the nervous system of parasites, particularly fleas. When applied to the skin, it spreads and is absorbed into the bloodstream of the cat. Fleas that come into contact with the medication are affected by imidacloprid, which disrupts their nervous system, leading to paralysis and ultimately their death. Imidacloprid also has an insect growth regulator (IGR) effect, preventing the development of flea eggs and larvae, thereby breaking the flea life cycle.
2. Moxidectin: Moxidectin is an anthelmintic, which means it is effective against various types of parasites, including heartworms, ear mites, roundworms, and hookworms. It works by interfering with the nerve impulses in these parasites, leading to paralysis and death.

• Heartworm prevention: When applied topically, moxidectin is absorbed into the cat's bloodstream, where it circulates and kills heartworm larvae that may have been transmitted through mosquito bites. It prevents the larvae from developing into adult heartworms, thereby protecting the cat from heartworm disease.
• Ear mite treatment: Moxidectin in Advantage Multi helps eliminate ear mites by targeting their nervous system. It kills both adult mites and their eggs, providing relief from the symptoms associated with ear mite infestations.
• Intestinal parasite control: Moxidectin is effective against roundworms and hookworms, which commonly affect cats. It disrupts the nerve impulses of these parasites, leading to paralysis and elimination from the cat's system.

Advantage Multi is applied topically to the back of the cat's neck, where it is absorbed into the skin and then distributed throughout the cat's body. The active ingredients work systemically, providing continuous protection against fleas, heartworms, ear mites, and intestinal parasites for up to a month.

It's important to follow the instructions provided by your veterinarian and the product label carefully when applying Advantage Multi to ensure proper dosage and application for optimal effectiveness and safety.

View View Advantage Multi for Cats Drug Facts Sheet.

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once amonth, by topical administration.

Do not apply to irritated skin

1. Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the Advantage Multi for Cats tube that correctly corresponds with the body weight of the cat.

Cat (lb.)	Advantage Multi For Cats	Volume (mL)	Imidacloprid (mg)	Moxidectin (mg)
2.5	Advantage Multi 5	0.23	23	2.3
5.1-9	Advantage Multi 9	0.4	40	4
9.1-18*	Advantage Multi 18	0.8	80	8

*Cats over 18 lbs. should be treated with the appropriate combination of Advantage Multi for Cats tubes.

2. While holding the tube in an upright position, remove the cap from the tube.
3. Turn the cap over and push the other end of cap onto the tip of the tube.
4. Twist the cap to break the seal and then remove cap from the tube.



5. Part the hair on the back of the cat's neck at the base of the head, until the skin is visible. Place the top of the tube on the skin and apply the entire contents directly on the exposed skin. Lift tube away from skin before releaseing pressure on tube.

Do not get this product in the cat's mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animal separated to prevent licking of the application site.

Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product.

Avantage Multi® for Cats offers broad-spectrum protection.

In addition to killing fleas and treating and controlling ear mites, Advantage Multi® for Cats also treats and controls roundworms and hookworms, and prevents heartworm disease in cats. This broad-spectrum protection is critically important to your cat's health because:

Heartworm disease can pose serious health risks for cats, like respiratory disease and even sudden death. Even indoor-only cats are at risk for heartworm disease. Since there are no products approved to kill adult heartworms in cats, heartworm prevention is key.

Hookworms can be ingested or penetrate your cat's skin. When they're fully grown, hookworms attach to the intestinal wall, and can leave bleeding ulcers behind.

Heartworm Prevention:

For prevention of heartworm disease, Advantage Multi for Cats should be administered at one-month intervals. Advantage Multi for Cats may be administered year-around or at a minimum should start one month beforethe first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposureto mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Cats immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heart-worm prevention program, the first treatment with Advantage Multi for Cats should be given within one month of the lastdose of the former medication. At the discretion of the veterinarian, cats older than 6 months of age may be tested to deter-mine the presence of existing heartworm infection before treatment with Advantage Multi for Cats (See ADVERSE REAC-TIONS - Post-Approval Experience).

Flea Treatment:

For the treatment of flea infestations, Advantage Multi for Cats should be administered at one-month inter-vals. If the cat is already infested with fleas when the first dose of Advantage Multi for Cats is administered, adult fleas onthe cat will be killed. However, re-infestation from the emergence of pre-existing pupae in the environment may continue tooccur for six weeks or longer after treatment is initiated. Cats treated with imidacloprid, including those with pre-existing fleaallergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the cat.

Ear Mite Treatment:

For the treatment of ear mites (Otodectes cynotis), Advantage Multi for Cats should be administeredonce as a single topical dose. Monthly use of Advantage Multi for Cats will control any subsequent ear mite infestation.

Intestinal Nematode Treatment:

For the treatment and control of intestinal hookworm infections caused by Ancylostomatubaeforme (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara cati (adultsand fourth stage larvae), Advantage Multi for Cats should be administered once as a single topical dose

ANIMAL SAFETY:

Studies in Kittens:

Advantage Multi for Cats was topically applied at 0, 1, 3, and 5X the maximum dose to 48 healthy 9-week-old kittens on days 0, 28, and 56. Lethargy was observed in 1 kitten from the 3X group and 1 from the 5X groupon the day after initial treatment; the kitten from the 3X group was also disoriented and ataxic. One kitten from the 3X group had a slow pupillary light response two days after treatment and one had tremors the day after treatment. Hypersalivation was seen in one kitten from the 5X group approximately six hours post-treatment. One kitten from the 3X group was scratching at the treatment site 2 days after treatment. Slight cough was noted in 7 different kittens (2-0X,2-1X, and 3-5X) during the 13-day period following the first treatment. Histopathology showed granulomatous inflammation at the treatment site in three 1X kittens. Causal relationship to the drug could not be determined. Pulmonary inflammation (1-5X) and lymphoid hyperplasia (2-1X, 4-3X) were seen in treated kittens. In a second study, Advantage Multi for Cats was topically applied at 0, 1.7, 5.2 and 8.7X the maximum dose to 48 healthy 9-week-old kittens every two weeks for 6 doses.One kitten in the 8.7X group apparently ingested an unknown amount of the drug and developed the following clinical signs prior to euthanasia: mydriasis, salivation, depression, vomiting, unsteadiness, rapid to slow to difficult breathing, poorpupillary response, generalized tremors, inability to move, and nystagmus. Two kittens in the 5.2X group developedmydriasis, salivation, depression, squinting, and poor appetite. A kitten in the 1.7X group developed mydriasis.

Dose Tolerance Study:

Eight healthy juvenile cats were topically dosed with a single application of Advantage Multi for Cats at 10 times the recommended dose volume. Mild, transient hypersalivation occurred in two of the cats.

Oral Study in Cats:

The oral safety of Advantage Multi for Cats was tested in case of accidental oral ingestion. The maximum topical dose was orally administered to twelve healthy 9-week-old kittens. Hypersalivation (8 of 12 kittens) and vomiting (12of 12 kittens) were observed immediately post-treatment. Tremors developed in one kitten within 1 hour, resolving without treatment within the next hour. All 12 kittens were either anorexic or had decreased appetite for at least 1 day following treat-ment. In 3 kittens, the anorexia or decreased appetite continued into the second week following treatment. There was apost-treatment loss of body weight in treated kittens compared to control kittens. In a pilot safety study using kittens younger in age and lighter in weight than allowed by product labeling, an 8-week old kitten weighing 0.6 kg orally received 2X of the label topical dose (0.46 mL/kg). Immediately after dosing, it vomited, had labored breathing and slight tremors. Within 4 hours, it was normal, but was found dead on day 6. Necropsy could not determine the cause of death.

Study in Heartworm Positive Cats:

Young adult cats were inoculated subcutaneously with third-stage D. immitislarvae. At 243-245 days post-infection, immunoserology and echocardiography were performed to identify cats with adult heartworm burdens similar to naturally-acquired infections. Two groups were treated topically with either Advantage Multi for Cats at the label dose or placebo, once every 28 days, for three consecutive treatments. A third group was treated topically, once, with Advantage Multi for Cats at 5X the label dose. Sporadic vomiting and labored breathing related to heartworm burden were observed in the treatment and control groups. There was no difference between treatment groups in the numbers ofadult D.immitis recovered at study conclusion. No adverse reactions were associated with the topical application of Advantage Multi for Cats to experimentally heartworm-infected cats.

Precautions:

Do not dispense dose applicator tubes without complete safety and administration information. Avoid oral ingestion. The safety of Advantage Multi for Cats has not been established in breeding, pregnant, or lactating cats or ferrets. The effectiveness of Advantage Multi for Cats against heartworm infections (D. immitis) after bathing has not been evaluated in cats. Use of this product in geriatric pets with subclinical conditions has not been adequately studied. Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug.