What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
Advantage Multi for Cats kills adult fleas through contact meaning they don't have to bite and feed on your cat to die. It treats flea infestations as well as treats and controls the common occurring ear mite and intestinal parasites roundworms and hookworms. Advantage Multi for Cats prevents also heartworm disease, an often overlooked concern in cats. Additionally, Advantage Multi for Cats is also the first and only FDA-approved product to kill adult fleas, treat flea infestations, and prevent heartworm disease in ferrets.
Advantage Multi® (imidacloprid + moxidectin) provides broad-spectrum parasite protection in a convenient monthly topical application, potentially increasing compliance for dogs and cats that may not prefer oral medications.
For dogs, Advantage Multi® prevents heartworm disease and treats heartworm microfilaria, kills fleas and treats and controls roundworms, hookworms, whipworms and sarcoptic mange. For cats, Advantage Multi® kills fleas, treats and controls ear mites, roundworms and hookworms and prevents heartworm disease all in one easy-to-use topical application. Plus, it's the only FDA-approved product indicated for ferrets for the treatment of fleas and prevention of heartworm disease.
The active ingredient moxidectin is used for the prevention and control of heartworms and intestinal worms by disrupting nerve transmission resulting in the paralysis and death of the parasite. The active ingredient imidacloprid, acts on the nervous system of the flea to cause paralysis and subsequent death.
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once amonth, by topical administration.
Do not apply to irritated skin
|Cat (lb.)||Advantage Multi For Cats||Volume (mL)||Imidacloprid (mg)||Moxidectin (mg)|
|2.5||Advantage Multi 5||0.23||23||2.3|
|5.1-9||Advantage Multi 9||0.4||40||4|
|9.1-18*||Advantage Multi 18||0.8||80||8|
*Cats over 18 lbs. should be treated with the appropriate combination of Advantage Multi for Cats tubes.
Do not get this product in the cat's mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animal separated to prevent licking of the application site.
Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product.
In addition to killing fleas and treating and controlling ear mites, Advantage Multi® for Cats also treats and controls roundworms and hookworms, and prevents heartworm disease in cats. This broad-spectrum protection is critically important to your cat's health because:
Heartworm disease can pose serious health risks for cats, like respiratory disease and even sudden death. Even indoor-only cats are at risk for heartworm disease. Since there are no products approved to kill adult heartworms in cats, heartworm prevention is key.
Hookworms can be ingested or penetrate your cat's skin. When they're fully grown, hookworms attach to the intestinal wall, and can leave bleeding ulcers behind.
For prevention of heartworm disease, Advantage Multi for Cats should be administered at one-month intervals. Advantage Multi for Cats may be administered year-around or at a minimum should start one month beforethe first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposureto mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Cats immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heart-worm prevention program, the first treatment with Advantage Multi for Cats should be given within one month of the lastdose of the former medication. At the discretion of the veterinarian, cats older than 6 months of age may be tested to deter-mine the presence of existing heartworm infection before treatment with Advantage Multi for Cats (See ADVERSE REAC-TIONS - Post-Approval Experience).
For the treatment of flea infestations, Advantage Multi for Cats should be administered at one-month inter-vals. If the cat is already infested with fleas when the first dose of Advantage Multi for Cats is administered, adult fleas onthe cat will be killed. However, re-infestation from the emergence of pre-existing pupae in the environment may continue tooccur for six weeks or longer after treatment is initiated. Cats treated with imidacloprid, including those with pre-existing fleaallergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the cat.
For the treatment of ear mites (Otodectes cynotis), Advantage Multi for Cats should be administeredonce as a single topical dose. Monthly use of Advantage Multi for Cats will control any subsequent ear mite infestation.
For the treatment and control of intestinal hookworm infections caused by Ancylostomatubaeforme (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara cati (adultsand fourth stage larvae), Advantage Multi for Cats should be administered once as a single topical dose
Advantage Multi for Cats was topically applied at 0, 1, 3, and 5X the maximum dose to 48 healthy 9-week-old kittens on days 0, 28, and 56. Lethargy was observed in 1 kitten from the 3X group and 1 from the 5X groupon the day after initial treatment; the kitten from the 3X group was also disoriented and ataxic. One kitten from the 3X group had a slow pupillary light response two days after treatment and one had tremors the day after treatment. Hypersalivation was seen in one kitten from the 5X group approximately six hours post-treatment. One kitten from the 3X group was scratching at the treatment site 2 days after treatment. Slight cough was noted in 7 different kittens (2-0X,2-1X, and 3-5X) during the 13-day period following the first treatment. Histopathology showed granulomatous inflammation at the treatment site in three 1X kittens. Causal relationship to the drug could not be determined. Pulmonary inflammation (1-5X) and lymphoid hyperplasia (2-1X, 4-3X) were seen in treated kittens. In a second study, Advantage Multi for Cats was topically applied at 0, 1.7, 5.2 and 8.7X the maximum dose to 48 healthy 9-week-old kittens every two weeks for 6 doses.One kitten in the 8.7X group apparently ingested an unknown amount of the drug and developed the following clinical signs prior to euthanasia: mydriasis, salivation, depression, vomiting, unsteadiness, rapid to slow to difficult breathing, poorpupillary response, generalized tremors, inability to move, and nystagmus. Two kittens in the 5.2X group developedmydriasis, salivation, depression, squinting, and poor appetite. A kitten in the 1.7X group developed mydriasis.
Eight healthy juvenile cats were topically dosed with a single application of Advantage Multi for Cats at 10 times the recommended dose volume. Mild, transient hypersalivation occurred in two of the cats.
The oral safety of Advantage Multi for Cats was tested in case of accidental oral ingestion. The maximum topical dose was orally administered to twelve healthy 9-week-old kittens. Hypersalivation (8 of 12 kittens) and vomiting (12of 12 kittens) were observed immediately post-treatment. Tremors developed in one kitten within 1 hour, resolving without treatment within the next hour. All 12 kittens were either anorexic or had decreased appetite for at least 1 day following treat-ment. In 3 kittens, the anorexia or decreased appetite continued into the second week following treatment. There was apost-treatment loss of body weight in treated kittens compared to control kittens. In a pilot safety study using kittens younger in age and lighter in weight than allowed by product labeling, an 8-week old kitten weighing 0.6 kg orally received 2X of the label topical dose (0.46 mL/kg). Immediately after dosing, it vomited, had labored breathing and slight tremors. Within 4 hours, it was normal, but was found dead on day 6. Necropsy could not determine the cause of death.
Young adult cats were inoculated subcutaneously with third-stage D. immitislarvae. At 243-245 days post-infection, immunoserology and echocardiography were performed to identify cats with adult heartworm burdens similar to naturally-acquired infections. Two groups were treated topically with either Advantage Multi for Cats at the label dose or placebo, once every 28 days, for three consecutive treatments. A third group was treated topically, once, with Advantage Multi for Cats at 5X the label dose. Sporadic vomiting and labored breathing related to heartworm burden were observed in the treatment and control groups. There was no difference between treatment groups in the numbers ofadult D.immitis recovered at study conclusion. No adverse reactions were associated with the topical application of Advantage Multi for Cats to experimentally heartworm-infected cats.
Do not dispense dose applicator tubes without complete safety and administration information. Avoid oral ingestion. The safety of Advantage Multi for Cats has not been established in breeding, pregnant, or lactating cats or ferrets. The effectiveness of Advantage Multi for Cats against heartworm infections (D. immitis) after bathing has not been evaluated in cats. Use of this product in geriatric pets with subclinical conditions has not been adequately studied. Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug.
Do not apply to irritated skin.
Life happens. If you forget or miss a dose, simply treat your cat immediately. Advantage Multi® for Cats is heartworm prevention that forgives if you forget.* It kills newly acquired heartworm larvae (baby worms) throughout the month to prevent further infection.
*After a single dose, if you forget and go more than 30 days in between treatments, just treat immediately and resume your monthly schedule.