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Heartgard Plus for Dogs

Heartgard Plus for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews

Description

Heartgard Plus is a monthly, FDA-Approved, pet medication for the prevention of heartworm disease. Heartgard Plus is 100% effective against heartworms; and it controls roundworms and hookworms. Heartgard Plus treats and controls more effectively than the next leading brand and is veterinarian recommended. Heartgard Plus is approved for puppies as young as 6 weeks of age. Help your pet by ordering Heartgard Plus today.

Key Benefits

  • Highly effective in preventing heartworms
  • Prevents development of adult stage heartworms
  • Treats and controls both hookworms and roundworms
  • Convenient, chewable form for easy administration
  • Delicious beef flavor that most dogs will eat

Indications

For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense).

How It Works

Heartgard Plus prevents heartworm disease by eliminating the tissue stage of heartworm larvae for a month after infection. Treating your dog with Heartgard Plus is as easy as feeding one chewable a month.

Ingredients

Active Ingredient Heartgard Blue Heartgard Green Heartgard Brown
Ivermectin 68 mcg 136 mcg 272 mcg
Pyrantel 57 mg 114 mg 227 mg

Directions

View Heartgard Plus Drug Facts Sheet.

Heartgard Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Dog Weight Chewables Per Month Ivermectin Content Pyrantel Content Color Coding on Foil-Backing and Carton
Up to 25 lb 1 68 mcg 57 mg Blue
26-50 lbs 1 136 mcg 114 mg Green
51-100 lbs 1 272 mcg 227 mg Brown
Over 100 lbs Use the appropriate combination of these chewables.

Heartgard Plus is recommended for dogs 6 weeks of age and older.

Quick Tips

  • Give Heartgard Plus Chewables once a month on the same day of each month year round.
  • Heartgard Plus Chewables are for dogs only.
  • Heartgard Plus Chewables should not be swallowed whole.
  • Chewables may be broken and fed to dogs as pieces, or crumbled and mixed with food.
  • Watch dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
  • Do not remove chewable from its wrapper until ready to give to pet.
  • Use the Witness Heartworm Test Kit to test your dog prior to using Heartgard Plus

Administration:

Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find Heartgard Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Heartgard Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Heartgard Plus must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Heartgard Plus and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

Monthly treatment with Heartgard Plus also provides effective treatment and control of ascarids (T. canis, T. leonina)and hookworms (A. caninum, U. stenocephala, A. braziliense) . Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

Acceptability:

Heartgard Plus was shown to be an acceptable oral dosage form that was consumed at first offering by the majority of dogs.

Precautions:

All dogs should be tested for existing heartworm infection before starting treatment with Heartgard Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Heartgard Plus.

While some microfilariae may be killed by the ivermectin in Heartgard Plus at the recommended dose level, Heartgard Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Store between 68°- 77°F (20°- 25°C). Excursions between 59° - 86°F (15° - 30°C) are permitted. Protect product from light.

Adverse Reactions:

Vomiting or diarrhea within 24 hours of dosing was rarely observed in clinical trials. The following adverse reactions have been reported: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.

Safety:

Heartgard Plus has been shown to be bioequivalent to Heartgard, with respect to the bioavailability of ivermectin. The dose regimens of Heartgard Plus and Heartgard are the same with regard to ivermectin (6 mcg/kg). Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Heartgard demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of Heartgard products in dogs, including Collies, when used as recommended.

Heartgard Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with Heartgard Plus in a heartworm disease preventive program.

Possible Side Effects

In clinical field trials with Heartgard Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have also been reported: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.

FAQ

The active ingredients in Heartgard Plus Chewables are ivermectin and pyrantel pamoate. Use with caution, as Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Heartgard Plus Chewables for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. In addition, Heartgard Plus Chewables have shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding dogs, stud dogs and puppies aged 6 or more weeks.
Tell your veterinarian if your pet has ever had an allergic reaction to the medication, any of its individual ingredients, or to beef.
Give Heartgard Plus Chewables exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Heartgard Plus Chewables must be chewed. They should not be swallowed whole.
Side effects of Heartgard Plus Chewables are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight and/or death.
Give the missed dose as soon as you remember. Do not give a double dose of the medication.
Seek emergency veterinary medical treatment.
Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.
Do not give Heartgard Plus Chewables to your pet if he or she is already taking another heartworm medication.

Reviews

Review Summary
4.8
179 Reviews
5
84% (151)
4
15% (26)
3
1% (1)
2
0% (0)
1
1% (1)
99% Recommend this product (177 of 179 responses)
By Robin C.
Fountain Inn, SC
Heartgard Plus
December 6, 2020
Have used for years and never had a heartworm issue.
ProsDogs love it.
ConsN/A
By Lynn W.
Portland, Oregon
Heartgard Plus 26 to 50lbs.
March 18, 2021
Easy to use. My Brittany dog loves it. Good price and value.
By Doggie l.
Wilmington, Nc
My #1 choice
March 12, 2021
Since my yorkie was a puppy, I've always gave him this heartworm prevention. He loves it because I guess he thinks it's a treat. The cost is well worth it when you buy a year supply. Shipping was extremely fast, no more than a 2 weeks.
ProsIt has stickers you can attached to the monthly calendar as either a reminder to give your pet their pill or like a check off
ConsNone at the moment
By Nicky
Germantown
Great Product
February 5, 2021
Great
ProsGreat
ConsGreat
By Chris P.
New Jersey
Fast delivery
January 31, 2021
Fast delivery and good price.
By Lynn
Plantation, Florida
Easy, Peasy
January 30, 2021
They offered the best price and fast delivery.
They got the script from my vet promptly.
This is not my first time ordering from them.
Merchant Response:Lynn, we try to better ourselves every day. Happy to be of help. Take care.
By Lol
Sacramento, CA
My dog loves these
January 28, 2021
My dog gobbles these chewable meds up to prevent heart worm. Easy to administer once per month and comes with a calendar to track. Great product and vet verification was easy.
By John
Santa Rosa, CA
Love this product
January 15, 2021
My dog loves the taste and I feel better about him being protected against heartworm!
By Bill S.
Gloucester, VA
Great Price but delayed Delivery
January 13, 2021
Took too many contacts to get item shipped despite actually mailing in the Rx from the Vet.
By Erin
Pemberton, New Jersey
SUPER EASY!
January 11, 2021
Easy method to administer, the chewable tablet is soft and what I would assume to be tastey for my dogs as they eat it plain and right out of my hand!
ProsEasy to feed Dogs enjoy the taste
By Janis B.
Michigan
Treats
January 9, 2021
My picky dogs think they're treats!
Thanks
By Tom N.
Elmira,NY
Heartgurd for dags
January 9, 2021
we have been useing it for over 25 tears and had its been the beat that we have found.
ProsNothing but PROS for this product
Consonly con is the price but its worth it
By Happy s.
Ohio
Affordable pricing for multiple pet owners
January 7, 2021
I have multiple dogs ranging in size from 30 # to 80#. Finding Heartgard for less than I was paying is a bonus, since I have been using this medication for the last 5 years and have never had any issues.
By Claudia G.
OK
All good
January 6, 2021
Very fast
By Dani
Virginia
Highly Recommended
December 20, 2020
My mind is at ease knowing my puppy will never have any health issues in the future. The medication beats having to deal with further complications due to negligent behavior such as not giving your dog the medication they need!
By D
Lubbock, TX
Great Place to Order Pet Meds
December 17, 2020
I have been using Entirely Pets for several years, to order most all of my pets medications, when needed. They have always been professional of contacting my vet when a prescription is needed, and then process my order. Very fast and prompt service. I highly recommend Entirely Pets, for ALL of your pets needs.
By Bassetmom
Rougemont,NC
Fast, reliable service, prices are best I’ve found
December 11, 2020
I’m very pleased with Entirely Pets, evening requiring approval from my vet for the prescription, I received everything quickly. Makes it so much easier, and the prices make it a little more affordable. With 6 dogs, ever little bit helps.
By SHANNON S.
Wisconsin
Great Price
November 29, 2020
Very thorough in getting approval from our veterinarian.
By Christine R.
West Lafayette, IN
Easy to order
October 23, 2020
EntirelyPets made ordering my dog's heartworm medicine very easy and it was much cheaper than most places. THANK YOU!
By Ellen
New York
Great product, good price
October 23, 2020
We use this consistently for years with all our dogs
By Carol
Gibson, PA
Does the Job
October 7, 2020
This product has been a safeguard for us. We have had no problem with heart worm, but if you do, it is probably too late for your pet. Knowing he has this in his system gives me peace of mind. He seems to love the pill and has no notable reaction to the product.
Merchant Response:
By Bruce
Alexandria, LA
Great price and good timing
September 28, 2020
the proce was like $15 less than other online stores, and $25 cheaper than the vet clinic.
By PJ
AZ
Price and Delivery
September 27, 2020
price was the best I found. Easy to order. Delivery was quick.
By Maria D.
MI
Best price
September 25, 2020
Best pricing and quick service
By B B.
Texas
Heartgard
September 17, 2020
Again, same product as purchased at the vet's office, but cheaper.
Merchant Response:We work directly with manufactures to deliver the best pricing.
By Mary F.
MD
Great Product Great Delivery
September 11, 2020
I have used Heartgard for all my dogs and love this product. The dogs love the taste so I never have to worry about making sure they eat it. EntirelyPets Pharmacy was quick to get my order processed and delivered.
By Glenna H.
Iowa
Heartgard
September 3, 2020
She likes Heartgardd. Makes it easy for me to give her.
By Bexky
Georgia
Great to do business with
August 15, 2020
Fast shipping and great prices! I would definitely do business with them again!
By Jim
New york
Heart guard
August 13, 2020
Heart guard was exactly as described, great pricing, and fast shipping. Couldn’t ask for anything better
By Christy
Ninnekah, OK
Review
August 13, 2020
awesome experience
Proscheaper than vet

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