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Heartgard Plus for Dogs

Heartgard Plus for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Heartgard Plus is a monthly, FDA-Approved, pet medication for the prevention of heartworm disease. Heartgard Plus is 100% effective against heartworms; and it controls roundworms and hookworms. Heartgard Plus treats and controls more effectively than the next leading brand and is veterinarian recommended. Heartgard Plus is approved for puppies as young as 6 weeks of age. Help your pet by ordering Heartgard Plus today.

Key Benefits

  • Highly effective in preventing heartworms
  • Prevents development of adult stage heartworms
  • Treats and controls both hookworms and roundworms
  • Convenient, chewable form for easy administration
  • Delicious beef flavor that most dogs will eat


For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense).

How It Works

Heartgard Plus prevents heartworm disease by eliminating the tissue stage of heartworm larvae for a month after infection. Treating your dog with Heartgard Plus is as easy as feeding one chewable a month.


Active Ingredient Heartgard Blue Heartgard Green Heartgard Brown
Ivermectin 68 mcg 136 mcg 272 mcg
Pyrantel 57 mg 114 mg 227 mg


View Heartgard Plus Drug Facts Sheet.

Heartgard Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Dog Weight Chewables Per Month Ivermectin Content Pyrantel Content Color Coding on Foil-Backing and Carton
Up to 25 lb 1 68 mcg 57 mg Blue
26-50 lbs 1 136 mcg 114 mg Green
51-100 lbs 1 272 mcg 227 mg Brown
Over 100 lbs Use the appropriate combination of these chewables.

Heartgard Plus is recommended for dogs 6 weeks of age and older.

Quick Tips

  • Give Heartgard Plus Chewables once a month on the same day of each month year round.
  • Heartgard Plus Chewables are for dogs only.
  • Heartgard Plus Chewables should not be swallowed whole.
  • Chewables may be broken and fed to dogs as pieces, or crumbled and mixed with food.
  • Watch dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
  • Do not remove chewable from its wrapper until ready to give to pet.


Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find Heartgard Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Heartgard Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Heartgard Plus must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Heartgard Plus and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

Monthly treatment with Heartgard Plus also provides effective treatment and control of ascarids (T. canis, T. leonina)and hookworms (A. caninum, U. stenocephala, A. braziliense) . Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.


Heartgard Plus was shown to be an acceptable oral dosage form that was consumed at first offering by the majority of dogs.


All dogs should be tested for existing heartworm infection before starting treatment with Heartgard Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Heartgard Plus.

While some microfilariae may be killed by the ivermectin in Heartgard Plus at the recommended dose level, Heartgard Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Store between 68°- 77°F (20°- 25°C). Excursions between 59° - 86°F (15° - 30°C) are permitted. Protect product from light.

Adverse Reactions:

Vomiting or diarrhea within 24 hours of dosing was rarely observed in clinical trials. The following adverse reactions have been reported: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


Heartgard Plus has been shown to be bioequivalent to Heartgard, with respect to the bioavailability of ivermectin. The dose regimens of Heartgard Plus and Heartgard are the same with regard to ivermectin (6 mcg/kg). Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Heartgard demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of Heartgard products in dogs, including Collies, when used as recommended.

Heartgard Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with Heartgard Plus in a heartworm disease preventive program.

Possible Side Effects

In clinical field trials with Heartgard Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have also been reported: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


The active ingredients in Heartgard Plus Chewables are ivermectin and pyrantel pamoate. Use with caution, as Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Heartgard Plus Chewables for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. In addition, Heartgard Plus Chewables have shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding dogs, stud dogs and puppies aged 6 or more weeks.
Tell your veterinarian if your pet has ever had an allergic reaction to the medication, any of its individual ingredients, or to beef.
Give Heartgard Plus Chewables exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Heartgard Plus Chewables must be chewed. They should not be swallowed whole.
Side effects of Heartgard Plus Chewables are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight and/or death.
Give the missed dose as soon as you remember. Do not give a double dose of the medication.
Seek emergency veterinary medical treatment.
Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.
Do not give Heartgard Plus Chewables to your pet if he or she is already taking another heartworm medication.


Review Summary
189 Reviews
84% (159)
14% (27)
1% (1)
0% (0)
1% (2)
98% Recommend this product (186 of 189 responses)
By Robin C.
Fountain Inn, SC
Heartgard Plus
December 6, 2020
Have used for years and never had a heartworm issue.
  • Dogs love it.
  • N/A
Mecca, Ohio
Heartguard Plus
October 10, 2021
We have given this to our dog Lilly for many years and she has never gotten heartworm. It works, trust it!
By D M.
Keeps my dog safe
September 10, 2021
Descent pricing. Should allow faxing of prescriptions. ...takes you long to wait on US Post Office.
By AnnaMarie
Mount Laurel NJ 98953
Heartguard for Jack Russell terrier mix
July 25, 2021
Heartguard has been our choice for all our dogs now and in the past that we have owned and loved. It has also done its job and our terrier loves the flavor so there isn't any fighting or convincing her to take it she looks forward to it and it makes it easier for us at our age. We will continue to purchase the product at the name brand formula.
By Khusbu
Doesn't prevent tapeworms
June 27, 2021
During covid I was trying to find shippable alternatives because the vet visits were more difficult at the time. He was on this for 2 months and my pup is known to each random things every now and then. Normally he gets the runnys for a day and done. While on heartgard plus, he got a tapeworm. His vet gave him something to flush it out. He was not feeling well for a couple weeks. Poor thing. Check your dog's poop. It's the answer to everything.

So if your dog has a habit or something eats leftover rotted whatever, chances are your doog may get a tapeworm, and heartgard plus won't help prevent that.
By Joanne
Hamden, CT
Great product
June 2, 2021
Dogs love it! And it has worked well preventing heartworm.
By Deb W.
Lake Placid, Florida
Great Price, Fast Delivery
May 19, 2021
Ordered and received within 1 week. They obtained RX from my Vet. Easy as could be.
  • Ordered and received within 1 week. They obtained RX from my Vet. Easy as could be.
By Marlene C.
Stacy MN
Heartgard Plus
May 19, 2021
Easy ordering. Exceptional price
By Joanne
Hamden CT
Takoda loves these treats
May 16, 2021
Great service and great product!
By Jules
Louisville, KY
using for years
May 6, 2021
No side effects and my dogs love the taste of Heartgard.
By Brenda
Alvin, TX
Must have!
May 3, 2021
This is a great product. This is a must have for your canine children.
By Lynn W.
Portland, Oregon
Heartgard Plus 26 to 50lbs.
March 18, 2021
Easy to use. My Brittany dog loves it. Good price and value.
By Doggie l.
Wilmington, Nc
My #1 choice
March 12, 2021
Since my yorkie was a puppy, I've always gave him this heartworm prevention. He loves it because I guess he thinks it's a treat. The cost is well worth it when you buy a year supply. Shipping was extremely fast, no more than a 2 weeks.
  • It has stickers you can attached to the monthly calendar as either a reminder to give your pet their pill or like a check off
  • None at the moment
By Nicky
Great Product
February 5, 2021
  • Great
  • Great
By Chris P.
New Jersey
Fast delivery
January 31, 2021
Fast delivery and good price.
By Lynn
Plantation, Florida
Easy, Peasy
January 30, 2021
They offered the best price and fast delivery.
They got the script from my vet promptly.
This is not my first time ordering from them.
Merchant Response:Lynn, we try to better ourselves every day. Happy to be of help. Take care.
By Lol
Sacramento, CA
My dog loves these
January 28, 2021
My dog gobbles these chewable meds up to prevent heart worm. Easy to administer once per month and comes with a calendar to track. Great product and vet verification was easy.
By John
Santa Rosa, CA
Love this product
January 15, 2021
My dog loves the taste and I feel better about him being protected against heartworm!
By Bill S.
Gloucester, VA
Great Price but delayed Delivery
January 13, 2021
Took too many contacts to get item shipped despite actually mailing in the Rx from the Vet.
By Erin
Pemberton, New Jersey
January 11, 2021
Easy method to administer, the chewable tablet is soft and what I would assume to be tastey for my dogs as they eat it plain and right out of my hand!
  • Easy to feed
  • Dogs enjoy the taste
By Janis B.
January 9, 2021
My picky dogs think they're treats!
By Tom N.
Heartgurd for dags
January 9, 2021
we have been useing it for over 25 tears and had its been the beat that we have found.
  • Nothing but PROS for this product
  • only con is the price but its worth it
By Happy s.
Affordable pricing for multiple pet owners
January 7, 2021
I have multiple dogs ranging in size from 30 # to 80#. Finding Heartgard for less than I was paying is a bonus, since I have been using this medication for the last 5 years and have never had any issues.
By Claudia G.
All good
January 6, 2021
Very fast
By Dani
Highly Recommended
December 20, 2020
My mind is at ease knowing my puppy will never have any health issues in the future. The medication beats having to deal with further complications due to negligent behavior such as not giving your dog the medication they need!
By D
Lubbock, TX
Great Place to Order Pet Meds
December 17, 2020
I have been using Entirely Pets for several years, to order most all of my pets medications, when needed. They have always been professional of contacting my vet when a prescription is needed, and then process my order. Very fast and prompt service. I highly recommend Entirely Pets, for ALL of your pets needs.
By Bassetmom
Fast, reliable service, prices are best I’ve found
December 11, 2020
I’m very pleased with Entirely Pets, evening requiring approval from my vet for the prescription, I received everything quickly. Makes it so much easier, and the prices make it a little more affordable. With 6 dogs, ever little bit helps.
Great Price
November 29, 2020
Very thorough in getting approval from our veterinarian.
By Christine R.
West Lafayette, IN
Easy to order
October 23, 2020
EntirelyPets made ordering my dog's heartworm medicine very easy and it was much cheaper than most places. THANK YOU!
By Ellen
New York
Great product, good price
October 23, 2020
We use this consistently for years with all our dogs

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