Heartgard Plus Chewables for Dogs | On Sale | EntirelyPets Rx
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Heartgard Plus for Dogs

Heartgard Plus for Dogs

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  • Description
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  • FAQ
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Heartgard Plus is a monthly, FDA-Approved, pet medication for the prevention of heartworm disease. Heartgard Plus is 100% effective against heartworms; and it controls roundworms and hookworms. Heartgard Plus treats and controls more effectively than the next leading brand and is veterinarian recommended. Heartgard Plus is approved for puppies as young as 6 weeks of age. Help your pet by ordering Heartgard Plus today.

Key Benefits

  • Highly effective in preventing heartworms
  • Prevents development of adult stage heartworms
  • Treats and controls both hookworms and roundworms
  • Convenient, chewable form for easy administration
  • Delicious beef flavor that most dogs will eat


For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense).

How It Works

Heartgard Plus prevents heartworm disease by eliminating the tissue stage of heartworm larvae for a month after infection. Treating your dog with Heartgard Plus is as easy as feeding one chewable a month.

Prescription Required


Active Ingredient Heartgard Blue Heartgard Green Heartgard Brown
Ivermectin 68 mcg 136 mcg 272 mcg
Pyrantel 57 mg 114 mg 227 mg


View Heartgard Plus Drug Facts Sheet.

Heartgard Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Dog Weight Chewables Per Month Ivermectin Content Pyrantel Content Color Coding on Foil-Backing and Carton
Up to 25 lb 1 68 mcg 57 mg Blue
26-50 lbs 1 136 mcg 114 mg Green
51-100 lbs 1 272 mcg 227 mg Brown
Over 100 lbs Use the appropriate combination of these chewables.

Heartgard Plus is recommended for dogs 6 weeks of age and older.

Quick Tips

  • Give Heartgard Plus Chewables once a month on the same day of each month year round.
  • Heartgard Plus Chewables are for dogs only.
  • Heartgard Plus Chewables should not be swallowed whole.
  • Chewables may be broken and fed to dogs as pieces, or crumbled and mixed with food.
  • Watch dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
  • Do not remove chewable from its wrapper until ready to give to pet.
  • Use the Witness Heartworm Test Kit to test your dog prior to using Heartgard Plus


Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find Heartgard Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Heartgard Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Heartgard Plus must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Heartgard Plus and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

Monthly treatment with Heartgard Plus also provides effective treatment and control of ascarids (T. canis, T. leonina)and hookworms (A. caninum, U. stenocephala, A. braziliense) . Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.


Heartgard Plus was shown to be an acceptable oral dosage form that was consumed at first offering by the majority of dogs.


All dogs should be tested for existing heartworm infection before starting treatment with Heartgard Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Heartgard Plus.

While some microfilariae may be killed by the ivermectin in Heartgard Plus at the recommended dose level, Heartgard Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Store between 68°- 77°F (20°- 25°C). Excursions between 59° - 86°F (15° - 30°C) are permitted. Protect product from light.

Adverse Reactions:

Vomiting or diarrhea within 24 hours of dosing was rarely observed in clinical trials. The following adverse reactions have been reported: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


Heartgard Plus has been shown to be bioequivalent to Heartgard, with respect to the bioavailability of ivermectin. The dose regimens of Heartgard Plus and Heartgard are the same with regard to ivermectin (6 mcg/kg). Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Heartgard demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of Heartgard products in dogs, including Collies, when used as recommended.

Heartgard Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with Heartgard Plus in a heartworm disease preventive program.

Possible Side Effects

In clinical field trials with Heartgard Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have also been reported: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


The active ingredients in Heartgard Plus Chewables are ivermectin and pyrantel pamoate. Use with caution, as Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Heartgard Plus Chewables for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. In addition, Heartgard Plus Chewables have shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding dogs, stud dogs and puppies aged 6 or more weeks.
Tell your veterinarian if your pet has ever had an allergic reaction to the medication, any of its individual ingredients, or to beef.
Give Heartgard Plus Chewables exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Heartgard Plus Chewables must be chewed. They should not be swallowed whole.
Side effects of Heartgard Plus Chewables are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight and/or death.
Give the missed dose as soon as you remember. Do not give a double dose of the medication.
Seek emergency veterinary medical treatment.
Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.
Do not give Heartgard Plus Chewables to your pet if he or she is already taking another heartworm medication.


Review Summary
131 Reviews
90% (118)
8% (11)
1% (1)
0% (0)
1% (1)
98% Recommend this product (129 of 131 responses)
By Maria D.
June 5, 2020
Product has been very effective for all seven of our rescue dogs even if we travel to other locations with more prevalent threats of getting mosquito bite
By Cheryl p.
February 16, 2020
Good product and price
By Linnardo
Parker CO
Hapoy to be back on Heartgard
January 24, 2020
My Vet started carrying another brand of Heartworm medication and my dog hated it. After struggling with her for a couple of months on brand X, we are back to Heartgard. My pups tail is wagging again.
By Paul B.
Strongsville, OH
It's the Cadillac of heartworm medicine
January 11, 2020
Beyond costing too much, it's the gold standard of heartworm medicine
ProsThe dog eats it like any other treat. At least all my dogs used to just chow it down. If yours doesn't than maybe your dog doesn't trust you and you need to search your soul and ask God "why doesn't my pooch trust me God?".
ConsI'm not a vet but every vet I ever went to wanted this one over priced pill chew given once month.
By Joel
katy, TX
gard that dog
January 10, 2020
good product for my large dog, he gobbles the med right up
By Karen
Key West
Good price
December 30, 2019
Heartgard for 3 large dogs can push the budget. The prices are good and the service is fast.
By Regina D.
Covington Georgia
December 8, 2019
Recieved quickly and prices are significantly lower than vets office
By Pat/Mike N.
Queens, NY
Higher Price
November 11, 2019
This year, I paid $10 more for the exact same item, as last year. No reason/explanation.
Merchant Response:Hi Pat & Mike, Heartgard PLUS pricing goes up every year. Wish we could do more to help with the pricing.
By tom
saint simons is ga
cost ok/ seems to keep our dog healthy
November 8, 2019
same as headline
By Florina
Huntingdon valley, PA
October 11, 2019
Delicious for my dog. He loves it and thinks it's a meaty chunk. Easy way to get ur pooch to take his meds.
By MTom
Norwood, MA
GREAT Customer Service!
September 30, 2019
Order a years' supple of the Heartworm medicine. Vet only authorized 6 months until an exam was done. Appointment was 2 months away. Explained to Customer service to hold the order until after the appointment till the vet authorized. They placed me on their calendar and held the order until AFTER the appointment. Very easy to work with and extremely customer service oriented. Thank you!
ProsGreat customer service and the prices were VERY competitive. Very quick delivery.
ConsNone that comes to mind!
By Gary
Lebanon, Ohio
September 7, 2019
Very effective and the only heart worm medicine my small dog can take without reaction. Also, he loves taking it.
By Frank P.
River Vale NJ
Great Experience
August 28, 2019
They took care of contacting the vet, made it easy and affordable.
By Caren
Greenville SC
August 18, 2019
Great product and my dog chews them without peanut butter smeared all my over it. I have using them for years. Great price with Entirely Pets
By Kay
Greenville, SC
Great Product
August 16, 2019
My Vet recommended Heartguard for my German Shepperd puppy. I really like the ease of giving him a chew that he is excited to take. Process with Entirely Pets was a breeze. Place the order and they handle the rest.
By gus
Pioneer, Ca
easy to use
May 24, 2019
this item works and is easy to apply
By gus
pioneer, ca
this item works
May 24, 2019
this item works and is easy to apply
By Wendy
Tarpon Springs, FL
Great price and fast delivery
February 24, 2019
Easy to order, mailed in my prescription. The whole process took about 1.5 weeks. The pricing was spectacular!
By Doreen
Farmingdale, New York
January 25, 2019
I am very happy with my purchase of heartguard from Entirely Pets Pharmacy. Price was better than competitors which included free shipping. If there is a charge for shipping I consider it part of total cost. Item came promptly even though I had to mail in prescription. Pet ownership can be costly! Thanks for helping my keep my baby dog healthy...
By Paula
San Francisco Bay Area
loves to take her medicine!
December 28, 2018
Can't ask for better when my dog thinks her meds are a treat... even does all her commands just to get it!
By Mary
Minneapolis, MN
Great service
November 15, 2018
The company handles all communication with the veterinary hospital so I didn't have to fax any information.
ProsGreat communication, easy ordering, fast shipping
By Robin
Boca Raton, Florida
The BEST prices!
November 4, 2018
The BEST prices and very fast service! I will definitely order from you again!
By Bill S.
Hutto TX
good product
October 25, 2018
The service of Entirely Pets Pharmacy is excellent, their prices are the best I can find and the product has a very good expiration, overall they are a really good pharmacy to deal with.
By Susie
Life Saver
October 18, 2018
Great product. This is also the best price on the internet. Protect your dog from heart worm!
By Robin
Dallas TX area
Dogs love this and it works!
October 7, 2018
I have tried generic heartworm prevention with the same ingredients, but this is worth the little extra. The generics are difficult to give to a picky dog or a dog who doesn't like to chew hard pills. This is a soft 'treat' and when the dogs hear me unwrap the monthly Heartgard Plus, they are beside themselves with excitement. We live in a horrible area for heartworms (Texas) as they are so prevalent here. I have lived here 20 years and over that course have had 6 dogs, and this medicine has prevented heartworms in all cases.
ProsDogs love the taste; easy to give
Consat this pharmacy, the price is super low, but this medicine is a little more expensive than generic. It's definiely worth it though.
By Fran
Lebanon ,Pa
September 22, 2018
Fast , excellent price- versus vets and stores. Great customer service A++++
Merchant Response:Thanks Fran! Happy to have you and your dog as customers. =)
By Kathy
South Carolina
Great price, wonderful customer service
September 14, 2018
Item was shipped quickly and the price was much less than at the vets office
Merchant Response:Kathy, we aim to please. Thank you for choosing EntirleyPets Pharmacy.
By Armand M.
Best product for your Dog
August 30, 2018
Well known, quality product to protext it from a bad disease. Trust your dog to this product.
By Diana
Vancouver Washington
Heartgard Plus
August 26, 2018
My dog eats them like it is a treat
Merchant Response:Heartgard PLUS has the whole flavor thing down. You both take care!
By Sadie's m.
West Chester, Ohio
August 18, 2018
Not only is it exactly what the vet prescribed, but EntirelyPets price was half of what it would have cost at the vet’s office! The heartguard came quickly and packaged safely.
Merchant Response:Sadie's mom, we are quite pleased to be able to do business for you and Sadie. Take care!

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