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Heartgard Plus for Dogs

Heartgard Plus for Dogs

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  • Description
  • Ingredients
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  • FAQ
  • Reviews


Heartgard Plus is a monthly, FDA-Approved, pet medication for the prevention of heartworm disease. Heartgard Plus is 100% effective against heartworms; and it controls roundworms and hookworms. Heartgard Plus treats and controls more effectively than the next leading brand and is veterinarian recommended. Heartgard Plus is approved for puppies as young as 6 weeks of age. Help your pet by ordering Heartgard Plus today.

Key Benefits

  • Highly effective in preventing heartworms
  • Prevents development of adult stage heartworms
  • Treats and controls both hookworms and roundworms
  • Convenient, chewable form for easy administration
  • Delicious beef flavor that most dogs will eat


For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense).

How It Works

Heartgard Plus prevents heartworm disease by eliminating the tissue stage of heartworm larvae for a month after infection. Treating your dog with Heartgard Plus is as easy as feeding one chewable a month.


Active Ingredient Heartgard Blue Heartgard Green Heartgard Brown
Ivermectin 68 mcg 136 mcg 272 mcg
Pyrantel 57 mg 114 mg 227 mg


View Heartgard Plus Drug Facts Sheet.

Heartgard Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Dog Weight Chewables Per Month Ivermectin Content Pyrantel Content Color Coding on Foil-Backing and Carton
Up to 25 lb 1 68 mcg 57 mg Blue
26-50 lbs 1 136 mcg 114 mg Green
51-100 lbs 1 272 mcg 227 mg Brown
Over 100 lbs Use the appropriate combination of these chewables.

Heartgard Plus is recommended for dogs 6 weeks of age and older.

Quick Tips

  • Give Heartgard Plus Chewables once a month on the same day of each month year round.
  • Heartgard Plus Chewables are for dogs only.
  • Heartgard Plus Chewables should not be swallowed whole.
  • Chewables may be broken and fed to dogs as pieces, or crumbled and mixed with food.
  • Watch dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
  • Do not remove chewable from its wrapper until ready to give to pet.
  • Use the Witness Heartworm Test Kit to test your dog prior to using Heartgard Plus


Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find Heartgard Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Heartgard Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Heartgard Plus must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Heartgard Plus and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

Monthly treatment with Heartgard Plus also provides effective treatment and control of ascarids (T. canis, T. leonina)and hookworms (A. caninum, U. stenocephala, A. braziliense) . Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.


Heartgard Plus was shown to be an acceptable oral dosage form that was consumed at first offering by the majority of dogs.


All dogs should be tested for existing heartworm infection before starting treatment with Heartgard Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Heartgard Plus.

While some microfilariae may be killed by the ivermectin in Heartgard Plus at the recommended dose level, Heartgard Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Store between 68°- 77°F (20°- 25°C). Excursions between 59° - 86°F (15° - 30°C) are permitted. Protect product from light.

Adverse Reactions:

Vomiting or diarrhea within 24 hours of dosing was rarely observed in clinical trials. The following adverse reactions have been reported: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


Heartgard Plus has been shown to be bioequivalent to Heartgard, with respect to the bioavailability of ivermectin. The dose regimens of Heartgard Plus and Heartgard are the same with regard to ivermectin (6 mcg/kg). Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Heartgard demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of Heartgard products in dogs, including Collies, when used as recommended.

Heartgard Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with Heartgard Plus in a heartworm disease preventive program.

Possible Side Effects

In clinical field trials with Heartgard Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have also been reported: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


The active ingredients in Heartgard Plus Chewables are ivermectin and pyrantel pamoate. Use with caution, as Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Heartgard Plus Chewables for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. In addition, Heartgard Plus Chewables have shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding dogs, stud dogs and puppies aged 6 or more weeks.
Tell your veterinarian if your pet has ever had an allergic reaction to the medication, any of its individual ingredients, or to beef.
Give Heartgard Plus Chewables exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Heartgard Plus Chewables must be chewed. They should not be swallowed whole.
Side effects of Heartgard Plus Chewables are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight and/or death.
Give the missed dose as soon as you remember. Do not give a double dose of the medication.
Seek emergency veterinary medical treatment.
Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.
Do not give Heartgard Plus Chewables to your pet if he or she is already taking another heartworm medication.


Review Summary
159 Reviews
86% (137)
13% (20)
1% (1)
0% (0)
1% (1)
99% Recommend this product (157 of 159 responses)
By Carol
Gibson, PA
Does the Job
October 7, 2020
This product has been a safeguard for us. We have had no problem with heart worm, but if you do, it is probably too late for your pet. Knowing he has this in his system gives me peace of mind. He seems to love the pill and has no notable reaction to the product.
Merchant Response:
By Bruce
Alexandria, LA
Great price and good timing
September 28, 2020
the proce was like $15 less than other online stores, and $25 cheaper than the vet clinic.
Price and Delivery
September 27, 2020
price was the best I found. Easy to order. Delivery was quick.
By Maria D.
Best price
September 25, 2020
Best pricing and quick service
By B B.
September 17, 2020
Again, same product as purchased at the vet's office, but cheaper.
Merchant Response:We work directly with manufactures to deliver the best pricing.
By Mary F.
Great Product Great Delivery
September 11, 2020
I have used Heartgard for all my dogs and love this product. The dogs love the taste so I never have to worry about making sure they eat it. EntirelyPets Pharmacy was quick to get my order processed and delivered.
By Glenna H.
September 3, 2020
She likes Heartgardd. Makes it easy for me to give her.
By Bexky
Great to do business with
August 15, 2020
Fast shipping and great prices! I would definitely do business with them again!
By Jim
New york
Heart guard
August 13, 2020
Heart guard was exactly as described, great pricing, and fast shipping. Couldnít ask for anything better
By Christy
Ninnekah, OK
August 13, 2020
awesome experience
Proscheaper than vet
By Lisa
Easy to order and quick ship
August 8, 2020
Happy with product. Easy to order. Quick ship once my Rx arrived to company. Best price compared to two other online companies.
By Jenny
heartgard plus
July 28, 2020
Entirelypets had the best prices on the medications i need for my dog.
unfortunately my order took a month to get to me.
it took 10 days alone for someone to notify me that my vet had not responded to their fax requesting the Rx for the heartgard.
placed order june 25, received product july 27.
Prosgood prices
Constook over a month to get my order
By Hugh
fast shipping
July 18, 2020
easy to order
Easy Transaction
July 10, 2020
EntirelyPets made getting my dog's Heartgard so easy! I placed the order, provided my vet's info & they handled the rest.
Price was better than all other places I checked & they kept me in the loop with updates!
Very happy with my purchase!
5 star rating
July 8, 2020
Heartgard was received exactly as promised swiftly and correctly
By Galina
Vista, Ca
great product
June 12, 2020
Dog loves this product. As soon as I open the cupboard she runs and sits in front of me . She knows she is going to get her favorite Heartgard chew.
By Gina
Chicago Illinois
Heartgard Plus
June 11, 2020
Received quickly. Less expensive
By Elizabeth
Great Product Terrible Service
June 5, 2020
Missing item from order. I called 5 days in a row. On hold for over 30 minutes each time. I first sent them an email asking if they could please send missing item as soon as possible. After not hearing back, I sent several more emails asking them to just refund my money. Finally received an email saying they received my email but it would take up to 10 days for them to reply. Not that is would up to 10 days for refund. JUST for them to reply. Still havenít heard back. Trying to be patient with current state of affairs but, when your dog needs meds on the first of every month and you canít get them and no one seems to care, itís frustrating.
ProsGreat Product
ConsTerrible customer service
By Maria D.
June 5, 2020
Product has been very effective for all seven of our rescue dogs even if we travel to other locations with more prevalent threats of getting mosquito bite
By Sara
Good product
June 4, 2020
I was very pleased with my purchase. The package arrived on time. No issues with the shipment.
By Kathy
Hot Springs, Arkansas
June 3, 2020
I have used this product for many years with our 3 dogs. It works great!
ProsSimple to use and the dogs like the taste.
By Bob H.
Park Hill, OK
Exceeded expectations.
May 30, 2020
We are very satisfied with our recent dealings with E.P.P. and with the product. Our dog, Cosmo, gobbles the product right up. So far, it has little or no side effects. With the product that we used in the past, Cosmo hated the smell and taste. He would do everything possible to avoid ingesting it. We are very happy with our experience with EntirelyPets Pharmacy. P.S. The price was the best we could find, too.
By Kathy B.
May 30, 2020
You were great to get these to us in a timely manner. Thanks, Kathy
By doris p.
lapine oregon
Good product Good company
May 14, 2020
This is second time lve ordered from this company.First time everything was excellent l did it all on line.Got items in correct time was great prices .l shopped around on line and they have the best prices and discounts.We can use that these days good prices good service.Second time l could not get my order to go thru on line had to call in my order.Took me 2 days to get thru on the phone they were very bizzy (corona virus April2020) so l understood how they were so bizzy.Agent gave me additional discount than l already was getting for my inconvience so that made me very happy.Should have had it in 5-10 days but did not .Recalled them on this and it was just sitting there and had not been sent out for no reason.So they apoligized and sent it out l got it in 7 days.So over all this company is good l think they were over welmed with orders at that time and thats why the mess up on my order getting shipped l really didnt mind overall l really like this company for price you cant beat it Doris ,Lapine Oregon
Prosgood product great prices awesome discounts friendly customer service
By Susan
Pittsburgh pa
Easy to order
April 28, 2020
Our dog took the chew very easily. Product arrived quickly for our puppy to get her medicine.
By Betsy
Excellent Service
April 23, 2020
My order arrived in a very timely manner. The product is the same brand and quality as I would receive from my vet. The price is excellent.
By Amanda
Portland, OR
Great product
April 3, 2020
This product is easy to give to my dog, she thinks it's a dog treat!
By April
Shelby County, TN
April 1, 2020
Good price and was delivered without any issues.
By R M.
Larchmont. NY
Good product
March 21, 2020
Using it for years. No problems
By Cheryl p.
February 16, 2020
Good product and price

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