Rimadyl (Carprofen) | 25, 75, & 100 mg | EntirelyPets Rx
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Rimadyl (Carprofen) Chewable Tablets

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews

Description

Rimadyl is a non-steroidal anti-inflammatory (NSAID) used to treat pain and inflammation due to arthritis and other joint diseases, including hip dysplasia. It's also used to reduce pain associated with surgery or dental procedures, as well as to reduce fever. Rimadyl works by reducing hormones that cause pain and inflammation in the body. Rimadyl may also be used for purposes other than those listed here. Rimadyl requires a prescription from your veterinarian.

Key Benefits

  • Can be given as a single daily dose
  • Effective relief from pain and inflammation caused by OA
  • Easy to administer available as a chewable tablet or caplet
  • Well tolerated by dogs
  • Veterinarian Recommended
  • Palatable liver flavor your dog will love

How It Works

Rimadyl works by reducing hormones that cause pain and inflammation in your dog's body.

Indications

Rimadyl is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associatedwith soft tissue and orthopedic surgeries in dogs.

Prescription Required

Ingredients

Rimadyl (carprofen) 25 mg
Active Ingredients (per caplet or chewable tablet) Amount
Carprofen 25 mg
Rimadyl (carprofen) 75 mg
Active Ingredients (per caplet or chewable tablet) Amount
Carprofen 75 mg
Rimadyl (carprofen) 100 mg
Active Ingredients (per caplet or chewable tablet) Amount
Carprofen 100 mg

Directions

View Rimadyl Drug Facts Sheet.

Always provide Client Information Sheet with prescription. Carefully consider the potential benefits and risk of Rimadyl and other treatment options before deciding to use Rimadyl. Use the lowest effective dose for the shortest duration consistent with individual response. The recommended dosage for oral administration to dogs is 2 mg/lb (4.4 mg/kg) of body weight daily. The total daily dose may be administered as 2 mg/lb of body weight once daily or divided and administered as 1 mg/lb (2.2 mg/kg) twice daily. For the control of postoperative pain, administer approximately 2 hours before the procedure. Rimadyl tablets are scored and dosage should be calculated in half-tablet increments. Tablets can be halved by placing the tablet on a hard surface and pressing down on both sides of the score. Rimadyl chewable tablets are palatable and willingly consumed by most dogs when offered by the owner. Therefore, they may be fed by hand or placed on food. Care should be taken to ensure that the dog consumes the complete dose.

The recommended dosage for subcutaneous administration to dogs is 2 mg/lb (4.4 mg/kg) of body weight daily. The total daily dose may be administered as either 2 mg/lb of body weight once daily or divided and administered as 1 mg/lb (2.2 mg/kg) twice daily. For control of post-operative pain, administer approximately 2 hours before the procedure.

Caution:

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications:

Rimadyl should not be used in dogs exhibiting previous hypersensitivity to carprofen.

Warnings:

Keep out of reach of children. Not for human use. Consult a physician in cases of accidental ingestion by humans. For use in dogs only.Do not use in cats.

All dogs should undergo a thorough history and physical examination before initiation of NSAID therapy. Appropriate laboratory tests to establish hematolo gical and serum biochemical baseline data prior to, and periodically during, administration of any NSAID should be considered. Owners should be advised to observe for signs of potential drug toxicity (see Information for Dog Owners, Adverse Reactions, Animal Safety and Post-Approval Experience).

Precautions:

As a class, cyclooxygenase inhibitory NSAIDs may be associated with gastrointestinal, renal and hepatic toxicity. Effects may result from decreased prostaglandin production and inhibition of the enzyme cyclooxygenase which is responsible for the formation of prosta glandins from arachidonic acid.1114 When NSAIDs inhibit prosta glandins that cause inflammation they may also inhibit those prosta glandins which maintain normal homeostatic function. These anti-prostaglandin effects may result in clinically sig nificant disease in patients with underlying or pre-existing disease more often than in healthy patients.12,14 NSAID therapy could unmask occult disease which has previously been undiagnosed due to the absence of apparent clinical signs. Patients with underlying renal disease for example, may experience exacerbation or decompensation of their renal disease while on NSAID therapy.1114The use of parenteral fluids during surgery should be considered to reduce the potential risk of renal complications when using NSAIDs perioperatively.

Carprofen is an NSAID, and as with others in that class, adverse reactions may occur with its use. The most frequently reported effects have been gastrointestinal signs. Events involving suspected renal, hematologic, neurologic, dermatologic, and hepatic effects have also been reported. Patients at greatest risk for renal toxicity are those that are dehydrated, on concomitant diuretic therapy, or those with renal, cardiovascular, and/or hepatic dysfunction. Concurrent administration of potentially nephrotoxic drugs should be approached cautiously, with appropriate monitoring. Concomitant use of Rimadyl with other anti-inflammatory drugs, such as other NSAIDs or corticosteroids, should be avoided because of the potential increase of adverse reactions, including gastrointestinal ulcerations and/or perforations. Sensitivity to drug-associated adverse reactions varies with the individual patient. Dogs that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. Rimadyl treatment was not associated with renal toxicity or gastrointestinal ulceration in well-controlled safety studies of up to 10 times the dose in healthy dogs. As with any parenterally injected product, good hygienic procedures should be used when administering Rimadyl Injectable.

Rimadyl is not recommended for use in dogs with bleeding disorders (e.g., Von Willebrand's disease), as safety has not been established in dogs with these disorders. The safe use of Rimadyl in animals less than 6 weeks of age, pregnant dogs, dogs used for breeding purposes, or in lactating bitches has not been established. Safety has not been established for IV or IM administration. Studies to determine the activity of Rimadyl when administered concomitantly with other protein-bound or similarly metabolized drugs have not been conducted. Drug compatibility should be monitored closely in patients requiring additional therapy. Such drugs commonly used include cardiac, anticonvulsant and behavioral medications. It has been suggested that treatment with carprofen may reduce the level of inhalant anesthetics needed.15 It is suggested to use different sites for additional injections. If additional pain medication is warranted after administration of the total daily dose of Rimadyl, alternative analgesia should be considered. The use of another NSAID is not recommended. Consider appropriate washout times when switching from one NSAID to another or when switching from corticosteroids use to NSAID use.

Due to the palatable nature of Rimadyl chewable tablets, store out of reach of dogs in a secured location. Severe adverse reactions may occur if large quantities of tablets are ingested. If you suspect your dog has consumed Rimadyl chewable tablets above the labeled dose, please call your veterinarian for immediate assistance and notify Zoetis at 1-888-963-8471.

Information for Dog Owners:

Rimadyl, like other drugs of its class, is not free from adverse reactions. Owners should be advised of the potential for adverse reactions and be informed of the clinical signs associated with drug intolerance. Adverse reactions may include decreased appetite, vomiting, diarrhea, dark or tarry stools, increased water consumption, increased urination, pale gums due to anemia, yellowing of gums, skin or white of the eye due to jaundice, lethargy, incoordination, seizure, or behavioral changes.

Serious adverse reactions associated with this drug class can occur without warning and in rare situations result in death (see Adverse Reactions). Owners should be advised to discontinue Rimadyl therapy and contact their veterinarian immediately if signs of intolerance are observed.

The vast majority of patients with drug related adverse reactions have recovered when the signs are recognized, the drug is withdrawn, and veterinary care, if appropriate, is initiated. Owners should be advised of the importance of periodic follow up for all dogs during administration of any NSAID.

Palatability:

A controlled palatability study was conducted which demonstrated that Rimadyl chewable tablets were readily accepted and consumed on first offering by a majority of dogs.

Effectiveness:

Confirmation of the effectiveness of Rimadyl for the relief of pain and inflammation associated with osteoarthritis, and for the control of postoperative pain associated with soft tissue and orthopedic surgeries, was demonstrated in 7 placebo-controlled, masked studies examining the anti-inflammatory and analgesic effectiveness of Rimadyl caplets and injectable in various breeds of dogs.

Separate placebo-controlled, masked, multicenter field studies confirmed the anti-inflammatory and analgesic effectiveness of Rimadyl caplets when dosed at 2 mg/lb once daily or when divided and administered at 1 mg/lb twice daily. In these 2 field studies, dogs diagnosed with osteoarthritis showed statistically significant overall improvement based on lameness evaluations by the veterinarian and owner observations when administered Rimadyl at labeled doses.

Based upon the blood level comparison between subcutaneous and oral administration, Rimadyl effectiveness for osteoarthritis after dorsoscapular subcutaneous and oral administration should be similar, although there may be a slight delay in the onset of relief after subcutaneous injection.

Separate placebo-controlled, masked, multicenter field studies confirmed the effectiveness of Rimadyl caplets and injectable for the control of postoperativepain when dosed at 2 mg/lb once daily in various breeds of dogs. In these studies, dogs presented for ovariohysterectomy, cruciate repair and aural surgeries were administered Rimadyl preoperatively and for a maximum of 3 days (soft tissue) or 4 days (orthopedic) postoperatively. In general, dogs administered Rimadyl showed statistically significant reduction in pain scores compared to controls.

Animal Safety:

Laboratory studies in unanesthetized dogs and clinical field studies have demonstrated that Rimadyl is well tolerated in dogs after oral administration.

In target animal safety studies, Rimadyl was administered orally to healthy Beagle dogs at 1, 3, and 5 mg/lb twice daily (1, 3 and 5 times the recommended total daily dose) for 42 consecutive days with no significant adverse reactions. Serum albumin for a single female dog receiving 5 mg/lb twice daily decreased to 2.1 g/dL after 2 weeks of treatment, returned to the pre-treatment value (2.6 g/dL) after 4 weeks of treatment, and was 2.3 g/dL at the final 6-week evaluation. Over the 6-week treatment period, black or bloody stools were observed in 1 dog (1 incident) treated with 1 mg/lb twice daily and in 1 dog (2 incidents) treated with 3 mg/lb twice daily. Redness of the colonic mucosa was observed in 1 male that received 3 mg/lb twice daily.

Two of 8 dogs receiving 10 mg/lb orally twice daily (10 times the recommended total daily dose) for 14 days exhibited hypoalbuminemia. The mean albumin level in the dogs receiving this dose was lower (2.38 g/dL) than each of 2 placebo control groups (2.88 and 2.93 g/dL, respectively). Three incidents of black or bloody stool were observed in 1 dog. Five of 8 dogs exhibited reddened areas of duodenal mucosa on gross pathologic examination. Histologic exam of these areas revealed no evidence of ulceration, but did show minimal congestion of the lamina propria in 2 of the 5 dogs.

In separate safety studies lasting 13 and 52 weeks, respectively, dogs were administered orally up to 11.4 mg/lb/day (5.7 times the recommended total daily dose of 2 mg/lb) of carprofen. In both studies, the drug was well tolerated clinically by all of the animals. No gross or histologic changes were seen in any of the treated animals. In both studies, dogs receiving the highest doses had average increases in serum L-alanine aminotransferase (ALT) of approximately 20 IU.

In the 52-week study, minor dermatologic changes occurred in dogs in each of the treatment groups but not in the control dogs. The changes were described as slight redness or rash and were diagnosed as non-specific dermatitis. The possibility exists that these mild lesions were treatment related, but no dose relationship was observed.

Clinical field studies were conducted with 549 dogs of different breeds at the recommended oral doses for 14 days (297 dogs were included in a study evaluating 1 mg/lb twice daily and 252 dogs were included in a separate study evaluating 2 mg/lb once daily). In both studies the drug was clinically well tolerated and the incidence of clinical adverse reactions for Rimadyl-treated animals was no higher than placebo-treated animals (placebo contained inactive ingredients found in Rimadyl). For animals receiving 1 mg/lb twice daily, the mean post-treatment serum ALT values were 11 IU greater and 9 IU less than pre-treatment values for dogs receiving Rimadyl and placebo, respectively. Differences were not statistically significant. For animals receiving 2 mg/lb once daily, the mean post-treatment serum ALT values were 4.5 IU greater and 0.9 IU less than pre-treatment values for dogs receiving Rimadyl and placebo, respectively. In the latter study, 3 Rimadyl-treated dogs developed a 3-fold or greater increase in (ALT) and/or (AST) during the course of therapy. One placebo-treated dog had a greater than 2-fold increase in ALT. None of these animals showed clinical signs associated with laboratory value changes. Changes in the clinical laboratory values (hematology and clinical chemistry) were not considered clinically significant. The 1 mg/lb twice daily course of therapy was repeated as needed at 2-week intervals in 244 dogs, some for as long as 5 years.

Clinical field studies were conducted in 297 dogs of different breeds undergoing orthopedic or soft tissue surgery. Dogs were administered 2 mg/lb of Rimadyl 2 hours prior to surgery then once daily, as needed for 2 days (soft tissue surgery) or 3 days (orthopedic surgery). Rimadyl was well tolerated when used in conjunction with a variety of anesthetic-related drugs. The type and severity of abnormal health observation in Rimadyl- and placebo-treatedanimals were approximately equal and few in number (see Adverse Reactions). The most frequent abnormal health observation was vomiting and was observed at approximately the same frequency in Rimadyl- and placebo-treated animals. Changes in clinicopathologic indices of hematopoietic, renal, hepatic, and clotting function were not clinically significant. The mean post- treatment serum ALT values were 7.3 IU and 2.5 IU less than pre-treatment values for dogs receiving Rimadyl and placebo, respectively. The mean post-treatment AST values were 3.1 IU less for dogs receiving Rimadyl and 0.2 IU greater for dogs receiving placebo.

Clinical field studies on the use of Rimadyl Injectable were conducted on 331 dogs undergoing orthopedic or soft tissue surgery. Dogs were administered 2 mg/lb of Rimadyl subcutaneously 2 hours prior to surgery and once daily thereafter, as needed, for 2 days (soft tissue surgery) or 3 days (orthopedic surgery). Rimadyl was well tolerated when used in conjunction with a variety of anesthetic-related drugs. The type and severity of abnormal health observations in Rimadyl- and placebo-treated animals were approximately equal and few in number (see Adverse Reactions). The most frequent abnormal health observation was vomiting and was observed at approximately the same frequency in Rimadyl- and placebo-treated animals. Changes in clinico-pathologic indices of hematopoetic, renal, hepatic, and clotting function were not clinically significant. The mean post-treatment serum ALT values were 8.4 IU and 7.0 IU less than pre-treatment values for dogs receiving Rimadyl and placebo, respectively. The mean post-treatment AST values were 1.5 IU and 0.7 IU greater for dogs receiving Rimadyl and placebo, respectively.

Swelling and warmth were associated with the injection site after subcutaneous administration of Rimadyl Injectable. These findings were not clinically significant. Long term use of the injectable has not been studied.

Storage:

Store tablets at controlled room temperature 15°30°C (59°86°F). Store injectable under refrigeration 2°8°C (36°46°F). Once broached, product may be stored at temperatures up to 25°C (77°F) for 28 days.

FAQ

Rimadyl is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation (soreness) due to osteoarthritis andsurgery in dogs. A licensed veterinarian must prescribe Rimadyl for your dog. It is available as a caplet and chewable tablet and is given to dogsby mouth.

Osteoarthritis (OA) is a painful condition caused by "wear and tear" ofcartilage and other parts of the joints that may result in the followingchanges or signs in your dog:

  • Limping or lameness
  • Decreased activity or exercise (difficulty or reluctance in standing, climbing stairs, jumping or running)
  • Stiffness or decreased movement of joints

To control surgical pain (for example, for surgeries such as spays, earprocedures or orthopedic repairs), your veterinarian may administer Rimadyl before the procedure and recommend that your dog be treated for several days after going home.

While Rimadyl is not a cure for osteoarthritis, it can relieve the pain andinflammation of OA and improve your dog's mobility.

  • Response varies from dog to dog but can be quite dramatic.
  • In most dogs, improvement can be seen in a matter of days.
  • If Rimadyl is discontinued or not given as directed, your dog's pain and inflammation may come back.

Your dog should not be given Rimadyl if he/she:

  • Has had an allergic reaction to carprofen, the active ingredient of Rimadyl.
  • Has had an allergic reaction to aspirin or other NSAIDs (for example, etodolac, meloxicam or deracoxib) such as hives, facial swelling, or red or itchy skin.

Rimadyl should be given to dogs only. Cats should not be given Rimadyl. Call your veterinarian immediately if your cat receives Rimadyl. People should not take Rimadyl. Keep Rimadyl and all medicines out of reach of children. Call your physician immediately if you accidentally take Rimadyl.

Rimadyl should be given according to your veterinarian's instructions. Your veterinarian will tell you what amount of Rimadyl is right for your dog and for how long it should be given. Rimadyl Caplets should be given by mouth. Most dogs will take Rimadyl Chewable Tablets right out of your hand or the tablet can be placed in the mouth. Rimadyl maybe given with or without food.

Talk to your veterinarian about:

  • The signs of OA you have observed (for example, limping, stiffness).
  • The importance of weight control and exercise in the management of OA.
  • What tests might be done before Rimadyl is prescribed.
  • How of ten your dog may need to be examined by your veterinarian.
  • The risks and benefits of using Rimadyl.

Tell your veterinarian if your dog has ever had the following medical problems:

  • Experienced side effects from Rimadyl or other NSAIDs, such as aspirin
  • Digestive upset (vomiting and /or diarrhea)
  • Liver disease
  • Kidney disease
  • A bleeding disorder (for example, Von Willebrand's disease)

Tell your veterinarian about:

  • Any other medical problems or allergies that your dog has now or has had.
  • All medicines that you are giving your dog or plan to give your dog, including those you can get without a prescription.

Tell your veterinarian if your dog is:

  • Pregnant, nursing or if you plan to breed your dog.

Rimadyl, like other drugs, may cause some side effects. Serious but rare side effects have been reported in dogs taking NSAIDs, including Rimadyl. Serious side effects can occur with or without warning andin rare situations result in death.

The most common NSAID-related side effects generally involve the stomach (such as bleeding ulcers). Kidneys and liver can also be affected. Look for the following side effects that can indicate your dog may be having a problem with Rimadyl or may have another medical problem:

  • Decrease or increase in appetite
  • Vomiting
  • Change in bowel movements (such as diarrhea, or black, tarry or bloody stools)
  • Change in behavior (such as decreased or increased activity level, incoordination, seizure or aggression)
  • Yellowing of gums, skin, or whites of the eyes (jaundice)
  • Change in drinking habits (frequency, amount consumed)
  • Change in urination habits (frequency, color or smell)
  • Change in skin (redness, scabs or scratching)

It is important to stop therapy and contact your veterinarian immediately if you think your dog has a medical problem or side effect from Rimadyl therapy. If you have additional questions about possible side effects, talkto your veterinarian.

Rimadyl should not be given with other NSAIDs (for example,aspirin, etodolac) or steroids (for example, cortisone, prednisone, dexamethasone, triamcinolone).

Tell your veterinarian about all medicines you have given your dog in the past, and any medicines that you are planning to give with Rimadyl. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog's medicines can be given together.

Contact your veterinarian immediately if your dog eats more than the prescribed amount of Rimadyl.
Rimadyl Chewable Tablets are designed to taste good to animals. Keep Rimadyl Chewable Tablets in a secured storage area out of the reach of your dog and other pets. If your dog ingests more than your veterinarian prescribed, or if your other pets take Rimadyl Chewable Tablets, contact your veterinarian right away.

This sheet provides a summary of information about Rimadyl. If you have any questions or concerns about Rimadyl or osteoarthritis or surgical pain, talk to your veterinarian.

As with all prescribed medicines, Rimadyl should only be given to the dog for which it was prescribed. It should be given to your dog only for the condition for which it was prescribed.

It is important to periodically discuss your dog's response to Rimadyl at regular checkups. Your veterinarian will best determine if your dog is responding as expected and if your dog should continue receiving Rimadyl. To report a suspected adverse reaction call Zoetis at 1-888-963-8471.

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