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Vetprofen (carprofen)

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews

Description

Vetprofen is a prescription medication that contains carprofen, a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking certain chemicals in the body called prostaglandins that cause inflammation. Carprofen is commonly used to relieve joint pain and inflammation associated with conditions like arthritis and to help improve mobility in aging dogs. It is also used in for pain management after surgery, or injury. If your dog has been diagnosed with a joint problem such as arthritis, or experiences limited mobility caused by joint pain, your veterinarian may prescribe a NSAID such as Vetprofen.

Animals Treated

Dogs (6 weeks or older)

Key Benefits

  • Treats Pain and inflammation from arthritis and joint diseases
  • Used to treat pain associated with hip-dysplasia
  • Reduce Fever in Dogs
  • Minimizes postoperative pain and inflammation
  • Non-steroidal, anti-inflammatory drug (NSAID) for dogs
  • Beef flavored for easy administration

Prescription Required

Ingredients

Active Ingredients:

Carprofen

Directions

View Vetprofen Drug Facts Sheet.

Always provide Client Information Sheet with prescription. Carefully consider the potential benefits and risk of Vetprofen and other treatment options before deciding to use Vetprofen. Use the lowest effective dose for the shortest duration consistent with individual response. The recommended dosage for oral administration to dogs is 2 mg/lb (4.4 mg/kg) of body weight daily. The total daily dose may be administered as 2 mg/lb of body weight once daily or divided and administered as 1 mg/lb (2.2 mg/kg) twice daily. For the control of postoperative pain, administer approximately 2 hours before the procedure. Tablets are scored and dosage should be calculated in half-tablet increments.

Indications:

Vetprofen is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.

Contraindications:

Vetprofen should not be used in dogs exhibiting previous hypersensitivity to carprofen.

Warnings:

Keep out of reach of children. Not for human use. Consult a physician in cases of accidental ingestion by humans. For use in dogs only. Do not use in cats.

All dogs should undergo a thorough history and physical examination before initiation of NSAID therapy. Appropriate laboratory tests to establish hematological and serum biochemical baseline data prior to, and periodically during, administration of any NSAID should be considered. Owners should be advised to observe for signs of potential drug toxicity (see Information for Dog Owners, Adverse Reactions, Animal Safety and Post-Approval Experience).

Precautions:

As a class, cyclooxygenase inhibitory NSAIDs may be associated with gastrointestinal, renal and hepatic toxicity. Effects may result from decreased prostaglandin production and inhibition of the enzyme cyclooxygenase which is responsible for the formation of prostaglandins from arachidonic acid.11-14 When NSAIDs inhibit prostaglandins that cause inflammation they may also inhibit those prostaglandins which maintain normal homeostatic function. These anti-prostaglandin effects may result in clinically significant disease in patients with underlying or pre-existing disease more often than in healthy patients.12-14 NSAID therapy could unmask occult disease which has previously been undiagnosed due to the absence of apparent clinical signs. Patients with underlying renal disease for example, may experience exacerbation or decompensation of their renal disease while on NSAID therapy.11-14 The use of parenteral fluids during surgery should be considered to reduce the potential risk of renal complications when using NSAIDs perioperatively.

Carprofen is an NSAID, and as with others in that class, adverse reactions may occur with its use. The most frequently reported effects have been gastrointestinal signs. Events involving suspected renal, hematologic, neurologic, dermatologic, and hepatic effects have also been reported. Patients at greatest risk for renal toxicity are those that are dehydrated, on concomitant diuretic therapy, or those with renal, cardiovascular, and/or hepatic dysfunction. Concurrent administration of potentiall nephrotoxic drugs should be approached cautiously, with appropriate monitoring. Concomitant use of Vetprofen with other anti-inflammatory drugs, such as other NSAIDs or corticosteroids, should be avoided because of the potential increase of adverse reactions, including gastrointestinal ulcerations and/or perforations. Sensitivity to drug-associated adverse reactions varies with the individual patient. Dogs that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. Vetprofen treatment was not associated with renal toxicity or gastrointestinal ulceration in well controlled safety studies of up to ten times the dose in healthy dogs.

Vetprofen is not recommended for use in dogs with bleeding disorders (e.g., Von Willebrand's disease), as safety has not been established in dogs with these disorders. The safe use of Vetprofen in animals less than 6 weeks of age, pregnant dogs, dogs used for breeding purposes, or in lactating bitches has not been established. Studies to determine the activity of Vetprofen when administered concomitantly with other protein-bound or similarly metabolized drugs have not been conducted. Drug compatibility should be monitored closely in patients requiring additional therapy. Such drugs commonly used include cardiac, anticonvulsant and behavioral medications. It has been suggested that treatment with carprofen may reduce the level of inhalant anesthetics needed.15

If additional pain medication is warranted after administration of the total daily dose of Vetprofen, alternative analgesia should be considered. The use of another NSAID is not recommended. Consider appropriate washout times when switching from one NSAID to another or when switching from corticosteroid use to NSAID use.

Effectiveness:

Confirmation of the effectiveness of Vetprofen for the relief of pain and inflammation associated with osteoarthritis, and for the control of postoperative pain associated with soft tissue and orthopedic surgeries was demonstrated in 5 placebo-controlled, masked studies examining the antiinflammatory and analgesic effectiveness of Vetprofen in various breeds of dogs.

Separate placebo-controlled, masked, multicenter field studies confirmed the anti-inflammatory and analgesic effectiveness of Vetprofen when dosed at 2 mg/lb once daily or when divided and administered at 1 mg/lb twice daily. In these two field studies, dogs diagnosed with osteoarthritis showed statistically significant overall improvement based on lameness evaluations by the veterinarian and owner observations when administered Vetprofen at labeled doses.

Separate placebo-controlled, masked, multicenter field studies confirmed the effectiveness of Vetprofen for the control of postoperative pain when dosed at 2 mg/lb once daily in various breeds of dogs. In these studies, dogs presented for ovariohysterectomy, cruciate repair and aural surgeries were administered Vetprofen preoperatively and for a maximum of 3 days (soft tissue) or 4 days (orthopedic) postoperatively. In general, dogs administered Vetprofen showed statistically significant improvement in pain scores compared to controls.

Animal Safety:

Laboratory studies in unanesthetized dogs and clinical field studies have demonstrated that Vetprofen is well tolerated in dogs after oral administration.

In target animal safety studies, Vetprofen was administered orally to healthy Beagle dogs at 1, 3, and 5 mg/lb twice daily (1, 3 and 5 times the recommended total daily dose) for 42 consecutive days with no significant adverse reactions. Serum albumin for a single female dog receiving 5 mg/lb twice daily decreased to 2.1 g/dL after 2 weeks of treatment, returned to the pre-treatment value (2.6 g/dL) after 4 weeks of treatment, and was 2.3 g/dL at the final 6-week evaluation. Over the 6-week treatment period, black or bloody stools were observed in 1 dog (1 incident) treated with 1 mg/lb twice daily and in 1 dog (2 incidents) treated with 3 mg/lb twice daily. Redness of the colonic mucosa was observed in 1 male that received 3 mg/lb twice daily.

Two of 8 dogs receiving 10 mg/lb orally twice daily (10 times the recommended total daily dose) for 14 days exhibited hypoalbuminemia. The mean albumin level in the dogs receiving this dose was lower (2.38 g/dL) than each of 2 placebo control groups (2.88 and 2.93 g/dL, respectively). Three incidents of black or bloody stool were observed in 1 dog. Five of 8 dogs exhibited reddened areas of duodenal mucosa on gross pathologic examination. Histologic examination of these areas revealed no evidence of ulceration, but did show minimal congestion of the lamina propria in 2 of the 5 dogs.

In separate safety studies lasting 13 and 52 weeks, respectively, dogs were administered orally up to 11.4 mg/lb/day (5.7 times the recommended total daily dose of 2 mg/lb) of carprofen. In both studies, the drug was well tolerated clinically by all of the animals. No gross or histologic changes were seen in any of the treated animals. In both studies, dogs receiving the highest doses had average increases in serum L-alanine aminotransferase (ALT) of approximately 20 IU.

In the 52 week study, minor dermatologic changes occurred in dogs in each of the treatment groups but not in the control dogs. The changes were described as slight redness or rash and were diagnosed as nonspecific dermatitis. The possibility exists that these mild lesions were treatment related, but no dose relationship was observed.

Clinical field studies were conducted with 549 dogs of different breeds at the recommended oral doses for 14 days (297 dogs were included in a study evaluating 1 mg/lb twice daily and 252 dogs were included in a separate study evaluating 2 mg/lb once daily). In both studies the drug was clinically well tolerated and the incidence of clinical adverse reactions for Vetprofen-treated animals was no higher than placebo-treated animals (placebo contained inactive ingredients found in Vetprofen). For animals receiving 1 mg/lb twice daily, the mean post-treatment serum ALT values were 11 IU greater and 9 IU less than pre-treatment values for dogs receiving Vetprofen and placebo, respectively. Differences were not statistically significant. For animals receiving 2 mg/lb once daily, the mean post-treatment serum ALT values were 4.5 IU greater and 0.9 IU less than pre-treatment values for dogs receiving Vetprofen and placebo, respectively. In the latter study, 3 Vetprofen-treated dogs developed a 3-fold or greater increase in (ALT) and/or (AST) during the course of therapy. One placebo-treated dog had a greater than 2-fold increase in ALT. None of these animals showed clinical signs associated with laboratory value changes. Changes in the clinical laboratory values (hematology and clinical chemistry) were not considered clinically significant. The 1 mg/lb twice daily course of therapy was repeated as needed at 2-week intervals in 244 dogs, some for as long as 5 years.

Clinical field studies were conducted in 297 dogs of different breeds undergoing orthopedic or soft tissue surgery. Dogs were administered 2 mg/lb of Vetprofen two hours prior to surgery then once daily, as needed for 2 days (soft tissue surgery) or 3 days (orthopedic surgery). Vetprofen was well tolerated when used in conjunction with a variety of anesthetic-related drugs. The type and severity of abnormal health observations in Vetprofen and placebo-treated animals were approximately equal and few in number (see Adverse Reactions). The most frequent abnormal health observation was vomiting and was observed at approximately the same frequency in Vetprofen and placebo-treated animals. Changes in clinicopathologic indices of hematopoietic, renal, hepatic, and clotting function were not clinically significant. The mean post-treatment serum ALT values were 7.3 IU and 2.5 IU less than pre-treatment values for dogs receiving Vetprofen and placebo, respectively. The mean post-treatment AST values were 3.1 IU less for dogs receiving Vetprofen and 0.2 IU greater for dogs receiving placebo.

Information for Dog Owners:

Vetprofen, like other drugs of its class, is not free from adverse reactions. Owners should be advised of the potential for adverse reactions and be informed of the clinical signs associated with drug intolerance. Adverse reactions may include decreased appetite, vomiting, diarrhea, dark or tarry stools, increased water consumption, increased urination, pale gums due to anemia, yellowing of gums, skin or white of the eye due to jaundice, lethargy, incoordination, seizure, or behavioral changes. Serious adverse reactions associated with this drug class can occur without warning and in rare situations result in death (see Adverse Reactions). Owners should be advised to discontinue Vetprofen therapy and contact their veterinarian immediately if signs of intolerance are observed. The vast majority of patients with drug related adverse reactions have recovered when the signs are recognized, the drug is withdrawn, and veterinary care, if appropriate, is initiated. Owners should be advised of the importance of periodic follow up for all dogs during administration of any NSAID.

Adverse Reactions:

During investigational studies of osteoarthritis with twice daily administration of 1 mg/lb, no clinically significant adverse reactions were reported. Some clinical signs were observed during field studies (n=297) which were similar for carprofen and placebo-treated dogs. Incidences of the following were observed in both groups: vomiting (4%), diarrhea (4%), changes in appetite (3%), lethargy (1.4%), behavioral changes (1%), and constipation (0.3%). The product vehicle served as control.

There were no serious adverse events reported during clinical field studies of osteoarthritis with once daily administration of 2 mg/lb. The following categories of abnormal health observations were reported. The product vehicle served as control.

Percentage of Dogs with Abnormal Health Observations Reportedin Osteoarthritis Field Study (2 mg/lb once daily)
Observation Carprofen (n=129) Placebo (n=132)
Inappetence 1.6 1.5
Vomiting 3.1 3.8
Diarrhea/Soft stool 3.1 4.5
Behavior change 0.8 0.8
Dermatitis 0.8 0.8
PU/PD 0.8 ---
SAP increase 7.8 8.3
ALT increase 5.4 4.5
AST increase 2.3 0.8
BUN increase 3.1 1.5
Bilirubinuria 16.3 12.2
Ketonuria 14.7 9.1

Clinical pathology parameters listed represent reports of increases from pre-treatment values; medical judgment is necessary to determine clinical relevance.

During investigational studies of surgical pain for the tablet formulation, no clinically significant adverse reactions were reported. The product vehicle served as control.

Percentage of Dogs with Abnormal Health Observations Reportedin Surgical Pain Field Studies with Tablets (2 mg/lb once daily)
Observation* Carprofen (n=148) Placebo (n=149)
Inappetence 1.4 0
Vomiting 10.1 13.4
Diarrhea/Soft stool 6.1 6.0
Dermatitis/skin lesion 2.0 1.3
Ocular disease 2.7 0
Dysrhythmia 0.7 0
Apnea 1.4 0
Oral/periodontal disease 1.4 0
Pyrexia 0.7 1.7
Urinary tract disease 1.4 1.3
Wound drainage 1.4 0

*A single dog may have experienced more than one occurrence of an event

FAQ

Vetprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation (soreness) due to osteoarthritis and pain following surgery in dogs. Vetprofen is a prescription drug for dogs. It is available as a tablet and is given to dogs by mouth.

Osteoarthritis (OA) is a painful condition caused by "wear and tear" of cartilage and other parts of the joints that may result in the following changes or signs in your dog:

  • Limping or lameness
  • Decreased activity or exercise (reluctance to stand, climb stairs, jump or run, or difficulty in performing these activities)
  • Stiffness or decreased movement of joints

To control surgical pain (e.g. for surgeries such as spays, ear procedures or orthopedic repairs) your veterinarian may administer Vetprofen Flavored Tab before the procedure and recommend that your dog be treated for several days after going home.

While Vetprofen is not a cure for osteoarthritis, it can relieve the pain and inflammation of OA and improve your dog's mobility.

  • Response varies from dog to dog but can be quite dramatic.
  • In most dogs, improvement can be seen in a matter of days.
  • If Vetprofen is discontinued or not given as directed, your dog's pain and inflammation may come back.

Your dog should not be given Vetprofen if he/she:

  • Has had an allergic reaction to carprofen, the active ingredient of Vetprofen.
  • Has had an allergic reaction to aspirin or other NSAIDs (for example deracoxib, etodolac, firocoxib, meloxicam, phenylbutazone or tepoxalin) such as hives, facial swelling, or red or itchy skin.
Cats should not be given Vetprofen. Call your veterinarian immediately if your cat receives Vetprofen. People should not take Vetprofen. Keep Vetprofen and all medicines out of reach of children. Call your physician immediately if you accidentally take Vetprofen.
Vetprofen should be given according to your veterinarian's instructions. Your veterinarian will tell you what amount of Vetprofen is right for your dog and for how long it should be given. Vetprofen should be given by mouth and may be given with or without food.

Talk to your veterinarian about:

  • The signs of OA you have observed (for example limping, stiffness).
  • The importance of weight control and exercise in the management of OA.
  • What tests might be done before Vetprofen is prescribed.
  • How often your dog may need to be examined by your veterinarian.
  • The risks and benefits of using Vetprofen.

Tell your veterinarian if your dog has ever had the following medical problems:

  • Experienced side effects from Vetprofen or other NSAIDs, such as aspirin
  • Digestive upset (vomiting and/or diarrhea)
  • Liver disease
  • Kidney disease
  • A bleeding disorder (for example, Von Willebrand's disease)

Tell your veterinarian about:

  • Any other medical problems or allergies that your dog has now or has had.
  • All medicines that you are giving your dog or plan to give your dog, including those you can get without a prescription.

Tell your veterinarian if your dog is:

  • Pregnant, nursing or if you plan to breed your dog.

Vetprofen, like other drugs, may cause some side effects. Serious but rare side effects have been reported in dogs taking NSAIDs, including carprofen. Serious side effects can occur with or without warning and in rare situations result in death.

The most common NSAID-related side effects generally involve the stomach (such as bleeding ulcers), and liver or kidney problems. Look for the following side effects that can indicate your dog may be having a problem with Vetprofen or may have another medical problem:

  • Decrease or increase in appetite
  • Vomiting
  • Change in bowel movements (such as diarrhea, or black, tarry or bloody stools)
  • Change in behavior (such as decreased or increased activity level, incoordination, seizure or aggression)
  • Yellowing of gums, skin, or whites of the eyes (jaundice)
  • Change in drinking habits (frequency, amount consumed)
  • Change in urination habits (frequency, color, or smell)
  • Change in skin (redness, scabs, or scratching)

It is important to stop therapy and contact your veterinarian immediately if you think your dog has a medical problem or side effect from Vetprofen therapy. If you have additional questions about possible side effects, talk to your veterinarian.

Vetprofen should not be given with other NSAIDs (for example, aspirin, deracoxib, etodolac, firocoxib, meloxicam, tepoxalin) or steroids (for example, cortisone, dexamethasone, prednisone, triamcinolone).

Tell your veterinarian about all medicines you have given your dog in the past, and any medicines that you are planning to give with Vetprofen. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog's medicines can be given together.

Contact your veterinarian immediately if your dog eats more than the prescribed amount of Vetprofen.

This sheet provides a summary of information about Vetprofen. If you have any questions or concerns about Vetprofen, or osteoarthritis, or postoperative pain, talk to your veterinarian.

As with all prescribed medicines, Vetprofen should only be given to the dog for which it was prescribed. It should be given to your dog only for the condition for which it was prescribed.

It is important to periodically discuss your dog's response to Vetprofen at regular check ups. Your veterinarian will best determine if your dog is responding as expected and if your dog should continue receiving Vetprofen.

Reviews

Review Summary
4.8
17 Reviews
5
88% (15)
4
6% (1)
3
6% (1)
2
0% (0)
1
0% (0)
100% Recommend this product (17 of 17 responses)
By Brian
Seattle
Generics work as well as big name drugs
June 14, 2015
As our dogs age and arthritis grabs ahold of their hips, shoulders and other joints, much like humans, a drug that helps with the inflammation is a blessing. Our two big dogs are able to negotiate stairs with less discomfort and pain. We recommend talking to your vet about prescribing this medication to help your dogs in their golden years.
ProsGenerics are less than the brand name drugs and equally as effective. Place the order here online, they will contact your vet for the authorization and within a few days the prescription will be at your front door. It's just that simple.
By Dan
Tucson, Az.
As advertised..!!!
April 10, 2015
This worked great, I ordered the medication for my dog, they called my vet to confirm and shipped out the medication. As advertised..!!!
By David V.
Wheeling, IL.
Vetprofen
August 1, 2020
We love this medicine for our dog. She was having hip & back leg problems and when we took her to the Vet, they prescribed Vetprofen. The Vet charges way more than Entirely Pets Pharmacy does and we couldn't be happier. Our dog is 10 years old and now she acts like a 2 year old.
By Milena J.
CO
Vetprofen ( Carprofen 100mg )
July 12, 2020
Fast shipping ! Helping my dog ! Thank you !
By Bob
Belleville I?ll
Order
June 26, 2020
First order took awhile and had trouble getting delivery information
I am sure future orders will go smoother
Merchant Response:Hi Bob, sometimes some prescriptions take longer than others to get approval. We are working on streamlining our process every day. Take care
By Ed
Clarksburg, Md
Vetprofen
March 16, 2019
I'm happy with the product, happy with the price, happy with the quick delivery.
By Shelley
Shamrock, Ok
Great service
December 27, 2018
Refills were easy when my vet is quick to reply. Quality product and fast
By Michael
St. Louis
Great
August 2, 2018
Same as what my fur baby was taking from the Vet but a lot cheaper. Thank you for the great prices and product.
By Marge
Harrisville, PA
Arthritis relief
July 16, 2018
Vetprofen has helped my dog move better. He has arthritis in his hips and has less trouble moving since he started taking this pill.
By Morgan
Oregon Coast
Excellent anti-inflammatory medication for dogs!
April 7, 2017
I am very pleased with Entirely Pets Pharmacy. The prices are very good and considerably less expensive than the veterinarian.

My Smooth Fox Terrier has been using this product for approximately 10 months. Vetprofen has enabled her to be more active, mobile and most important, it has made her more comfortable with a better quality of life. My dog was prescribed this medication (25 mg.) for hip arthritis pain.
ProsVetprofen is an excellent and reliable generic for Rimadyl. Entirely Pets Pharmacy has very good prices with free shipping (minimum purchase criteria). Convenience of prescription delivered to your home, instead of a visit to the veterinarian.
By Sharon S.
Pahrump, Nevada
Great
February 5, 2017
Great
ProsGreat
ConsNone
By Colleen K.
Temple City, CA
Best Price Excellent Product
July 24, 2016
I have ordered the Vetprofen 100mg Capsule 240 count two times. I did quite a bit of research pricing this item. I searched Rimadyl, Carprofen, and Vetprofen. This Pharmacy offers one of the best prices for the product. It always pays to do a search at several well known company names before you commit to buy. Entirely Pets Pharmacy has been there for me during the last two years helping me provide my aging pet dog, Max with the appropriate pain medications he needed to make his last year with me more comfortable. This product works the same as Rimadyl for aiding with arthritis pain, spinal degenerative disease pain, and post surgery or generalized pain. It is the base from which your vet will build your pain management plan for your pet. Be sure to ask your vet before administering any medication to your pet and especially those prescribed for dogs - do not give to your cat without checking with your vet first - this could be a lethal mistake. Also, note that you will be required to have labs done to monitor liver function while using this drug. Your vet may recommend full blood work up which is ideal, however if you are in a pinch for cash you can substantially reduce your labwork cost by having the liver panel done alone. Do not overlook this important step and do follow up to complete the other labs as soon as possible. I recommend this product and have seen how it has helped my Max during his last year with me. Hope you find this beneficial. Thank You! Colleen, LVN
By Ken
Austin, Tx
Vetprofen purchase
June 10, 2016
product received in good order and in a timely manner
By Izzy
Midlothian IL
Great
May 27, 2016
Great product, my dog was to the point of not being able to walk up and down the stairs because of her arthritis . Now she's like a puppy again. She runs and plays and has no problem with stairs.
By Sharon
Thomaston GA
Great Prices
September 4, 2015
This medication works as well as the medication puchased from my veterinarian at a much lower price. Good communication throughout process with fast shipping.
By Vicki
Americus, Ga
The Best Thing I Ever Did
June 18, 2015
How great to discover Entirely Pets Pharmacy. After rescuing a puppy on the side of the road, his x rays showed a major hip & pelvis problem. Mac had probably been hit by a car on that old back farm road. I stood there in tears when my vet said he'd never get better & it would just get worse. I had new hope after one of the techs said he was too good a dog to put down & that I should try meds. first. Macs medicine cost from the vets office for the first month, lead me to search the web for an affordable program. I can't believe how easy Entirely Pets Pharmacy has made my transition. Within 3 days they had obtained my prescription info. for Vetprofen from my vet & Macs meds were on their way. It's made all the difference in the world. Mac is happy & I'm saving over half of what I paid at my vets office for the same exact medicine. Thank You for alleviating the stress that comes with a special needs dog, thank you for FAST SHIPPING, thank you for competent reps. who answer the phones & help ease the situation. Now I'm on the auto refill plan & that makes me very happy.
By Judi
Olympia, WA
Pain Relief
May 22, 2015
Reduces pain and lets my golden retriever stay active.

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