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  • Description
  • Directions
  • Reviews


Apoquel treats acute and chronic pruritus in dogs and provides fast-acting relief from its symptoms. Though pruritus can be caused by skin disease, cancer, and other conditions- this treatment is specifically formulated to fight pruritus associated with skin allergies. It can also be taken in conjunction with other medications meant to treat your dog’s seasonal allergies as directed by your veterinarian.

Apoquel starts working within 4 hours of administering the first dose and controls itching within 24 hours. To ensure that it’s easy to administer the proper dosage to your dog, this treatment comes in three different dosages, each of which is sold individually, in packs of 100.

  • Combats both acute and chronic pruritus
  • Fast-acting relief with itch-control effective within 24 hours of first dose
  • Available in three different dosages, each in three different sizes

  • Uses for Apoquel
  • Helps in particular with control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs 12 months of age or older
  • Provides relief within 4 hours of the first dosage and effectively controls itch within first 24 hours
  • Isolates symptoms to allow for an accurate diagnosis of underlying conditions
  • Improves quality of life for dogs and owners experiencing certain symptoms of skin conditions.

  • Prescription Required


  • Should be administered twice daily during the therapeutic period and once daily for maintenance period
  • May be used with other common therapies including NSAIDs, antibiotics, vaccines, and allergen immunotherapy
  • More information on dosing should be available in the prescription information.

  • Administration:
  • Administer doses orally twice daily for up to 14 days, then reduced by half for maintenance
  • May be administered with or without food
  • Tablets of Apoquel can be administered when split to allow for partial doses

  • Conditions Treated
  • Controls acute and chronic canince pruritus associated with allergic dermatitis
  • Relieves itching associated with skin conditions
  • Controls atopic dermatitis

  • Side Effects
  • Diarrhea
  • Anorexia
  • Polydipsia
  • Occasionally vomiting and lethargy
  • New dermal, epidermal or subcutaneous lump may form when treating atopic dermatitis
  • Reviews

    Review Summary
    22 Reviews
    82% (18)
    18% (4)
    0% (0)
    0% (0)
    0% (0)
    95% Recommend this product (21 of 22 responses)
    By Marla K. Berry
    Prince George, VA
    October 25, 2018
    Apoquel & Entirely Pets
    So far the Apoquel seems to be doing fine. Thank you for the discount and fast shipping,
    ProsGood Product excellent company
    By Jane A Flanigan
    September 15, 2018
    Reliable Service
    Order process easy, received order in an appropriate amount of time in good condition.
    By Bob Underwood
    Albuquerque, New Mexico
    September 6, 2018
    Best Service
    This works great. No more Scratching.
    ProsWhile this med was prescribed by our vet, we couldn't have asked for a better experience than we received from Entirely Pets customer service. He was helpful, personable, and helped expedite our order. Thanks for the experience Entirely Pets. Bob Underwood
    By Jennifer
    Cadyville, Ny
    August 29, 2018
    This is the cheapest price that I've found! Works great for our dogs allergies & we're very happy, thank you!
    Merchant Response: Hi Jennifer, thank you for your feedback and it's great to hear the Apoquel works so well for your dogs!
    By CAROL
    August 28, 2018
    Merchant Response:Hello Carol, thank you for your comment and we are happy to hear the APOQUEL is working well for your dog!
    By Marianne
    New River, Arizona
    August 13, 2018
    Apoquel is the "Magic Itch Relief"
    We live out in the country on 1 acre, lots of trees and bushes, allergies use to win with my doggies but Apoquel has provided the best relief ever!
    Merchant Response:Glad to hear this keep all the dogs allergy-free and happy! :)
    By SUSAN
    June 21, 2018
    allergy medication
    It works well for our Cavalier King Charles. The only problem was miscommunication on getting the order via our vet.
    Merchant Response:Hi Susan, We apologize for the miscommunication on our end and for any inconvenience it might have given you. We hope everything is working well with APOQUEL? and its to your satisfaction.
    Prosworks well
    ConsLong time to get prescription. No follow-up from entirelypet ;
    By Patty Miller
    May 16, 2018
    It works!
    Buddy has environmental allergies. His paws would swell and itch so bad he licked until his hair fell out. Apoquel helped him immediately. Within minutes. Now I only have to give as needed. It’s expensive but Entirely Pets have the best prices!
    By Kathy
    Pleasant Hill, CA
    May 13, 2018
    This product has saved my dog from her allergies.
    By Haley
    Ripon, ca
    April 13, 2018
    Works for my pup
    My dog has suffered from itching his whole entire life!!!!!! I would visit the vet multiple times a year to help my dog feel some relief from the constant itching and nothing we did would help him ... and then I asked the vet if I could try apoquel and it is a complete miracle!!!!! My pitbull is finally itch free!!! He has been taking this medicine for about a year now and still works wonderfully!!!! expensive but totally worth it!
    By Kirsten
    Riverside, CA
    April 9, 2018
    Works great
    I have a min-pin and nothing else works. My only issue is with EntirelyPets since they raise the price so often. I bought it 5 months ago at $178.99 a bottle and now it is $206.00 a bottle. So even if I use the new 15% off code its just as expensive as it was.
    By Maria Garrett
    Fort Worth,Texas
    October 2, 2017
    Doing a good job
    Barky is doing a lot better with her skin problems. Does not have hot spots like she suffered from before.
    Merchant Response:Hi Maria, we are so glad to hear Barky's skin problems are getting better!
    Prosworking well.
    Consvery pricey ,but it works well.
    By Sharon Ottomeyer
    Indian Wells, CA
    September 15, 2017
    Works Great!
    Apoquel started giving our toy poodle, Peanut, relief from here itching, within four hours of her first dosage! She stopped licking her paws and the constant scratching. She hasn't had any side affects from the medication. She is so much happier now!🐶💗
    Merchant Response:Hi Sharon, thank you for the great feedback and we're so happy Peanut is much more comfortable and happy now!
    By Sue B.
    July 23, 2017
    Works But Had To Reduce Dose
    The Vet prescribed two of these per day for our 72lb. Lab/Border Collie mix. But our dog began throwing up immediately. and we were told to reduce the dose to one tablet, half twice per day. Our dog seems to be getting along OK at this dose.
    ProsEasy to use; seems to be working
    ConsDogs throwing up and having other negative side-effects is all too normal
    By Jenn Santel
    Vista, CA
    June 19, 2017
    Thank goodness for Apoquel
    My dog has been having issues with allergies for years. We tried so many things, and combinations of things. Herbs. Shampoos medicated shampoos. Pills. Whatever. Nothing worked and she was so uncomfortable. And her skin was always irritated. Apoquel works. No further issues with her allergies. So happy that we found Apoquel.
    ProsNo more issues with skin allergies following years of exerpirmenting
    Wdnvl WA
    May 27, 2017
    Great itch control
    Great itch control- no more scratching
    Merchant Response:Thank you for your great feedback Norm, and we are so happy to hear the Apoquel is helping your pet!
    Proseasy to split for prescribed amount
    Conssmaller dose pills same price as higher dose pills
    By Kathy Vitue
    Wdnvl WA
    May 27, 2017
    Itch is Under Control
    Apoquel reliably cuts down my girls itch!
    Merchant Response:Thank you for your feedback Kathy, and we are so happy to hear the Apoquel is making a big difference for your pet!
    ProsEffective, easy to portion,
    By Mark
    Hemet, CA
    May 10, 2017
    great service
    always fast and accurate service from Entirely Pets Pharmacy. Apoquel has worked wonders for my 12 year pit bull who has had bad allergies all his life. Being allergic to beef, chicken, pork and environmental things as well, he was always having issues. I even had to make his own food. He was on steroids and Benadryl for years and still had bad itching, rashes Virtually all the skin problems have gone away and we have been on Apoquel for about 6 months with no noticeable side effects. He is also eating a variety of things with no problems.
    By R
    April 30, 2017
    Closest thing to a miracle drug for itchy dogs
    My dog was very itchy before he was prescribed this drug. It's worked miracles for him.
    Merchant Response:Thank you so much for your feedback and we are so happy to hear that the Apoquel is doing such a great job keeping your dog itch-free and comfortable!
    By Linda
    Seattle, WA
    March 23, 2017
    Practically magic
    I never thought this would work, felt like I'd done everything else & tried so many shampoos and salves and lotions and powders and food changes. So painful to watch your precious baby suffer. I don't know why it has to be so expensive but hey, it totally works.
    By Kathie
    Conneaut ohio
    March 17, 2017
    The best
    My 8 year old golden doodle has been suffering with skin allergy about 3-4 years. I have spent hundreds of dollars on anything the vet recommended and any holistic pills and sprays. She was on this pill for 4 hours and I could see a difference. Within 2 days she was 80% better. After one week she was 100% that's right. No more digging bloody hot spots, no more smell, no more hair falling out. The hardest part is the expense of the pill I am retired 10 years now. She is 100# so the dose is 1and1/2 twice a day for two weeks and now she takes 1and1/2 a day. She digs a little now that I cut her back but still really good. She is like a puppy again and wants to play with my 4 year old multipoo again. Thank you so much for this miracle drug.
    By Richard
    Frisco Tx
    November 25, 2016
    It was very easy to obtain this Rx and it saved me considerable money. I will definitely use Entirely Pets next time.