Apoquel | 3.6, 5.4, & 16 mg | Free Shipping | EntirelyPets Rx
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Apoquel Tablets for Dogs

Apoquel Tablets for Dogs

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Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
$2.29Reg $2.99
$45.80Reg $56.68
$229.00Reg $297.99
$2.29Reg $2.99
$45.80Reg $56.68
$229.00Reg $297.99
$2.29Reg $2.99
$229.00Reg $297.99
$224.95Reg $245.99
$224.95Reg $245.99
$45.80Reg $56.68
$224.95Reg $245.99
  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Apoquel (oclacitinib) is an FDA-Approved medication that provides fast-acting relief from its symptoms and treats acute and chronic pruritus in dogs. Apoquel is specifically formulated to relieve itchiness associated with skin allergies. It can also be taken in conjunction with other medications meant to treat your dog's seasonal allergies as directed by your veterinarian.

Apoquel starts working within 4 hours of administering the first dose and controls itching within 24 hours. To ensure that it's easy to administer the proper dosage to your dog, this treatment comes in three different dosages. Each dosage is sold per tablet, in 20 count, or 100 count bottles.

What is Apoquel Used For?

  • Relieves itching associated with skin conditions and allergic reactions
  • Controls acute and chronic canince pruritus associated with allergic dermatitis
  • Controls atopic dermatitis

What Animals can use Apoquel?


Key Benefits

  • Fast-acting itch relief within 4 hours
  • Sustained relief up to 24 hours after first dosage
  • Easy dosing and administration with three different dosages for every size dog
  • Can be given with or without food.

How It Works

  • Helps in particular with control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs 12 months of age or older
  • Isolates symptoms to allow for an accurate diagnosis of underlying conditions


Active Ingredient:



View Apoquel Drug Facts Sheet.

  • The dose of APOQUEL tablets is 0.18 to 0.27 mg/lb (0.4 to 0.6 mg/kg)
  • APOQUEL should be given twice daily (BID) for up to 14 days of therapy and once daily (SID) thereafter for maintenance
  • APOQUEL may be given with or without food
  • APOQUEL may be discontinued without tapering

Quick Tips

  • Should be administered twice daily during the therapeutic period and once daily for maintenance period
  • May be used with other common therapies including NSAIDs, antibiotics, vaccines, and allergen immunotherapy
  • More information on dosing should be available in the prescription information.
  • Administer doses orally twice daily for up to 14 days, then reduced by half for maintenance
  • May be administered with or without food
  • Tablets of Apoquel can be administered when split to allow for partial doses


The safety profile of APOQUEL is supported by pharmacovigilance data over 5 years

The overall adverse reactions incidence rate during a 5-year review is rare (more than 1 but less than 10 animals reacting per 10,000 treatments administered)

  • The incidence rate of the most commonly reported individual adverse reactions (in decreasing order: vomiting, diarrhea, lethargy, anorexia and bloodwork changes) associated with the use of APOQUEL was very rare (less than 1 dog out of 10,000 treated)
  • Results are consistent with pre-approval pivotal safety and efficacy studies. APOQUEL is performing as expected under field conditions

Safe to use in dogs 12 months of age and older

Side effects were similar to placebo over short term

  • Most common side effects in a short-term clinical trial included vomiting and diarrhea and were self-limiting

Can be used long term for maintenance therapy

Can be used concomitantly with many medications, including NSAIDs, anti-infectives, parasiticides, antifungals and allergen-specific immunotherapy

  • The use of APOQUEL has not been evaluated in combination with other systemic immuno suppressants, such as corticosteroids and cyclosporine

Not for use in dogs with serious infections or for use in breeding, pregnant or lactating dogs

Rare is defined as more than 1 but less than 10 animals reacting per 10,000 treatments administered; very rare is defined as less than 1 animal reacting per 10,000 treatments administered. Reported incidence rate (calculated) is an estimated rate. Includes all ARs regardless of whether the product was administered per label directions, concomitantly or if a potential causal relationship existed.

See signs of allergic itch? See your veterinarian

All dogs scratch, lick, and chew - but if it's becoming more frequent and excessive, it may mean something more.

Common signs

  • Frequent scratching, licking, biting, or chewing
  • Excessive rolling, rubbing, or scooting
  • Recurrent ear problems (such as head shaking, ear discharge/odor, or scratching at ears)
  • Hair loss, body odor, or skin changes (such as rash, redness, greasy skin, or scabs)

Common causes

  • Flea allergy
  • Food allergy
  • Environmental indoor and outdoor allergens (such as pollen, dust mites, and mold)
  • Contact allergy (such as carpet cleaners, shampoos, plants, and insecticidal products)


Federal (USA) Law restricts this drug to use by or on the order of a licensed veterinarian.


APOQUEL is not for use in dogs less than 12 months of age (see Animal Safety).

APOQUEL is not for use in dogs with serious infections.

APOQUEL may increase susceptibility to infection, including demodicosis, and exacerbate neoplastic conditions (see Adverse Reactions and Animal Safety).

Human Warnings:

This product is not for human use. Keep this and all drugs out of reach of children. For use in dogs only. Wash hands immediately after handling the tablets. In case of accidental eye contact, flush immediately with water or saline for at least 15 minutes and then seek medical attention. In case of accidental ingestion, seek medical attention immediately.


APOQUEL is not for use in breeding dogs, or pregnant or lactating bitches.

The use of APOQUEL has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents.

Dogs receiving APOQUEL should be monitored for the development of infections, including demodicosis, and neoplasia.


APOQUEL should be stored at controlled room temperature between 20° to 25°C (68° to 77°F) with excursions between 15° to 40°C (59° to 104°F)


Yes, you can use APOQUEL for short periods. APOQUEL begins relieving allergic dog itch within 4 hours, and controls it within 24 hours.

Yes, APOQUEL may be used with other treatment such as:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, carprofen)
  • Vaccines (rabies)
  • Allergen-specific immunotherapy (allergy shots or drops)

The use of APOQUEL has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporine.

The US Food and Drug Administration (FDA) has not placed any time restrictions on the use of APOQUEL. Your dog can continue to be treated with APOQUEL as long as your veterinarian recommends. In a study, dogs were treated with APOQUEL for more than 2 years.
Yes, APOQUEL can be given with or without food.
APOQUEL is given twice daily for up to 14 days, and then given once daily for maintenance therapy.
APOQUEL starts relieving allergic itch within 4 hours of giving the treatment to your dog.
The most common side effects of APOQUEL in a short-term clinical trial were vomiting and diarrhea. These occurred in only a small percentage of dogs treated with APOQUEL. These side effects typically stopped on their own.
APOQUEL is a medication for dogs prescribed by a veterinarian for dogs 12 months of age or older to control the itch and inflammation associated with allergic and atopic dermatitis.
Occasional itching is a fact of life for dogs. However, allergies, fleas, mites, infection, and other diseases may cause more frequent or constant itching, indicating a more serious condition. If you notice your dog is itching more often, and/or you see changes in your dog's skin, including hot spots, redness, or rash, make an appointment to visit your veterinarian and get it checked out.
If your dog is scratching, licking, or biting the same area repeatedly, the skin can become damaged, red, and sore. It's a good idea to ask your dog's veterinarian about the possible causes. It could be due to allergies, and in this event, your pet may require a prescription treatment such as APOQUEL to treat the underlying cause. There also may be a skin infection that requires antibiotic or antifungal treatment from your veterinarian.
APOQUEL is not a steroid, antihistamine, or cyclosporine (a type of drug that reduces immune system activity). APOQUEL is in a different category of medications. Unlike other medicines, APOQUEL blocks allergic itch at the source. So, it works at the underlying cause of itch to provide relief fast.

If your dog's itching persists or you notice any of the following signs, you should make an appointment to visit your veterinarian to find out if the itching is caused by a medical condition:

  • Frequent scratching, licking, biting, or chewing
  • Excessive rolling, rubbing, or scooting
  • Recurrent ear problems (head shaking, ear discharge/odor, or scratching at ears)
  • Hair loss, body odor, or skin changes (such as rash, redness, greasy skin, or scabs)


Review Summary
36 Reviews
81% (29)
19% (7)
0% (0)
0% (0)
0% (0)
94% Recommend this product (34 of 36 responses)
By Sandra S.
Easy and cost effective pet prescription renewal
December 26, 2020
I have been please with Entirely Pets Pharmacy service. Everything is done online and the meds are delivered to my home. The price is competitive too.
By Theresa M.
December 2, 2020
Fast shipping and great price!!��
By Magical12
San Fernando Valley
Great Service
November 28, 2020
Easy to find product, they handle all the details on prescription orders, good order updates, good prices and quick delivery.
Merchant Response:Thanks, we are taking steps to give even better service. You just wait!
By Barb
Tulalip, WA
November 12, 2020
Exactly what I ordered
ProsGreat price
By Dennis
VERO Beach, Florida
Apoquel 16 mg
October 16, 2020
Apoquel is working quite well for my 1 year old female golden retriever.
With the discount there is no better place to buy Apoquel than Entirely Pets Pharmacy.
By John
Upstate NY
Apoquel order
April 8, 2020
Iím disappointed in the shipping time frame, 3 weeks for delivery is excessive!
By Sue
Great site to get my pup's meds
February 10, 2020
My chihuahua has so many allergies. Our vet was having trouble keeping this medication in stock so they directed me to 1800PetMeds and now EntirelyPetsPharmacy. I was very pleased with the prices, ease of navigation of the site, the at-my-door delivery, and the ease of them getting the required prescription from our vet. Thank you!!!
By Joline
San Mateo, CA
February 6, 2020
The person to whom I gave the order was knowledgeable and friendly. Order was processed and received in a timely manner. I was bit surprised at how much the cost had increased since my last order.
ProsCustomer service
By Joel
katy, TX
stops the itch
January 10, 2020
One of my dogs needs this and it works wonders. Very good. Pricey but effective
Prosworks great and fast
By Karen
Key West
It just works
December 30, 2019
One of our dogs had terrible problems with itchy skin. Tried everything and was at the end of my rope. Started her on Apoquel, the results were immediate.
By LouAnne
Riverside, California
Excellence in Action
December 5, 2019
Fast efficient service getting approval from my vet, and getting the product out the door for quick delivery. The price was so much more reasonable than I have found elsewhere. I am a loyal customer for sure.
By Deile S.
Allouez, WI
Great Service-Great Price
October 20, 2019
I was very happy with how easy it was to have my dog's prescription filled through Entirely Pets Pharmacy and especially how much more affordable it was. Thanks.
By Jana
This Medicine Works Wonderfully
August 8, 2019
Apoquel has been a life saver for our dog.
Customer Service
March 7, 2019
I had a great experience with ordering from this company. Product was shipped fast and customer service was very helpful.
ProsFast shipping Responsive customer service
By Jodi B.
Port Charlotte FL
More affordable
January 19, 2019
After doing some searching, this is the least expensive way to keep my dog on this medication for itching. Customer service was helpful, and the product arrived quickly.
By Patricia
santa maria, CA
December 20, 2018
Apoquel has been a miracle for our Zoe. Instead of living her days panting and scratching her skin raw, she now has quality of life! We are grateful that our vet recommended it. Thank you!!
By Kristen
Great for the itchies
December 14, 2018
My dog had been taking this for about 8 months now. Before he started, he had raw and red spots from allergies causing itchy skin. Since starting, he's stopped the incessant itching and biting, his skin is no longer red and raw, and his hair has grown back.
By Jane F.
Reliable Service
September 15, 2018
Order process easy, received order in an appropriate amount of time in good condition.
By Bob U.
Albuquerque, New Mexico
Best Service
September 6, 2018
This works great. No more Scratching.
ProsWhile this med was prescribed by our vet, we couldn't have asked for a better experience than we received from Entirely Pets customer service. He was helpful, personable, and helped expedite our order. Thanks for the experience Entirely Pets. Bob Underwood
August 28, 2018
Merchant Response:Hello Carol, thank you for your comment and we are happy to hear the APOQUEL is working well for your dog!
By Marianne
New River, Arizona
Apoquel is the "Magic Itch Relief"
August 13, 2018
We live out in the country on 1 acre, lots of trees and bushes, allergies use to win with my doggies but Apoquel has provided the best relief ever!
Merchant Response:Glad to hear this keep all the dogs allergy-free and happy! :)
allergy medication
June 21, 2018
It works well for our Cavalier King Charles. The only problem was miscommunication on getting the order via our vet.

Merchant Response:Hi Susan, We apologize for the miscommunication on our end and for any inconvenience it might have given you. We hope everything is working well with APOQUEL? and its to your satisfaction.
Prosworks well
ConsLong time to get prescription. No follow-up from entirelypet ;
By Patty M.
It works!
May 16, 2018
Buddy has environmental allergies. His paws would swell and itch so bad he licked until his hair fell out.
Apoquel helped him immediately. Within minutes.
Now I only have to give as needed.

Itís expensive but Entirely Pets have the best prices!
By Kathy
Pleasant Hill, CA
May 13, 2018
This product has saved my dog from her allergies.
By Haley
Ripon, ca
Works for my pup
April 13, 2018
My dog has suffered from itching his whole entire life!!!!!! I would visit the vet multiple times a year to help my dog feel some relief from the constant itching and nothing we did would help him ... and then I asked the vet if I could try apoquel and it is a complete miracle!!!!! My pitbull is finally itch free!!! He has been taking this medicine for about a year now and still works wonderfully!!!! expensive but totally worth it!
By Kirsten
Riverside, CA
Works great
April 9, 2018
I have a min-pin and nothing else works. My only issue is with EntirelyPets since they raise the price so often. I bought it 5 months ago at $178.99 a bottle and now it is $206.00 a bottle. So even if I use the new 15% off code its just as expensive as it was.
By Maria G.
Fort Worth,Texas
Doing a good job
October 2, 2017
Barky is doing a lot better with her skin problems. Does not have hot spots like she suffered from before.
Merchant Response:Hi Maria, we are so glad to hear Barky's skin problems are getting better!
Prosworking well.
Consvery pricey ,but it works well.
By Sharon O.
Indian Wells, CA
Works Great!
September 15, 2017
Apoquel started giving our toy poodle, Peanut, relief from here itching, within four hours of her first dosage! She stopped licking her paws and the constant scratching. She hasn't had any side affects from the medication. She is so much happier now!🐶💗
Merchant Response:Hi Sharon, thank you for the great feedback and we're so happy Peanut is much more comfortable and happy now!
By Sue B.
Works But Had To Reduce Dose
July 23, 2017
The Vet prescribed two of these per day for our 72lb. Lab/Border Collie mix. But our dog began throwing up immediately. and we were told to reduce the dose to one tablet, half twice per day. Our dog seems to be getting along OK at this dose.
ProsEasy to use; seems to be working
ConsDogs throwing up and having other negative side-effects is all too normal
By Jenn S.
Vista, CA
Thank goodness for Apoquel
June 19, 2017
My dog has been having issues with allergies for years. We tried so many things, and combinations of things. Herbs. Shampoos medicated shampoos. Pills. Whatever. Nothing worked and she was so uncomfortable. And her skin was always irritated.

Apoquel works. No further issues with her allergies. So happy that we found Apoquel.
ProsNo more issues with skin allergies following years of exerpirmenting

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