Apoquel | 3.6, 5.4, & 16 mg | Free Shipping | EntirelyPets Rx
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Apoquel Tablets for Dogs Video
Apoquel Tablets for Dogs Video

Apoquel Tablets for Dogs

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Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
$3.04Reg $3.99
$57.76Reg $75.99
$86.64Reg $112.99
$173.48Reg $225.99
$303.98Reg $395.99
$3.04Reg $3.99
$57.76Reg $75.99
$86.64Reg $112.99
$173.48Reg $225.99
$303.98Reg $395.99
$3.04Reg $3.99
$57.76Reg $75.99
$86.64Reg $112.99
$173.48Reg $225.99
$303.98Reg $395.99
$2.98Reg $3.99
$57.76Reg $75.99
$86.64Reg $112.99
$173.48Reg $225.99
$288.80Reg $375.99
$2.98Reg $3.99
$57.76Reg $75.99
$86.64Reg $112.99
$173.48Reg $225.99
$288.80Reg $375.99
$2.98Reg $3.99
$54.00Reg $68.89
$86.64Reg $112.99
$173.48Reg $225.99
$288.80Reg $375.99
  • Description
  • Ingredients
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  • FAQ
  • Reviews


Apoquel (oclacitinib) Tablets for Dogs are a breakthrough treatment for allergic skin conditions that cause itching and inflammation in dogs. This prescription medication offers fast and effective relief, allowing your dog to enjoy a better quality of life without the discomfort of itching and inflammation.

The active ingredient in Apoquel, oclacitinib, works by targeting the underlying cause of itching and inflammation in allergic dermatitis. It inhibits the activity of certain enzymes that are involved in the inflammatory response, providing rapid relief from itching within 4 hours and effectively controlling itching within 24 hours.

Unlike traditional treatments for allergic skin conditions, such as steroids, which can have undesirable side effects, Apoquel is specifically designed to target the itch and inflammation without suppressing the entire immune system. This means that it can provide relief without compromising your dog's overall health and well-being.

Apoquel is available in tablet form, making it easy to administer to your dog. It can be given with or without food, and the dosage can be adjusted to suit your dog's needs. With Apoquel, you can help your dog find relief from itching and inflammation, allowing them to live a happier, more comfortable life.

Key Benefits:

  • Fast-Acting Relief: Apoquel starts relieving itching within 4 hours and effectively controls itching within 24 hours.
  • Targeted Relief: Targets the underlying cause of itching and inflammation to provide long-lasting relief.
  • Safe and Effective: FDA-approved for the control of itching associated with allergic dermatitis and the control of atopic dermatitis in dogs.
  • Easy to Administer: Available in tablet form, making it easy to give to your dog with or without food.

How It Works

Apoquel (oclacitinib) Tablets for Dogs work by targeting and inhibiting certain enzymes in the body that are involved in the itching and inflammation response associated with allergic skin conditions. Specifically, oclacitinib inhibits the activity of Janus kinase (JAK) enzymes, which play a key role in the inflammatory signaling pathway.

By inhibiting these enzymes, Apoquel helps to reduce the itchiness and inflammation caused by allergic dermatitis in dogs. This helps to provide fast relief from itching and discomfort, allowing dogs to feel more comfortable and improving their overall quality of life.

Apoquel is designed to provide targeted relief, addressing the underlying cause of itching and inflammation without suppressing the entire immune system. This makes it a safe and effective option for managing allergic skin conditions in dogs.


Apoquel (oclacitinib) Tablets for Dogs are indicated for the control of itching and inflammation associated with allergic dermatitis in dogs. It is also indicated for the control of atopic dermatitis in dogs.


  • Brand: Apoquel
  • Active Ingredient: Oclacitinib
  • Type: Tablets
  • Indicated For: Itching and inflammation due to allergic skin conditions in dogs
  • Dosage Form: Oral tablets
  • Strength: Available in 3.6 mg, 5.4 mg, and 16 mg tablets


Active Ingredient:



View Apoquel Drug Facts Sheet.

  • The dose of APOQUEL tablets is 0.18 to 0.27 mg/lb (0.4 to 0.6 mg/kg)
  • APOQUEL should be given twice daily (BID) for up to 14 days of therapy and once daily (SID) thereafter for maintenance
  • APOQUEL may be given with or without food
  • APOQUEL may be discontinued without tapering

Quick Tips

  • Should be administered twice daily during the therapeutic period and once daily for maintenance period
  • May be used with other common therapies including NSAIDs, antibiotics, vaccines, and allergen immunotherapy
  • More information on dosing should be available in the prescription information.
  • Administer doses orally twice daily for up to 14 days, then reduced by half for maintenance
  • May be administered with or without food
  • Tablets of Apoquel can be administered when split to allow for partial doses


The safety profile of APOQUEL is supported by pharmacovigilance data over 5 years

The overall adverse reactions incidence rate during a 5-year review is rare (more than 1 but less than 10 animals reacting per 10,000 treatments administered)

  • The incidence rate of the most commonly reported individual adverse reactions (in decreasing order: vomiting, diarrhea, lethargy, anorexia and bloodwork changes) associated with the use of APOQUEL was very rare (less than 1 dog out of 10,000 treated)
  • Results are consistent with pre-approval pivotal safety and efficacy studies. APOQUEL is performing as expected under field conditions

Safe to use in dogs 12 months of age and older

Side effects were similar to placebo over short term

  • Most common side effects in a short-term clinical trial included vomiting and diarrhea and were self-limiting

Can be used long term for maintenance therapy

Can be used concomitantly with many medications, including NSAIDs, anti-infectives, parasiticides, antifungals and allergen-specific immunotherapy

  • The use of APOQUEL has not been evaluated in combination with other systemic immuno suppressants, such as corticosteroids and cyclosporine

Not for use in dogs with serious infections or for use in breeding, pregnant or lactating dogs

Rare is defined as more than 1 but less than 10 animals reacting per 10,000 treatments administered; very rare is defined as less than 1 animal reacting per 10,000 treatments administered. Reported incidence rate (calculated) is an estimated rate. Includes all ARs regardless of whether the product was administered per label directions, concomitantly or if a potential causal relationship existed.

See signs of allergic itch? See your veterinarian

All dogs scratch, lick, and chew - but if it's becoming more frequent and excessive, it may mean something more.

Common signs

  • Frequent scratching, licking, biting, or chewing
  • Excessive rolling, rubbing, or scooting
  • Recurrent ear problems (such as head shaking, ear discharge/odor, or scratching at ears)
  • Hair loss, body odor, or skin changes (such as rash, redness, greasy skin, or scabs)

Common causes

  • Flea allergy
  • Food allergy
  • Environmental indoor and outdoor allergens (such as pollen, dust mites, and mold)
  • Contact allergy (such as carpet cleaners, shampoos, plants, and insecticidal products)


Federal (USA) Law restricts this drug to use by or on the order of a licensed veterinarian.


APOQUEL is not for use in dogs less than 12 months of age (see Animal Safety).

APOQUEL is not for use in dogs with serious infections.

APOQUEL may increase susceptibility to infection, including demodicosis, and exacerbate neoplastic conditions (see Adverse Reactions and Animal Safety).

Human Warnings:

This product is not for human use. Keep this and all drugs out of reach of children. For use in dogs only. Wash hands immediately after handling the tablets. In case of accidental eye contact, flush immediately with water or saline for at least 15 minutes and then seek medical attention. In case of accidental ingestion, seek medical attention immediately.


APOQUEL is not for use in breeding dogs, or pregnant or lactating bitches.

The use of APOQUEL has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents.

Dogs receiving APOQUEL should be monitored for the development of infections, including demodicosis, and neoplasia.


APOQUEL should be stored at controlled room temperature between 20° to 25°C (68° to 77°F) with excursions between 15° to 40°C (59° to 104°F)


Yes, you can use APOQUEL for short periods. APOQUEL begins relieving allergic dog itch within 4 hours, and controls it within 24 hours.

Yes, APOQUEL may be used with other treatment such as:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, carprofen)
  • Vaccines (rabies)
  • Allergen-specific immunotherapy (allergy shots or drops)

The use of APOQUEL has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporine.

The US Food and Drug Administration (FDA) has not placed any time restrictions on the use of APOQUEL. Your dog can continue to be treated with APOQUEL as long as your veterinarian recommends. In a study, dogs were treated with APOQUEL for more than 2 years.
Yes, APOQUEL can be given with or without food.
APOQUEL is given twice daily for up to 14 days, and then given once daily for maintenance therapy.
APOQUEL starts relieving allergic itch within 4 hours of giving the treatment to your dog.
The most common side effects of APOQUEL in a short-term clinical trial were vomiting and diarrhea. These occurred in only a small percentage of dogs treated with APOQUEL. These side effects typically stopped on their own.
APOQUEL is a medication for dogs prescribed by a veterinarian for dogs 12 months of age or older to control the itch and inflammation associated with allergic and atopic dermatitis.
Occasional itching is a fact of life for dogs. However, allergies, fleas, mites, infection, and other diseases may cause more frequent or constant itching, indicating a more serious condition. If you notice your dog is itching more often, and/or you see changes in your dog's skin, including hot spots, redness, or rash, make an appointment to visit your veterinarian and get it checked out.
If your dog is scratching, licking, or biting the same area repeatedly, the skin can become damaged, red, and sore. It's a good idea to ask your dog's veterinarian about the possible causes. It could be due to allergies, and in this event, your pet may require a prescription treatment such as APOQUEL to treat the underlying cause. There also may be a skin infection that requires antibiotic or antifungal treatment from your veterinarian.
APOQUEL is not a steroid, antihistamine, or cyclosporine (a type of drug that reduces immune system activity). APOQUEL is in a different category of medications. Unlike other medicines, APOQUEL blocks allergic itch at the source. So, it works at the underlying cause of itch to provide relief fast.

If your dog's itching persists or you notice any of the following signs, you should make an appointment to visit your veterinarian to find out if the itching is caused by a medical condition:

  • Frequent scratching, licking, biting, or chewing
  • Excessive rolling, rubbing, or scooting
  • Recurrent ear problems (head shaking, ear discharge/odor, or scratching at ears)
  • Hair loss, body odor, or skin changes (such as rash, redness, greasy skin, or scabs)


Review Summary
122 Reviews
78% (95)
20% (24)
0% (0)
1% (1)
2% (2)
95% Recommend this product (116 of 122 responses)
By Cheryl J.
Bedford NH
June 28, 2024
Awesome customer service!
  • Cheaper than other stores
By Olive
Great product
June 13, 2024
Great product and great service.
By David
Auto order not cancelled
June 7, 2024
The auto shipment notice arrived and we asked it be cancelled, but was sent anyway at high expense for something not needed.
  • Never responded to request to not send the shipment. Paid high price with no normal discount applied.
By Tammy
Cleveland, TN
First time order
April 19, 2024
Excellent service, kept me informed. Arrived as expected. Will definitely use this pet pharmacy again.
  • Service
  • Shipping
  • Expected delivery
  • Price
  • My vets office won
By Marie o.
Paradise pa
Miracle worker
April 16, 2024
My dog has been itchy for months and this finally helped calm her and bring her back to the happy playful dog she was.
By Chrystal
Very Frustrated
April 15, 2024
This is day 16 and I still don't have product. Company did not respond to my email.
By Dolores
Eat my paw
March 14, 2024
As advertised. Scored nicely for half dose.
By Michelle
Apoquel Works!
February 1, 2024
Apoquel has been the only medication to keep BellaGirl comfortable, great itch relief, and out of the vet’s office.
  • Little to no vet visits due to itchy and skin irritations
  • Pricey
By Karla K.
Will use again
January 22, 2024
I’ve ordered from several places & this site had the best price by far. I also appreciated being notified when attempts to contact my vet were going unanswered. I’m giving 4/5 stars only because I was not told I would need to sign for my purchase, so I missed the mailman and item was delayed until I was able to sign for at the post office
By David
Easy ordering
December 14, 2023
This was my first Apoquel order from EntirelyPetsPharmacy.com. The process was simple and the confirmation from my vet was done quickly and efficiently. Then I just waited a few days and my order arrived. Would definitely recommend!
  • Easy ordering and vet confirmation
By Maggie
Excellent package for excellent medication
November 26, 2023
My cat has been taking apoquel quite awhile now. I appreciate being able to buy it on-line and am delighted with this easy-to-open bottle. Thanks so much!
By Susan
Woodstock, GA
The headline is precise and easy to read
November 19, 2023
The price of the Apoquel tablet saves me a lot of money versus purchasing the Apoquel from my vet.
  • The medication starts working fast and has no adverse side effects on my dog
By Kim
Greeneville TN
AAA rating!
November 9, 2023
I’ve been quite pleased with the timeliness and communications, regarding my deliveries. This is aside from the Apoquel making my cat feel better!
By Hugo C.
Kissimmee, FL
allergy meds
October 8, 2023
I think my dog got too used to the med and now it does not work as it did when he started to take it
By Suzanne H.
Ewa Beach Hawaii
Great price/fast shipping
September 28, 2023
I’m very satisfied with using your prescription pharmacy. Process was very easy, great price and fast shipping. This was the first shipment and I hope it continues to be excellent. My veterinarian office staff recommended that I look online for better pricing and asked me were I buy my supplements. I told her Entirely pets. She then looked it up for me and said that they also have a pharmacy section.
By Angie G.
September 18, 2023
Great customer service satisfaction… I will be ordering again real soon
By Michelle
Killeen, Texas
Great Customer Service
August 13, 2023
This product came in on the perfect timing. It was accurate and their customer service was amazing. I appreciate the follow up email. Thank you so much.
By Elaine
June 30, 2023
I was very pleased with the price. I had to up the mg. Mimi was taking per our vet. It is working so well. I will definitely check out other products.
By Donna P.
69 Ridge Rd Unit M Greenbelt MD 20770
It works
June 28, 2023
My dog's chronic rash is erased
By Mary I.
Baltimore, MD
Fast service
June 14, 2023
This pharmacy reached out to my vet very fast, and I received pills for my cat very quickly.
By Barbara
Pittsfield, MA
June 7, 2023
Our dog has allergies and last year at this time was having a horrible time with symptoms. The medication we were giving him stopped working. He was started on Apoquel and improved very quickly. We are grateful for his continued comfort and control of his symptoms.
By Renate S.
Ludlow MA
May 26, 2023
My dog is allergic to just about anything except the air. If she doesn't have this medicine, she scratches herself until she has scabs. This is the only medicine so far that has stopped her itching, along with a fish and sweet potato dog food. Yes this is expensive, but it works! And Entirely Pets has the best price!
By Michael s.
Thanks so much
April 29, 2023
Thanks for great customer care you don’t see that much anymore
By Wayne C.
Yuba city ca
Worry free
March 23, 2023
Have auto ship for my dogs meds. Entirely pets notifies me when order is being processed, when shipped n when it’s delivered. Make life easy. Great company

Merchant Response:Hello Wayne, We appreciate your positive feedback and hope you continue to enjoy using EntirelyPets Pharmacy for all your pets needs. Sincerely, EntirelyPets Pharmacy
By Kinipela
Oahu, HI
Online meds
March 3, 2023
Entirely Pet’s Pharmacy is a very convenient way to order pet medications without having to drive to your local veterinarian clinic or pharmacy, wait in lines, and sometimes encounter that meds are not in stock.
By using this company I have avoided the above hassles and conveniently receive the meds in the mail in a timely manner. I also receive regular emails letting me know when my products are being filled and shipped. If there is a back order on a certain med, they let me know immediately. The customer service has been top notch.

Merchant Response:Hello Kinipela, Thank you so much for your feedback, our pharmacy works diligently to get the approval and process the prescription as fast as possible. Sincerely, EntirelyPets Pharmacy
By Erica
Easy ordering/shipping
February 16, 2023
Arrived quickly, easy to order. Price was cheapest I could find compared to other sites/pharmacies
By tanya e.
henderson, nv
easy peasy
February 11, 2023
Easy to order at a great price. Received quickly.
By Jen
So far, So good
January 22, 2023
So far I haven't had any problems with this company. I've received my pets med twice so far.
By Marge
Prompt and Accurate Service
January 18, 2023
Immediate attention to or order. Very impressed.
By April C.
Atlanta, Georgia
Great Buy
January 6, 2023
Ordered 3.6mg Apoquel for my Shihtzu (18lbs)
This has helped him tremendously and also a big relief to me at bed time. He use to scratch all night and keep me up but now we both sleep like a baby. Tito is living his best life now 💙
He takes one 3.6mg tablet at bedtime.
  • Able to rest

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