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Sentinel Spectrum for Dogs

Sentinel Spectrum for Dogs

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  • Description
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  • FAQ
  • Reviews


Sentinel Spectrum Chews for Dogs help ensure the health and happiness of your dog and your family. They are the most convenient way to provide all-round protection against 6 different kinds of parasites including tapeworms.


Monthly treatment prevents heartworm (Dirofilaria immitis) infection; controls adult roundworm (Toxocara canis and Toxascaris leonina), immature roundworm (Toxocara canis), adult whipworm (Trichuris vulpis), adult hookworm (Ancylostoma caninum), adult tapeworm (Echinococcus granulosus, Taenia pisiformis and Dipylidium caninum), aids in the control of adult hookworm (Uncinaria stenocephala) infection, provides long term protection and control of flea (Ctenocephalides felis) infestations, and forms part of a treatment strategy for flea allergy dermatitis in dogs. Flea allergy dermatitis (FAD). The most important part of the treatment of FAD is preventing flea bites. Lufenuron reduces the number of fleas in the pet's environment to a negligible level. Treatment with lufenuron for several months has been shown to dramatically improve the clinical signs of FAD in dogs.

Key Benefits

  • Effective protection against 6 types of parasites including tapeworms
  • Long-lasting with 1 month effectiveness
  • Easy administration through soft chew form
  • Palatable soft beef and bacon flavor your dog will love
Prescription Required

NADA #141-333


Active Ingredients

Milbemycin Oxime, Lufenuron, Praziquantel


Dosage and Administration

Sentinel Spectrum should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, 4.55 mg/lb (10 mg/kg) lufenuron, and 2.28 mg/lb (5 mg/kg) praziquantel. For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes.

View Sentinel Spectrum Drug Facts Sheet.

Dosage Table

Body Weight Milbemycin Oxime per Chewable Lufenuron per Chewable Praziquantel per Chewable Number of Chewables
2 to 8 lbs.2.3 mg46 mg22.8 mgOne (Orange)
8.1 to 25 lbs.5.75 mg115 mg57 mgOne (Green)
25.1 to 50 lbs.11.5 mg230 mg114 mgOne (Yellow)
50.1 to 100 lbs.23.0 mg460 mg228 mgOne (Blue)
Over 100 lbs.Administer the appropriate combination of chewables

To ensure adequate absorption, always administer Sentinel Spectrum to dogs immediately after or in conjunction with a normal meal

Sentinel Spectrum may be offered to the dog by hand or added to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the doses have been lost, redosing is recommended.

Heartworm Prevention

Sentinel Spectrum should be administered at monthly intervals beginning within 1 month of the dog's first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog's last seasonal exposure (see Effectiveness). Sentinel Spectrum may be administered year-around without interruption. When switching from another heartworm preventative product to Sentinel Spectrum, the first dose of Sentinel Spectrum should be given within a month of the last dose of the former product.

Flea Treatment and Prevention

Treatment with Sentinel Spectrum may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with Sentinel Spectrum should continue the entire year without interruption.

To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product, as necessary.

Intestinal Nematode and Cestode Treatment and Control

Dogs may be exposed to and can become infected with roundworms, whipworms, hookworms, and tapeworms throughout the year, regardless of season or climate. Clients should be advised of appropriate measures to prevent reinfection of their dog with intestinal parasites. Because the prepatent period for E. multilocularis may be as short as 26 days, dogs treated at the labeled monthly intervals may become reinfected and shed eggs between treatments.

Storage Directions

Store in a dry place at controlled room temperature, between 59° and 77°F (15-25°C).


Not for use in humans. Keep this and all drugs out of the reach of children.


There are no known contraindications to the use of Sentinel Spectrum.


Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention (see Effectiveness).

Before administration of Sentinel Spectrum, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Sentinel Spectrum is not effective against adult D. immitis.

Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. These reactions are presumably caused by the release of protein from dead or dying microfilariae.

Do not use in puppies less than six weeks of age.

Do not use in dogs or puppies less than two pounds of body weight.

The safety of Sentinel Spectrum has not been evaluated in dogs used for breeding or in lactating females. Studies have been performed with milbemycin oxime and lufenuron alone.

Possible Side Effects

The following adverse reactions have been reported in dogs after administration of milbemycin oxime, lufenuron, or praziquantel: vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia, convulsions, salivation, and weakness.

To report suspected adverse drug events, contact Virbac at 1-800-338-3659 or the FDA at 1-888-FDA-VETS.

For technical assistance call Virbac at 1-800-338-3659.


How is Sentinel Spectrum Chews (milbemycin oxime / lufenuron / praziquantel) different from Heartgard Plus (ivermectin / pyrantel)?

Both products protect dogs against heartworms, roundworms, and hookworms, but Sentinel Spectrum Chews, with its unique combination of ingredients, protects against 3 additional common parasites that Heartgard doesn’t: fleas, whipworms, and tapeworms.

Sentinel Spectrum Chews (milbemycin oxime/lufenuron/praziquantel) - Dogs should be tested for heartworm prior to use. Mild hypersensitivity reactions have been noted in some dogs carrying a high number of circulating microfilariae. Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention.

Why should I give my dog Sentinel Spectrum Chews?

In addition to providing flea and heartworm prevention, you’ll also be protecting your dog against other important and common intestinal parasites: roundworms, hookworms, whipworms, and tapeworms.

How often do I give my dog Sentinel Spectrum Chews?

For optimal flea and heartworm protection, you should give your dog Sentinel Spectrum Chews every 30 days.

How do I give my dog Sentinel Spectrum Chews?

Sentinel Spectrum Chews makes treating and controlling parasites easy and delicious. Simply give the tasty, beef and bacon-flavored chew to your dog along with a meal. Giving the product with a meal helps ensure full absorption and effectiveness of the medicine.

What if I miss giving a dose of Sentinel Spectrum Chews?

If you forget to give your dog a dose, then administer the missed dose as soon as possible and contact your veterinarian for instructions regarding next steps.


Review Summary
13 Reviews
85% (11)
15% (2)
0% (0)
0% (0)
0% (0)
100% Recommend this product (13 of 13 responses)
By Sue
Great price
January 12, 2020
I got a great deal on the product. It was shipped promptly and it is the same quality I get from my vet for a lot less.
By Debby
Silver Springs, FL
Definitely prevents flea eggs
January 3, 2020
I live in central Florida where fleas are active year round. I have to keep a close eye out for fleas all the time. I have found eggs on my dog that never hatched so Sentinel does sterilize the female. I just wish it killed the adults because they stay active and continue to bite.
ProsSterilizes adults. Eggs don't hatch.
ConsDoes not kill adult fleas.
By Ken
Sentinel Spectrum
October 3, 2019
Switched to Sentinel Spectrum several years ago after one pet got a type of whipworm while using Heartguard. While Sentinel Spectrum is pricey it prevents a wider variety of internal parasites and fleas. We have four healthy parasite free dogs. Only issue is getting them to eat the chew-able which is solved by cutting them in quarters and mixing with food and a little fish oil.
ProsCovers wider variety of internal parasites and fleas.
ConsPricey and dogs may not eat them without mixing with food and fish oil or peanut butter.
By Dan
Great price & service
July 5, 2018
I have ordered this several times from EPP and they have always provided a great experience. Price and shipping are top notch.I will continue to order from them.
ConsDan, you are too kind. Thanks for the positive feedback!
By Barri
Great Sale Price
June 16, 2018
great sale price and quick delivery
By Grandma G.
Salem OR
My favorite site for my baby girls!
May 28, 2018
Love Entirely Pets! So easy to use and items come right away. Great site.
Merchant Response:Too kind Grandma GG, glad to help! Take care of your baby girls. =)
By Rosemary
Coronado, CA
Best price for quality product
March 1, 2018
Received my order in a timely manner. Professionalism at its best! Low costs. Wonderful experience. I would recommend to others.
By Susan
Salem, OR
Works great
December 15, 2017
Sentinel Spectrum works really well for both my dogs, no side effects at all. Entirely Pets makes it easy to get what I need for my 4-legged family members!
Merchant Response:Hello Susan, thank you for the feedback and we're so happy to hear the Sentinel works so well for your fur-kids!
By Melodee
Elkhart, TX
Sentinel Spectrum is the BEST!
December 16, 2016
All of our dogs just love this monthly "treat" ..Ordered it for a great special price, they got a new RX from our vet and the meds were on the way. Quick turnaround on our order. Thanks Entirely Pets Pharmacy for your caring.
By Mandi S.
Saratoga, CA
Sentinel Spectrum for Dogs 50.1-100 Lbs (6 Month)
October 7, 2016
The derlivry was right on time, and this product works well for my Doberman.
By SidM
Tucson, AZ
Great product, great price
July 24, 2016
I love using the Sentinel Spectrum for my dog. As a service dog, I need to make sure that she is healthy and safe to go into public restaurants and grocery stores. With Sentinel Spectrum, I never have to worry. She has been taking it for 6 years and she always gets a gold star from the vet! Two big thumbs up for me.
By Liz
Dallas, Texas
April 3, 2016
Product arrived quickly and just as described. Best price you can find anywhere.
By Holly
Reading, PA
Protection for my dogs...
March 25, 2016
With three dogs the medicines become costly... But a necessity.... I am very pleased at this time that the product was sent quickly and was also cost effective from this pharmacy...
ProsQuick shipping Lower cost than others This product actually covers whip worms where the other products do not...

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