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NexGard Flea & Tick Chewables for Dogs

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  • Description
  • Ingredients
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  • FAQ
  • Reviews

Description

NexGard Flea & Tick Chewables for dogs is a brand new, revolutionary flea and tick preventative from the makers of Frontline®, the #1 choice of veterinarians. It's the first flea and tick killer of its kind because it comes in a yummy, beef-flavored soft chew that protects your dog from flea and tick infestations for a full 30 days. That means you no longer have to worry about messy topicals or accidentally washing it off your dog while bathing! It can also be taken alongside your dog's heartworm medication without interruption for your convenience.

NexGard keeps your pet protected from adult fleas by killing them before they have a chance to lay eggs, which reduces the possibility of a flea infestation. It also kills the American dog tick, which decreases the risk of your pet developing a deadly tick-borne disease.

Key Benefits

  • First ever flea and tick preventative from the makers of Frontline that comes in a tasty beef-flavored chew
  • No more messy topical preventatives, and no more worrying about washing off your dog's flea protection
  • Safe, effective, FDA-approved, and lasts for 30 days
  • Can be taken alongside heartworm medication

Indications

NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of Black-legged tick (Ixodes scapularis), American Dog tick (Dermacentor variabilis), Lone Star tick (Amblyomma americanum), and Brown dog tick (Rhipicephalus sanguineus) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month.

How It Works

NexGard contains a brand new ingredient not used in any other flea and tick protection. Afoxolaner, the ingredient in NexGard, is rapidly absorbed into your pet's bloodstream where a good concentration makes your pet's blood toxic to insects without affecting your pet's health. The Afoxolaner is metabolized gradually to ensure that it remains in your pet's bloodstream in the appropriate concentration for a full 30 days.

When a flea or tick attempts to feast on your pet's blood, Afoxolaner acts on their Central Nervous System by impeding an important neurotransmitter, which causes instantaneous death. This means your pet receives amazing protection in one tasty morsel! NexGard is a prescription-only medication, so talk to your veterinarian about using it for your pet.

Ingredients

NexGard Chewables for Small Dogs 4-10 lbs
Active Ingredient (per tablet) Amount
Afoxolaner 11.3 mg
NexGard Chewables - For Medium Dogs 10.1-24 lbs
Active Ingredient (per tablet) Amount
Afoxolaner 28.3 mg
NexGard Chewables - For Large Dogs 24.1-60 lbs
Active Ingredient (per tablet) Amount
Afoxolaner 68 mg
NexGard Chewables - For Extra Large Dogs 60-121 lbs
Active Ingredient (per tablet) Amount
Afoxolaner 136 mg

Directions

View Nexgard Drug Facts Sheet.

NexGard is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg).

Dosing Schedule:
Body Weight Afoxolaner Per Chewable (mg) Chewables Administered
4.0 to 10.0 lbs 11.3 1 Orange
10.1 to 24.0 lbs 28.3 1 Blue
24.1 to 60.0 lbs 68 1 Purple
60.1 to 121.0 lbs 136 1 Red
Over 121.0 lbs Administer the appropriate combination of chewables

NexGard can be administered with or without food. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. If a dose is missed, administer NexGard and resume a monthly dosing schedule.

Flea Treatment and Prevention:

Treatment with NexGard may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption.

To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product.

Tick Treatment and Control:

Treatment with NexGard may begin at any time of the year (see Effectiveness).

Contraindications:

There are no known contraindications for the use of NexGard.

Warnings:

Not for use in humans. Keep this and all drugs out of the reach of children. In case of accidental ingestion, contact a physician immediately.

Precautions:

The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures (see Adverse Reactions).

Adverse Reactions:

In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard.

Over the 90-day study period, all observations of potential adverse reactions were recorded. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. The most frequently reported adverse reaction was vomiting. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses.

Dogs With Adverse Reactions.
Treatment Group
Afoxolaner Oral active control
N1 % (n=415 N2 % (n=200)
Anorexia 5 1.2 9 4.5
Vomiting (with and without blood 17 4.1 25 12.5
Dry/Flaky Skin 13 3.1 2 1.0
Diarrhea (with and without blood) 13 3.1 7 3.5
Lethargy 7 1.7 4 2.0

1Number of dogs in the afoxolaner treatment group with the identified abnormality.

2Number of dogs in the control group with the identified abnormality.

In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. This dog experienced a third seizure one week after receiving the third dose. The dog remained enrolled and completed the study. Another dog with a history of seizures had a seizure 19 days after the third dose of NexGard. The dog remained enrolled and completed the study. A third dog with a history of seizures received NexGard and experienced no seizures throughout the study.

To report suspected adverse events, for technical assistance or to obtain a copy of the MSDS, contact Merial at 1-888-637-4251 or www.merial.com/nexgard. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth.

Mode of Action:

Afoxolaner is a member of the isoxazoline family, shown to bind at a binding site to inhibit insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines. The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines' GABA receptors versus mammalian GABA receptors.

Effectiveness:

In a well-controlled laboratory study, NexGard began to kill fleas four hours after initial administration and demonstrated >99% effectiveness at eight hours. In a separate well-controlled laboratory study, NexGard demonstrated 100% effectiveness against adult fleas 24 hours post-infestation for 35 days, and was ≥93% effective at 12 hours post infestation through Day 21, and on Day 35. On Day 28, NexGard was 81.1% effective 12 hours post-infestation. Dogs in both the treated and control groups that were infested with fleas on Day 1 generated flea eggs at 12 and 24 hours post-treatment (0-11 eggs and 1-17 eggs in the NexGard treated dogs, and 4-90 eggs and 0-118 eggs in the control dogs, at 12 and 24-hours, respectively). At subsequent evaluations post infestation, fleas from dogs in the treated group were essentially unable to produce any eggs (0-1 eggs) while fleas from dogs in the control group continued to produce eggs (1-141 eggs).

In a 90-day US field study conducted in households with existing flea infestations of varying severity, the effectiveness of NexGard against fleas on the Day 30, 60 and 90 visits compared with baseline was 98.0%, 99.7%, and 99.9%, respectively.

Collectively, the data from the three studies (two laboratory and one field) demonstrate that NexGard kills fleas before they can lay eggs, thus preventing subsequent flea infestations after the start of treatment of existing flea infestations.

In well-controlled laboratory studies, NexGard demonstrated >97% effectiveness against Dermacentor variabilis, >94% effectiveness against Ixodes scapularis, and >93% effectiveness against Rhipicephalus sanguineus, 48 hours post-infestation for 30 days. At 72 hours post-infestation, NexGard demonstrated >97% effectiveness against Amblyomma americanum for 30 days.

Animal Safety:

In a margin of safety study, NexGard was administered orally to 8 to 9-week-old Beagle puppies at 1, 3, and 5 times the maximum exposure dose (6.3 mg/kg) for three treatments every 28 days, followed by three treatments every 14 days, for a total of six treatments. Dogs in the control group were sham-dosed. There were no clinically-relevant effects related to treatment on physical examination, body weight, food consumption, clinical pathology (hematology, clinical chemistries, or coagulation tests), gross pathology, histopathology or organ weights. Vomiting occurred throughout the study, with a similar incidence in the treated and control groups, including one dog in the 5x group that vomited four hours after treatment.

In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, NSAIDS, anesthetics, and antihistamines. No adverse reactions were observed from the concomitant use of NexGard with other medications.

Storage

Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F).

FAQ

If a dose is missed, administer the usual dose of NexGard Chewables and resume a monthly dosing schedule.
NexGard Chewables require a prescription. Give the appropriate dosage based on your dog's weight. (See How to Use). If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration redose with another full dose. NexGard Chewables can be administered with or without food. NexGard Chewables should be administered all year round. Treat all the pets in your home to reduce the risk of a flea infestation.
The most frequently reported adverse reactions include vomiting, dry/flaky skin, diarrhea, lethargy, and lack of appetite. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses. There are no known contraindications for the use of NexGard Chewables.
Seek emergency veterinary medical treatment.
Avoid giving NexGard Chewables if your pet is pregnant, lactating or has a known history of seizures.
There are no known contraindications for the use of NexGard Chewables.
The active ingredient in NexGard Chewables is Afoxolaner. NexGard Chewables kill adult fleas and are indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of the American dog tick (Dermacentor variabilis), black-legged (deer) tick (Ixodes scapularis) and Lone star tick (Amblyomma americanum) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month.
Tell your veterinarian if your dog is pregnant, lactating or has a history of seizures. The safe use of NexGard Chewables in breeding, pregnant or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures.
NexGard also kills the Lone Star tick, Black-legged tick, American Dog tick and Brown dog tick.
NexGard (afoxolaner) is safe and effective for use in puppies 8 weeks of age or older, weighing 4 pounds or more.
In a study, NexGard killed 100% of fleas within 24 hours.
NexGard stimulates the flea's nervous system, causing them to rise to the top of your dog's haircoat as they die.
Two years from the date of manufacture. You can locate the expiration date on the outside of the package of NexGard.
Because NexGard is an oral product, swimming or bathing has no effect on NexGard. Your dog's coat can get wet immediately after taking NexGard.
In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), anesthetics, and antihistamines.
NexGard is safe and effective in any breed of dog when used as directed.
No. NexGard should be used on dogs only.
Don't re-administer NexGard before the month is through. It keeps working for a full 30 days.
The most commonly reported adverse reactions found in NexGard for Dogs include vomiting, itching, diarrhea, lethargy and lack of appetite. Use with caution in dogs with a history of seizures.

Reviews

Review Summary
4.7
71 Reviews
5
76% (54)
4
23% (16)
3
0% (0)
2
1% (1)
1
0% (0)
100% Recommend this product (71 of 71 responses)
By Carol
Gibson, PA
Does the Job
October 7, 2020
We live in an area that has a lot of ticks.This medication does what the manufacturers claim. Although I check for ticks on my red merle mini Aussie, I just can't find them all. About an hour after our walk, I will see them crawling around on the top of his fur and I can pick them off. If some end up biting him, I find them attached but dead. I am hoping that as they claim, the ticks die before they have time to transfer harmful bacteria. On top of that, my dog loves the tablet! He is all excited as I am opening up the packaging.
By MommaKatt
Ohio
Affordable Pricing
October 1, 2020
My vet recommends this but the cost on Entirely Pets is so much better than at the Vets Office
ProsValue
By Trudy C.
Hayward, WI
Fabulous Product
September 27, 2020
Our English Spring Spaniel has been on several flea and tick products, but Nexgard has been best for her. For several years in a row she tested positive for anaplasmosis, but when we switched her to Nexgard, she tested negative. Our vet suggested a different flea and tick product because they no longer offered Nexgard. I gave it a shot because it was less expensive and supposedly as good. When she went for her wellness exam the following year, she tested positive for anaplasmosis. The following year after going back on Nexgard, she tested negative. Nexgard is the best!
By Sue
Memphis, TN
Great price and service
September 19, 2020
Was already a great price. When I phoned to ask a question about my rx, they very informative and pleasant
Merchant Response:That's great feedback Sue. I have shared it with the team.
ProsPrice Easy to deal with
By Big W.
Homosassa FL.
Great stuff
September 19, 2020
The best flea and tick med for a dog made...
By Bruce
Tennessee
NexGard
September 16, 2020
Easy to give fleas are at bay great product
By Christine
Fl
NEXGARD
September 13, 2020
The only flea medicine that my Dog does not mind taking. I can't get the medicine opened fast enough. My dog loves the taste
ProsWorks dog does not mind taking it
ConsNone
By Sabrina
MA
Amazing
August 21, 2020
Recommended among other pharmacies I have tried.
By sheryl s.
Oregon
5 stars
August 15, 2020
your service was fast and I can rely on you for our baby boy's needs. Thank you
By Angela
Missouri
A Little Luv
July 13, 2020
Love this....no more fighting to get my dogs to take their medicine. It is just like giving them a treat, so easy and they love it.
By Angela
Missouri
A Little Luv
July 13, 2020
This chewable is a godsend...My dog thinks it is a treat so there is no more fighting to give her medicine.
By Patricia
Texas
Best price!
July 10, 2020
Super fast shipping & saved money. Always a plus!!
By Krystal
Claremont, CA
Great Product
July 2, 2020
Works great on my dog. Keeps all the ticks and fleas away with zero side effects for my pup.
By DP
Florida
Good Price
June 29, 2020
I have been getting this product from the Vet this was a better price however I would rather give the business to the local economy. will buy from Vet next time
By Von
WA
Works well
June 24, 2020
Nexgard was my pets vet recommendation. I needed an oral medication because we have a toddler in the house. But the choice was difficult as I have an Aussie, a Chihuahua,and a lab mix. I wanted something that was safe for the Aussie. This fits the bill.
By Terry
Northborough, MA
Great price & quick delivery!
June 24, 2020
Placed my first order with Entirely Pets, and was impressed with the discount and the quick delivery!
By Melissa
Hopkinsville, Kentucky
NexGard
June 13, 2020
I’m happy with this product!
By Kevin
Blacksburg, VA
Well-priced medicine
May 26, 2020
This medicine works well for our dog and is decently priced on this website.
By Patti
Arkansas
Great price
May 13, 2020
I realize that the whole world is on a tilt right now due to the Covid 19 situation, so I wasn’t surprised that my email regarding my order was never answered and that my two phone calls had me on hold for SO long. But, the prescription was finally confirmed with my veterinarian. Once that happened, my NexGard arrived fairly quick. I plan to use EntirelyPets again.

And a PS- once I finally reached a customer rep, they were extremely nice and caring.
ProsPrice and pleasant customer service experience
ConsDifficulty in reaching EntirelyPets. ( Hoping this is temporary due to current circumstances)
By Louise
La Porte, Indiana
Easy
April 25, 2020
It was very easy to order from and shipped quite quickly. Would order from again.
By Brenda
Phila
great product, but a glitch with the ordering process
April 10, 2020
This is a great product, and the delivery was timely, once the pharmacy received my prescription order in the mail from me
ProsThe price is so much less than my vet charges - love it!
ConsA glitch with the ordering process: I ordered this online and noted that I had a written prescription in my possession from my vet and would be mailing it in. Your pharmacy STILL called my vet looking for a prescription from them! Why is that? I believe the exact same thing occurred when I went through this process last time.
By Jeff
Marina Del Rey, CA
Best Flea Medicine around
April 9, 2020
Nexgard is the best flea medicine around. Easy to give as my dog like the flavor. Entirely Pets delivered quickly
By Jessica B.
Ohio
Flee and tick free
April 3, 2020
Have been using this for 4 months no flees or ticks will continue using
By Rain h.
Arlington tx
This item is freaking awesome!
April 2, 2020
Literally an hour after giving my puppy nex guard the flees just started to come to the top of his hair and fall off. It was amazing to see what a great product..
By April
Shelby County, TN
NexGard
April 1, 2020
Good price and was delivered without any issues.
By CJ
Rancho Cucamonga, CA
NexGard Flea Tablet
March 11, 2020
Product works great. Product delivered quickly
By Fran
South Padre Island
Awesome product
February 13, 2020
Only flea med I’ve seen results from. Quick shipment! Thanks.
By Angie
Minnesota
Product is great customer service isn’t
January 29, 2020
I constantly responded to emails and it was evident they never check their customer service email. Until I called no one reached out to my vet for the prescription.
By Daisy
Stockton, CA
Terrific Service!
January 24, 2020
This was the first time I used this service. I have used NexGard and HeartGard for my dog and am very pleased with the product and now I found a service with good prices and excellent service. I will continue with this company if they continue their promotions.
ProsExcellent service and promotion prices
By Gail G.
IL
Best company!
September 19, 2019
This medication was the most reasonable I found and came quickly

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