Etodolac (Manufacture may vary)
is a non-steroidal anti-inflammatory drug that relieves pain and inflammation in dogs suffering from osteoarthritis. Most NSAIDs work by inhibiting cyclooxygenase enzymes which produce prostaglandins, the hormones that cause localized inflammation. While many NSAIDs inhibit the cyclooxygenase COX-1 enzymes, which can cause gastrointestinal upset, Etodolac works specifically on COX-2 enzymes. Inhibiting the COX-2 enzymes can prevent inflammation without disturbing the gastrointestinal tract.