Simparica (sarolaner) Chewables Tablets for Dogs | On Sale | EntirelyPets Rx
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Simparica (sarolaner) Chewables Tablets for Dogs

Simparica (sarolaner) Chewables Tablets for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Simparica™ (sarolaner) chewables are a safe monthly chewable for dogs that offers persistent protection from fleas and ticks. It is fast-acting and has been shown to kill 95% of fleas within 8 hours and 100% of fleas within 24 hours.

Medical Use

Simparica is used to treat and prevent flea infestations. It is also used to treat and controls tick infestations of lone star ticks, Gulf Coast ticks, American dog tics, black-legged ticks, and brown dog ticks.

Key Benefits

  • Kills over 95% of adult fleas within 8 hours
  • Treats and prevents flea infestations
  • Treats and controls tick infestations
  • Can use in dogs dogs as young as 6 months and small as 2.8 lbs
  • Delicious liver-flavored tablet your dog will love

How It Works

Simparica is taken orally through tablet form. After you give your dog Simparica the ingredient sarolaner travels in your dog's blood and quickly reaches tissue fluids just under your dog's skin. As fleas and ticks bite their nervous system becomes over-stimulated and they die.


Not for use in humans. Keep this and all drugs out of reach of children and pets. For use in dogs only. The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs. Simparica should not be used in dogs less than 6 months of age (see Animal Safety).

Prescription Required

NADA #141-452

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Active Ingredient


Inactive Ingredients

Hydrolyzed Soy Protein, Starch, Corn, Wheat Germ, Anhydrous Dibasic Calcium Phosphate, Corn Syrup, Gelatin


Dosage and Administration

Simparica is given orally once a month at the recommended minimum dosage of 0.91 mg/lb (2 mg/kg).

Simparica can be offered by hand, in the food, or administered like other tablet medications. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. If a dose is missed, administer Simparica and resume a monthly dosing schedule.

View Simparica Drug Facts Sheet.

Quick Tips

  • Treatment with Simparica may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with Simparica can continue the entire year without interruption.
  • To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.
  • Simparica should be administered at monthly intervals.

Dosage Table

Body Weight Sarolaner per Tablet (mg) Number of Tablets Administered
2.8 to 5.5 lbs.5One (Yellow)
5.6 to 11.0 lbs.10One (Purple)
11.1 to 22.0 lbs.20One (Orange)
22.1 to 44.0 lbs.40One (Blue)
44.1 to 88.0 lbs.80One (Green)
88.1 to 132.0 lbs.120One (Brown)
>132.1 lbs.Administer the appropriate combination of tablets

Storage Directions

Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F). Keep out of reach of children and pets.


There are no known containdications for the use of Simparica.

Possible Side Effects

Less than 1% reported with vomiting, diarrhea, lethargy.*

*Simparica was administered in a well-controlled US field study with 315 dogs treated with Simparica and 164 dogs treated with active control once monthly for 3 treatments. Observations were recorded during the 90-day period.


How long does Simparica keep my dog protected from fleas and ticks?

Simparica works fast. It starts killing fleas within 3 hours and ticks within 8 hours and it keeps killing them for the full month.

What happens if I am late giving my dog the monthly treatment? Will my dog be protected?

The great thing about Simparica is that your dog is covered for an extra 4-5 days if you are a few days late with your monthly treatment date. Simparica has continuous killing activity for 35 days so it keeps going strong between doses, unlike some of the other products available. This extra coverage keeps the dog protected for the 4 out of 5 owners who admit to giving the treatment late. See how it compares against other popular treatments in our competitor section.

Can I give Simparica at any time of the day?

Yes. Simparica can be given to your dog any time of the day as it can be given with or without food.

Why can I still see fleas on my dog after giving Simparica?

Fleas can live in a variety of areas outside of your home as well as on other dogs that your dog may encounter. Simparica provides flea protection that works fast and lasts for a full month, so any newly arrived fleas will be killed. There’s no need to re-treat your dog until the next monthly dose is due.

I just gave my dog Simparica so why is it still scratching?

As fleas begin to die they will start to move around erratically as they start to lose their coordination, resulting in a transient increase in scratching behavior of your dog. Simparica starts killing fleas within 3 hours with 100% eliminated within 8 hours providing a fast resolution for your dog.

How long after administering Simparica can my dog be bathed or go swimming?

Immediately. Simparica can be given directly before or after bathing or swimming. Bathing, shampooing or swimming will not affect how well Simparica works.


Review Summary
9 Reviews
89% (8)
0% (0)
0% (0)
0% (0)
11% (1)
89% Recommend this product (8 of 9 responses)
By barbara
Conyers, GA
herding breed flea prevention
March 2, 2020
We are very careful about what our rare breed, Entlebucher Mountain Dog is given for routine medications. She has had no problems with Simparica and we have had no fleas.
By Joanne
MS gulf coast
Happy Pup
August 22, 2019
We adopted a heartworm positive dog. Following 3 months of treatment, our vet recommended the heartworm prevention shots & Simparica for monthly flea & tick prevention. Our dog loves Simparica & eats it from our hands like a treat.
ProsPup likes the product & it isn't a topical treatment that rubs off on our hands or other items. No fleas nor ticks bothering us or the pup.
By Allison
August 18, 2019
Arrived timely. Excellent price! They contacted my vet! It’s the same medication we receive from the vet but cheaper!!!!
By Gudrun B.
Simparica oral flea treatment for dogs
October 17, 2018
This prescription oral flea treatment works great for my dog, no more messy ointments. She has not had any adverse reactions to the medication.

It's not cheap but it's worth it.

Good product.

By Annie
June 10, 2018
Chewables are so easy to use. This is also an excellent price.
Merchant Response:Dear Annie, It's great to hear that the Simparica chewables are easy to use and to your satisfaction. EntirelyPets Pharmacy appreciates your business.
ProsEasy to use.
By Patty M.
Very satisfied
May 16, 2018
I like using a chewable flea medication instead of a tropical one. I was using Nexguard until my Vet told me about Simparica. She said it’s as safe and as effective as Nexguard, and it’s less expensive.
That really helps especially when you have multiple dogs!
By Rich
March 7, 2018
Entirelypets Pharmacy is a great place to get your meds for your pet. Great communication and customer service is awesome!
ProsGreat communication, awesome customer service, and great prices
By JuicyJ
Shipping is SLOW!
February 21, 2018
I've ordered from them 3-4 times now and their ordering processing is terribly slow. It took 2 weeks for this order to ship for a Rx that has unlimited refills! Seeking another company to order my dog's Rx from as they continue to disappoint.
ConsSLOW shipping
By Lisa J.
Galveston TX
Great product
July 2, 2017
I have tried them all and this works the best for my dogs. We have a lot of fleas here and the summer time it's brutal. Simperica works great and works all month. I have a finicky chi and the Simperica is small enough and doesn't have a foul odor..
ProsSmall, no foul odor

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