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Previcox Chewable Tablets for Dogs

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Description

Previcox is a type of veterinary-prescribed pain reliever called an NSAID (nonsteroidal anti-inflammatory drug) that your veterinarian may prescribe for your dog to help treat the pain and inflammation associated with OA. Previcox is designed just for dogs and acts fast to help relieve pain and inflammation associated with canine OA,3 which may help your dog get around more easily.5,6 Talk to your veterinarian about including Previcox as part of your dog's OA treatment plan, and help get him on his way to getting back to himself.

Key Benefits

  • Limping or lameness.
  • Decreased activity or exercise (reluctant to stand, climb stairs, jump or run, or difficulty in performing these activities)
  • Stiffness or decreased movement of joints.
  • Easy to administer because it is available as a flavored chewable tablet
  • Can be given with or without food
  • Very effective and fast acting

How It Works

Previcox works by inhibiting the COX-2 (cyclooxygenase-2) enzyme which generates chemicals that are responsible for pain, inflammation and even fever in the body.

Indications

Previcox (firocoxib) Chewable Tablets are indicated for the control of pain and inflammation associated with osteoarthritis and for the control of postoperative pain and inflammation associated with soft-tissue and orthopedic surgery in dogs.

Ingredients

Previcox 57 mg tablets:
Active Ingredients Amount
Firocoxib 57 mg
Previcox 227 mg tablets:
Active Ingredients Amount
Firocoxib 227 mg

Directions

View Previcox Drug Facts Sheet.

Always provide the Client Information Sheet with prescription. Carefully consider the potential benefits and risks of Previcox and other treatment options before deciding to use Previcox. Use the lowest effective dose for the shortest duration consistent with individual response. The recommended dosage of Previcox (firocoxib) for oral administration in dogs is 2.27 mg/lb (5.0mg/kg) body weight once daily as needed for osteoarthritis and for 3 days as needed for postoperative pain and inflammation associated with soft-tissue and orthopedic surgery. The dogs can be treated with Previcox approximately two hours prior to surgery. The tablets are scored and dosage should be calculated in half tablet increments. Previcox Chewable Tablets can be administered with or without food.

Contraindications:

Dogs with known hypersensitivity to firocoxib should not receive Previcox.

Warnings:

Not for use in humans. Keep this and all medications out of the reach of children. Consult a physician in case of accidental ingestion by humans.

For oral use in dogs only. Use of this product at doses above the recommended 2.27 mg/lb (5.0 mg/kg) in puppies less than seven months of age has been associated with serious adverse reactions, including death (see Animal Safety). Due to tablet sizes and scoring, dogs weighing less than 12.5 lb (5.7 kg) cannot be accurately dosed.

All dogs should undergo a thorough history and physical examination before the initiation of NSAID therapy. Appropriate laboratory testing to establish hematological and serum baseline data is recommended prior to and periodically during administration of any NSAID. Owners should be advised to observe for signs of potential drug toxicity (see Adverse Reactions and Animal Safety) and be given a Client Information Sheet about Previcox Chewable Tablets.

For technical assistance or to report suspected adverse events, call 1-877-217-3543.

Precautions:

This product cannot be accurately dosed in dogs less than 12.5 pounds in body weight.

Consider appropriate washout times when switching from one NSAID to another or when switching from corticosteroid use to NSAID use.

As a class, cyclooxygenase inhibitory NSAIDs may be associated with renal, gastrointestinal and hepatic toxicity. Sensitivity to drug-associated adverse events varies with the individual patient. Dogs that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. Patients at greatest risk for adverse events are those that are dehydrated, on concomitant diuretic therapy,or those with existing renal, cardiovascular, and/or hepatic dysfunction. Concurrent administration of potentially nephrotoxic drugs should be carefully approached and monitored. NSAIDs may inhibit the prostaglandins that maintain normal homeostatic function. Such anti-prostaglandin effects may result in clinically significant disease in patients with underlying or pre-existing disease that has not been previously diagnosed. Since NSAIDs possess the potential to produce gastrointestinal ulceration and/or gastrointestinal perforation, concomitant use of Previcox Chewable Tablets with other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided. The concomitant use of protein-bound drugs with Previcox Chewable Tablets has not been studied in dogs. Commonly used protein-bound drugs include cardiac, anticonvulsant, and behavioral medications. The influence of concomitant drugs that may inhibit the metabolism of Previcox Chewable Tablets has not been evaluated. Drug compatibility should be monitored in patients requiring adjunctive therapy.

If additional pain medication is needed after the daily dose of Previcox, a non-NSAID class of analgesic may be necessary.

Appropriate monitoring procedures should be employed during all surgical procedures. Anesthetic drugs may affect renal perfusion, approach concomitant use of anesthetics and NSAIDs cautiously. The use of parenteral fluids during surgery should be considered to decrease potential renal complications when using NSAIDs perioperatively.

The safe use of Previcox Chewable Tablets in pregnant, lactating or breeding dogs has not been evaluated.

Information For Dog Owners:

Previcox, like other drugs of its class, is not free from adverse reactions. Owners should be advised of the potential for adverse reactions and be informed of the clinical signs associated with drug intolerance. Adverse reactions may include vomiting, diarrhea, decreased appetite, dark or tarry stools, increased water consumption, increased urination, pale gums due to anemia, yellowing of gums, skin or white of the eye due to jaundice, lethargy, incoordination, seizure, or behavioral changes. Serious adverse reactions associated with this drug class can occur without warning and in rare situations result in death (see Adverse Reactions). Owners should be advised to discontinue Previcox therapy and contact their veterinarian immediately if signs of intolerance are observed. The vast majority of patients with drug-related adverse reactions have recovered when the signs are recognized, the drug is withdrawn, and veterinary care, if appropriate, is initiated. Owners should be advised of the importance of periodic follow up for all dogs during administration of any NSAID.

Effectiveness:

Two hundred and forty-nine dogs of various breeds, ranging in age from 11 months to 20 years, and weighing 13 to 175 lbs, were randomly administered Previcox or an active control drug in two field studies. Dogs were assessed for lameness, pain on manipulation, range of motion, joint swelling, and overall improvement in a non-inferiority evaluation of Previcox compared with the active control. At the study's end, 87% of the owners rated Previcox-treated dogs as improved. Eighty-eight percent of dogs treated with Previcox were also judged improved by the veterinarians. Dogs treated with Previcox showed a level of improvement in veterinarian-assessed lameness, pain on palpation, range of motion, and owner-assessed improvement that was comparable to the active control. The level of improvement in Previcox-treated dogs in limb weight bearing on the force plate gait analysis assessment was comparable to the active control.

In a separate field study, two hundred fifty-eight client-owned dogs of various breeds, ranging in age from 10.5 weeks to 16 years and weighing from 7 to 168 lbs, were randomly administered Previcox or a control (sham-dosed-pilled) for the control of postoperative pain and inflammation associated with soft-tissue surgical procedures such as abdominal surgery (e.g. ovariohysterectomy, abdominal cryptorchidectomy, splenectomy, cystotomy) or major external surgeries (e.g. mastectomy, skin tumor removal ≥8 cm). The study demonstrated that Previcox-treated dogs had significantly lower need for rescue medication than the control (sham-dosed-pilled) in controlling postoperative pain and inflammation associated with soft-surgery.

A multi-center field study with 226 client-owned dogs of various breeds, and ranging in age from 1 to 11.9 years in the Previcox-treated groups and 0.7 to 17 years in the control group was conducted. Dogs were randomly assigned to either the Previcox or the control (sham-dosed-pilled) group for the control of postoperative pain and inflammation associated with orthopedic surgery. Surgery to repair a ruptured cruciate ligament included the following stabilization procedures: fabellar suture and/or imbrication, fibular head transposition, tibial plateau leveling osteotomy (TPLO), and ‘over the top' technique. The study (n = 220 for effectiveness) demonstrated that Previcox-treated dogs had significantly lower need for rescue medication than the control (sham-dosed-pilled) in controlling postoperative pain and inflammation associated with orthopedic surgery.

Palatability:

Previcox Chewable Tablets were rated both convenient to administer (97.2%) and palatable to the dog (68.5%) by owners in multi-center field studies involving client-owned dogs of various breeds and sizes.

Animal Safety:

In a target animal safety study, firocoxib was administered orally to healthy adult Beagle dogs (eight dogs per group) at 5, 15, and 25 mg/kg (1, 3, and 5 times the recommended total daily dose) for 180 days. At the indicated dose of 5 mg/kg, there were no treatment-related adverse events. Decreased appetite, vomiting, and diarrhea were seen in dogs in all dose groups, including unmedicated controls, although vomiting and diarrhea were seen more often in dogs in the 5X dose group. One dog in the 3X dose group was diagnosed with juvenile polyarteritis of unknown etiology after exhibiting recurrent episodes of vomiting and diarrhea, lethargy, pain, anorexia, ataxia, proprioceptive deficits, decreased albumin levels, decreased and then elevated platelet counts, increased bleeding times, and elevated liver enzymes. On histopathologic examination, a mild ileal ulcer was found in one 5X dog. This dog also had a decreased serum albumin which returned to normal by study completion. One control and three 5X dogs had focal areas of inflammation in the pylorus or small intestine. Vacuolization without inflammatory cell infiltrates was noted in the thalamic region of the brain in three control, one 3X, and three 5X dogs. Mean ALP was within the normal range for all groups but was greater in the 3X and 5X dose groups than in the control group. Transient decreases in serum albumin were seen in multiple animals in the 3X and 5X dose groups, and in one control animal.

In a separate safety study, firocoxib was administered orally to healthy juvenile (10-13 weeks of age) Beagle dogs at 5, 15, and 25 mg/kg (1, 3, and 5 times the recommended total daily dose) for 180 days. At the indicated (1X) dose of 5 mg/kg, on histopathologic examination, three out of six dogs had minimal periportal hepatic fatty change. On histopathologic examination, one control, one 1X, and two 5X dogs had diffuse slight hepatic fatty change. These animals showed no clinical signs and had no liver enzyme elevations. In the 3X dose group, one dog was euthanized because of poor clinical condition (Day 63). This dog also had a mildly decreased serum albumin. At study completion, out of five surviving and clinically normal 3X dogs, three had minimal periportal hepatic fatty change. Of twelve dogs in the 5X dose group, one died (Day 82) and three moribund dogs were euthanized (Days 38, 78, and 79) because of anorexia, poor weight gain, depression, and in one dog, vomiting. One of the euthanized dogs had ingested a rope toy. Two of these 5X dogs had mildly elevated liver enzymes. At necropsy all five of the dogs that died or were euthanized had moderate periportal or severe panzonal hepatic fatty change; two had duodenal ulceration; and two had pancreatic edema. Of two other clinically normal 5X dogs (out of four euthanized as comparators to the clinically affected dogs), one had slight and one had moderate periportal hepatic fatty change. Drug treatment was discontinued for four dogs in the 5X group. These dogs survived the remaining 14 weeks of the study. On average, the dogs in the 3X and 5X dose groups did not gain as much weight as control dogs. Rate of weight gain was measured (instead of weight loss) because these were young growing dogs. Thalamic vacuolation was seen in three of six dogs in the 3X dose group, five of twelve dogs in the 5X dose group, and to a lesser degree in two unmedicated controls. Diarrhea was seen in all dose groups, including unmedicated controls.

In a separate dose tolerance safety study involving a total of six dogs (two control dogs and four treated dogs), firocoxib was administered to four healthy adult Beagle dogs at 50 mg/kg (ten times the recommended daily dose) for twenty-two days. All dogs survived to the end of the study. Three of the four treated dogs developed small intestinal erosion or ulceration. Treated dogs that developed small intestinal erosion or ulceration had a higher incidence of vomiting, diarrhea, and decreased food consumption than control dogs. One of these dogs had severe duodenal ulceration, with hepatic fatty change and associated vomiting, diarrhea, anorexia, weight loss, ketonuria, and mild elevations in AST and ALT. All four treated dogs exhibited progressively decreasing serum albumin that, with the exception of one dog that developed hypoalbuminemia, remained within normal range. Mild weight loss also occurred in the treated group. One of the two control dogs and three of the four treated dogs exhibited transient increases in ALP that remained within normal range.

Storage:

Store at room temperature, between 59°–86° F (15°–30° C). Brief periods up to 104° F (40° C) are permitted.

FAQ

PREVICOX should not be given with other NSAIDs (for example, aspirin, carprofen, etodolac, deracoxib, meloxicam, or tepoxalin) or corticosteroids (for example, prednisone, cortisone, dexamethasone, or triamcinolone). Tell your veterinarian about all medications that you have given your dog in the past, and any medications that you are planning to give. This should include other medicines that you can get without a prescription or any dietary supplements. Your veterinarian may want to check that all of your dog's medicines and supplements can be given together.
PREVICOX should be given according to your veterinarian's instructions. Do not change the way you give PREVICOX to your dog without first speaking with your veterinarian. Your veterinarian will tell you what amount of PREVICOX is right for your dog and for how long it should be given. Most dogs will take PREVICOX chewable tablets from your hand, but you can also place the tablet directly into your dog's mouth. PREVICOX may be given with or without food.
PREVICOX is designed specifically for dogs. As such, people should not take PREVICOX or administer it to any animal other than a dog as prescribed by your veterinarian. Keep PREVICOX and all medications out of the reach of children. Call your physician immediately if you or a member of your family accidentally ingests PREVICOX.
Consult your veterinarian immediately if your dog consumes more than the prescribed amount of PREVICOX.

PREVICOX, like other NSAIDs, may cause some side effects. Serious side effects associated with NSAID therapy in dogs can occur with or without warning. The most common side effects associated with PREVICOX therapy involve the digestive tract (vomiting and decreased food consumption). Liver and kidney problems have also been reported with the use of NSAIDs. Look for the following side effects that may indicate your dog is having a problem with PREVICOX or may have another medical problem in addition to arthritis.

  • Vomiting
  • Change in bowel movements (such as diarrhea or black, tarry or bloody stools)
  • Change in behavior (such as decreased or increased activity level, lack of coordination, seizure, or aggression)
  • Yellowing of gums, skin, or whites of the eyes (jaundice)
  • Change in drinking habits (frequency or amount consumed)
  • Change in urination habits (frequency, color, or smell)
  • Change in skin (redness, scabs, or scratching)
  • Unexpected weight loss

It is important to stop treatment and contact your veterinarian immediately if you think your dog has a medical problem or side effect while taking PREVICOX tablets. If you have additional questions about possible side effects, talk with your veterinarian or call 888-637-4251.

Talk with your veterinarian about:

  • The signs of canine arthritis you have observed in your dog, such as limping or stiffness. You can print our checklist of common signs and take it with you to help you talk with your veterinarian.
  • The importance of weight control in the management of arthritis in dogs
  • What tests might be done before PREVICOX is prescribed
  • How often your dog may have to be examined by your veterinarian
  • The risks and benefits of using PREVICOX

Tell your veterinarian if your dog has ever had one or more of the following medical problems:

  • Any side effects from taking PREVICOX or other NSAIDs
  • Any digestive upset (vomiting and/or diarrhea)
  • Any kidney disease
  • Any liver disease

Tell your veterinarian about:

  • Any other medical problems or allergies that your dog has now, or has had in the past
  • All medicines that you are giving or planning to give your dog, including those you can get without a prescription and any dietary supplements

Your dog should not be given PREVICOX if he/she:

  • Has had an allergic reaction to firocoxib, the active ingredient in PREVICOX
  • Has had an allergic reaction (such as hives, facial swelling, or red or itchy skin) to aspirin or other NSAIDs
  • Is presently taking aspirin, other NSAIDs, or corticosteroids
  • Is under 12.5 pounds in body weight

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