Optimmune Ointment for Dogs 3.5 gm | On Sale | EntirelyPets Rx
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Optimmune Ophthalmic Ointment for Dogs 3.5 gm

Item# IWM011928
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Optimmune Ophthalmic Ointment is a sterile eye ointment containing cyclosporine, which helps to treat keratoconjunctivitis sicca (KCS or dry eye) in dogs. It reduces inflammation, stimulates tear production, and helps to reduce damage to the tear glands.

Key Benefits

  • The only FDA-approved veterinary cyclosporine ophthalmic product
  • Can increase natural tear production
  • Reduces inflammation
  • Shelf life up to 24 months with no refrigeration

How It Works

Optimmune Ophthalmic Ointment contains cyclosporine, which has broad anti-inflammatory effects that help to reduce damage to the tear glands while also stimulating tear production. Optimmune Ophthalmic Ointment also reduces eye inflammation.


Optimmune Ophthalmic Ointment is indicated for management of chronic keratoconjunctivitis sicca(KCS) and chronic superficial keratitis (CSK) in dogs.

Optimmune Ophthalmic Ointment is a registered trademark of Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck & Co. Inc.


View Optimmune Drug Facts Sheet.

  • Remove debris with suitable nonirritating solutions. Apply a 1/4 inch strip of ointment to the affected eye every 12 hours. The ointment may be placed directly on the cornea or into the conjunctival sac.
  • It is recommended that dogs exhibiting chronic recurring conjunctivitis be tested for adequate tear production to determine if they are suffering from early stages of chronic KCS.
  • For best results in treating KCS, cyclosporine ophthalmic ointment should be administered early in the course of the disease before irreversible damage to the lacrimal tissue, or dense corneal scarring or pigmentation occurs.
  • Dogs afflicted with KCS or CSK will most likely require lifelong consistent therapy (see Efficacy section above). For CSK, because environmental factors such as ultraviolet (UV) radiation are implicated in the pathogenesis, clinical signs may subside in the winter months when light intensity is reduced or if the dog is moved to a lower altitude, or indoors, and thus exposed to less UV radiation.
  • In cases refractory to cyclosporine, the diagnosis should be reevaluated and a different course oftherapy considered. Periodic reassessment of the need for Optimmune Ophthalmic Ointmenttherapy is recommended.


US Federal law restricts this drug to use by or on the order of a licensed veterinarian.


The clinical effects of Optimmune Ophthalmic Ointment have not been determined in dogs with KCS due to the following conditions: congenital alacrima, sulfonamide usage, canine distemper virus, metabolic disease, surgical removal of the third eyelid gland, and facial nerve paralysis with loss of the palpebral reflex. Some of the underlying conditions which may lead to KCS can be either transient (eg,facial nerve trauma) or correctable with appropriate treatment. Consequently, recovery from clinical signs attributed to KCS may be observed and treatment options may need reconsideration.

When switching to cyclosporine from another therapeutic agent (eg, frequent application of an artificialtear preparation) for KCS or CSK, it should be kept in mind that clinical efficacy is not necessarily apparent immediately after initiation of Optimmune Ophthalmic Ointment therapy. Several days to afew weeks may be required before the clinical effects of Optimmune Ophthalmic Ointment are of sufficient magnitude such that previously initiated therapy can be safely withdrawn. Abrupt cessation of a therapeutic agent immediately upon initiation of Optimmune Ophthalmic Ointment therapy can result in rapid clinical relapse which may be erroneously interpreted as an adverse reaction to Optimmune Ophthalmic Ointment.

The safety of Optimmune Ophthalmic Ointment has not been determined in cases of preexisting viral or fungal ocular infections. It is recommended that in such cases, Optimmune Ophthalmic Ointment therapy be delayed until the fungal/viral ocular infection has been successfully treated.

The safety of Optimmune Ophthalmic Ointment in puppies, pregnant bitches, or dogs used for breeding has not been determined.


A target animal safety study and clinical field studies with Optimmune Ophthalmic Ointment showed a wide safety margin in adult dogs. In the 6-month target animal safety study, dogs weresubjected twice daily to up to 10 times the approved concentration of Optimmune Ophthalmic Ointment. No apparent toxicity or adverse reactions were observed. Dogs in this study were vaccinated with commercially available vaccines. No effect on antibody titer response was noted. Epiphora was noted in all groups, including the placebo group, and was not associated with any inflammatory change,nor was there any correlation to gross and histopathological changes.

Adverse Reactions

In the KCS clinical field trial, there were 20 adverse reactions reported out of 132 cases enrolled. This corresponds to an adverse reaction rate of 12.9% (13 of 101 cases) for Optimmune Ophthalmic Ointment treated dogs and 22.6% (7 of 31) for placebo treated dogs. The reactions described were primarily ocular and periocular inflammatory reactions. These were likely a function of therapy being unable to fully control the keratoconjunctivitis, rather than a true "adverse reaction." Similarly, in the CSK trial, of 36 cases evaluated for safety, adverse reactions were noted in 2 animals (5.6%). One involved transient hyperemia, epiphora, and mild discomfort of the eye. The other involved periocular/palpebral inflammation and mild alopecia.

On rare occasion, instillation of Optimmune Ophthalmic Ointment may be associated with local irritation as manifested by periocular redness, lid spasm, and excessive rubbing. As the eyes of dogs with KCS often demonstrate considerable inflammation, it will be difficult to determine whether this local irritation constitutes a hyper sensitivity to Optimmune Ophthalmic Ointment. If this ocular irritation persists beyond 7 days, hyper sensitivity to a component of Optimmune Ophthalmic Ointment should be suspected and therapeutic options reassessed.


Store between 2° and 25° C (36° and 77° F).


Optimmune Ophthalmic Ointment is an immunosuppressive agent used to reduce inflammation in the eye(s). It is used to treat chronic dry eye (KCS, keratoconjunctivitis sicca) that may be caused by inflammation. Optimmune Ophthalmic Ointment may also be used for purposes other than those listed. Optimmune Ophthalmic Ointment is FDA approved for veterinary use in dogs only. Optimmune Ophthalmic Ointment is a prescription medication available as a sterile eye ointment. The sterile ointment is usually applied as a ¼ inch strip to the eye(s) every 12 hours. Do not touch the tube opening to any surface, including eyes and hands. The tube opening is sterile. If it becomes contaminated, it could cause an infection in the eye.
Do not use Optimmune Ophthalmic Ointment if your pet has any type of infection in the eye(s). Tell your veterinarian if your pet is pregnant or lactating.
Use this medication exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Wash your hands prior to using the eye ointment. Apply a ¼ inch strip of the ointment into the lower eyelid. Store Optimmune Ophthalmic Ointment at room temperature, away from moisture and heat. Keep the tube properly capped.
Serious side effects are not expected. Some burning, redness, tearing, discharge, pain, itching, stinging, or blurring of the vision may occur. Continue the medication and talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not give a double dose of the medication.
An overdose of this medication is unlikely. If an overdose is suspected, wash the eye with water and seek emergency veterinary medical treatment.
Do not touch the tube opening to any surface including eyes or hands. This medication may cause blurred vision. Avoid using other eye medications unless approved by your veterinarian.
Before using Optimmune Ophthalmic Ointment, tell your veterinarian if your pet is using other eye ointment or eye medications. Drugs other than those listed may also interact with Optimmune Ophthalmic Ointment. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.


Review Summary
108 Reviews
75% (81)
17% (18)
3% (3)
4% (4)
2% (2)
94% Recommend this product (101 of 108 responses)
By Dave
Good value.
February 6, 2021
Good value. Good service and shipping.
By Leonard R.
Jacksonville FL
Price increased
January 30, 2021
If you're going to increase the price by that much, I might as well get it from the vet. It's only a few dollars more.
Merchant Response:Hi Leonard, we understand about the price. We will continue to do our best to keep the price as low as possible. Give us a call, we'll see what we can do for you.
By Rae
So. CA
Eye ointment
January 2, 2021
Fast and courteous service. I appreciate that they get the refill orders from the Vet quickly and then mail out the prescription so that the medication does not run out. Thank you.
ProsQuick service and good pricing
ConsHaven't found any yet
By Susan
Only alternative I can find
December 30, 2020
I previously ordered this medication from a compounding pharmacy. It was oil based eye drops and seemed to provide more relief for my dogs chronic dry eye. This is more expensive and less effective but it is all I can find.
ConsPrice Less effective
By Robin M.
Cedar creek
Product is great .... getting it is a problem
December 30, 2020
My dog had to have this medication for his eyes. There is no alternative and without it he would be miserable. Itís is expensive and in no longer eligible for the 15% discount. My vet has to fax it multiple times to the company and then weeks later I get an email if I donít receive my shipment in the next day or two to call. I call and am told it is on back order. I have to find another reliable source for this medication because I canít depend on your company.
Merchant Response:Hi Robin, we are working every day to keep prices as low as possible. This medication is quite expensive. We couldn't keep giving 15% off on this product. We apologize. Give us a call for your next order.
By Jessica
Newport Coast, CA
Quality Medication at the best price!
December 20, 2020
My vet charges nearly double for this! It has done wonders for my dog's eyes - fixing his dry-eye problems.
Prosgreat price
By Judith
Good deal
December 18, 2020
Finding this deal on Optimmune was great. The price was $10 cheaper than other sources. Who doesnít love saving money?
Merchant Response:Judith, Happy to be of help!
By Laurie
December 11, 2020
Best eye drops ever really help my pug with dry eyes and great price !
By Bill N.
Great price and Very helpful staff
December 10, 2020
Great place to shop for veterinarian products.
By Shadow
Frederick MD
One good eye medicine
December 6, 2020
I've been using it for 2 years now and it works well for my dog
By Paige
Madison, WI
Great product!
November 29, 2020
I have to put this ointment in my pugís eyes twice a day and it helps with his dry eye so he doesnít get ulcers.
By updateCategoryParent
My opinion
November 21, 2020
Good product with good price and great service. Thank you.
By Dottie
Good products, great prices, and attentive, timely service
November 15, 2020
I'm so grateful to have found Entirely Pets Pharmacy online. Their prices are so reasonable and their service is outstanding.
By Barb
November 12, 2020
Saved 25% over my vets price
ProsPerfect delivery, great value
Pleasanton CA
Really helps
November 11, 2020
Our dog has a detached retina. We noticed her eye was getting goopy. We were told her bad eye was dry and she would need this ointment daily for the duration of her life. I bought the first tube from our vet and then found it here for almost half price! Very easy to get prescription to Entirely Pets Pharmacy and shipping was very fast.
Thank you
By Corinne H.
Gig Harbor, Wa
November 9, 2020
Product was the same as our original purchase made through our vetrinary. Only difference was the cost. We saved a considerable amount of money. And during this hard times that is extremely important. Along with keeping our pet healthy and safe.
By Teresa
Sardis, Ohio
Awesome prices
September 19, 2020
My 16 1/2 year old Shih Tzu will be on this medication for the rest of his life..best price I found was with Entirely Pets Pharmacy.
By Ginny
September 19, 2020
Great product
San Antonio
Re-order of above prescription went flawless
September 11, 2020
Received in timely manner. Satisfied
By Martin
Tucson, AZ
Pretty handy for using
August 27, 2020
Easy to apply, but the tubes are quite small and run out after several weeks.
Merchant Response:We hear you on that Martin. We would fill them with more if we could. Maybe bring it up with MERCK. 3.5g is very lightweight (1/8 ounce).
ProsDoes the job, convenient to apply
ConsExpensive and tubes do not contain much medicine!
By Tajblittle
Central MA
Great service and prompt delivery
August 22, 2020
My order came quickly. The team was great ... they tried to assist me with obtaining the RX from my vet. Much cheaper to order online. Thank you!
ProsCost Auto refill
By Kelly
DE Forest, Wi
Best price
August 20, 2020
I had to get this ointment for my new rescue. It was $80 at the vet! Chewy had it for $54. Entirely Pets has it for $40. Thank you for making this affordable so I can make sure my dog has what she needs for her care.
Merchant Response:Doing our best Kelly, Thanks for the glowing review!
By John L.
Nevada City, California
Five star service
August 19, 2020
Customer service was polite and helpful in placing my order. Pharmacy filled my order quickly and sent it in a reasonable time. Overall I could not ask for better service. Keep up the good work!
By Betty
Clearwater, FL
Optimmune for life
August 16, 2020
My doxy has very dry eyes. The vet has ordered optimmune for life both eyes. The tubes are very small, even has a lot air pockets , so I go through 2 tubes a month. I'm only on retirement income. Entirely Pets Pharmacy enables me to afford this for my doxy. More convenient with auto delivery too!
ProsSave money Very convenient Very good customer service
By Connie W.
Optimmune Ointment
August 12, 2020
Good price and great service.
By Paul
Western Massachusetts
August 9, 2020
Given the eye ointment we purchase for our dog requires a prescription, the ordering process, including communication with out local vet's office, is seamless.
Merchant Response:Hi Paul, We hear you loud and clear. We will work on that login. You can checkout as guest any time as well.
ProsGreat and easy service when ordering. Acceptable time for order processing, turnaround and delivery.
ConsDifficultly accessing website with my login information.
By Nanci
Eugene OR
Great Bargain!
August 9, 2020
This prescription was literally 50% of what my veterinary clinic charged for the same medicine. My dog has to take it for chronic eye infections and I will get all future refills from Entirely Pets.
By Alicia
Sherman Oaks, CA
Great Product!
August 2, 2020
Our Lhasa mix has chronic dry eye and this is the only thing that makes his eyes look and feel better. Shipping was quick too!
By Suzie
Pebble Beach, California
Optimmune Ophthalmic Ointment for Dogs
July 18, 2020
Again, an important medicine for a dog who recently had Cataract surgery.
Highly recommended by his surgeon!!
ProsTaking care of your pet is so important. Thats exactly why I've followed my Vet's recommendation and will be giving my dog this medicine probably for th rest of his life!!
By Wynne
Laughlin, NV
July 18, 2020
This product along with Ofloxin keeps our little dog's dry eyes in control and experiences no pain.
ProsProtects out little dog's eyes clear and pain free.
ConsTube is so small, but if very careful, will last about 31/2 weeks.

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