Optimmune Ointment for Dogs 3.5 gm | On Sale | EP Rx
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Optimmune Ophthalmic Ointment for Dogs 3.5 gm

Item# IWM011928
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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Optimmune is a sterile eye ointment containing cyclosporine which helps to treat keratoconjunctivitis Sica (KCS or dry eye) and chronic superficial keratitis (CSK) in dogs.

Key Benefits

  • The only FDA-approved veterinary cyclosporine ophthalmic product
  • Can increase natural tear production
  • Reduces inflammation
  • Shelf life up to 24 months with no refrigeration

How It Works

Cyclosporine has broad anti-inflammatory effects that help to reduce damage to the tear glands while also stimulating tear production.


Do not touch the tube opening to any surface including eyes or hands. This medication may cause blurred vision. Avoid using other eye medications unless approved by the veterinarian.

Prescription Required

NDC 0061-1088-01


Active Ingredients (per gram)

2 mg cyclosporine USP, petrolatum USP, corn oil NF, petrolatum and lanolin alcohol.


Use this medication exactly as directed by your veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you.

View product label for more information

Dosage & Administration

  1. Remove debris with suitable nonirritating solutions. Apply a 1/4 inch strip of ointment to the affected eye(s) every 12 hours. The ointment may be placed directly on the cornea or into the conjunctival sac.
  2. It is recommended that dogs exhibiting chronic recurring conjunctivitis be tested for adequate tear production to determine if they are suffering from early stages of chronic KCS.
  3. For best results in treating KCS, cyclosporine ophthalmic ointment should be administered early in the course of the disease before irreversible damage to the lacrimal tissue, or dense corneal scarring or pigmentation occurs.
  4. Dogs afflicted with KCS or CSK will most likely require lifelong consistent therapy (see Efficacy section). For CSK, because environmental factors such as ultraviolet (UV) radiation are implicated in the pathogenesis, clinical signs may subside in the winter months when light intensity is reduced or if the dog is moved to a lower altitude, or indoors, and thus exposed to less UV radiation.1
  5. In cases refractory to cyclosporine, the diagnosis should be re-evaluated and a different course of therapy considered. Periodic reassessment of the need for Optimmune Ophthalmic Ointment therapy is recommended.

Quick Tips

  • Optimmune Ophthalmic Ointment, a prescription medication, is used in dogs for the management of chronic keratoconjunctivitis sicca (KCS or 'dry eye').
  • Optimmune Ophthalmic Ointment is an immunosuppressive agent used to reduce inflammation in the eye(s).
  • Optimmune Ophthalmic Ointment is used in dogs only. Do not use in cats.
  • Remove debris from eye(s) with a nonirritating solution. The sterile ointment is usually applied as a 1/2 inch strip to the lower eyelid(s) every 12 hours. Wash your hands prior to using the eye ointment

Extra Tip

The tube opening is sterile. Do not touch the tube opening to any surface, including eyes and hands. If the opening becomes contaminated, it could cause an infection in the eye(s).

Dosage Table

Dogs:All weightsApply a 1/2 inch strip to the lower eyelid(s) every 12 hours

Storage Directions

Store between 36°F - 77°F (2°C -25°C). Keep away from moisture and heat. Keep the tube properly capped.


A target animal safety study and clinical field studies with Optimmune Ophthalmic Ointment showed a wide safety margin in adult dogs. In the 6-month target animal safety study, dogs were subjected twice daily to up to 10 times the approved concentration of Optimmune Ophthalmic Ointment. No apparent toxicity or adverse reactions were observed. Dogs in this study were vaccinated with commercially available vaccines. No effect on antibody titer response was noted. Epiphora was noted in all groups, including the placebo group, and was not associated with any inflammatory change, nor was there any correlation to gross and histopathological changes.


The clinical effects of Optimmune Ophthalmic Ointment have not been determined in dogs with KCS due to the following conditions: congenital alacrima, sulfonamide usage, canine distemper virus, metabolic disease, surgical removal of the third eyelid gland, and facial nerve paralysis with loss of the palpebral reflex. Some of the underlying conditions which may lead to KCS can be either transient (eg, facial nerve trauma) or correctable with appropriate treatment. Consequently, recovery from clinical signs attributed to KCS may be observed and treatment options may need reconsideration.

When switching to cyclosporine from another therapeutic agent (eg, frequent application of an artificial tear preparation) for KCS or CSK, it should be kept in mind that clinical efficacy is not necessarily apparent immediately after initiation of Optimmune Ophthalmic Ointment therapy. Several days to a few weeks may be required before the clinical effects are of Optimmune Ophthalmic Ointment are of sufficient magnitude such that a previously initiated therapy can be safely withdrawn. Abrupt cessation of a therapeutic agent immediately upon initiation of Optimmune Ophthalmic Ointment therapy can result in rapid clinical relapse which may be erroneously interpreted as an adverse reaction to the Optimmune Ophthalmic Ointment.

The safety of Optimmune Ophthalmic Ointment has not been determined in cases of preexisting viral or fungal ocular infections. It is recommended that in such cases, Optimmune Ophthalmic Ointment therapy be delayed until the fungal/viral ocular infection has been successfully treated.

The safety of Optimmune Ophthalmic Ointment in puppies, pregnant bitches, or dogs used for breeding has not been determined.

Adverse Reactions

In the KCS clinical field trial, there were 20 adverse reactions reported out of 132 cases enrolled. This corresponds to an adverse reaction rate of 12.9% (13 of 101 cases) for Optimmune Ophthalmic Ointment treated dogs and 22.6% (7 of 31) for placebo treated dogs. The reactions described were primarily ocular and periocular inflammatory reactions. These were likely a function of therapy being unable to fully control the keratoconjunctivitis, rather than a true adverse reaction. Similarly, in the CSK trial, of 36 cases evaluated for safety, adverse reactions were noted in 2 animals (5.6%). One involved transient hyperemia, epiphora, and mild discomfort of the eye. The other involved periocular/palpebral inflammation and mild alopecia.

On rare occasion, instillation of Optimmune Ophthalmic Ointment may be associated with local irritation as manifested by periocular redness, lid spasm, and excessive rubbing. As the eyes of dogs with KCS often demonstrate considerable inflammation, it will be difficult to determine whether this local irritation constitutes a hypersensitivity to Optimmune Ophthalmic Ointment. If this ocular irritation persists beyond 7 days, hypersensitivity to a component of Optimmune Ophthalmic Ointment should be suspected and therapeutic options reassessed.


What is the most important thing I should know about Optimmune Ophthalmic Ointment?

Optimmune Ophthalmic Ointment is an immunosuppressive agent used to reduce inflammation in the eye(s). It is used to treat chronic dry eye (KCS, keratoconjunctivitis sicca) that may be caused by inflammation. Optimmune Ophthalmic Ointment may also be used for purposes other than those listed. Optimmune Ophthalmic Ointment is FDA approved for veterinary use in dogs only. Optimmune Ophthalmic Ointment is a prescription medication available as a sterile eye ointment. The sterile ointment is usually applied as a ¼ inch strip to the eye(s) every 12 hours. Do not touch the tube opening to any surface, including eyes and hands. The tube opening is sterile. If it becomes contaminated, it could cause an infection in the eye.

What happens if I miss giving a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet?

An overdose of this medication is unlikely. If an overdose is suspected, wash the eye with water and seek emergency veterinary medical treatment.

What should I avoid while giving Optimmune to my pet?

Do not touch the tube opening to any surface including eyes or hands. This medication may cause blurred vision. Avoid using other eye medications unless approved by the veterinarian.

What other drugs will affect Optimmune?

Before using Optimmune Ophthalmic, tell your veterinarian if your pet is using other eye ointment or eye medications. Drugs other than those listed may also interact with Optimmune Ophthalmic. Talk to the veterinarian or pharmacist before giving any prescription or over the counter medicines.

What should I discuss with my veterinarian before giving Optimmune to my pet?

Do not use Optimmune Ophthalmic if the pet has any type of infection in the eye(s). Tell your veterinarian if your pet is pregnant or lactating.

How should Optimmune Ophthalmic Ointment be used?

Use this medication exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Wash your hands prior to using the eye ointment. Apply a ¼ inch strip of the ointment into the lower eyelid. Store Optimmune Ophthalmic Ointment at room temperature, away from moisture and heat. Keep the tube properly capped.

What are the potential side effects of Optimmune Ophthalmic Ointment?

Serious side effects are not expected. Some burning, redness, tearing, discharge, pain, itching, stinging, or blurring of the vision may occur. Continue the medication and talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.


Review Summary
49 Reviews
73% (36)
18% (9)
2% (1)
4% (2)
2% (1)
94% Recommend this product (46 of 49 responses)
By Dawn
Stuyvesant, NY
Effective eye moisture
June 6, 2020
My yorkie-poo has dry eyes and we put optimuum drops in twice per day. It keeps her eyes lubricated and controls the mucus.
By Greg1234
panhandle of Florida
Excellent price for permanent dry eye ointment
March 13, 2020
My new rescue's eyes do not make tears so my get prescribed this product. Works well and the price is very good. I have it on a monthly delivery plan.
ProsEasy to apply
By Tom
Fairport, NY
Optimmune eye ointment
March 6, 2020
Optimmune eye ointment is outrageously expensive for a 3.5g ($60.00+) tube. Entirely Pets Pharmacy had the best price ($39.99), availability and easy Vet contact with fast free shipping.... A+
By Sally M.
Hackensack, MN
Optimmune Ointment
February 11, 2020
My Shih Tzu has an eye condition that many Shih Tzu have that requires them to use Optimmune daily for the rest of their lives. When it is time for me to purchase more Optimmune ointment I go on line to search for the best price. EntirelyPets had the best price and a 15% off coupon making my purchase a great value. Placing the order was very easy and the communication was outstanding. I will certainly look for them again when placing my next order.
ProsGood prices Good communication Love the extra coupon savings
By Jan
February 2, 2020
great service
great prices
By Tully
Point of Rocks, MD
Worth the Money
January 31, 2020
I looked all over and this was the best price I could find. The ointment has been the best thing for my bulldogs dry eye and I couldn't be happier. (he is pretty happy himself now that I am not always messing with his eye)
By Michele
North Port, FL
Very Convenient!
January 31, 2020
Very happy to have found this ointment at this price. This is the lowest I have ever been able to find it, and the ordering process was very easy with Entirely Pet Pharmacy contacting my dogs doctor for me. I will definitely check with you for all of my pups prescription needs.
By Bryan
Really poor service so far
January 26, 2020
First I had to get my veterinarian to fax a prescription because EPP was unable to reach the clinic by phone, despite the fact the clinic is open 5 days a week from 9am to 5pm. Then EPP messed up my mailing address and the package got sent back to them. That was 9 days ago and now I have to chase EPP to find out if they intend to try again, this time to the correct address. Good prices though, if it ever arrives.
By Teresa C.
Sevierville, Tn
Fantastic Prices and service
January 26, 2020
My vet told me my service dog had an eye condition that would in time cause her to go blind. The only hope I had was to put an ointment in her eyes for the rest of her life. This medicine was going to cost almost $300.00 each month. I am on a fixed income and there was no way I could afford it. Then I heard about Entirely Pets. Her prescription is only half of what the vet was going to charge me. I have an automatic shipment sent to me every two weeks. Her eyes are doing great and I can afford to keep her.
By Shirley L.
Yuma Arizona
Be Aware
January 25, 2020
After opening the first box I was very disappointed to find 1/4 of the tube was empty. There's no way to contact Merk to complain. Since this is going to be a lifetime project I am grateful your prices for at least the first order was almost buy one get one free. I haven't opened the other box yet.
Constube wasnt full
January 21, 2020
By Jennifer
Danville, CA
dog have been on this for over a year and it seems to help
January 14, 2020
my dog's dry eye is beteer since using this. also, this place has the best pricing on these.
By Mickie
Best price on the market
January 10, 2020
Hopefully you can keep the price of this product right where it is. We bought from you after our former pet med company raised the price of this product by $20!
ProsGood quality eye ointment.
ConsWish the tube were larger for the price.
By Cindy
Plattsmouth, Nebraska
Eye Med for my Dog
January 9, 2020
My Yorkie, Stella, has been on this med for a few years. She has to have it for her dry eye, and this site offers the cheapest pricing. I really appreciate it as this in all probability will be a life long affliction.
By Marilyn
Oro Valley, AZ
Best Price
January 5, 2020
Thank you for providing the best price for this long term eye ointment! Placing my order was easy and staff very knowledgeable and helpful.
By Julie
Laguna Woods CA
January 4, 2020
Bought 2 great price hope when needed next time it will be on sale again as retired living on fixed income
Orlando, Fl
December 29, 2019
My dog requires this med due his dry eye syndrome. I find this ridiculously overpriced. I wish someone would make this in a generic form. Entirely Pets at least has the lowest price available.
ProsThe only pro for this med is that it works.
ConsThe con is that this is WAY overpriced at 40., much less the retail price of 52. I am on a fixed income and it is very hard to afford this med for my dog. Someone needs to make a generic form of this. It should be simple as all the ingredients are generic.
By Jim85254
Scottsdale, AZ
Great Price
December 28, 2019
This product is at a great price...
November 23, 2019
By Clinton
Needles California
Excellent price
November 18, 2019
Find the pricing be extremely economical.
Merchant Response:Clinton, We do our very best to get your the best pricing! Wishing you and your animals the best
By Cathy
Central New England
Great price
November 16, 2019
Best price online. Really helps with Ruby's dry eye.
Merchant Response:Hi Cathy, I would like to personally thank you for ordering with EntirelyPets Pharmacy. We appreciate your business and the opportunity to service. We are so glad to hear that this has helped with Ruby's Dry eyes.
By TexPet
Well done
November 3, 2019
Entirelypets went above and beyond to make sure my pet's vet approved the prescription. They both faxed and made multiple calls when no response was forthcoming. The price was also reasonable comparatively speaking. Very pleased.
Merchant Response:HI, we are so glad to here that we were able to provide your with great customer service so that your pet could get there medication.
By Loretta T.
Columbus, Ohio
Can't beat the price!!!!!
October 24, 2019
I loved that I could save almost half price by ordering this instead of buying it from my vet office. It cut the price in almost half which helped so much when you do rescue.
ProsPrice can't be beat
By T
Pewaukee WI
Fast and Helpful Service!
October 19, 2019
One of my dogs was diagnosed with dry eye by our vet which requires twice daily doses of Optimmune ointment.

Entirely Pets went to my vet to get the prescription and filled the order quickly and at about half the cost of buying from the clinic. This eased the pain of his diagnosis as he will need the medication for the rest of his life.
By Julie C.
Scary good service and pricing
October 9, 2019
Best price for Optimmune eye ointment. Placed my first order a few weeks ago. Their email communication for statuses is excellent. Be sure to provide a fax number for your vet, they will need that, I had neglected that when I initially placed my order. Once my vet approved, it shipped quickly.
September 3, 2019
Besides the pricing being the cheapest out there that I could find, their staff also stays on top of the Dr. office to get your prescription approved! Thank you Entirely Pets Pharmacy, you have acquired a new long time client!
By Yaneli S.
Chicago, Illinois
Great experience!
September 1, 2019
Awesome product! Got shipped to me super fast even though they had to get dogs prescription. It was very affordable compared to other places too.
My dog kodac and me thank you for this product.
Merchant Response:Hi Yaneli, I am so happy to hear that we were able to get you and your dog Kodac this medication on time. I am so happy that we were able to provide you with the great service. I want to thank you and your dog Kodac for using our pharmacy for the medication.
By Diane V.
Latham, New York
Optimmune Ointment
August 29, 2019
My dog has dry eyes. Optimmune Opthalmic Ointment has just about cured his problems with dry eyes. The vet said that his tear ducts are now producing tears again to some degree. He will be on this medicine for the rest of his life, but now he is no longer suffering with eye problems. I am so grateful for that. No one wants to see their dog in discomfort.
Merchant Response:HI Diane, I am so glad that this product has helped your dogs dry eye problems. I know that your dog are our family members. I am so happy that we were able to help you get the right product for your dog.
By Wanda
Anderson, TX
Works well
August 3, 2019
This medication is helping to make our Toby more comfortable with his chronic dry eyes.
ProsOintment, easy to apply
By Kim
Boston, Massachusetts
Great price!
March 22, 2019
I typically buy Zep's medicine from his veterinarian but it is expensive so I did some research and found a great price at Entirely Pets! I will continue to buy from this venue as long as prices don't climb too much.
ProsGreat price and timely delivery!

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