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Optimmune Ophthalmic Ointment for Dogs 3.5 gm

Item# IWM011928
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Optimmune Ophthalmic Ointment is a sterile eye ointment containing cyclosporine, which helps to treat keratoconjunctivitis sicca (KCS or dry eye) in dogs. It reduces inflammation, stimulates tear production, and helps to reduce damage to the tear glands.

Key Benefits

  • The only FDA-approved veterinary cyclosporine ophthalmic product
  • Can increase natural tear production
  • Reduces inflammation
  • Shelf life up to 24 months with no refrigeration

How It Works

Optimmune Ophthalmic Ointment contains cyclosporine, which has broad anti-inflammatory effects that help to reduce damage to the tear glands while also stimulating tear production. Optimmune Ophthalmic Ointment also reduces eye inflammation.


Optimmune Ophthalmic Ointment is indicated for management of chronic keratoconjunctivitis sicca(KCS) and chronic superficial keratitis (CSK) in dogs.

Optimmune Ophthalmic Ointment is a registered trademark of Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck & Co. Inc.


View Optimmune Drug Facts Sheet.

  • Remove debris with suitable nonirritating solutions. Apply a 1/4 inch strip of ointment to the affected eye every 12 hours. The ointment may be placed directly on the cornea or into the conjunctival sac.
  • It is recommended that dogs exhibiting chronic recurring conjunctivitis be tested for adequate tear production to determine if they are suffering from early stages of chronic KCS.
  • For best results in treating KCS, cyclosporine ophthalmic ointment should be administered early in the course of the disease before irreversible damage to the lacrimal tissue, or dense corneal scarring or pigmentation occurs.
  • Dogs afflicted with KCS or CSK will most likely require lifelong consistent therapy (see Efficacy section above). For CSK, because environmental factors such as ultraviolet (UV) radiation are implicated in the pathogenesis, clinical signs may subside in the winter months when light intensity is reduced or if the dog is moved to a lower altitude, or indoors, and thus exposed to less UV radiation.
  • In cases refractory to cyclosporine, the diagnosis should be reevaluated and a different course oftherapy considered. Periodic reassessment of the need for Optimmune Ophthalmic Ointmenttherapy is recommended.


US Federal law restricts this drug to use by or on the order of a licensed veterinarian.


The clinical effects of Optimmune Ophthalmic Ointment have not been determined in dogs with KCS due to the following conditions: congenital alacrima, sulfonamide usage, canine distemper virus, metabolic disease, surgical removal of the third eyelid gland, and facial nerve paralysis with loss of the palpebral reflex. Some of the underlying conditions which may lead to KCS can be either transient (eg,facial nerve trauma) or correctable with appropriate treatment. Consequently, recovery from clinical signs attributed to KCS may be observed and treatment options may need reconsideration.

When switching to cyclosporine from another therapeutic agent (eg, frequent application of an artificialtear preparation) for KCS or CSK, it should be kept in mind that clinical efficacy is not necessarily apparent immediately after initiation of Optimmune Ophthalmic Ointment therapy. Several days to afew weeks may be required before the clinical effects of Optimmune Ophthalmic Ointment are of sufficient magnitude such that previously initiated therapy can be safely withdrawn. Abrupt cessation of a therapeutic agent immediately upon initiation of Optimmune Ophthalmic Ointment therapy can result in rapid clinical relapse which may be erroneously interpreted as an adverse reaction to Optimmune Ophthalmic Ointment.

The safety of Optimmune Ophthalmic Ointment has not been determined in cases of preexisting viral or fungal ocular infections. It is recommended that in such cases, Optimmune Ophthalmic Ointment therapy be delayed until the fungal/viral ocular infection has been successfully treated.

The safety of Optimmune Ophthalmic Ointment in puppies, pregnant bitches, or dogs used for breeding has not been determined.


A target animal safety study and clinical field studies with Optimmune Ophthalmic Ointment showed a wide safety margin in adult dogs. In the 6-month target animal safety study, dogs weresubjected twice daily to up to 10 times the approved concentration of Optimmune Ophthalmic Ointment. No apparent toxicity or adverse reactions were observed. Dogs in this study were vaccinated with commercially available vaccines. No effect on antibody titer response was noted. Epiphora was noted in all groups, including the placebo group, and was not associated with any inflammatory change,nor was there any correlation to gross and histopathological changes.

Adverse Reactions

In the KCS clinical field trial, there were 20 adverse reactions reported out of 132 cases enrolled. This corresponds to an adverse reaction rate of 12.9% (13 of 101 cases) for Optimmune Ophthalmic Ointment treated dogs and 22.6% (7 of 31) for placebo treated dogs. The reactions described were primarily ocular and periocular inflammatory reactions. These were likely a function of therapy being unable to fully control the keratoconjunctivitis, rather than a true "adverse reaction." Similarly, in the CSK trial, of 36 cases evaluated for safety, adverse reactions were noted in 2 animals (5.6%). One involved transient hyperemia, epiphora, and mild discomfort of the eye. The other involved periocular/palpebral inflammation and mild alopecia.

On rare occasion, instillation of Optimmune Ophthalmic Ointment may be associated with local irritation as manifested by periocular redness, lid spasm, and excessive rubbing. As the eyes of dogs with KCS often demonstrate considerable inflammation, it will be difficult to determine whether this local irritation constitutes a hyper sensitivity to Optimmune Ophthalmic Ointment. If this ocular irritation persists beyond 7 days, hyper sensitivity to a component of Optimmune Ophthalmic Ointment should be suspected and therapeutic options reassessed.


Store between 2° and 25° C (36° and 77° F).


Optimmune Ophthalmic Ointment is an immunosuppressive agent used to reduce inflammation in the eye(s). It is used to treat chronic dry eye (KCS, keratoconjunctivitis sicca) that may be caused by inflammation. Optimmune Ophthalmic Ointment may also be used for purposes other than those listed. Optimmune Ophthalmic Ointment is FDA approved for veterinary use in dogs only. Optimmune Ophthalmic Ointment is a prescription medication available as a sterile eye ointment. The sterile ointment is usually applied as a ¼ inch strip to the eye(s) every 12 hours. Do not touch the tube opening to any surface, including eyes and hands. The tube opening is sterile. If it becomes contaminated, it could cause an infection in the eye.
Do not use Optimmune Ophthalmic Ointment if your pet has any type of infection in the eye(s). Tell your veterinarian if your pet is pregnant or lactating.
Use this medication exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Wash your hands prior to using the eye ointment. Apply a ¼ inch strip of the ointment into the lower eyelid. Store Optimmune Ophthalmic Ointment at room temperature, away from moisture and heat. Keep the tube properly capped.
Serious side effects are not expected. Some burning, redness, tearing, discharge, pain, itching, stinging, or blurring of the vision may occur. Continue the medication and talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not give a double dose of the medication.
An overdose of this medication is unlikely. If an overdose is suspected, wash the eye with water and seek emergency veterinary medical treatment.
Do not touch the tube opening to any surface including eyes or hands. This medication may cause blurred vision. Avoid using other eye medications unless approved by your veterinarian.
Before using Optimmune Ophthalmic Ointment, tell your veterinarian if your pet is using other eye ointment or eye medications. Drugs other than those listed may also interact with Optimmune Ophthalmic Ointment. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.


Review Summary
128 Reviews
73% (93)
20% (25)
2% (3)
4% (5)
2% (2)
94% Recommend this product (120 of 128 responses)
By Maria
Keeps my dog's eyes from drying out
February 26, 2023
My vet recommended that I use this ointment on my 13 year old pug's eyes. I use it daily (once altho my vet recommended twice) and it keeps his eyes from drying out. It helps and seems to soothe his eyes.
Merchant Response:Hello Maria, That's great to hear! We hope to hear more about how your pet improves. Sincerely, EntirelyPets Pharmacy
By Lily
Did Eye Meds
January 14, 2023
The medicine is effective in helping with our dogís dry eye condition and the discount is great.
Merchant Response:Hello Lily, We love hearing your pet is improving, and we try hard to provide quality products at competitive prices. Sincerely, EntirelyPets Pharmacy
By Robbie
North Carolina
Optimmune Is Awesome!
October 19, 2022
Optimmune worked immediately to stop the thick goop and dry clumping mess in my precious girl's eyes. It is an excellent product in my opinion. The tube is tiny but what is inside really works. We have used a couple different products the veterinarian sold to us but then I asked him to write a script for Optimmune since he did not carry it and my sweet girl felt better almost immediately. Yes, the eyes still run but less so nor is there any dry crusty mess.
Very soothing with a thick, light texture that immediately makes the eyes sparkle with moisture. Just wipe with a soft, damp, clean face cloth. Avoid those eye wipes with all the harsh chemicals that cause irritation! Tube is tiny but squeeze gently so not to waste.
By Kelly
Columbus, wi
My dog needs this
August 14, 2022
I have to get this for my little dog. It is so costly at the vet. The thing is, many times, the price changes. So I shop around for the best price. This website is the one I visit often.
Merchant Response:A lot of things are getting expensive these days. We continue to do our best to keep pricing as low as possible.
By PattiH
Centennial, CO
Easy to order
June 19, 2022
Got a good deal on this medication. Delivery was quick and accurate. Ordering was easy. Would definitely order again.
Merchant Response:Thank you Patti
By Mandy
Denton Tx
Great product
June 18, 2022
Received product very quickly
Merchant Response:We do our best! Happy you like our service and Optimmune
By Scotti
January 16, 2022
My pup needs this and if I forgot to put it in.i get that evil look, I need my meds
By Marylou
Shingle Springs, CA
Perfect order from Entirely Pets
December 23, 2021
My dog needs Optimmune for his eyes for the rest of his life. When the vet charged me, it was $69 for a small tube. It lasted about two weeks. I went to Costco and it cost $57 for a tube. I found the three pack at Entirely Pets for $147 and I could get it on an automatic shipment so I jumped at it. The young lady on the phone helped me do the order and sent it to my vet. After approval, the shipment came in 3 days. They emailed me at every point. Iím very pleased with Entirely Pets and may order Other meds from them. �🤗
By Laura
December 12, 2021
The service is pleasant and accurate when ordered. Fast service! Received my mail.
Pricing is the best.
Cape Cod
Eye Health
December 9, 2021
Our dogís animal ophthalmologist prescribed Optimmune to treat both of his eyes. He is a Boston Terrier and the breed is known for eye problems. His eyes have greatly improved. He will be on Optimmune for life, and we are glad we have this medication available from Entirely Pet Pharmacy at a savings.
By Heidim
Cleveland, OH
Fast service!
May 11, 2021
My order was shipped quickly. I use the automatic refill option & they communicate with my vet when itís time for a prescription refill to be ordered, so I donít even need to place a call to the vet.
Merchant Response:
By Prince K.
Alexandria, VA
Optimmune Review
April 25, 2021
My pup has dry eye and this product helps him immensely. We are very satisfied with it and the service from Entirely Pets. They deliver quickly and have good customer service.
By sherry a.
upper michigan
great price and fast delivery
April 23, 2021
Customer service is very informational and assists with orders. Prompt delivery and notification when prescription is sent and delivery date.
great price and customer service none
By Charlotte
Indianapolis, Indiana
Optimmune is a Great Product!
April 11, 2021
We are very happy with Optimmune that we get through Entirely Pets Pharmacy. The product is great and helps our dog's eyes. Our dog is on this medication long-term. We also appreciate any discounts offered! We get complete orders every time, and we get them quickly. If there is ever an issue, the Customer Service Representatives are helpful, efficient, and know whom to contact to resolve any issue. We really appreciate Entirely Pets Pharmacy and its staff.
Accurate Quick Efficient Great Customer Service
By john g.
optimune pricing
April 3, 2021
Finally, I have found someone who realizes I'm treating a dog and not a human. I have had to pay $70.00 + for the Optimune over the past two years.
By John
As always....
March 31, 2021
Fast delivery at a great price!
By Parker B.
Fast shipping
March 18, 2021
Got my dog's medicine very quickly and ordering was pretty straightforward.
By Olivia O.
The tube splits and wastes all the product
March 12, 2021
Obviously I like this product because it keeps my dog's eye healthy, but very frustrated with the tube! Twice now it's broken on the sides letting the gel leak out, and it's wasted most of the product. One tube should last me 3ish months, but it's only been a month and I have to get a new one. Very annoying just because it's so expensive!
By Eugene p.
Round lake Illinois
Great product
March 4, 2021
I have Been ordering from them for a while. This past order I guess because they change the computer screens or something on your ordering my order seem to be delayed for a while and finally they had the tracking number sent to me and I was able to track it but are there and then that one problem theyíve been great
Merchant Response:Thanks for your patience Eugene. We did upgrade our office+warehouse software and some orders could have shipped out faster. We are going through growing pains. We hope to have you as a long-time customer and we will be better than ever on your next order. Take care!
By Russ
Effective and Expensive
February 25, 2021
Optimmune helps my 14-year old pugís chronic dry eye. The vetís instructions are to use it twice daily, indefinitely. Itís pricey $50-$65 for such a small 3.5 gram tube!
By Dave
Good value.
February 6, 2021
Good value. Good service and shipping.
By Leonard R.
Jacksonville FL
Price increased
January 30, 2021
If you're going to increase the price by that much, I might as well get it from the vet. It's only a few dollars more.
Merchant Response:Hi Leonard, we understand about the price. We will continue to do our best to keep the price as low as possible. Give us a call, we'll see what we can do for you.
By Rae
So. CA
Eye ointment
January 2, 2021
Fast and courteous service. I appreciate that they get the refill orders from the Vet quickly and then mail out the prescription so that the medication does not run out. Thank you.
Quick service and good pricing Haven't found any yet
By Susan
Only alternative I can find
December 30, 2020
I previously ordered this medication from a compounding pharmacy. It was oil based eye drops and seemed to provide more relief for my dogs chronic dry eye. This is more expensive and less effective but it is all I can find.
Price Less effective
By Robin M.
Cedar creek
Product is great .... getting it is a problem
December 30, 2020
My dog had to have this medication for his eyes. There is no alternative and without it he would be miserable. Itís is expensive and in no longer eligible for the 15% discount. My vet has to fax it multiple times to the company and then weeks later I get an email if I donít receive my shipment in the next day or two to call. I call and am told it is on back order. I have to find another reliable source for this medication because I canít depend on your company.
Merchant Response:Hi Robin, we are working every day to keep prices as low as possible. This medication is quite expensive. We couldn't keep giving 15% off on this product. We apologize. Give us a call for your next order.
By Jessica
Newport Coast, CA
Quality Medication at the best price!
December 20, 2020
My vet charges nearly double for this! It has done wonders for my dog's eyes - fixing his dry-eye problems.
great price
By Judith
Good deal
December 18, 2020
Finding this deal on Optimmune was great. The price was $10 cheaper than other sources. Who doesnít love saving money?
Merchant Response:Judith, Happy to be of help!
By Laurie
December 11, 2020
Best eye drops ever really help my pug with dry eyes and great price !
By Bill N.
Great price and Very helpful staff
December 10, 2020
Great place to shop for veterinarian products.
By Shadow
Frederick MD
One good eye medicine
December 6, 2020
I've been using it for 2 years now and it works well for my dog

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