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Optimmune Ophthalmic Ointment for Dogs - (0.2% Cyclosporine,USP) - 3.5 gm - [Dry Eye]

Item# IWM011928
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Optimmune ophthalmic ointment is a veterinary medication used for the treatment of chronic keratoconjunctivitis sicca (dry eye) in dogs. It contains 0.2% cyclosporine, which helps to increase tear production and reduce inflammation in the eye. Optimmune is formulated as an ophthalmic ointment for easy application to the eye. This medication is available only with a prescription from a licensed veterinarian and is typically administered twice daily as directed. Optimmune is a trusted choice for managing dry eye in dogs, providing relief from symptoms and promoting eye health.

Key Benefits

  • Relieves Discomfort: Optimmune Ophthalmic Ointment provides relief from the discomfort associated with chronic dry eye, such as itching, burning, and irritation.
  • Promotes Healing: By reducing inflammation and increasing tear production, Optimmune helps promote healing of the surface of the eye, reducing the risk of further complications.
  • Improves Eye Health: The lubricating effect of Optimmune helps maintain the health of the cornea and conjunctiva, reducing the risk of corneal ulcers and other eye problems.
  • Easy to Use: The ointment is easy to apply, making it convenient for pet owners to administer at home.
  • Trusted by Veterinarians: Optimmune is a trusted choice of veterinarians for the management of chronic dry eye in dogs, with a proven track record of safety and effectiveness.

How It Works

Optimmune Ophthalmic Ointment works by containing cyclosporine, a medication that helps reduce inflammation and increase tear production in the eyes.

  1. Reduces Inflammation: Cyclosporine inhibits the activity of certain immune cells that contribute to inflammation in the eye. By reducing inflammation, Optimmune helps relieve discomfort and prevent further damage to the eye.
  2. Increases Tear Production: In cases of dry eye (keratoconjunctivitis sicca), the eyes do not produce enough tears to keep the surface of the eye moist. Cyclosporine in Optimmune stimulates the production of tears, which helps lubricate the eyes and improve overall eye health.

By reducing inflammation and increasing tear production, Optimmune Ophthalmic Ointment helps manage the symptoms of chronic dry eye in dogs, improving their comfort and quality of life.


Optimmune Ophthalmic Ointment is indicated for management of chronic keratoconjunctivitis sicca(KCS) and chronic superficial keratitis (CSK) in dogs.


  • Brand: Optimmune
  • Active Ingredient: Cyclosporine, USP
  • Type: Ophthalmic Ointment
  • Indicated For: Chronic dry eye (keratoconjunctivitis sicca) in dogs
  • Dosage Form: Ointment
  • Strength: 0.2% cyclosporine, USP

Optimmune Ophthalmic Ointment is a registered trademark of Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck ∓ Co. Inc.


Active Ingredient: Cyclosporine 2 Mg, USP.

Inactive Ingredients: Petrolatum, USP; Corn Oil, NF; Petrolatum and Lanolin Alcohol.


View Optimmune Drug Facts Sheet.

  • Remove debris with suitable nonirritating solutions. Apply a 1/4 inch strip of ointment to the affected eye every 12 hours. The ointment may be placed directly on the cornea or into the conjunctival sac.
  • It is recommended that dogs exhibiting chronic recurring conjunctivitis be tested for adequate tear production to determine if they are suffering from early stages of chronic KCS.
  • For best results in treating KCS, cyclosporine ophthalmic ointment should be administered early in the course of the disease before irreversible damage to the lacrimal tissue, or dense corneal scarring or pigmentation occurs.
  • Dogs afflicted with KCS or CSK will most likely require lifelong consistent therapy (see Efficacy section above). For CSK, because environmental factors such as ultraviolet (UV) radiation are implicated in the pathogenesis, clinical signs may subside in the winter months when light intensity is reduced or if the dog is moved to a lower altitude, or indoors, and thus exposed to less UV radiation.
  • In cases refractory to cyclosporine, the diagnosis should be reevaluated and a different course oftherapy considered. Periodic reassessment of the need for Optimmune Ophthalmic Ointmenttherapy is recommended.


US Federal law restricts this drug to use by or on the order of a licensed veterinarian.


The clinical effects of Optimmune Ophthalmic Ointment have not been determined in dogs with KCS due to the following conditions: congenital alacrima, sulfonamide usage, canine distemper virus, metabolic disease, surgical removal of the third eyelid gland, and facial nerve paralysis with loss of the palpebral reflex. Some of the underlying conditions which may lead to KCS can be either transient (eg,facial nerve trauma) or correctable with appropriate treatment. Consequently, recovery from clinical signs attributed to KCS may be observed and treatment options may need reconsideration.

When switching to cyclosporine from another therapeutic agent (eg, frequent application of an artificialtear preparation) for KCS or CSK, it should be kept in mind that clinical efficacy is not necessarily apparent immediately after initiation of Optimmune Ophthalmic Ointment therapy. Several days to afew weeks may be required before the clinical effects of Optimmune Ophthalmic Ointment are of sufficient magnitude such that previously initiated therapy can be safely withdrawn. Abrupt cessation of a therapeutic agent immediately upon initiation of Optimmune Ophthalmic Ointment therapy can result in rapid clinical relapse which may be erroneously interpreted as an adverse reaction to Optimmune Ophthalmic Ointment.

The safety of Optimmune Ophthalmic Ointment has not been determined in cases of preexisting viral or fungal ocular infections. It is recommended that in such cases, Optimmune Ophthalmic Ointment therapy be delayed until the fungal/viral ocular infection has been successfully treated.

The safety of Optimmune Ophthalmic Ointment in puppies, pregnant bitches, or dogs used for breeding has not been determined.


A target animal safety study and clinical field studies with Optimmune Ophthalmic Ointment showed a wide safety margin in adult dogs. In the 6-month target animal safety study, dogs weresubjected twice daily to up to 10 times the approved concentration of Optimmune Ophthalmic Ointment. No apparent toxicity or adverse reactions were observed. Dogs in this study were vaccinated with commercially available vaccines. No effect on antibody titer response was noted. Epiphora was noted in all groups, including the placebo group, and was not associated with any inflammatory change,nor was there any correlation to gross and histopathological changes.

Adverse Reactions

In the KCS clinical field trial, there were 20 adverse reactions reported out of 132 cases enrolled. This corresponds to an adverse reaction rate of 12.9% (13 of 101 cases) for Optimmune Ophthalmic Ointment treated dogs and 22.6% (7 of 31) for placebo treated dogs. The reactions described were primarily ocular and periocular inflammatory reactions. These were likely a function of therapy being unable to fully control the keratoconjunctivitis, rather than a true "adverse reaction." Similarly, in the CSK trial, of 36 cases evaluated for safety, adverse reactions were noted in 2 animals (5.6%). One involved transient hyperemia, epiphora, and mild discomfort of the eye. The other involved periocular/palpebral inflammation and mild alopecia.

On rare occasion, instillation of Optimmune Ophthalmic Ointment may be associated with local irritation as manifested by periocular redness, lid spasm, and excessive rubbing. As the eyes of dogs with KCS often demonstrate considerable inflammation, it will be difficult to determine whether this local irritation constitutes a hyper sensitivity to Optimmune Ophthalmic Ointment. If this ocular irritation persists beyond 7 days, hyper sensitivity to a component of Optimmune Ophthalmic Ointment should be suspected and therapeutic options reassessed.


Store between 2° and 25° C (36° and 77° F).


Optimmune Ophthalmic Ointment is an immunosuppressive agent used to reduce inflammation in the eye(s). It is used to treat chronic dry eye (KCS, keratoconjunctivitis sicca) that may be caused by inflammation. Optimmune Ophthalmic Ointment may also be used for purposes other than those listed. Optimmune Ophthalmic Ointment is FDA approved for veterinary use in dogs only. Optimmune Ophthalmic Ointment is a prescription medication available as a sterile eye ointment. The sterile ointment is usually applied as a ¼ inch strip to the eye(s) every 12 hours. Do not touch the tube opening to any surface, including eyes and hands. The tube opening is sterile. If it becomes contaminated, it could cause an infection in the eye.
Do not use Optimmune Ophthalmic Ointment if your pet has any type of infection in the eye(s). Tell your veterinarian if your pet is pregnant or lactating.
Use this medication exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Wash your hands prior to using the eye ointment. Apply a ¼ inch strip of the ointment into the lower eyelid. Store Optimmune Ophthalmic Ointment at room temperature, away from moisture and heat. Keep the tube properly capped.
Serious side effects are not expected. Some burning, redness, tearing, discharge, pain, itching, stinging, or blurring of the vision may occur. Continue the medication and talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not give a double dose of the medication.
An overdose of this medication is unlikely. If an overdose is suspected, wash the eye with water and seek emergency veterinary medical treatment.
Do not touch the tube opening to any surface including eyes or hands. This medication may cause blurred vision. Avoid using other eye medications unless approved by your veterinarian.
Before using Optimmune Ophthalmic Ointment, tell your veterinarian if your pet is using other eye ointment or eye medications. Drugs other than those listed may also interact with Optimmune Ophthalmic Ointment. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.


Review Summary
149 Reviews
75% (112)
17% (26)
2% (3)
3% (5)
2% (3)
94% Recommend this product (140 of 149 responses)
By Elmo's M.
North Carolina
Same Medication - Great Price
February 28, 2024
So glad I found ths pet pharmacy. Free delivery of same medication with savings. Thank you for the service.
Optimmune Ophthalmic Ointment for Dogs 3.5 gm
February 22, 2024
Great service and fast delivery. Thank you.
By Evelyn R.
Weatherford, Texas
Great Product!
February 20, 2024
I have used Optimune ointment on our pug for 1 year and it has helped her eyes tremendously!
By Scott
San Francisco, California
I appreciate a good deal and this was a good deal.
January 11, 2024
The price was right AND the shipping was prompt and trouble-free. Thanks!
By Enza J.
Great eye ointment
January 6, 2024
I still haven’t received the item yet to comment hope the tube is full with ointment, it took a long time to get item over 2 weeks hope next time I will get it a lot earlier
By Christine
Gulfport, MS
Really Great Price
December 28, 2023
Have not found this any cheaper! Really fast shipping, also.
By Terri S.
Evansville, IN
Eye Ointment
December 23, 2023
We have been prescribed Optimmune previously. This a great overall product for most any eye problem we have encountered with our many dogs. The ointment residue wipes easily from around the eye where there may be excess hair. We have long haired dogs and have no issue with this product.
  • Easy to clean off of surrounding area
akron, ohio
December 21, 2023
My Joy is doing great with this script, this is the cheapest place I have found it at.
  • great works
By Diane
Good product
November 18, 2023
My dog has used this for years for his dry eye.
By Becky
Cincinnati, Ohio
Quick delivery and best price!
November 17, 2023
Without this medication quickly and you had a great price! I have to look around for medicine for my dog because it was expensive so this was the best choice.
By Nancy
Reasonably Priced Pet Meds
October 23, 2023
Finally, a place to get reasonably priced pet meds for my dog! And got them mailed to my door. Had a little problem getting my vet to get back to them for authorization but once that happened I received the meds (in quantity of 3) in just a few days. Will continue to use them.
By Santina
Henderson, NV
Good product
October 16, 2023
Good product for my dogs eyes and customer service is great!
  • It works well for my dogs eyes
  • Very expensive
By Charlotte
Pittsburgh PA
Great Service
October 3, 2023
Easy ordering, nice discount, very well packaged, and received shipment quickly. Thank you
By Fastfred
Great to deal with
September 8, 2023
Easy and quick to get my dogs eye drops from, thank you!
By Eileen
Thank you for making my life easier and at a good price
September 5, 2023
My dog has to use Optimmune Ointment for the rest of her life. She has chronic dry eye. Entirely Pets has made my life easier by sending her prescription to the mail box a couple of days after I order it. No more monthly trips to the vet. Their prices are good also and they are so nice when I call to reorder. Love this company.
A note to the pharma company that supplies the medication...
I just wish the tube was a little bigger and that the ointment in the top of the tube when the tube is nearly empty would come out easier. It is a waste to not be able to use it.
By No C.
Entirely Pets is Entirely Intrusive Pests
September 3, 2023
One of my dogs has been using Optimmune for quite some time. I was happy with Entirely Pets price right up until I was checking their prices for comparison, on other products which I did not purchase at the time. Immediately after, and again the next day, I received emails from Entirely Intrusive Pests, who were obviously spying on me, attempting to push me into purchasing those products. Their loss, as I would rather pay more elsewhere than do business with Entirely Intrusive Pests.
  • Optimmune works well for my dog, but Entirely Intrusive Pests does not.
  • Entirely Intrusive Pests sums them up for me.
By Mary
Broken Arrow, OK
As ordered.
June 21, 2023
  • Price.
By Michael B.
June 8, 2023
So easy to order and great prices.
By Miguel
Manchester, New Hampshire
Works great but is expensive.
June 2, 2023
It worked great but the tubes are small and expensive. Unfortunately its the best option we were able to find. EntirelyPets helped out by having the lowest price I could find.
  • It works great.
  • Expensive
By Sandra
Great Price
May 25, 2023
My vet suggested I check out online pharmacies to see if I could find a better price. She said her price was better than another popular online pet company, but she felt I could do better. I went back to EntirelyPets and found an excellent price with the discount on the Optimmune ointment. It came out to $47 per tube versus my vet’s $58. A big savings since my dog ‘s dry eyes require repeated use. Thanks for keeping your prices reasonable.
  • My dog
  • It
By Pam
Philippi, WV
I Love a Sale
April 27, 2023
I was pleased to get these regular meds at a reduced price through a sale.
By Maria
Keeps my dog's eyes from drying out
February 26, 2023
My vet recommended that I use this ointment on my 13 year old pug's eyes. I use it daily (once altho my vet recommended twice) and it keeps his eyes from drying out. It helps and seems to soothe his eyes.

Merchant Response:Hello Maria, That's great to hear! We hope to hear more about how your pet improves. Sincerely, EntirelyPets Pharmacy
By Lily
Did Eye Meds
January 14, 2023
The medicine is effective in helping with our dog’s dry eye condition and the discount is great.

Merchant Response:Hello Lily, We love hearing your pet is improving, and we try hard to provide quality products at competitive prices. Sincerely, EntirelyPets Pharmacy
By Robbie
North Carolina
Optimmune Is Awesome!
October 19, 2022
Optimmune worked immediately to stop the thick goop and dry clumping mess in my precious girl's eyes. It is an excellent product in my opinion. The tube is tiny but what is inside really works. We have used a couple different products the veterinarian sold to us but then I asked him to write a script for Optimmune since he did not carry it and my sweet girl felt better almost immediately. Yes, the eyes still run but less so nor is there any dry crusty mess.
  • Very soothing with a thick, light texture that immediately makes the eyes sparkle with moisture. Just wipe with a soft, damp, clean face cloth. Avoid those eye wipes with all the harsh chemicals that cause irritation!
  • Tube is tiny but squeeze gently so not to waste.
By Kelly
Columbus, wi
My dog needs this
August 14, 2022
I have to get this for my little dog. It is so costly at the vet. The thing is, many times, the price changes. So I shop around for the best price. This website is the one I visit often.

Merchant Response:A lot of things are getting expensive these days. We continue to do our best to keep pricing as low as possible.
  • Price
By PattiH
Centennial, CO
Easy to order
June 19, 2022
Got a good deal on this medication. Delivery was quick and accurate. Ordering was easy. Would definitely order again.

Merchant Response:Thank you Patti
By Mandy
Denton Tx
Great product
June 18, 2022
Received product very quickly

Merchant Response:We do our best! Happy you like our service and Optimmune
By Scotti
January 16, 2022
My pup needs this and if I forgot to put it in.i get that evil look, I need my meds
By Marylou
Shingle Springs, CA
Perfect order from Entirely Pets
December 23, 2021
My dog needs Optimmune for his eyes for the rest of his life. When the vet charged me, it was $69 for a small tube. It lasted about two weeks. I went to Costco and it cost $57 for a tube. I found the three pack at Entirely Pets for $147 and I could get it on an automatic shipment so I jumped at it. The young lady on the phone helped me do the order and sent it to my vet. After approval, the shipment came in 3 days. They emailed me at every point. I’m very pleased with Entirely Pets and may order Other meds from them. ❤️🤗
By Laura
December 12, 2021
The service is pleasant and accurate when ordered. Fast service! Received my mail.
Pricing is the best.

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