Trifexis 10.1-20 lbs for Dogs, 12 Chewable Tablets
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Trifexis For Dogs 10.1-20 lbs|Heartworm Prevention|Treats & Controls Flea Infestations + 4 Other Worms|12- Chewable Tablets Video

Trifexis For Dogs 10.1-20 lbs|Heartworm Prevention|Treats & Controls Flea Infestations + 4 Other Worms|12- Chewable Tablets

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Description

Trifexis is a popular brand of chewable tablets for dogs that is used for the prevention and treatment of multiple parasites. It is a prescription medication that combines two active ingredients: Spinosad and Milbemycin oxime.

Spinosad is an insecticide that effectively kills fleas. It works by targeting the nervous system of the fleas, causing them to become paralyzed and eventually die. This helps in the prevention and control of flea infestations on dogs.

Milbemycin oxime is an anthelmintic, which means it is effective against intestinal parasites such as roundworms, hookworms, and whipworms. It works by interfering with the nervous system of these parasites, causing paralysis and ultimately leading to their elimination from the dog's body.

Trifexis is available in chewable tablet form, making it easy to administer to dogs. It is typically given once a month with a full meal to ensure proper absorption. The dosage depends on the dog's weight, so it is important to follow the veterinarian's instructions regarding the correct dosage for your dog.

  • NADA 141-321
  • NDC 58198-4332-6 (Pink)
  • NDC 58198-4333-6 (Orange)
  • NDC 58198-4334-6 (Green)
  • NDC 58198-4335-6 (Blue)
  • NDC 58198-4336-6 (Brown)

Key Benefits:

  • Broad-spectrum parasite protection: Trifexis provides protection against multiple parasites, including fleas, intestinal worms (such as roundworms, hookworms, and whipworms), and heartworms. This comprehensive coverage helps to ensure that your dog is protected against a range of common parasites.
  • Convenient administration: Trifexis comes in the form of chewable tablets, which are typically palatable and easy to administer to dogs. This makes it more convenient for pet owners compared to other methods of parasite prevention, such as topical treatments or injections.
  • Effective flea control: The active ingredient Spinosad in Trifexis quickly kills fleas upon contact, effectively controlling flea infestations on your dog. This can help alleviate itching and discomfort caused by fleas and reduce the risk of flea-borne diseases.
  • Prevents heartworm disease: Trifexis contains Milbemycin oxime, which is effective in preventing heartworm disease. Heartworms are transmitted through mosquito bites and can lead to serious health issues in dogs. By using Trifexis regularly, you can help protect your dog from this potentially life-threatening condition.
  • Intestinal parasite control: Trifexis helps in the prevention and control of common intestinal worms, including roundworms, hookworms, and whipworms. These parasites can cause digestive issues, weight loss, and other health problems in dogs. By regularly administering Trifexis, you can help keep your dog's gastrointestinal system free from these parasites.

Indications:

Flea Infestation: Trifexis is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) on dogs. It rapidly kills fleas upon contact and provides ongoing protection to prevent re-infestation.

Heartworm Disease: Trifexis is indicated for the prevention of heartworm disease (Dirofilaria immitis) in dogs. Heartworm disease is a serious and potentially fatal condition transmitted through mosquito bites. Trifexis kills the immature stages of heartworm larvae and helps prevent the development of adult heartworms.

Intestinal Parasites: Trifexis is indicated for the treatment and control of intestinal parasite infections in dogs. It is effective against roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), and whipworms (Trichuris vulpis).

Prevention of Zoonotic Diseases: By controlling fleas and intestinal parasites, Trifexis can also help prevent zoonotic diseases. These are diseases that can be transmitted from animals to humans, such as certain types of worms (e.g., roundworms).

How it works:

Trifexis Chewable Tablets for Dogs work through the combined action of two active ingredients: Spinosad and Milbemycin oxime.

  1. Spinosad: This ingredient is an insecticide that targets the nervous system of fleas. When a flea ingests or comes into contact with Spinosad, it causes overstimulation of its nerve cells, leading to rapid paralysis and subsequent death. Spinosad is effective against adult fleas, and its quick action helps in the control and prevention of flea infestations on dogs.
  2. Milbemycin oxime: This ingredient is an anthelmintic, which means it is effective against parasitic worms. Milbemycin oxime works by interfering with the nerve transmission in these parasites, causing muscle paralysis and ultimately leading to their elimination from the dog's body. It is effective against intestinal worms, including roundworms, hookworms, and whipworms.

When a dog ingests Trifexis, the active ingredients are absorbed into the bloodstream. Spinosad targets and eliminates fleas, while Milbemycin oxime acts against intestinal worms. The combined action of these ingredients helps in the control and prevention of fleas and intestinal parasites, providing comprehensive protection for your dog.

It's important to administer Trifexis with a full meal, as this enhances its absorption and effectiveness. Following the recommended dosage and administration instructions provided by your veterinarian is crucial to ensure the proper functioning of the medication and the well-being of your dog.

Ingredients

Active Ingredient Trifexis Pink Trifexis Orange Trifexis Green Trifexis Blue Trifexis Brown
Spinosad 140 mg 270 mg 560 mg 810 mg 1620 mg
Milbemycin Oxime 2.3 mg 4.5 mg 9.3 mg 13.5 mg 27 mg

Directions

View Trifexis Drug Facts Sheet.

TRIFEXIS is given orally, once a month at the minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes (see EFFECTIVENESS).

Quick Tips

  • Give Trifexis chewable tablets with food.
  • Give Trifexis chewable tablets once a month.
  • Please view the chart below for the correct dosage of Trifexis for your dog.
  • Trifexis does not protect against ticks.
  • If vomiting occurs within 1 hour of administration, redose the pet with another full dose.
  • Consult your veterinarian for pregnant or lactating dogs.
Dosage Schedule:
Body Weight Spinosad Per Tablet (mg) Milbemycin oxime Per Tablet (mg) Tablets Administered
5 to 10 lbs 140 2.3 One
10.1 to 40 lbs 270 4.5 One
20.1 to 40 lbs 560 9.3 One
40.1 to 60 lbs 810 13.5 One
60.1 to 120 lbs 1620 27 One
Over 120 lbs Administer the appropriate combination of tablets

Administer TRIFEXIS with food for maximum effectiveness. To ensure heartworm prevention, owners should observe the dog for one hour after dosing. If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of TRIFEXIS with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations.

Powerful 3-in-1 parasite protection in one convenient tablet

Just one beef-flavored tablet each month protects your dog against:

  • Heartworm disease
  • Fleas
  • Intestinal parasites: adult hookworm*, roundworm and whipworm
  • *Ancylostoma caninum

Is Trifexis right for your dog?

If your dog spends time outdoors (or shares a home with outdoor pets), exposure to fleas, heartworm disease and intestinal parasites is a given. However, even dogs that spend the majority of their time indoors benefit from parasite protection.

The American Heartworm Society (AHS) and the Companion Animal Parasite Council (CAPC) recommend annual testing and year-round heartworm disease prevention to ensure your dog is heartworm-free.1,2

Three key threats to your dog's health

Fleas

  • Trifexis provides fast relief. It starts killing fleas within 30 minutes, before they can lay eggs, and keeps working to prevent flea infestations all month long.
  • Fleas may cause extreme discomfort for your dog: scratching, chewing, biting, fur loss and restlessness.
  • Fleas are the source of flea allergy dermatitis (FAD), a common veterinary skin condition.
  • Severe infestations may cause anemia.3

Heartworm disease1

  • Heartworms are transmitted by mosquitoes and heartworm infection in dogs has been reported in all 50 states
  • Symptoms include coughing, sluggishness and difficulty breathing; however some dogs show no signs of any kind.
  • Treatment is difficult and costly, and complications may occur.
  • If left untreated it can be fatal to your dog

Intestinal parasites

  • Intestinal parasites can cause dehydration, anemia, diarrhea and even death in puppies.4,5
  • Unfortunately, these parasites are all around, and your dog can contract them almost anywhere on a daily walk, in your yard or at the local dog park.

Heartworm Prevention:

TRIFEXIS should be administered at monthly intervals beginning within 1 month of the dog's first seasonal exposure and continuing until at least 3 months after the dog's last seasonal exposure to mosquitoes (see EFFECTIVENESS). TRIFEXIS may be administered year round without interruption. When replacing another heartworm preventative product, the first dose of TRIFEXIS should be given within a month of the last dose of the former medication.

Flea Treatment and Prevention:

Treatment with TRIFEXIS may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with TRIFEXIS should continue the entire year without interruption.

To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.

ntestinal Nematode Treatment and Control:

TRIFEXIS also provides treatment and control of roundworms (T. canis, T. leonina), hookworms (A. caninum) and whipworms (T. vulpis). Dogs may be exposed to and can become infected with roundworms, whipworms and hookworms throughout the year, regardless of season or climate. Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

Contraindications:

There are no known contraindications to the use of TRIFEXIS.

Warnings:

Not for human use. Keep this and all drugs out of the reach of children.

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, a component of TRIFEXIS (see ADVERSE REACTIONS).

Precautions:

Treatment with fewer than 3 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention (see EFFECTIVENESS).

Prior to administration of TRIFEXIS, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. TRIFEXIS is not effective against adult D. immitis. While the number of circulating microfilariae may decrease following treatment, TRIFEXIS is not indicated for microfilariae clearance (see ANIMAL SAFETY).

Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.

Use with caution in breeding females (see ANIMAL SAFETY). The safe use of TRIFEXIS in breeding males has not been evaluated.

Use with caution in dogs with pre-existing epilepsy (see ADVERSE REACTIONS).

Puppies less than 14 weeks of age may experience a higher rate of vomiting (see ANIMAL SAFETY).

Adverse Reactions:

In a well-controlled US field study, which included a total of 352 dogs (176 treated with TRIFEXIS and 176 treated with an active control), no serious adverse reactions were attributed to administration of TRIFEXIS. All reactions were regarded as mild.

Over the 180-day study period, all observations of potential adverse reactions were recorded. Reactions that occurred at an incidence >1% (average monthly rate) within any of the 6 months of observation are presented in the following table. The most frequently reported adverse reaction in dogs in the TRIFEXIS group was vomiting.

Average Monthly Rate (%) of Dogs With Adverse Reactions
Adverse Reaction TRIFEXIS Chewable Tabletsa Active Control Tabletsa
Vomiting 6.13 3.08
Pruritus 4.00 4.91
Lethargy 2.63 1.54
Diarrhea 2.25 1.54
Dermatitis 1.47 1.45
Skin Reddening 1.37 1.26
Decreased appetite 1.27 1.35
Pinnal Reddening 1.18 0.87

an=176 dogs

In the US field study, one dog administered TRIFEXIS experienced a single mild seizure 2 Ĺ hours after receiving the second monthly dose. The dog remained enrolled and received four additional monthly doses after the event and completed the study without further incident.

Following concomitant extra-label use of ivermectin with spinosad alone, a component of TRIFEXIS, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness and disorientation. Spinosad alone has been shown to be safe when administered concurrently with heartworm preventatives at label directions.

In US and European field studies, no dogs experienced seizures when dosed with spinosad alone at the therapeutic dose range of 13.5-27.3 mg/lb (30-60 mg/kg), including 4 dogs with pre-existing epilepsy. Four epileptic dogs that received higher than the maximum recommended dose of 27.3 mg/lb (60 mg/kg) experienced at least one seizure within the week following the second dose of spinosad, but no seizures following the first and third doses. The cause of the seizures observed in the field studies could not be determined.

For technical assistance or to report suspected adverse drug events, contact Elanco US Inc. at 1-888-545-5973. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth

Mode of Action:

The primary target of action of spinosad, a component of TRIFEXIS, is an activation of nicotinic acetylcholine receptors (nAChRs) in insects. Spinosad does not interact with known insecticidal binding sites of other nicotinic or GABAergic insecticides such as neonicotinoids, fiproles, milbemycins, avermectins and cyclodienes. Insects treated with spinosad show involuntary muscle contractions and tremors resulting from activation of motor neurons. Prolonged spinosad-induced hyperexcitation results in prostration, paralysis and flea death. The selective toxicity of spinosad between insects and vertebrates may be conferred by the differential sensitivity of the insect versus vertebrate nAChRs.

Milbemycin oxime, a component of TRIFEXIS, acts by binding to glutamate-gated chloride ion channels in invertebrate nerve and muscle cells. Increased permeability by the cell membrane to chloride ions causes hyperpolarization of affected cells and subsequent paralysis and death of the intended parasites. Milbemycin oxime may also act by disrupting the transmission of invertebrate neurotransmitters, notably gamma amino butyric acid (GABA).

Effectiveness:

Heartworm Prevention:

In a well-controlled laboratory study, TRIFEXIS was 100% effective against induced heartworm infections when administered for 3 consecutive monthly doses. Two consecutive monthly doses did not provide 100% effectiveness against heartworm infection. In another well-controlled laboratory study, a single dose of TRIFEXIS was 100% effective against induced heartworm infections.

In a well-controlled six-month US field study conducted with TRIFEXIS, no dogs were positive for heartworm infection as determined by heartworm antigen testing performed at the end of the study and again three months later

Flea Treatment and Prevention:

In a well-controlled laboratory study, TRIFEXIS demonstrated 100% effectiveness on the first day following treatment and 100% effectiveness on Day 30. In a well-controlled laboratory study, spinosad, a component of TRIFEXIS, began to kill fleas 30 minutes after administration and demonstrated 100% effectiveness within 4 hours. Spinosad, a component of TRIFEXIS, kills fleas before they can lay eggs. If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment. In field studies conducted in households with existing flea infestations of varying severity, flea reductions of 98.0% to 99.8% were observed over the course of 3 monthly treatments with spinosad alone. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus as a direct result of eliminating the fleas.

Treatment and Control of Intestinal Nematode Infections:

In well-controlled laboratory studies, TRIFEXIS was ? 90% effective in removing naturally and experimentally induced adult roundworm, whipworm and hookworm infections.

Palatability:

TRIFEXIS is a flavored chewable tablet. In a field study of client-owned dogs where 175 dogs were each offered TRIFEXIS once a month for 6 months, dogs voluntarily consumed 54% of the doses when offered plain as if a treat, and 33% of the doses when offered in or on food. The remaining 13% of doses were administered like other tablet medications.

Animal Safety:

TRIFEXIS was tested in pure and mixed breeds of healthy dogs in well-controlled clinical and laboratory studies. No dogs were withdrawn from the field studies due to treatment-related adverse reactions.

In a margin of safety study, TRIFEXIS was administered orally to 8-week-old Beagle puppies at doses of 1, 3, and 5 times the upper half of the therapeutic dose band, every 28 days for 6 dosing periods. Vomiting was seen in all groups including control animals with similar frequency. Adverse reactions seen during the course of the study were salivation, tremors, decreased activity, coughing and vocalization.

Body weights were similar between control and treated groups throughout the study. Treatment with TRIFEXIS was not associated with any clinically significant hematology, clinical chemistry or gross necropsy changes. One 5X dog had minimal glomerular lipidosis observed microscopically. The clinical relevance of this finding is unknown.

Plasma spinosyn A, spinosyn D, milbemycin A3 5-oxime and milbemycin A4 5-oxime concentrations increased throughout the study. At each dosing period, plasma spinosyn A and spinosyn D concentrations were greater than proportional across the dose range 1 to 5X. Plasma milbemycin A4 5-oxime concentrations appeared to be dose proportional across range 1 to 5X by the end of the study. Plasma concentrations of spinosad and milbemycin oxime indicate that expected systemic exposures were achieved throughout the study.

In an avermectin-sensitive Collie dog study, TRIFEXIS was administered orally at 1, 3, and 5 times the upper half of the recommended therapeutic dose band every 28 days. No signs of avermectin sensitivity were observed after administration of TRIFEXIS during the study period to avermectin-sensitive Collie dogs. The adverse reactions observed in the treatment groups were vomiting and diarrhea. Body weights in all treatment groups were comparable to the control group. Hematology and clinical chemistry parameters showed no clinically significant changes from study start to end, and all dogs were considered healthy throughout the study.

In a heartworm positive safety study, TRIFEXIS was administered orally at 1, 3, and 5 times the upper half of the therapeutic dose band to Beagle dogs with adult heartworm infections and circulating microfilariae, every 28 days for 3 treatments. Vomiting was observed in one dog in the 1X group, in three dogs in the 3X group, and in one dog in the 5X group. All but one incident of vomiting was observed on the treatment day during the first treatment cycle. The vomiting was mild and self-limiting. Hypersensitivity reactions were not observed in any of the treatment groups. Microfilariae counts decreased with treatment.

In a reproductive safety study, TRIFEXIS was administered orally to female dogs at 1 and 3 times the upper half of the therapeutic dose band every 28 days prior to mating, during gestation and during a six-week lactation period. Dogs with confirmed fetal heartbeats on ultrasound examination were evaluated for reproductive safety. One 3X and one 1X group female did not become pregnant. No treatment-related adverse reactions or signs of avermectin toxicosis were noted for adult females. Adult females in the 3X group lost weight during the 6-week pre-mating period, while control group females gained weight during that time. The body weights of the treated groups were comparable to the control group during gestation and post-parturition phases of the study. Gestation length, litter average body weight, litter size, stillborn pups, pup survival and the proportion of pups with malformations were comparable between treated and control dam groups. Malformations in the 1X group included a pup with cleft palate and a littermate with anophthalmia, fused single nares, misshapen palate, hydrocephalus, omphalocele and malpositioned testes; a pup with a malformation of the anterior tip of the urinary bladder and umbilical blood vessel; and a pup with patent ductus arteriosus (PDA). Malformations in the 3X group included three littermates with PDA. Malformations in the control group included a pup with a malformed sternum and a pup with PDA and a malpositioned superior vena cava. Clinical findings in pups of the treated groups were comparable to the control group except for one 1X group pup that was smaller and less coordinated than its littermates and had tremors when excited. The relationship between spinosad and milbemycin oxime treatment and the 1X and 3X dogs that did not become pregnant, the specific pup malformations and the unthrifty 1X group pup are unknown. The incidence of cleft palate is not unexpected based on the historical data collected at the breeding site.

In a margin of safety study with spinosad alone, 6-week old Beagle puppies were administered average doses of 1.5, 4.4, and 7.4 times the maximum recommended dose at 28-day intervals over a 6-month period. Vomiting was observed across all treatments, including controls, and was observed at an increased rate at elevated doses. Vomiting most often occurred 1 hour following administration and decreased over time and stabilized when puppies reached 14 weeks of age.

Storage Information:

Store at 20-25°C (68-77°F), excursions permitted between 15-30°C (59-86°F).

FAQ

Interceptor Plus should be administered in a manner that encourages your dog to chew, rather than swallow whole. However, we do not expect a difference in the effectiveness of the product if your dog consumes it whole.
Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.
Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

Trifexis is indicated to treat and control intestinal parasite infections of adult hookworms, roundworms and whipworms in dogs. In occasional cases, it is possible that you might see intestinal worms being expelled in your dog's stool, this means Trifexis is working. If you have questions, consult your veterinarian for measures you can take to prevent a reinfection of intestinal parasites.

Hookworm (A. caninum), roundworm (T. canis, T. leonina), whipworm (T. vulpis) and tapeworm (T. pisiformis, E. multilocularis, E. granulosus and D. caninum)

Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, itching, hyperactivity. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to your pet. The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects.
Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.
Trifexis has been demonstrated to be safe in healthy dogs when used according to label directions. Spinosad, one of its active ingredients, is produced by a bacterium first isolated from natural sources (a soil sample collected in the Caribbean).1 Spinosad selectively targets the nervous system of the flea (and other insects) due to differences in the targeted receptors compared to mammalian nervous systems.2 However, as with all medications, sensitivities due to individual animals can occur, sometimes resulting in side effects. See the Trifexis label for complete safety information.
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.3
Spinosad and milbemycin oxime are the two active ingredients in Trifexis.
Administer Trifexis with food for maximum effectiveness. Trifexis is a chewable beef-flavored tablet that can be given as a treat.
Trifexis kills fleas on dogs before they can lay eggs when used monthly and according to the label directions. Remember that all animals in the household should be treated with an approved flea product to help control the flea population. Your dog can continue to be exposed to fleas that live in the environment. When fleas jump onto and bite your dog, they will be killed by Trifexis. If, within a month after your dog receives Trifexis, you see fleas on your dog, they are most likely new fleas. These new fleas will be killed before they can produce eggs that contaminate the environment. Continued monthly use of Trifexis can protect against any new infestations.
You may maintain normal activities and interactions with your dog.
No, Trifexis is not approved for use in cats. Trifexis was developed exclusively for administration to dogs.

Reviews

Review Summary
4.8
86 Reviews
5
87% (75)
4
8% (7)
3
2% (2)
2
1% (1)
1
1% (1)
98% Recommend this product (84 of 86 responses)
By Steve
Atlanta
Competitive Price and High Quality Customer Service
October 30, 2020
Second time I‚€™ve used them and despite
online, account history and Rx issues they
did a great job and exceeded my expectations in addition to best pricing.
My go to for pet needs!
Merchant Response:Thanks Steve! We are striving to be better than we were yesterday. Enjoy the Trifexis and we'll see you next time.
By Timothy
Edgewater, Fla.
Good service
August 17, 2023
Good service, great communication, good price.
By Joseph G.
Houston, Texas
Prompt service
August 2, 2023
Entirely pets is a great no hassle company. They take care of the logistics with your veterinarian, and your order is delivered promptly.
By Eileen
Santa Monica, CA
Trifexis
June 18, 2023
Ginger's been on this medication for years without a problem. And sans fleas!!

Merchant Response:Ginger is such a cutie with her toy. Glad to hear you got the Rx resolved. =)
The EPP staff were great. We had problems getting the Rx approved by my veterinary hospital because their staff failed to carefully look in Ginger's chart to see that her heartworm test was negative within the past year. Once they notified me, I got on the stick to get them to look carefully and worked with the EPP staff to get the faxed Rx appropriately signed. It took patience and perseverance but I have both and so do the EPP staff. All got resolved but they let me know by email and phone so I could get things resolved. None
By ELIZABETH
Bunker Hill, WV
Order takes forever
May 23, 2023
I ordered this in hopes it would only take the 4-6 days they say. It took two weeks. My order didn't come til May 8th and so my pets were late getting their monthly. Today I finaly got someone on the phone and he says he will change the Auto ship date. Then I receive the shipping order status for last months order and not this months. I feel like cancelling my order and going some where else.
I got my order Can't check my account as the information doesn't update. Didn't come on time. Can never get someone on phone.
By Barbara G.
Nipomo, California
Trifexis
January 27, 2023
I have been giving my dog this medication for several years now and I find the best price at Entirely Pet Pharmacy. I'm on a very fixed income so I use to shop around for the best buy. I'm so happy to have found Entirely Pets Pharmacy working with them have been a pleasure they are so caring and answer any questions I may have had. Thank you

Barbara Giniewicz and Ziggy
Merchant Response:Hello Barbara, Thank you for the feedback, we try our best to over quality products at a great value. Sincerely, EntirelyPets Pharmacy
By Sondra K.
Vinton, La
Trifexes
January 22, 2023
This product works great
My pups also have skin problems and it helps with that ad well.
By Franchesca
Brandon, FL
Great Product
January 5, 2023
This has been the preferred method of flea and heart worm control for my dog. No reactions and easy to give to my dog. Will continue to use!
By Tom
Portland, Oregon
Good product. Been using 10+ years.
August 20, 2022
I started using Trifexis when my dog was old enough to have it prescribed. She will be 11 in November. I‚€™ve been satisfied with the results of the product all these years. The only thing I would say is curious is the product is advertised as chewable, and in all these years I haven‚€™t been able to get my dog to chew the tablet! I just place it deep in her mouth and stroke her throat.
Merchant Response:Tom, we are glad you found a delivery system that works.
By Roz
Indiana
Trifexis
April 22, 2022
We have used this product on several of our pet dogs with no side effects. We also use it year around for protection. Good results easy to give orally to pet.
Easy chewable tab. Year round protection given once a month. No side effects for any of our pet dogs. Watch for any side effects or allergies. Always check with your vet.
By Jeryl
Sandy OR
Patsy’s Medication Order
April 10, 2022
The order was made quickly online and I received Patsy‚€™s medication within 2 days. The price for this product was affordable. Thank you for your outstanding service. I will continue to buy from your company. Kind regards, Jeryl
By Kayla
San Marcos, TX
Great for my fur baby
January 4, 2022
I love trifexis for my fur baby because I know that it takes care of him and it lasts a whole month. I love EntirelyPets pharmacy because it has everything I need to take care of my pup.
By Kimberly
Florida
Medication
May 19, 2021
Very easy to order and fast delivery! Very happy with this company
By Pam
Inglis Fl
Trifexis
March 16, 2021
The Entirely pets pharmacy website was easy to manage. They took info on my pets and their vet, to get the prescription. Then they mailed our Trifexis in good time. The dogs took their pills wrapped in lunch meat. Worked on my dogs just fine... I took advantage of ordering the 12 month supply for each dog. My only concern was the price, Trifexis needs to be able to trim their expensive prices!!!
Easy to give Takes care of both fleas and heartworm Price
By Micah H.
Alabama
Easy way to treat your dog for flea, tick, and heart worms
January 25, 2021
I have been very pleased with Trixfexis. My dog does not like taking medicine so having the option to have flea, tick, and heart worm into one pill makes it much easier on both of us.
All medications rolled into one Does not taste great, so even though it is a chewable tablet my dog will not eat it.
By Tracy K.
Calabash NC
Trifexis Order
January 7, 2021
Great Product plane and simple as that!! It gets No Better then that except, if you have ticks in your yard.
Great Product and would recommend Entirely Pets to anyone of my Friends or Family members. I have been using Trifexis for the 2 years I've had my Dog and I've never seen any fleas on her this is a great product and it works well. Tracy K. The Only downfall to Trifexis is that, if you have ticks in your yard Trifexis doesn't protect against them, other then that it cover everything else.
By Tawnie M.
Texas
Texting overload/Overpriced
January 6, 2021
I felt pressured by my vet (now ex-vet) to purchase this overpriced medication for my dog (probable because they get a kickback). I don‚€™t know if it‚€™s effective, how would I? Now, I am being bombarded with texts from your company. I don‚€™t want to hear from you. I find your company very annoying.
By Gale T.
Jacksonville, Florida
Trifexis
January 6, 2021
My puppies have been on Trifexis for many years. By ordering online through Entirely Pets Pharmacy you get the same product for less. I look forward to their sales.
Order online instead trip to vet Cannot fax or email RX-must mail original
By Karen H.
AL
Trifexis
December 23, 2020
I ordered Trifexis on line as my vet no longer carries this product. It was easy to order, they followed up with faxing the prescription to my vet and let me know when it was shipped. Due to the Christmas rush and Covid, it took a little longer to get there but arrived in plenty of time for my dog's monthly dose.
By Karena
LA
Works well
October 25, 2020
No fleas or heart worm in our house :)
By annmarie
orlando, fl
I've used this for years
October 19, 2020
The dogs don't like this so we put it in peanut butter. No adverse side effects. Takes care of everything except mange in one big pill
By Rebekah
College Station, TX
Great Product
October 16, 2020
This website makes it so easy to place and order and get the product in time. It is Great!
By Connie K.
Florida
great
October 5, 2020
great
By TRACY K.
CALABASH,NC
MY NEW PLACE TO SHOP FOR MY BABY!!!
August 22, 2020
THANK YOU FOR THE FAST SERVICE YOU PROVIDED AND THE EASE OF GETTINGMY DOGS MEDICATIONS. I ORDERED THIS FROM ANOTHER PET STORES ONLINE AND HAD PROBLEMS WITH GETTING IT ON AND WHEN THEY SHIPPED IT OUT FINALLY FEDEX LOST MY PACKAGE AND IT WAS TAKING THE OTHER COMPANY ALONG TIME JUST TO RESHIP THE REPLACEMENT OVER A WEEK AND 3 CALLS LATER I CANCELED THE REPLACEMENT ORDER AND ASKED FOR A REFUND...
I REORDERED HER MEDS FROM YOU AND HAD MY DOGS MEDS WAS HERE IN LESS THEN A WEEK!! THAT'S GETTING THE NEW PRESCRIPTION FROM DOCTOR AND WITH ME BEING A NEW CUSTOMER ON TOP OF THAT. THANKS FROM THE BOTTOM OF MY HEART!!

Very fast, professional and Fast Shipping!! This is a Company you can count on when needed most!! None that I know if at the moment.
By Sandy
Calvert County Maryland
Trifexis for Dogs
June 24, 2020
We have used this product for 8 years now. Its a one and done pill for all those nasty fleas and worms. Love it!
Takes care of all worms and fleas...great! Doesnt take care of ticks.
By Cathleen
Houston
Trifexis
June 20, 2020
I have been very happy with Trifexis. The dogs take it easily (with cream cheese) and the results are wonderful. The price at Entirely Pets has been way below the Vet's price.
By Wy
Texas
Quick
April 24, 2020
My flea meds were to my home within the week I ordered.
By Gale K.
Jacksonville
Trifexis for Dogs
April 23, 2020
Happy & Healthy fur babies is what Trifexis is what does for their owners. Entirely Pets Pharmacy has the real deal for quality & great price. I will definitely purchase again. Thank you!
By JoJo
Lakeland FL
Great price
April 17, 2020
Great price and fast shipping, referred by our vet more than happy thanks
By Linda
Effingham, il
Priced right
April 15, 2020
Timely delivery, especially in the uncertainty and disruption of these coronavirus times.

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