Comfortis Chewable Tablets for Dogs & Cats | EntirelyPets Pharmacy
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Comfortis for Dogs & Cats

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews

Description

Comfortis is the first FDA-approved, chewable beef-flavored tablet (derived from pork protein and hydrolyzed soy) that kills fleas and prevents flea infestations on dogs and cats for a full month. Comfortis for Dogs & Cats requires a prescription from your veterinarian.

Key Benefits

  • Starts killing fleas within 30 minutes
  • Lasts a full month
  • Kills fleas before they can lay eggs
  • Comes in a convenient chewable, beef-flavored tablet
  • Spinosad, the active ingredient in Comfortis, is environmentally friendly

Indications

Comfortis kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), for one month, on cats and kittens 14 weeks of age and older and 4.1 pounds of body weight or greater.

Comfortis Use

  • Dogs and puppies 14 weeks of age and older and 5.0 pounds of body weight or greater
  • Cats and kittens 14 weeks of age and older and 4.1 pounds of body weight or greater

Prescription Required

Ingredients

Comfortis for Dogs: 5-10 lbs - Comfortis for Cats: 4.1-6 lbs
Active Ingredient (per tablet) Amount
Spinosad 140 mg
Comfortis for Dogs 10.1-20 lbs - Comfortis for Cats: 6.1-12 lbs
Active Ingredient (per tablet) Amount
Spinosad 270 mg
Comfortis for Dogs 20.1-40 lbs - Comfortis for Cats: 12.1-24 lbs
Active Ingredient (per tablet) Amount
Spinosad 560 mg
Comfortis for Dogs 40.1-60 lbs
Active Ingredient (per tablet) Amount
Spinosad 810 mg
Comfortis for Dogs 60.1-120 lb
Active Ingredient (per tablet) Amount
Spinosad 1,620 mg

Directions

View Comfortis Drug Facts Sheet.

Dosage and Administration: for Dogs

Comfortis is given orally once a month, at the recommended minimum dosage of 13.5 mg/lb (30 mg/kg).

Do not use the dosing schedule below when administering Comfortis to cats, as it can result in an underdosage.

*Dogs over 120 lbs should be administered the appropriate combination of tablets.

Administer Comfortis with food for maximum effectiveness

Comfortis is a chewable tablet and is readily consumed by dogs when offered by the owner just prior to feeding. Alternatively, Comfortis may be offered in food or administered like other tablet medications. Comfortis should be administered at monthly intervals.

If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed, administer Comfortis with food and resume a monthly dosing schedule.

Treatment with Comfortis may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with Comfortis should continue the entire year without interruption.

To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.

Dosage and Administration: for Cats

Comfortis is given orally once a month, at the minimum dosage of 22.5 mg/lb (50 mg/kg).

Do not use the dosing schedule below when administering Comfortis to dogs, as it can result in an overdosage.

*Cats over 24 lbs should be administered the appropriate combination of tablets.

Administer Comfortis with food for maximum effectiveness.

Comfortis is a chewable tablet that can be consumed by cats when offered by the owner just prior to or after feeding. Alternatively, Comfortis may be offered in food or administered like other tablet medications. Comfortis should be administered at monthly intervals

If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed, administer Comfortis with food and resume a monthly dosing schedule.

Treatment with Comfortis may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with Comfortis should continue the entire year without interruption.

To minimize the likelihood of flea reinfestations, it is important to treat all animals within a household with an approved flea protection product.

Contraindications:

There are no known contraindications for the use of Comfortis.

Warnings:

Not for human use. Keep this and all drugs out of the reach of children.

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with COMFORTIS (see Post Approval Experience)

Precautions:

Comfortis is for use in dogs and puppies 14 weeks of age and older (see Animal Safety).

Use with caution in breeding females (see Animal Safety). Use with caution in dogs with pre-existing epilepsy (see Adverse Reactions). The safe use of Comfortis in breeding males has not been evaluated.

Use with caution with concomitant extra-label use of ivermectin (see Adverse Reactions).

The safe use of Comfortis in breeding, pregnant, or lactating cats has not been evaluated.

Storage:

Store at 20-25°C (68 -77°F), excursions permitted between 15 to 30°C (59 to 86°F).

Effectiveness:

In a well-controlled laboratory study, Comfortis began to kill fleas 30 minutes after administration and demonstrated 100% effectiveness within 4 hours. Comfortis kill fleas before they can lay eggs. If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment. In field studies conducted in households with existing flea infestations of varying severity, flea reductions of 98.0% to 99.8% were observed over the course of 3 monthly treatments with Comfortis. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus as a direct result of eliminating the fleas.

FAQ

They're beef-flavored, chewable tablets you give to your dog or cat to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are recommended for monthly use in cats 14 weeks of age or older and 4.1 lbs of body weight or greater and in dogs 14 weeks of age or older and 5 lbs of body weight or greater.
Spinosad is the active ingredient in Comfortis. It belongs to a class of antiparasitics known as spinosyns, which are derived from a naturally-occurring soil microbe. It works by attacking the nervous system of insects, causing the rapid death of adult fleas.
Treatment can begin at any time of the year. Comfortis is most effective when given one month before fleas become active, with continued monthly dosing through the end of the flea season. In areas where fleas are common year-round, monthly treatment with Comfortis chewable tablets should continue through the entire year without interruption. To minimize the likelihood of flea re-infestation, simultaneously treat all animals in your household with an approved flea protection product. Consult your veterinarian for the flea treatment options most appropriate for your area. See also, what should I discuss with my veterinarian regarding Comfortis for my dog or cat?
Spinosad, the active ingredient in Comfortis, began killing fleas in 30 minutes and killed 100% of fleas on dogs and 98% of fleas on cats in just four hours in controlled laboratory studies. Comfortis chewable tablets kill fleas before they can lay eggs.
Comfortis has demonstrated full effectiveness for an entire month.
Comfortis has demonstrated to be safe in healthy dogs and cats when used according to label directions. Use only for cats and kittens 14 weeks of age or older and 4.1 lbs of body weight or greater, and for dogs and puppies 14 weeks of age and older and 5.0 lbs of body weight or greater. The safe use of Comfortis in breeding, pregnant or lactating cats and dogs has not been evaluated.
Comfortis contains beef flavoring made from a pork-based protein. If your pet has an allergy to pork, you may need to consider an alternative for flea treatment and prevention. Please discuss these options with your pet's veterinarian. The use of ivermectin at higher than FDA-approved doses at the same time as Comfortis can result in serious side effects.

Comfortis kills fleas before they can lay eggs when used monthly, according to the label directions. If you see fleas on your dog or cat within a month after your pet receives Comfortis, they are most likely new fleas. Because your pet has been treated with Comfortis, these new fleas will be killed before they can produce eggs that contaminate your home. Continued monthly use of Comfortis can prevent any new flea infestations.

Your pet can experience continued exposure to fleas living in the environment. It's important to treat all animals in the household with an approved flea product to help control the flea population. Learn more about controlling flea infestations in your home.

As with any medication, sometimes side effects occur. See the Comfortis label for complete safety information.

For cats: In some cases, cats vomited after receiving Comfortis. If vomiting occurs within one hour of administration, re-dose with another full dose. Additional adverse reactions observed in studies were lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin. See the Comfortis label for complete safety information.

For dogs: The most common adverse reaction reported is vomiting. Other adverse reactions reported in decreasing order of frequency are depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures. Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness, and disorientation. See the Comfortis label for complete safety information.

Administer Comfortis with food for maximum effectiveness. Because Comfortis is a flavored tablet, it can be offered just prior to or just after feeding. You can also administer Comfortis as you would other tablet medications. Visit the Dosing & Administration page for more details, or download the Comfortis label. Each box includes reminder stickers for your calendar to help remind you to administer each dose. You can also sign up for monthly text or email reminders.
In field trials, dog and cat owners were instructed to give the Comfortis tablet with food. However, the quantity of food was not specified and Comfortis was still effective. An option is to give Comfortis immediately before a regularly scheduled meal. For free feeders (dogs or cats who nibble throughout the day), you might take food away at night, administer Comfortis first thing in the morning, then put the food back down.
Give your pet his or her regular dose immediately, then resume a regular monthly schedule. To help you remember to dose your pet, sign up for monthly email or text message reminders. For complete safety information, view the Comfortis label.
Contact your veterinarian if you believe your pet has ingested more than the recommended dose of Comfortis. Visit the Dosing & Administration page for more details, or see the Comfortis label for complete safety information.
No. You can continue normal activities and interactions with your pet.
Comfortis is not contraindicated for use with any veterinary drug/product when they are administered at labeled doses. However, while labeled heartworm preventatives are not an issue, you should not use Comfortis concurrently with extra-label doses of ivermectin in dogs and should use caution in cats. Make sure your veterinarian is aware of all products that you intend to administer to your pet. In well-controlled field studies, Comfortis chewable tablets were administered safely in conjunction with other frequently used labeled products, such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, tick control products, anesthetics, NSAIDs, antihistamines, alternative/herbal remedies, shampoos, prescription diets, and most generally prescribed medications.

Your veterinarian is your pet's healthcare expert and can make the best medication recommendations. This includes the prevention, control and/or treatment of parasites such as fleas, heartworms and intestinal parasites. These parasites can cause conditions including flea allergy dermatitis, anemia, and heart disease. Key points of your discussion might include:

  • The best time to start flea treatment in your geographic region.
  • What administration method will work best for your pet.
  • What to do if you miss a dose of Comfortis.
  • What other medications you give your pet.
  • What to do about a severe flea infestation.
  • What steps you can take to prevent a flea re-infestation in your home.

Reviews

Review Summary
4.7
23 Reviews
5
78% (18)
4
17% (4)
3
0% (0)
2
0% (0)
1
4% (1)
96% Recommend this product (22 of 23 responses)
By Sandy
Virginia
Does the job
August 21, 2020
Works great. No more fleas! I have been using for about four months, killed the fleas and have not seen any more.
By Barbara
Jacksonville Al
Very satisfied
May 1, 2020
Love the product and the timely delivery
By Valerie J.
Massachusetts
Awesome
April 30, 2020
Thank you for getting the order right! The gentleman I spoke with was awesome.
ProsThank you for getting the order right! The gentleman I spoke with was awesome.
By Kristi
Florida
The only flea and tick prevention that works!
March 15, 2020
I have tried all the other prevention such as frontline, etc and they were a huge waste of money! comfortis is the only prevention that has worked for all of our cats and dogs.
ProsComfortis is worth the money because it actually works.
By HBGary
Huntington Beach
Two dogs, no fleas
November 17, 2019
We have used Comfortis for many years since our vet recommended it during a time of major flea infestation in the area and our dog was suffering (as we were too), Our current two dogs have always used Comfortis after the good experience we had with our prior dogs.
Merchant Response:Flea-free is the way to be. Comfortis is pricy, but worth it in the long run. Take care Gary.
ProsEasy to administer product to the dogs.
ConsPricey
By Irene
Los Angeles, ca
Customer service
March 22, 2019
This review is for entirely pets pharmacy: great customer service! Wouldn't use any other online pet pharmacy
By ronald c.
1425 second ave Chula Vista, CA 91911
comfortis
February 8, 2019
I received product in a timely manner; so I'm well pleased! Thank you
By karla` s.
Miami, Florida
Works great
October 19, 2018
Always kills fleas within 30 minutes. Service was great and delivery on time.
By Katrina
Oregon Coast
Good Value
October 17, 2018
Easiest way to buy and a great price.
By Lu H.
Fresno
Recent order
August 29, 2018
First time using - great service - contacted my vet for a prescription right away and product arrived very soon after - will use again.
By spex
fountain valley , Ca.
I got it !
May 18, 2018
it was a little faster receiving the comfortis, and sale price was a bonus. I was pleased all around. It is easier to administer to my pet.
ProsEasier to give to my pet.
By KJ
San Diego, California
Stomach Upset
March 17, 2018
I provided the ComFortis tablet immediately following our dog™s breakfast. He vomited everything up within the hour. Gastrointestinal issues are not typical with our dog.
ConsStomach upset.
By Ella P.
San Diego, California
Comfortis for Dogs
January 18, 2018
Very pleased with the service received. There were no discrepancies with the product, or with the order. The customer service was excellent and quite comforting. I would suggest that Entirely Pets is used for all of your pet needs.
Merchant Response:Thank you for your kind words Ella! Glad we are able to help!
ProsGood prices, order in a timely manner!
ConsNo complaints!
By Orange m.
Huntington Beach California
Great product
October 5, 2017
The time it took to get the actual product was too long but the product itself and the price was great.
ConsTook too long
By Shelley
St. Louis, MO
Comfortis for dogs
October 4, 2017
good value, best price I could find
By Barcomb L.
Houston, Tx
Great product
April 23, 2017
Product works great. No live fleas found on my dog
No scratching.
Happy dog, 🐕
By pepperoni
san diego, California
Really effective; if only it weren't chewable
April 17, 2016
Great product but both dogs detest the flavor. So I'm left with huge pills I can't even disguise in food and it's the only medication I have to shove down their throats. Comfortis: PLEASE make a small pill that isn't chewable.
Proseffective
Consdogs hate the taste and it's so strong I can't even disguise it covering it with blue cheese!
By holly
Old Fort, NC
works great!
April 4, 2016
I have used this product on my cats. it works really really well and I like it much better than the topical. I hate that stuff. they sleep in my bed and the thought of that getting wiped everywhere freaks me out. the pills are easy, not messy, and really work!!! although I haven't ordered from entirely pets yet, I am planning on using them for my next order because their prices a MUCH less than at the vet!
Prosworks great, no mess, better prices than the vet
Consnone
By Vicky
McKinlyville CA
Finally NO FLEAs!
March 5, 2016
yày...this product actually works! I've spent hundreds of dollars trying to get the fleas off our Germàn Shepherd. For yearrs he would màke himself, ànd me, crazy and hairless from scratching at them. After 2 months, his hair is growing back now and he looks really nice and shiny and happy!! SSo glad I switched from topicals!
By Gary L.
Surf City, USA
Good price...same product as from my vet
August 26, 2015
Easy transaction. Simple and quick. Only delay was getting prescription from my own vet. Not Entirely Pet's problem. They fax'ed request to my vet. Once received from vet, shipped to me.
ProsGood price Easy transaction
ConsDelay in securing prescription from my vet
By Gary L.
Surf City, USA
Same as what I get at my vet
August 23, 2015
Same product sold by my vet at a higher price that was prescribed for my dog. Easy online transaction.
ProsGood Price Works for my dog
ConsTook awhile for my vet to approve the prescription for my dog. Not Entirely Pets' problem as they fax'ed request to vet right after receiving order. I had to follow up with vet to make sure they responded to Entirely Pets' request.
By Jean
Topeka, Kansas
Most reasonable deal found
July 9, 2015
I did a lot of research and found purchasing Comfortis from Entirely Pets Pharmacy was the best deal. Thanks - I always believe in saving money.
By Karen
Ventura County, Ca
Easy
June 21, 2015
Requested Comfortis. Provided my vet's name and fax #. EntirelyPets did the rest.

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