Heartgard Plus Green for Dogs 26-50 lbs (1 Chew) | EP Rx
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Heartgard PLUS for Dogs - 26-50 lbs (1 CHEW)

Item# IWM011055S
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Heartgard PLUS is a monthly pet medication for the prevention of heartworm disease. Heartgard PLUS is 100% effective against heartworms; and it controls roundworms and hookworms. Heartgard PLUS treats and controls more effectively than the next leading brand and is veterinarian recommended. Heartgard PLUS is approved for puppies and kittens as young as 6 weeks of age. Help your pet by ordering Heartgard PLUS today.

  • Prevents heartworm disease
  • Prevents development of adult stage heartworms
  • Treats and controls roundworms
  • Treats and controls hookworms
  • Beef flavor chewable
  • For dogs only
  • Highly effective in preventing heartworms
  • A convenient and tasty chewable for easy administration
  • Delicious beef flavor that most dogs will eat

How it works: Heartgard prevents heartworm disease by eliminating the tissue stage of heartworm larvae for a month after infection.

Prescription Required


Dosage & Administration: Give Heartgard Plus exactly as directed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Heartgard Plus chewable tablets must be chewed. They should not be swallowed whole. Use with caution, Collies and other herding dog breeds have been known to have adverse reactions to invermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If the animal is off Heartgard Plus for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Heartgard Plus at room temperature. Do not remove the tablet from its wrapper until ready to give the medicine. Keep this medication away from children and pets. In addition, Heartgard Plus has shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks.

View Heartgard Plus Drug Facts Sheet.

  • Give Heartgard Plus Chewables once a month on the same day of each month year round.
  • Heartgard Plus Chewables are for dogs only. Do not give to cats.
  • Heartgard Plus Chewables should not be swallowed whole.
  • Chewables may be broken and fed to dogs as pieces, or crumbled and mixed with food.
  • Watch dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.

Tip: Do not remove chewable from its wrapper until ready to give to pet.

Pet Weight Dosage
(6 weeks of age and older)
Up to 25 lbs Give 1 chewable every month (Blue Box)
  26-50 lbs Give 1 chewable every month (Green Box)
  51-100 lbs Give 1 chewable every month (Brown Box)
  Over 100 lbs Give combination of chewables based on weight
Cats: X X
Horses: X X
Storage: Store this product at room temperature. Keep out of reach of children.

What happens if I miss giving a dose: Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of overdose may include vomiting, diarrhea and incoordination in dogs.

What should I avoid while giving Heartgard Plus: Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on the pet and in the household and to not feed the pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.

What are the possible side effects of Heartgard Plus: Side effects of Heartgard Plus are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, and loss of body weight and death.

What other drugs will affect Heartgard Plus: Do not give Heartgard Plus to your pet if already taking another heartworm medication.

Cautions: Can cause sensitivities in herding dog breeds. It is important that you give your pet this preventative every month. If you miss more than two monthly doses, we recommend calling your vet before continuing the medication. Also, note that side effects are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight, and death. Side effects in cats include agitation, loss of appetite, staggering, dilated pupils, tremors, blindness and disorientation.


Review Summary
120 Reviews
92% (110)
7% (8)
1% (1)
0% (0)
1% (1)
98% Recommend this product (118 of 120 responses)
By Pat/Mike N.
Queens, NY
Higher Price
November 11, 2019
This year, I paid $10 more for the exact same item, as last year. No reason/explanation.
Merchant Response:Hi Pat & Mike, Heartgard PLUS pricing goes up every year. Wish we could do more to help with the pricing.
By tom
saint simons is ga
cost ok/ seems to keep our dog healthy
November 8, 2019
same as headline
By Florina
Huntingdon valley, PA
October 11, 2019
Delicious for my dog. He loves it and thinks it's a meaty chunk. Easy way to get ur pooch to take his meds.
By Gary
Lebanon, Ohio
September 7, 2019
Very effective and the only heart worm medicine my small dog can take without reaction. Also, he loves taking it.
By Caren
Greenville SC
August 18, 2019
Great product and my dog chews them without peanut butter smeared all my over it. I have using them for years. Great price with Entirely Pets
By Kay
Greenville, SC
Great Product
August 16, 2019
My Vet recommended Heartguard for my German Shepperd puppy. I really like the ease of giving him a chew that he is excited to take. Process with Entirely Pets was a breeze. Place the order and they handle the rest.
By gus
Pioneer, Ca
easy to use
May 24, 2019
this item works and is easy to apply
By gus
pioneer, ca
this item works
May 24, 2019
this item works and is easy to apply
By Paula
San Francisco Bay Area
loves to take her medicine!
December 28, 2018
Can't ask for better when my dog thinks her meds are a treat... even does all her commands just to get it!
By Mary
Minneapolis, MN
Great service
November 15, 2018
The company handles all communication with the veterinary hospital so I didn't have to fax any information.
ProsGreat communication, easy ordering, fast shipping
By Robin
Boca Raton, Florida
The BEST prices!
November 4, 2018
The BEST prices and very fast service! I will definitely order from you again!
By Bill S.
Hutto TX
good product
October 25, 2018
The service of Entirely Pets Pharmacy is excellent, their prices are the best I can find and the product has a very good expiration, overall they are a really good pharmacy to deal with.
By Susie
Life Saver
October 18, 2018
Great product. This is also the best price on the internet. Protect your dog from heart worm!
By Robin
Dallas TX area
Dogs love this and it works!
October 7, 2018
I have tried generic heartworm prevention with the same ingredients, but this is worth the little extra. The generics are difficult to give to a picky dog or a dog who doesn't like to chew hard pills. This is a soft 'treat' and when the dogs hear me unwrap the monthly Heartgard Plus, they are beside themselves with excitement. We live in a horrible area for heartworms (Texas) as they are so prevalent here. I have lived here 20 years and over that course have had 6 dogs, and this medicine has prevented heartworms in all cases.
ProsDogs love the taste; easy to give
Consat this pharmacy, the price is super low, but this medicine is a little more expensive than generic. It's definiely worth it though.
By Fran
Lebanon ,Pa
September 22, 2018
Fast , excellent price- versus vets and stores. Great customer service A++++
Merchant Response:Thanks Fran! Happy to have you and your dog as customers. =)
By Kathy
South Carolina
Great price, wonderful customer service
September 14, 2018
Item was shipped quickly and the price was much less than at the vets office
Merchant Response:Kathy, we aim to please. Thank you for choosing EntirleyPets Pharmacy.
By Armand M.
Best product for your Dog
August 30, 2018
Well known, quality product to protext it from a bad disease. Trust your dog to this product.
By Diana
Vancouver Washington
Heartgard Plus
August 26, 2018
My dog eats them like it is a treat
Merchant Response:Heartgard PLUS has the whole flavor thing down. You both take care!
By Sadie's m.
West Chester, Ohio
August 18, 2018
Not only is it exactly what the vet prescribed, but EntirelyPets price was half of what it would have cost at the vet’s office! The heartguard came quickly and packaged safely.
Merchant Response:Sadie's mom, we are quite pleased to be able to do business for you and Sadie. Take care!
By Karen A.
Torrance, Ca
Best price
August 5, 2018
After searching the Internet for Heartgard prices, I found that Entirely Pets Pharmacy offers the best price. Even though some other sources offer a discount, this is still the best price. I highly recommend this pharmacy
Merchant Response:That means a lot to us Karen. We do our best.
By Shelley
Shamrock, Ok
Better price
August 2, 2018
I get the same product but cheaper than I can get it at the vets office. The contact my vet for the prescription. That is convenient.
Merchant Response:Shelley, We are the best kept secret in pet pharmacy. Saving pet parents money one order at a time. =)
By Jo
Santa Rosa Beach
Great product for great price
July 19, 2018
Heartgard is a trusted product that protects my little one, esp in this insect prone area we live.
By Robb
Heartguard plus
July 15, 2018
Good product and reasonably priced.
By Malou
Plano TX
Heartgard 25 lbs
July 11, 2018
Great product. Shipped as soon as doctor responded on the negative heartworm test.
Great price
June 27, 2018
The heartgard was shipped promptly after authorization from my vet and I love the price!!
By Amy P.
Denton TX
Awesome customer service
June 7, 2018
I buy through you guys for the awesome price but this time the customer service was outstanding. Special thanks to Tyler for helping me get all the scripts from my Vet for my dogs. You guys are awesome.
Merchant Response:Amy, you are too kind! We have printed out your review, posted it on our announcement board in the office. Also, Tyler made Employee of the month! :) We are so glad you took the time to write your review, it is motivational.
By Debby
June 3, 2018
Great product, price and service. Would definitely order again from this company.
By James
Oregon, IL
Excellent ServiceEasy toder
May 23, 2018
Ordering was easy. Contact with my Vet was fast. Price was right. Delivery was timely.
By Denise
Denver, CO
Works every summer
May 17, 2018
These are recommended by my vet and seem to do the job quite well.
By Hammy M.
Lowest price in years!
May 17, 2018
I have used this product for 10 years on all my dogs (I had 10, now I am down to the remaining 2, ages 10 and 12 years old.) It has literally been years since I was able to purchase this 12 pack (with the add'l promo code) for such a great price. The service on this order was incredible and even tho they needed to contact my vet for approval, the product still arrived in just a few days! They communicate clearly and deliver quickly... a great combo. Thank you!
Merchant Response:Our motivation is for dogs just like Hammy & Velveteena! We work hard to keep Heartgard Plus and other products as low as possible. Glad to have you as a customer.