Heartgard Plus Green for Dogs 26-50 lbs (12 Chews) | EP Rx
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Heartgard Plus for Dogs - ivermectin|pyrantel- 26-50 lbs (12 Chews) - [Heartworm Prevention] Video
Heartgard Plus for Dogs - ivermectin|pyrantel- 26-50 lbs (12 Chews) - [Heartworm Prevention] Video

Heartgard Plus for Dogs - ivermectin|pyrantel- 26-50 lbs (12 Chews) - [Heartworm Prevention]

Item# IWM011055B
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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Heartgard Plus is a veterinary medication used for the prevention of heartworm disease in dogs. It contains two active ingredients - ivermectin and pyrantel - that work together to protect against heartworms and treat and control roundworms and hookworms. This chewable tablet is easy to administer orally, making it convenient for pet owners. Heartgard Plus Chew is a monthly treatment that provides protection for a full month with just one tablet. Please note that Heartgard Plus Chew is available only with a prescription from a licensed veterinarian, ensuring that it is used safely and effectively.

While Heartgard Plus is generally considered safe and effective, it's essential to consult with your veterinarian before starting your dog on any medication. Your vet can assess your dog's health status, take into account any potential drug interactions or contraindications, and recommend the appropriate dosage for your pet's size and breed.

Key Features:

  • Heartworm Prevention: Protects against heartworm disease in dogs.
  • Roundworm and Hookworm Treatment: Treats and controls roundworms and hookworms.
  • Chewable Tablet: Easy to administer orally, making it convenient for pet owners.
  • Monthly Treatment: Provides protection for a full month with one chewable tablet.
  • Suitable for Dogs: Formulated specifically for use in dogs.
  • Prescription Only: Available only with a prescription from a licensed veterinarian.


Heartgard Plus is indicated for the prevention of heartworm disease in dogs. It is effective against the immature stages of heartworms (larvae) that are transmitted through mosquito bites. By administering Heartgard Plus on a monthly basis, you can help protect your dog from heartworm infection.

Heartworm disease can be life-threatening for dogs. If a dog becomes infected with heartworms, the parasites can grow and live in the heart and blood vessels, causing damage to the heart, lungs, and other organs. Treatment for heartworm disease is complex, costly, and can have potential risks.

In addition to its primary indication for heartworm prevention, Heartgard Plus also provides protection against certain intestinal parasites in dogs. The active ingredient pyrantel helps control and treat common intestinal worms like roundworms and hookworms.

It's important to note that Heartgard Plus is specifically formulated for dogs and should not be used in other animals unless specifically prescribed by a veterinarian. Additionally, it is crucial to consult with your veterinarian to determine the appropriate dosage and administration schedule for your dog based on their individual needs and health status.

How it works:

  1. Active Ingredients: Heartgard Plus contains two main active ingredients: ivermectin and pyrantel. These ingredients work together to provide broad-spectrum protection against heartworms and certain intestinal parasites.
  2. Ivermectin: The primary ingredient, ivermectin, is effective against the larvae (immature stages) of heartworms. When a dog is bitten by an infected mosquito, the larvae are transmitted into the dog's bloodstream. Ivermectin acts by interfering with the nerve impulses of the larvae, causing paralysis and ultimately killing them. This prevents the larvae from developing into adult heartworms that can cause harm to the dog's cardiovascular system.
  3. Pyrantel: The second active ingredient in Heartgard Plus, pyrantel, is a deworming agent that targets and eliminates common intestinal parasites such as roundworms and hookworms. Pyrantel works by paralyzing and killing these parasites, preventing their ability to survive and reproduce within the dog's digestive system.
  4. Monthly Administration: Heartgard Plus is designed to be administered orally to dogs once a month. The chewable tablet formulation is typically palatable to dogs, making it easy to administer without the need for coercion or force. It's important to follow the recommended dosage instructions provided by your veterinarian to ensure the optimal effectiveness of the medication.
  5. Continuous Protection: Regular monthly administration of Heartgard Plus helps to maintain a consistent level of protection against heartworm disease. By administering the medication year-round, you can ensure that your dog remains protected during the entire mosquito season when heartworm transmission is most prevalent.


  • Brand: Heartgard Plus
  • Active Ingredients: Ivermectin, Pyrantel
  • Type: Chewable Tablet
  • Indicated For: Heartworm prevention, treatment, and control of roundworms and hookworms in dogs
  • Dosage Form: Chewable tablet
  • Strength: Various strengths available


Active Ingredient Heartgard Blue Heartgard Green Heartgard Brown
Ivermectin 68 mcg 136 mcg 272 mcg
Pyrantel 57 mg 114 mg 227 mg


Heartgard Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Dog Weight Chewables Per Month Ivermectin Content Pyrantel Content Color Coding on Foil-Backing and Carton
Up to 25 lb 1 68 mcg 57 mg Blue
26-50 lbs 1 136 mcg 114 mg Green
51-100 lbs 1 272 mcg 227 mg Brown
Over 100 lbs Use the appropriate combination of these chewables.

Heartgard Plus is recommended for dogs 6 weeks of age and older.

Quick Tips

  • Give Heartgard Plus Chewables once a month on the same day of each month year round.
  • Heartgard Plus Chewables are for dogs only.
  • Heartgard Plus Chewables should not be swallowed whole.
  • Chewables may be broken and fed to dogs as pieces, or crumbled and mixed with food.
  • Watch dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
  • Do not remove chewable from its wrapper until ready to give to pet.
  • Use the Witness Heartworm Test Kit to test your dog prior to using Heartgard Plus


Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find Heartgard Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Heartgard Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Heartgard Plus must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Heartgard Plus and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.

Monthly treatment with Heartgard Plus also provides effective treatment and control of ascarids (T. canis, T. leonina)and hookworms (A. caninum, U. stenocephala, A. braziliense) . Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.


Heartgard Plus was shown to be an acceptable oral dosage form that was consumed at first offering by the majority of dogs.


All dogs should be tested for existing heartworm infection before starting treatment with Heartgard Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Heartgard Plus.

While some microfilariae may be killed by the ivermectin in Heartgard Plus at the recommended dose level, Heartgard Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Store between 68°- 77°F (20°- 25°C). Excursions between 59° - 86°F (15° - 30°C) are permitted. Protect product from light.

Adverse Reactions:

Vomiting or diarrhea within 24 hours of dosing was rarely observed in clinical trials. The following adverse reactions have been reported: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


Heartgard Plus has been shown to be bioequivalent to Heartgard, with respect to the bioavailability of ivermectin. The dose regimens of Heartgard Plus and Heartgard are the same with regard to ivermectin (6 mcg/kg). Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Heartgard demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of Heartgard products in dogs, including Collies, when used as recommended.

Heartgard Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with Heartgard Plus in a heartworm disease preventive program.

Possible Side Effects

In clinical field trials with Heartgard Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have also been reported: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.


The active ingredients in Heartgard Plus Chewables are ivermectin and pyrantel pamoate. Use with caution, as Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Heartgard Plus Chewables for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. In addition, Heartgard Plus Chewables have shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding dogs, stud dogs and puppies aged 6 or more weeks.
Tell your veterinarian if your pet has ever had an allergic reaction to the medication, any of its individual ingredients, or to beef.
Give Heartgard Plus Chewables exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Heartgard Plus Chewables must be chewed. They should not be swallowed whole.
Side effects of Heartgard Plus Chewables are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight and/or death.
Give the missed dose as soon as you remember. Do not give a double dose of the medication.
Seek emergency veterinary medical treatment.
Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.
Do not give Heartgard Plus Chewables to your pet if he or she is already taking another heartworm medication.


Review Summary
218 Reviews
83% (181)
14% (30)
0% (1)
0% (1)
2% (5)
97% Recommend this product (212 of 218 responses)
By Glenn M.
Excellent pharmacy
May 2, 2024
Excellent prices and customer service.
  • Good prices and services and large quantities of animal medicines.
By Robin C.
Fountain Inn, SC
Heartgard Plus
December 6, 2020
Have used for years and never had a heartworm issue.
  • Dogs love it.
  • N/A
By vikram j.
austin, tx
deserves zero stars
May 23, 2024
they sent me stuff that's gonna expire before i get through with it...even though when i placed my order, i specifically asked them not to do that.

when i followed up via email to find out why, they simply stonewalled me.
  • they sent me stuff that's gonna expire before i get through with it...even though when i placed my order, i specifically asked them not to do that.
  • when i followed up via email to find out why, they simply stonewalled me.
By Patti
Elizabethtown, Pa.
Service revuewpa
April 12, 2024
Awesome company ! Received Hearguard Plus in timely manner.
By Rachel
Watertown, NY
Did not receive item
March 27, 2024
Typically I would not give a rating on something like this but I NEVER RECEIVED my order, I have sent two emails and no one has gotten back with me. I’m hoping this gets someone’s attention.
By Jan
Wallingford CT
Easy and effective
March 2, 2024
I've been using this product for a very long time and have had success in keeping my dogs healthy and free of heartworm disease. She eats it up enthusiastically and has had no negative side effects. Would highly recommend it!
By Linda R.
Newport News, VA
Heartguard Plus
February 22, 2024
I’ve been shopping with Entirely Pets for several years. I’ve found there priced very reasonable. I learned a long time ago it was foolish to get your pet products from the veterinarian. Although, they give me 10% off the cost is still not as reasonable as Entirely Pets. I also purchase Serenity flea collars from them. I make one call to their friendly staff and the purchase arrives in 3-4 days. I only go to the veterinarian when necessary. Please try their personal website.
By Barbara
Brick, NJ
Heartgard Plus for Dogs 26-50lbs
February 15, 2024
I am satisfied with this purchase, the price was a big plus in this purchase. Thank you
Milwaukee WI
Works great
December 27, 2023
Had an issue and after the vet visit this is keeping them healthy.
By Lisa
Heartgard green 26-50lb.
October 6, 2023
Received it quickly.
By Patricia
Wilbraham, MA
Purchasing a prescription
September 3, 2023
The process was easy & quick. I ordered the item, EntirelyPets contacted my vet and shipped the order right away! Price is reasonable also.
By Michele
Naperville, IL
Timely delivery and good price
August 24, 2023
Tried and true Heartguard delivered on time
By Emily
Folsom, CA
Never has ticks
August 22, 2023
My dog acts like this is a treat when it's time to give it to him. Not all meds get the same response. His heart is always healthy.
By Barb
Aurora, CO
July 18, 2023
My dog has been prescribed this for years. She loves the flavor and has never had heart worm!
By P{ius
Arnold, Missouri
Late Shipment without any Status Notification
May 16, 2023
Item was ordered on April 18 along with another item. One item was shipped, the Heartguard was out of stock and back-ordered. After two more weeks, I contacted EntirelyPets and was told it would be shipped "next week". Nothing happened! Today, I called again and was told it would be shipped later this week.

I am very disappointed for the non-existing flow of information from EntirelyPets regarding a medication that required a prescription and therefore must be considered important to a pet owner.

Pius Ruf
  • see above
  • see above
By Gina
Boone, IA
Easy to Use and Effective
March 4, 2023
We have used Heartgard for many years with all our dogs. Our dogs love the fact that it seems like a treat to them instead of medicine. Easy to use, once a month and more economical than other heartworm medications.
By Lauren
Mansfield, TX
Love it
January 22, 2023
Have always used this product my 5 lbs chihuahua eats them pretty easily
  • sizing is for up to 25 for the smallest
By Gary1826
Lakewood, CO
HeartGard is the best for preventative hookworms in dogs
January 14, 2023
I give my dog HeartGard Chewables once a month to prevent hookworms in dogs! My dog is 9 years old, and she hasn’t had a positive test for hookworms during her 9 years!

Merchant Response:Hello Gary, Now that is amazing to hear! Heartguard is one of our top-selling products and we're always glad to hear our customers are consisting having success with the product. Sincerely, EntirelyPets Pharmacy
By M A.
Murrells Inlet, SC
Heartgard plus for canine 26-50 libs
January 12, 2023
Order a 12 month supply with a great price.

Merchant Response:Hello Maryrose, Here at EntirelyPets Pharmacy, we try our best to provide quality products and prices, sometimes there can be delays on orders depending on the location of delivery and approval time, but we're happy to hear everything was received on time. Sincerely, EntirelyPets Pharmacy
  • Order was completed fast as it was a prescription order.
  • Took about a little over a week to receive. Might be because it came from the west coast and went to the east coast. If you are short on time, this was a close call.
By nancy
very good email communicating
January 11, 2023
kept in good contact

Merchant Response:Hello Nancy, Thank you for your feedback, we try out best to communicate with our customers through every step of the approval process.
By Ed C.
New Jersey
Overcharged on the item - order was $96 and I was charged $137
January 2, 2023
I put this order in and it required vet approval - the order total was $96 and I was charged $137. I have tried for 2 days to contact the Entirely Pets customer service phone number and was never able to get through. At this point I am frustrated and not sure why the order was overcharged.
  • Price seemed very good, but when my order was filled I was billed a different price
By Theresa P.
Cheaper then ordering from the vet
October 15, 2022
Comes in a timely manner and easy to order. They contact the vet for you
  • Easy to order with no hassel
  • None
By Aric
Champaign, IL
This is a great product
August 30, 2022
I bought this product for two lhasa apsos
  • Great for tiny dogs
  • Need to purchase this ongoingly
By Mya
Pensacola, FL
Excellent Service
August 15, 2022
We are very happy with the quick ordering process. Entirely Pets Pharmacy requested the prescription from our vet more than once. The short delay in filling it was due to the vet, not the pharmacy. Same day the vet responded, shipment was sent to us. Kudos for Entirely Pets!

Merchant Response:We are so happy that you liked your experience with us Mya. We try our best. Sometimes the veterinarians take a little bit to respond to prescription verification requests.
By Christine
Great product
June 24, 2022
It's a great product, I tried other ones and my dogs would not eat them.
  • Taste
By Nancy
Savage, Minnesota
June 3, 2022
My order was seamless and shipped quickly. Thank you.
By Kelly
Does a good job and my dog likes it
May 2, 2022
Have used this for many years and no heartworm issues. My dog thinks it's a treat and eats it right up with no issues.

Merchant Response:
  • Dog eats without any problems
By Cathy
April 24, 2022
I have used this product for many years. It is no longer carried by our vet, so I was delighted when I found it available at Entirely Pets Pharmacy. I much prefer giving my pets oral vs topical heartworm protection. With oral medication, I can be sure they get the drug rather than hope it absorbs through their skin and doesn't just stay on their fur.
By Elilane
Las Vegas, NV
Heartgard for dog
February 15, 2022
Easy way to renew your dog's medicine order, they will call your veterinarian to get the prescription, that simple!
  • it is usually fast and cheaper than the veterinarian office price
they work
February 10, 2022
LuLu like them

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