Comfortis for Dogs 60-120 lbs (Brown) - 12 Chew Tabs | On Sale | EntirelyPets Rx
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Comfortis for Dogs 60-120 lbs (Brown) - 12 Chew Tabs

Item# 2125152512
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COMFORTIS chewable tablets (spinosad) are available in five chewable flavored tablet sizes for oral administration to dogs and puppies according to their weight. Each chewable tablet is formulated to provide a minimum spinosad dosage of 13.5 mg/Ib (30 mg/kg).

Spinosad is a member of the spinosyns class of insecticides, which are non-antibacterial tetracyclic macrolides. Spinosad contains two major factors, spinosyn A and spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa. Spinosyn A and spinosyn D have the chemical compositions 2-[(6-deoxy-2,3,4-tri-O-methyl-á-L-mannopyranosyl)oxy]-13-[[5-dimethylamino)-tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1 H-as-Indaceno[3,2-d]oxacyclododecin-7, 15-dione and 2-[(6-deoxy-2,3,4-tri-O-methyl-á-L-mannopyranosyl)oxy]-13-[[5-dimethylamino)-tetrahydro-6-methyl-2H-pyran-2-yl] oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14, 16a,16b-tetradecahydro-4,14-dimethyl-1 H-as-Indaceno[3,2-d] oxacyclododecin-7,15-dione, respectively.

Indications:COMFORTIS chewable tablets kill fleas and are indicated for the prevention and treatment of flea infestations (Ctenocephalides felis) on dogs for one month.

Prescription Required


Dosage and Administration: COMFORTIS chewable tablets are given orally once a month, at the recommended minimum dosage of 13.5 mg/Ib (30 mg/kg).

Recommended Dosage Schedule:

Body Weight

Spinosad Per Tablet (mg)

Tablets Administered

3-5 lbs Dogs
2-4 lbs Cats



5-10 lbs Dogs
4-6 lbs Cats



10-20 lbs Dogs
6-12 lbs Cats



20-40 lbs Dogs
12-24 lbs Cats



40.1 to 60 Ibs



60.1 to 120* Ibs



* Dogs over 120 Ibs should be administered the appropriate combination of tablets.

Administer COMFORTIS chewable tablets with food for maximum effectiveness.

COMFORTIS is a chewable tablet and is readily consumed by dogs when offered by the owner just prior to feeding. Alternatively, COMFORTIS chewable tablets may be offered in food or administered like other tablet medications. COMFORTIS chewable tablets should be administered at monthly intervals.

If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed, administer COMFORTIS chewable tablets with food and resume a monthly dosing schedule.

Treatment with COMFORTIS chewable tablets may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with COMFORTIS chewable tablets should continue the entire year without interruption.

To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.


Review Summary
32 Reviews
78% (25)
13% (4)
3% (1)
0% (0)
6% (2)
94% Recommend this product (30 of 32 responses)
By irina
miami, FL
it really works
April 14, 2024
hi i have used comfortis for my cats since years- it is the best ,fastest flea medication on the market. entirely pets has the best prices
By Robin
All I ever use
March 26, 2024
Have been using this med for years for my inside dogs and my farm dogs. Love it
By Jaynie
Brunswick, GA
Comfortis is the best for my pets!
November 16, 2023
Nothing else works like Comfortis. No side effects, but I always give it on a full stomach. The fleas are dying in 30 minutes. Being able to purchase it in smaller quantities than the full 6 pack is a tremendous help due to the expense of the 6 pack. Thank you, EntirelyPets Pharmacy!
  • Extremely effective. Fleas start dying in 30 minutes. Since it's given orally, there is no wet spot on the fur.
  • Price, but being able to purchase 3 instead of the full 6 pack is greatly appreciated.
By Vicky
Piece of trash
October 12, 2023
It’s not working at all, don’t waste your money on it…
  • Nothing
  • Don
By Elizabeth G.
Atlanta, Georgia
Easy Peasy
September 20, 2023
It's easier to give my long-haired cat a tablet than it is to try and put liquid meds on his skin!
By Patricia K.
Harvey, LA
Great Company to work with
September 18, 2023
After my order was confirmed with my vet. they shipped my dogs prescription meds same day and provided a tracking number so I knew when they were going to arrive.
By Mobile
Confortis for Dogs
November 22, 2021
Works great.
  • No problem with fleas
By Kathy
North Carolina
Comfort for our 2 Cats
July 31, 2021
This medication makes a big difference to our 2 cats. We live in the country (in a renovated tobacco barn) so flea protection is important. Our girls are much happier and more relaxed because of it. It works quickly, too.
  • Works quickly. Our 2 cats have no adverse reactions from it. Amount given is determined by weight of animal.
  • None.
By Lynda
Princeton, TX
June 24, 2021
I was hoping it was a chewable instead of a hard pill
  • Hard pill. Hard to give to a cat
By Sandy
Does the job
August 21, 2020
Works great. No more fleas! I have been using for about four months, killed the fleas and have not seen any more.
By Barbara
Jacksonville Al
Very satisfied
May 1, 2020
Love the product and the timely delivery
By Valerie J.
April 30, 2020
Thank you for getting the order right! The gentleman I spoke with was awesome.
  • Thank you for getting the order right! The gentleman I spoke with was awesome.
By Kristi
The only flea and tick prevention that works!
March 15, 2020
I have tried all the other prevention such as frontline, etc and they were a huge waste of money! comfortis is the only prevention that has worked for all of our cats and dogs.
  • Comfortis is worth the money because it actually works.
By HBGary
Huntington Beach
Two dogs, no fleas
November 17, 2019
We have used Comfortis for many years since our vet recommended it during a time of major flea infestation in the area and our dog was suffering (as we were too), Our current two dogs have always used Comfortis after the good experience we had with our prior dogs.

Merchant Response:Flea-free is the way to be. Comfortis is pricy, but worth it in the long run. Take care Gary.
  • Easy to administer product to the dogs.
  • Pricey
By Irene
Los Angeles, ca
Customer service
March 22, 2019
This review is for entirely pets pharmacy: great customer service! Wouldn't use any other online pet pharmacy
By ronald c.
1425 second ave Chula Vista, CA 91911
February 8, 2019
I received product in a timely manner; so I'm well pleased! Thank you
By karla` s.
Miami, Florida
Works great
October 19, 2018
Always kills fleas within 30 minutes. Service was great and delivery on time.
By Katrina
Oregon Coast
Good Value
October 17, 2018
Easiest way to buy and a great price.
By Lu H.
Recent order
August 29, 2018
First time using - great service - contacted my vet for a prescription right away and product arrived very soon after - will use again.
By spex
fountain valley , Ca.
I got it !
May 18, 2018
it was a little faster receiving the comfortis, and sale price was a bonus. I was pleased all around. It is easier to administer to my pet.
  • Easier to give to my pet.
San Diego, California
Stomach Upset
March 17, 2018
I provided the ComFortis tablet immediately following our dog’s breakfast. He vomited everything up within the hour. Gastrointestinal issues are not typical with our dog.
  • Stomach upset.
By Ella P.
San Diego, California
Comfortis for Dogs
January 18, 2018
Very pleased with the service received. There were no discrepancies with the product, or with the order. The customer service was excellent and quite comforting. I would suggest that Entirely Pets is used for all of your pet needs.

Merchant Response:Thank you for your kind words Ella! Glad we are able to help!
  • Good prices, order in a timely manner!
  • No complaints!
By Orange m.
Huntington Beach California
Great product
October 5, 2017
The time it took to get the actual product was too long but the product itself and the price was great.
  • Took too long
By Shelley
St. Louis, MO
Comfortis for dogs
October 4, 2017
good value, best price I could find
By Barcomb L.
Houston, Tx
Great product
April 23, 2017
Product works great. No live fleas found on my dog
No scratching.
Happy dog, 🐕
By pepperoni
san diego, California
Really effective; if only it weren't chewable
April 17, 2016
Great product but both dogs detest the flavor. So I'm left with huge pills I can't even disguise in food and it's the only medication I have to shove down their throats. Comfortis: PLEASE make a small pill that isn't chewable.
  • effective
  • dogs hate the taste and it's so strong I can't even disguise it covering it with blue cheese!
By holly
Old Fort, NC
works great!
April 4, 2016
I have used this product on my cats. it works really really well and I like it much better than the topical. I hate that stuff. they sleep in my bed and the thought of that getting wiped everywhere freaks me out. the pills are easy, not messy, and really work!!! although I haven't ordered from entirely pets yet, I am planning on using them for my next order because their prices a MUCH less than at the vet!
  • works great, no mess, better prices than the vet
  • none
By Vicky
McKinlyville CA
Finally NO FLEAs!
March 5, 2016
yày...this product actually works! I've spent hundreds of dollars trying to get the fleas off our Germàn Shepherd. For yearrs he would màke himself, ànd me, crazy and hairless from scratching at them. After 2 months, his hair is growing back now and he looks really nice and shiny and happy!! SSo glad I switched from topicals!
By Gary L.
Surf City, USA
Good price...same product as from my vet
August 26, 2015
Easy transaction. Simple and quick. Only delay was getting prescription from my own vet. Not Entirely Pet's problem. They fax'ed request to my vet. Once received from vet, shipped to me.
  • Good price
  • Easy transaction
  • Delay in securing prescription from my vet
By Gary L.
Surf City, USA
Same as what I get at my vet
August 23, 2015
Same product sold by my vet at a higher price that was prescribed for my dog. Easy online transaction.
  • Good Price
  • Works for my dog
  • Took awhile for my vet to approve the prescription for my dog. Not Entirely Pets' problem as they fax'ed request to vet right after receiving order. I had to follow up with vet to make sure they responded to Entirely Pets' request.

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