Comfortis for Dogs 60-120 lbs (Brown) - 12 Chew Tabs - [Fleas]

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Comfortis is the first FDA-approved, prescription oral flea treatment that provides fast-acting, month-long protection for both dogs and cats. This convenient beef-flavored chewable tablet (made with pork protein and hydrolyzed soy) starts killing fleas in just 30 minutes and eliminates infestations before they can start. Comfortis requires a prescription from your veterinarian.

Key Benefits

• Fast-acting flea protection – Begins killing fleas within 30 minutes of administration
• Monthly dosing – One chew protects your pet for a full 30 days
• Breaks the flea life cycle – Kills fleas before they can lay eggs and reproduce
• Convenient chewable tablet – Beef-flavored and easy to administer with food
• Environmentally responsible – Contains spinosad, a naturally derived insecticide

Indications

Comfortis (spinosad) is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis) for one month on:

• Cats and kittens 14 weeks of age or older and weighing 4.1 pounds or more
• Dogs and puppies 14 weeks of age or older and weighing 5.0 pounds or more

How to Use

Comfortis should be administered once monthly with food for maximum effectiveness. Follow your veterinarian’s instructions for proper dosage and usage schedule.

Comfortis is a prescription-only, chewable flea tablet formulated with the active ingredient spinosad. It provides fast-acting, monthly protection for dogs and cats and should be administered with food for best results.

📄 View Comfortis Drug Facts Sheet (FDA PDF)

Dosage for Dogs

Minimum recommended dose: 13.5 mg/lb (30 mg/kg) of body weight, administered orally once per month.

Important: Do not use the dog dosage chart when dosing cats, as it may result in underdosing.

*Dogs over 120 lb should be administered the appropriate combination of tablet strengths. Comfortis is best administered with food. If vomiting occurs within 1 hour of dosing, repeat with a full dose.

Comfortis can be offered as a treat before feeding, mixed with food, or administered like a traditional tablet. If a dose is missed, resume monthly dosing with food as soon as possible.

Flea Prevention Strategy: Begin Comfortis at least one month before flea season starts and continue monthly through the end of flea season. In regions where fleas are present year-round, monthly treatment should be maintained continuously. All pets in the household should be treated with a vet-approved flea control product.

Dosage for Cats

Minimum recommended dose: 22.5 mg/lb (50 mg/kg) of body weight, administered orally once per month.

Important: Do not use the dog dosage chart for cats, as it may result in an overdose.

*Cats over 24 lb should be administered the appropriate combination of tablet strengths.

Comfortis should be given with food. It may be offered before or after feeding, mixed in food, or administered as a chewable tablet. If vomiting occurs within 1 hour of dosing, redose with a full dose. Resume regular monthly treatment if a dose is missed.

Treatment should begin before flea season and continue monthly through the end. In flea-prone areas, maintain year-round treatment. All pets in the home should receive approved flea control to prevent reinfestation.

Contraindications

No known contraindications are associated with Comfortis use.

Warnings

• Not for human use. Keep out of reach of children.
• Serious adverse reactions have been reported when Comfortis was used with extra-label doses of ivermectin.

Precautions

• For use in dogs and puppies 14 weeks and older (see veterinarian for animal safety guidance).
• Use caution in breeding females and dogs with pre-existing epilepsy.
• The safety of Comfortis has not been evaluated in breeding males, or in breeding, pregnant, or lactating cats.
• Concomitant extra-label use of ivermectin should be avoided unless directed by a veterinarian.

Storage Instructions

Store at controlled room temperature: 20–25°C (68–77°F), with excursions permitted between 15–30°C (59–86°F).

Effectiveness

In laboratory studies, Comfortis began killing fleas within 30 minutes and achieved 100% effectiveness within 4 hours. It kills fleas before they lay eggs, helping prevent infestations.

Field studies over 3 months demonstrated 98–99.8% flea reduction in infested households. Dogs with flea allergy dermatitis showed visible improvement in symptoms like itching, redness, and hair loss.