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Clavamox Tablets for Dogs

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Description

Clavamox Chewable Tablet (amoxicillin and clavulanate potassium tablets) is an orally administered formulation comprised of the broad-spectrum antibiotic Amoxi® (amoxicillin trihydrate) and the ß-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid).

Amoxicillin trihydrate is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative, aerobic and anaerobic microorganisms. It does not resist destruction by ß-lactamases; therefore, it is not effective against ß-lactamase-producing bacteria. Chemically, it is D(-)-a-amino-p-hydroxybenzyl penicillin trihydrate.

Clavulanic acid, an inhibitor of ?-lactamase enzymes, is produced by the fermentation of Streptomyces clavuligerus. Clavulanic acid by itself has only weak antibacterial activity. Chemically, clavulanate potassium is potassium z-(3R,5R)-2-ß-hydroxyethylidene clavam-3-carboxylate.

Key Benefits

  • Good for skin and soft tissue infections such as wounds, abscesses, and cellulitis
  • Effective for first-time skin infections and persistent pyodermas (skin inflammation marked by pus-filled lesions)
  • Proven to generally be a safe antibacterial treatment

How it works

Clavamox combines the broad-spectrum antibiotic activity of amoxicillin with the unique beta-lactamase inhibiting effect of clavulanic acid which makes this product effective against beta-lactamase and non-beta-lactamase producing organisms.

Indications:

Clavamox Chewable Tablets are indicated in the treatment of:

Dogs: Skin and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep pyoderma due to susceptible strains of the following organisms: ß-lactamase-producing Staphylococcus aureus, non-ß-lactamase-producing Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., and E. coli.

Periodontal infections due to susceptible strains of both aerobic and anaerobic bacteria. Clavamox Chwable has been shown to be clinically effective for treating cases of canine periodontal disease.

Cats: Skin and soft tissue infections such as wounds, abscesses, and cellulitis/dermatitis due to susceptible strains of the following organisms: ß-lactamase-producing Staphylococcus aureus, non-ß-lactamase-producing Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., E. coli, and Pasteurella spp.

Urinary tract infections (cystitis) due to susceptible strains of E. coli.

Therapy may be initiated with Clavamox Chewable prior to obtaining results from bacteriological and susceptibility studies. A culture should be obtained prior to treatment to determine susceptibility of the organisms to Clavamox. Following determination of susceptibility results and clinical response to medication, therapy may be reevaluated.

Ingredients

Clavamox 62.5 mg Chewable Tablet or Regular Tablet
Active Ingredient Amount
Amoxicillin Trihydrate 50 mg
Clavulanic Acid 12.5 mg
Clavamox 125 mg Chewable Tablet or Regular Tablet
Active Ingredient Amount
Amoxicillin Trihydrate 100 mg
Clavulanic Acid 25 mg
Clavamox 250 mg Chewable Tablet or Regular Tablet
Active Ingredient Amount
Amoxicillin Trihydrate 200 mg
Clavulanic Acid 50 mg
Clavamox 375 mg Chewable Tablet or Regular Tablet
Active Ingredient Amount
Amoxicillin Trihydrate 300 mg
Clavulanic Acid 75 mg

Directions

View Clavamox Drug Facts Sheet.

The dose should be prescribed using a combination of whole tablet strengths (62.5 mg, 125 mg, 250 mg, 375 mg). Do not remove from foil strip until ready to use. Even if the tablet is broken, the entire tablet should be consumed.

Dogs: The recommended dosage of Clavamox Chewable Tablet is 6.25mg/lb of body weight twice a day.

Skin and soft tissue infections such as abscesses, cellulitis, wounds, superficial/juvenile pyoderma, and periodontal infections should be treated for 5-7days or for 48hours after all symptoms have subsided. If no response is seen after 5days of treatment, therapy should be discontinued and the case reevaluated. Deep pyoderma may require treatment for 21days; the maximum duration of treatment should not exceed 30days.

Cats: The recommended dosage of Clavamox Chewable Tablet is 62.5mg twice a day.

Skin and soft tissue infections such as abscesses and cellulitis/dermatitis should be treated for 5-7days or for 48hours after all symptoms have subsided, not to exceed 30days. If no response is seen after 3days of treatment, therapy should be discontinued and the case reevaluated.

Urinary tract infections may require treatment for 10-14days or longer. The maximum duration of treatment should not exceed 30days.

Caution:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications:

The use of this drug is contraindicated in animals with a history of allergic reaction to any of the penicillins or cephalosporins.

Warnings:

Store Clavamox Chewable out of reach of dogs, cats, and other pets in a secured location in order to prevent accidental ingestion or overdose.

Human Warnings:

Not for human use. Keep this and all drugs out of reach of children. Antimicrobial drugs, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including amoxicillin and clavulanate potassium, are advised to avoid direct contact of the product with the skin and mucous membranes.

Precautions:

Prescribing antibacterial drugs in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to treated animals and may increase the risk of the development of drug-resistant animal pathogens. Safety of use in pregnant or breeding animals has not been determined.

Adverse Reactions:

Clavamox Chewable contains a semisynthetic penicillin (amoxicillin) and has the potential for producing allergic reactions. If an allergic reaction occurs, administer epinephrine and/or steroids.

To report suspected adverse events, for technical assistance or to obtain a copy of the SDS, contact Zoetis Inc. at 1-888-963-8471 or www.zoetis.com.

For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth.

Actions:

The 2 components are rapidly absorbed resulting in amoxicillin and clavulanic acid concentrations in serum, urine, and tissues similar to those produced when each is administered alone.

Amoxicillin and clavulanic acid diffuse readily into most body tissues and fluids with the exception of brain and spinal fluid, which amoxicillin penetrates adequately when meninges are inflamed. Most of the amoxicillin is excreted unchanged in the urine. Clavulanic acid’s penetration into spinal fluid is unknown at this time. Approximately 15% of the administered dose of clavulanic acid is excreted in the urine within the first 6 hours.

Clavamox Chewable combines the distinctive properties of a broad-spectrum antibiotic and a ?-lactamase inhibitor to effectively extend the antibacterial spectrum of amoxicillin to include ?-lactamase-producing as well as non-?-lactamase-producing aerobic and anaerobic organisms.

Microbiology:

Amoxicillin is bactericidal in action and acts through the inhibition of biosynthesis of cell wall mucopeptide of susceptible organisms. The action of clavulanic acid extends the antimicrobial spectrum of amoxicillin to include organisms resistant to amoxicillin and other ?-lactam antibiotics. Amoxicillin/clavulanate has been shown to have a wide range of activity which includes ?-lactamase-producing strains of both gram-positive and gram-negative aerobes, facultative anaerobes, and obligate anaerobes. Many strains of the following organisms, including ß-lactamase-producing strains, isolated from veterinary sources, were found to be susceptible to amoxicillin/clavulanate in vitro but the clinical significance of this activity has not been demonstrated for some of these organisms in animals.

Aerobic bacteria, including Staphylococcus aureus*, ß-lactamase-producing Staphylococcus aureus* (penicillin resistant), Staphylococcus species*, Staphylococcus epidermidis, Staphylococcus intermedius, Streptococcus faecalis, Streptococcusspecies*, Corynebacterium pyogenes, Corynebacterium species, Erysipelothrix rhusiopathiae, Bordetella bronchiseptica, Escherichia coli*, Proteus mirabilis, Proteusspecies, Enterobacter species, Klebsiella pneumoniae, Salmonella dublin, Salmonella typhimurium, Pasteurella multocida, Pasteurella hemolytica, Pasteurella species*.

* The susceptibility of these organisms has also been demonstrated in in vivo studies.Studies have demonstrated that both aerobic and anaerobic flora are isolated from gingival cultures of dogs with clinical evidence of periodontal disease. Both gram-positive and gram-negative aerobic and anaerobic subgingival isolates indicate sensitivity to amoxicillin/clavulanic acid during antimicrobial susceptibility testing.

Palatability:

The palatability of Clavamox Chewable Tablets was evaluated in a multi-location field trial. One hundred twelve (112) client-owned dogs were dosed with Clavamox Chewable Tablets at 6.25 mg/lb (12.5 mg/kg) twice daily for 7 days and evaluated for palatability of the product. Dogs freely consumed 83% of their doses within 5 minutes of offering from an empty bowl or owner’s hand. Of the 17% of doses unconsumed after 5 minutes, 16% were administered with a treat/food or forced intake and 1% of doses were refused.

Storage:

Store in a dry, cool place at temperatures not above 25°C (77°F). Do not remove from foil strip until ready to use.

FAQ

Clavamox is a broad spectrum antibiotic that fights bacteria in the body. Clavamox is a prescription medication available as regular tablets or chewable tablets in four different strengths: 62.5 mg, 125 mg, 250 mg, and 375 mg. Clavamox is also available as Clavamox Drops. When mixed with 14 ml of water, each ml contains 62.5 mg of Clavamox.
Tell your veterinarian if your pet has ever had an allergic reaction to another penicillin or to a cephalosporin. Tell your veterinarian if your pet has liver or kidney disease. Tell your veterinarian if your pet is pregnant or lactating or if your pet could become pregnant during treatment.
Give this medication exactly as directed by your veterinarian. Clavamox should be given with food. Keep water available for your pet. The usual dose of Clavamox in dogs is 6.25 mg/lb of dog's body weight twice a day, and in cats it is 62.5 mg (1 ml) twice a day. Clavamox can be used to treat many different types of bacterial infections such as respiratory, ear, urinary tract, and skin. Clavamox may also be used for purposes other than those listed. Give all of the Clavamox that is prescribed for your pet. Symptoms may improve before the infection is completely treated.
Contact your veterinarian immediately if your pet experiences diarrhea that is severe and lasts longer than 3 days. Stop giving Clavamox and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath, hives, swelling of the lips, tongue, or face, rash, or fainting). Other less serious side effects such as mild diarrhea, nausea, vomiting, or yeast or fungal infection may be more likely to occur. Continue to give Clavamox and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
Give the missed dose as soon as you remember unless it is almost time for the next regularly scheduled dose. Do not give a double dose unless otherwise directed by your veterinarian.
Seek emergency veterinary medical treatment if an overdose is suspected. Symptoms of Clavamox overdose may include nausea, vomiting, rash, drowsiness, hyperactivity, or kidney problems.
There are no restrictions on food or activity during treatment with Clavamox unless otherwise directed by your veterinarian.
Before giving Clavamox, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), allopurinol or probenecid. You may not be able to give Clavamox or you may need to have the dosage adjusted. Drugs other than those listed here may also interact with Clavamox. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

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