Interceptor Plus should be administered in a manner that encourages your dog to chew, rather than swallow whole. However, we do not expect a difference in the effectiveness of the product if your dog consumes it whole.
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Trifexis For Dogs - spinosad|milbenycin oxime - 5-10 lbs (1 chewable tablets) - [Heartworm Prevention]
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- Directions
- FAQ
- Reviews
Notices
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Description
Trifexis Chewable Tablets for Dogs: Comprehensive Parasite Protection
Trifexis is a popular, once-monthly chewable tablet for dogs, providing broad-spectrum protection against multiple parasites. This prescription medication combines two powerful active ingredients: spinosad for effective flea control and milbemycin oxime for the prevention of heartworm disease and the treatment and control of common intestinal worms (roundworms, hookworms, and whipworms).
Key Benefits of Trifexis for Dogs:
- Broad-Spectrum Protection: Offers comprehensive defense against fleas, heartworms, and key intestinal worms in one convenient monthly chew.
- Convenient Monthly Administration: Palatable chewable tablet is easy for dog owners to give, ensuring consistent protection.
- Rapid Flea Control: Spinosad swiftly kills fleas through nervous system targeting, effectively preventing and treating infestations.
- Heartworm Disease Prevention: Milbemycin oxime prevents potentially life-threatening heartworm disease by eliminating immature heartworm larvae.
- Intestinal Worm Control: Treats and controls roundworms, hookworms, and whipworms, promoting a healthy gastrointestinal system.
Indications:
Trifexis is indicated for:
- Flea Infestation: Treatment and prevention of flea infestations (*Ctenocephalides felis*) through rapid killing of adult fleas and prevention of reinfestation.
- Heartworm Disease: Monthly prevention of heartworm disease (*Dirofilaria immitis*) by eliminating the larval stages.
- Intestinal Parasites: Treatment and control of adult roundworms (*Toxocara canis*, *Toxascaris leonina*), hookworms (*Ancylostoma caninum*, *Uncinaria stenocephala*), and whipworms (*Trichuris vulpis*).
By controlling fleas and certain intestinal parasites, Trifexis may also aid in the prevention of some zoonotic diseases.
How Trifexis Works:
Trifexis chewable tablets combine the power of two active ingredients:
- Spinosad: An insecticide that overstimulates the flea's nervous system, leading to rapid paralysis and death upon ingestion or contact.
- Milbemycin Oxime: An anthelmintic that interferes with nerve transmission in roundworms, hookworms, and whipworms, causing paralysis and elimination.
Administering Trifexis with a full meal enhances the absorption of the active ingredients, ensuring optimal effectiveness. Always follow your veterinarian's recommended dosage based on your dog's weight.
Specifications:
- Brand: Trifexis
- Active Ingredients: Spinosad, Milbemycin Oxime
- Type: Oral chewable tablet
- Indicated for: Prevention of heartworm disease, flea infestations, and treatment/control of roundworms, hookworms, and whipworms in dogs
- Dosage Form: Chewable tablet
- Administration: Administer orally, once a month with a full meal
- Packaging: Available in packs of 6 or 12 tablets
- Storage: Store at room temperature, away from moisture and heat
- Manufacturer: Elanco Animal Health
- Prescription Required: Yes, prescription-only medication. Must be prescribed by a veterinarian.
NADA 141-321
NDC Codes: 58198-4332-6 (Pink), 58198-4333-6 (Orange), 58198-4334-6 (Green), 58198-4335-6 (Blue), 58198-4336-6 (Brown)
Ingredients
| Active Ingredient | Trifexis Pink | Trifexis Orange | Trifexis Green | Trifexis Blue | Trifexis Brown |
|---|---|---|---|---|---|
| Spinosad | 140 mg | 270 mg | 560 mg | 810 mg | 1620 mg |
| Milbemycin Oxime | 2.3 mg | 4.5 mg | 9.3 mg | 13.5 mg | 27 mg |
Directions
Trifexis Chewable Tablets for Dogs: 3-in-1 Parasite Protection
View Trifexis Drug Facts Sheet (PDF)
Trifexis offers convenient, once-monthly, beef-flavored chewable tablets for dogs, providing powerful 3-in-1 protection against heartworm disease, fleas, and common intestinal parasites (adult hookworm, roundworm, and whipworm). This prescription medication combines the effectiveness of spinosad and milbemycin oxime.
Quick Tips for Using Trifexis:
- Administer with food for maximum effectiveness.
- Give once a month.
- Refer to the dosage chart below for the correct tablet for your dog's weight.
- Does not protect against ticks. Consider a separate tick preventative if needed.
- If vomiting occurs within 1 hour of administration, redose with another full dose.
- Consult your veterinarian for pregnant or lactating dogs.
| Dosage Schedule: | |||
|---|---|---|---|
| Body Weight | Spinosad Per Tablet (mg) | Milbemycin oxime Per Tablet (mg) | Tablets Administered |
| 5 to 10 lbs | 140 | 2.3 | One |
| 10.1 to 40 lbs | 270 | 4.5 | One |
| 20.1 to 40 lbs | 560 | 9.3 | One |
| 40.1 to 60 lbs | 810 | 13.5 | One |
| 60.1 to 120 lbs | 1620 | 27 | One |
| Over 120 lbs | Administer the appropriate combination of tablets | ||
Administration Instructions:
Administer Trifexis with food for maximum effectiveness. For heartworm prevention, observe your dog for one hour after dosing. Redose if vomiting occurs within one hour. If a dose is missed by more than a month, administer immediately with food and resume monthly dosing.
Powerful 3-in-1 Parasite Protection:
Just one beef-flavored tablet each month protects your dog against:
- Heartworm disease
- Fleas (starts killing within 30 minutes)
- Intestinal parasites: Adult hookworm* (*Ancylostoma caninum*), roundworm, and whipworm
Is Trifexis Right for Your Dog?
Trifexis is beneficial for dogs who spend time outdoors or live with outdoor pets, as well as indoor dogs that can still be exposed to parasites. The American Heartworm Society (AHS) and the Companion Animal Parasite Council (CAPC) recommend annual testing and year-round heartworm prevention.
Key Threats to Your Dog's Health:
Fleas:
- Provides fast relief, killing fleas within 30 minutes and preventing infestations all month.
- Alleviates discomfort like scratching, chewing, biting, fur loss, and restlessness.
- Helps prevent flea allergy dermatitis (FAD).
- Severe infestations can cause anemia.
Heartworm Disease:
- Transmitted by mosquitoes and reported in all 50 states.
- Symptoms may include coughing, sluggishness, and difficulty breathing, but can be absent.
- Treatment is difficult, costly, and can have complications.
- Untreated, it can be fatal.
Intestinal Parasites:
- Can cause dehydration, anemia, diarrhea, and even death, especially in puppies.
- Dogs can contract them easily from the environment.
Heartworm Prevention:
Administer monthly, starting within 1 month of mosquito exposure and continuing for at least 3 months after the last exposure. Year-round administration is acceptable. When switching preventatives, give the first dose of Trifexis within 1 month of the last dose of the previous medication.
Flea Treatment and Prevention:
Begin treatment anytime, ideally one month before flea season and continue monthly through the end of the season. Year-round treatment is recommended in areas with constant flea activity. Treat all household pets to minimize reinfestation.
Intestinal Nematode Treatment and Control:
Trifexis treats and controls roundworms, hookworms, and whipworms. Advise clients on measures to prevent reinfection.
Contraindications:
There are no known contraindications to the use of Trifexis.
Warnings:
Not for human use. Keep out of reach of children. Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone (a component of Trifexis).
Precautions:
Heartworm testing is recommended prior to use. Treat infected dogs with an adulticide. Use with caution in breeding females and dogs with pre-existing epilepsy. Puppies less than 14 weeks old may experience a higher rate of vomiting.
Adverse Reactions:
The most common adverse reaction reported in clinical trials was vomiting, which was usually mild and self-limiting.
| Average Monthly Rate (%) of Dogs With Adverse Reactions | ||
|---|---|---|
| Adverse Reaction | TRIFEXIS Chewable Tabletsa | Active Control Tabletsa |
| Vomiting | 6.13 | 3.08 |
| Pruritus | 4.00 | 4.91 |
| Lethargy | 2.63 | 1.54 |
| Diarrhea | 2.25 | 1.54 |
| Dermatitis | 1.47 | 1.45 |
| Skin Reddening | 1.37 | 1.26 |
| Decreased appetite | 1.27 | 1.35 |
| Pinnal Reddening | 1.18 | 0.87 |
Storage Information:
Store at 20-25°C (68-77°F), excursions permitted between 15-30°C (59-86°F).
FAQ
Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.
Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.
Trifexis is indicated to treat and control intestinal parasite infections of adult hookworms, roundworms and whipworms in dogs. In occasional cases, it is possible that you might see intestinal worms being expelled in your dog's stool, this means Trifexis is working. If you have questions, consult your veterinarian for measures you can take to prevent a reinfection of intestinal parasites.
Hookworm (A. caninum), roundworm (T. canis, T. leonina), whipworm (T. vulpis) and tapeworm (T. pisiformis, E. multilocularis, E. granulosus and D. caninum)
Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, itching, hyperactivity. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to your pet. The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects.
Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.
Trifexis has been demonstrated to be safe in healthy dogs when used according to label directions. Spinosad, one of its active ingredients, is produced by a bacterium first isolated from natural sources (a soil sample collected in the Caribbean).1 Spinosad selectively targets the nervous system of the flea (and other insects) due to differences in the targeted receptors compared to mammalian nervous systems.2 However, as with all medications, sensitivities due to individual animals can occur, sometimes resulting in side effects. See the Trifexis label for complete safety information.
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.3
Spinosad and milbemycin oxime are the two active ingredients in Trifexis.
Administer Trifexis with food for maximum effectiveness. Trifexis is a chewable beef-flavored tablet that can be given as a treat.
Trifexis kills fleas on dogs before they can lay eggs when used monthly and according to the label directions. Remember that all animals in the household should be treated with an approved flea product to help control the flea population. Your dog can continue to be exposed to fleas that live in the environment. When fleas jump onto and bite your dog, they will be killed by Trifexis. If, within a month after your dog receives Trifexis, you see fleas on your dog, they are most likely new fleas. These new fleas will be killed before they can produce eggs that contaminate the environment. Continued monthly use of Trifexis can protect against any new infestations.
You may maintain normal activities and interactions with your dog.
No, Trifexis is not approved for use in cats. Trifexis was developed exclusively for administration to dogs.
Reviews
Review Summary
4.8
95 Reviews
5
88% (84)
4
7% (7)
3
2% (2)
2
1% (1)
1
1% (1)
98% Recommend this product (93 of 95 responses)
By Steve
Atlanta
Competitive Price and High Quality Customer Service
October 30, 2020
Second time I’ve used them and despiteonline, account history and Rx issues theydid a great job and exceeded my expectations in addition to best pricing.My go to for pet needs!
Merchant Response:Thanks Steve! We are striving to be better than we were yesterday. Enjoy the Trifexis and we'll see you next time.
By Keven
Florida
Great Price
November 23, 2024
Been using this established product and EntirelyPets had the best price, that I've ever found. The process was easy and the shipping was extremely fast.
By Wy
Texas
Great service
November 23, 2024
My order was here very quick and it was exactly what I ordered
By Sandra C.
Tampa Florida
Flea Meds
July 26, 2024
This medication works really, really well. I'm both fleas and heartworms. It's easy to give. I used to get it through my vet but it costs $25 more per pill so I started getting it through this company.
By steve
keokuk
great price
April 17, 2024
best price i could find
By Texassportsman
Temple, Texas
Easy!
March 24, 2024
It was was quick and easy, the customer service was excellent.
By Michael
Oregon
Best Price!
January 29, 2024
Received my dog's Rx quickly and paid the best price available, thanks!
By Laurie
Apple Valley, CA
Easy to Use and it Works
January 23, 2024
I have been using Trifexis for years on 3 dogs and none have ever had an issue with fleas or any type of worm. This is the best evidence for its efficacy. I highly recommend. Tip: check back at different times for sales.
Pros
- It works
Cons
- Expensive but they're all expensive.
By Frances W.
Florida
Honeys heartworm and flea medication
October 15, 2023
I like this Pharmacy they reach out for my dogs prescription several times inform me about it too I'd recommend this site. Can't wait a minute here
By Shaun M.
Alabama
Save some money
September 29, 2023
Saved over my local vet. Staff was very helpful. Shipping was normal. If you want to cut out your over priced vet call entirelypetspharmacy.con
Pros
- Great price
Cons
- None
By Timothy
Edgewater, Fla.
Good service
August 17, 2023
Good service, great communication, good price.
By Joseph G.
Houston, Texas
Prompt service
August 2, 2023
Entirely pets is a great no hassle company. They take care of the logistics with your veterinarian, and your order is delivered promptly.
By Eileen
Santa Monica, CA
Trifexis
June 18, 2023
Ginger's been on this medication for years without a problem. And sans fleas!!
Merchant Response:Ginger is such a cutie with her toy. Glad to hear you got the Rx resolved. =)
Pros
- The EPP staff were great. We had problems getting the Rx approved by my veterinary hospital because their staff failed to carefully look in Ginger's chart to see that her heartworm test was negative within the past year. Once they notified me, I got on the stick to get them to look carefully and worked with the EPP staff to get the faxed Rx appropriately signed. It took patience and perseverance but I have both and so do the EPP staff. All got resolved but they let me know by email and phone so I could get things resolved.
Cons
- None
By ELIZABETH
Bunker Hill, WV
Order takes forever
May 23, 2023
I ordered this in hopes it would only take the 4-6 days they say. It took two weeks. My order didn't come til May 8th and so my pets were late getting their monthly. Today I finaly got someone on the phone and he says he will change the Auto ship date. Then I receive the shipping order status for last months order and not this months. I feel like cancelling my order and going some where else.
Pros
- I got my order
Cons
- Can't check my account as the information doesn't update. Didn't come on time. Can never get someone on phone.
By Barbara G.
Nipomo, California
Trifexis
January 27, 2023
I have been giving my dog this medication for several years now and I find the best price at Entirely Pet Pharmacy. I'm on a very fixed income so I use to shop around for the best buy. I'm so happy to have found Entirely Pets Pharmacy working with them have been a pleasure they are so caring and answer any questions I may have had. Thank you Barbara Giniewicz and Ziggy
Merchant Response:Hello Barbara,
Thank you for the feedback, we try our best to over quality products at a great value.
Sincerely,
EntirelyPets Pharmacy
By Sondra K.
Vinton, La
Trifexes
January 22, 2023
This product works great My pups also have skin problems and it helps with that ad well.
By Franchesca
Brandon, FL
Great Product
January 5, 2023
This has been the preferred method of flea and heart worm control for my dog. No reactions and easy to give to my dog. Will continue to use!
By Tom
Portland, Oregon
Good product. Been using 10+ years.
August 20, 2022
I started using Trifexis when my dog was old enough to have it prescribed. She will be 11 in November. I’ve been satisfied with the results of the product all these years. The only thing I would say is curious is the product is advertised as chewable, and in all these years I haven’t been able to get my dog to chew the tablet! I just place it deep in her mouth and stroke her throat.
Merchant Response:Tom, we are glad you found a delivery system that works.
By Roz
Indiana
Trifexis
April 22, 2022
We have used this product on several of our pet dogs with no side effects. We also use it year around for protection. Good results easy to give orally to pet.
Pros
- Easy chewable tab. Year round protection given once a month. No side effects for any of our pet dogs.
Cons
- Watch for any side effects or allergies. Always check with your vet.
By Jeryl
Sandy OR
Patsy’s Medication Order
April 10, 2022
The order was made quickly online and I received Patsy’s medication within 2 days. The price for this product was affordable. Thank you for your outstanding service. I will continue to buy from your company. Kind regards, Jeryl
By Kayla
San Marcos, TX
Great for my fur baby
January 4, 2022
I love trifexis for my fur baby because I know that it takes care of him and it lasts a whole month. I love EntirelyPets pharmacy because it has everything I need to take care of my pup.
By Kimberly
Florida
Medication
May 19, 2021
Very easy to order and fast delivery! Very happy with this company
By Pam
Inglis Fl
Trifexis
March 16, 2021
The Entirely pets pharmacy website was easy to manage. They took info on my pets and their vet, to get the prescription. Then they mailed our Trifexis in good time. The dogs took their pills wrapped in lunch meat. Worked on my dogs just fine... I took advantage of ordering the 12 month supply for each dog. My only concern was the price, Trifexis needs to be able to trim their expensive prices!!!
Pros
- Easy to give
- Takes care of both fleas and heartworm
Cons
- Price
By Micah H.
Alabama
Easy way to treat your dog for flea, tick, and heart worms
January 25, 2021
I have been very pleased with Trixfexis. My dog does not like taking medicine so having the option to have flea, tick, and heart worm into one pill makes it much easier on both of us.
Pros
- All medications rolled into one
Cons
- Does not taste great, so even though it is a chewable tablet my dog will not eat it.
By Tracy K.
Calabash NC
Trifexis Order
January 7, 2021
Great Product plane and simple as that!! It gets No Better then that except, if you have ticks in your yard.
Pros
- Great Product and would recommend Entirely Pets to anyone of my Friends or Family members. I have been using Trifexis for the 2 years I've had my Dog and I've never seen any fleas on her this is a great product and it works well.
- Tracy K.
Cons
- The Only downfall to Trifexis is that, if you have ticks in your yard Trifexis doesn't protect against them, other then that it cover everything else.
By Tawnie M.
Texas
Texting overload/Overpriced
January 6, 2021
I felt pressured by my vet (now ex-vet) to purchase this overpriced medication for my dog (probable because they get a kickback). I don’t know if it’s effective, how would I? Now, I am being bombarded with texts from your company. I don’t want to hear from you. I find your company very annoying.
By Gale T.
Jacksonville, Florida
Trifexis
January 6, 2021
My puppies have been on Trifexis for many years. By ordering online through Entirely Pets Pharmacy you get the same product for less. I look forward to their sales.
Pros
- Order online instead trip to vet
Cons
- Cannot fax or email RX-must mail original
By Karen H.
AL
Trifexis
December 23, 2020
I ordered Trifexis on line as my vet no longer carries this product. It was easy to order, they followed up with faxing the prescription to my vet and let me know when it was shipped. Due to the Christmas rush and Covid, it took a little longer to get there but arrived in plenty of time for my dog's monthly dose.
By Karena
LA
Works well
October 25, 2020
No fleas or heart worm in our house :)
By annmarie
orlando, fl
I've used this for years
October 19, 2020
The dogs don't like this so we put it in peanut butter. No adverse side effects. Takes care of everything except mange in one big pill
