Interceptor Plus for Dogs - milbemycin oxime|praziquantel - 25.1-50 lbs. (1 chew) - [Heartworm Prevention]

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Interceptor Plus for Dogs is a monthly chewable tablet used for the prevention of heartworm disease and the treatment and control of roundworms, hookworms, whipworms, and tapeworms in dogs. It is a flavored chewable tablet that is easy to administer and can be given with or without food. Interceptor Plus is available in four different strengths, depending on the weight of your dog, and is safe for use in dogs 6 weeks of age and older. Interceptor Plus prevents heartworm disease in dogs when administered monthly and treats and controls roundworms, hookworms, whipworms, and tapeworms. The chewable tablet is flavored, making it palatable and easy to administer. It is administered monthly for continuous protection against heartworm disease and intestinal parasites, and is safe for use in dogs 6 weeks of age and older.

Key Features:

• Heartworm Prevention: Interceptor Plus prevents heartworm disease in dogs when administered monthly.
• Broad-Spectrum Parasite Control: It treats and controls roundworms, hookworms, whipworms, and tapeworms in dogs.
• Flavored Chewable Tablet: The chewable tablet is flavored, making it palatable and easy to administer.
• Monthly Dosage: It is administered monthly for continuous protection against heartworm disease and intestinal parasites.
• Safe for Dogs: Interceptor Plus is safe for use in dogs 6 weeks of age and older.

Indications:

• Prevention of Heartworm Disease: Interceptor Plus is used to prevent heartworm disease caused by the parasitic worm Dirofilaria immitis. It kills the immature heartworm larvae (microfilariae) that are transmitted to dogs through mosquito bites, preventing them from developing into adult heartworms.
• Control and Treatment of Roundworms: Interceptor Plus is effective against the gastrointestinal roundworms Toxocara canis and Toxascaris leonina. It helps control and treat these common intestinal parasites in dogs, preventing their growth and reproduction.
• Control and Treatment of Hookworms: Interceptor Plus is indicated for the control and treatment of Ancylostoma caninum and Uncinaria stenocephala, which are hookworms that can infect dogs. These parasites can cause anemia and other health issues in dogs, and Interceptor Plus helps eliminate and prevent their infestation.
• Control and Treatment of Whipworms: Whipworms (Trichuris vulpis) can cause gastrointestinal issues and inflammation in dogs. Interceptor Plus is effective in controlling and treating whipworm infections, reducing the number of adult worms in the intestine.
• Control and Treatment of Tapeworms: Interceptor Plus contains praziquantel, which is effective against tapeworms in dogs, including Dipylidium caninum and Taenia pisiformis. It causes muscle spasms and paralysis in the tapeworms, leading to their expulsion from the dog's body.

It's important to note that Interceptor Plus is meant for dogs and should not be used in other animal species or humans. The dosage and administration instructions should be followed as prescribed by a veterinarian to ensure the safety and effectiveness of the treatment.

How it works:

Interceptor Plus works through the combined action of its active ingredients, milbemycin oxime and praziquantel, to provide broad-spectrum parasite control in dogs. Here's how it works:

1. Milbemycin Oxime: This ingredient primarily targets heartworms, as well as other intestinal parasites such as roundworms, hookworms, and whipworms. When administered to a dog, milbemycin oxime is absorbed into the bloodstream, where it circulates throughout the body. It works by interfering with the nerve transmission in the parasites, leading to paralysis and ultimately their death. It prevents heartworm larvae from developing into adult heartworms, thus protecting dogs from heartworm disease. It also controls and treats the other mentioned intestinal parasites.
2. Praziquantel: This ingredient specifically targets tapeworms. After ingestion, praziquantel is rapidly absorbed from the dog's digestive system into the bloodstream. It then targets the tapeworms in the dog's intestine. Praziquantel disrupts the tapeworms' integument, leading to severe muscle spasms and paralysis. This paralysis weakens the tapeworms' grip on the intestinal wall, allowing them to be expelled from the dog's body through normal bowel movements.

By combining milbemycin oxime and praziquantel, Interceptor Plus provides comprehensive protection against heartworms, roundworms, hookworms, whipworms, and tapeworms. It effectively controls and treats these parasites, helping to maintain the health and well-being of dogs.

It's important to follow the veterinarian's instructions for dosage and administration to ensure the proper effectiveness of Interceptor Plus and to give the medication regularly as prescribed for optimal parasite prevention and control.

Specifications:

• Product Type: Chewable tablet
• Active Ingredients: Milbemycin oxime, praziquantel
• Dosage Form: Oral
• Available Sizes: Available in packages of 6 or 12 tablets
• Weight Range: Available for dogs of various weights, ranging from 2 to 100 pounds
• Age Range: Safe for use in puppies as young as 6 weeks old
• Frequency: Administer once a month, year-round
• Storage: Store at room temperature, away from moisture and heat
• Administration: Administer orally with or without food, as directed by your veterinarian

View Interceptor Plus Drug Facts Sheet

Interceptor Plus should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, and 2.28 mg/lb (5 mg/kg) praziquantel. For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes (see Effectiveness).

Interceptor Plus may be offered to the dog by hand or added to a small amount of dog food. The chewables should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Heartworm Prevention:

Interceptor Plus should be administered at monthly intervals beginning within 1 month of the dog's first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog's last seasonal exposure (see Effectiveness). Interceptor Plus may be administered year-round without interruption. When switching from another heartworm preventative product to Interceptor Plus, the first dose of Interceptor Plus should be given within a month of the last dose of the former product.

Intestinal Nematode and Cestode Treatment and Control:

Dogs may be exposed to and can become infected with roundworms, whipworms, hookworms, and tapeworms throughout the year, regardless of season or climate. Clients should be advised of appropriate measures to prevent reinfection of their dog with intestinal parasites. Because the prepatent period for E. multilocularis may be as short as 26 days, dogs treated at the labeled monthly intervals may become reinfected and shed eggs between treatments.

Contraindications:

There are no known contraindications to the use of Interceptor Plus.

Warnings:

Not for use in humans. Keep this and all drugs out of the reach of children.

Precautions:

Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention (see Effectiveness).

Prior to administration of Interceptor Plus, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Interceptor Plus is not effective against adult D. immitis.

Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.

Do not use in puppies less than six weeks of age.

Do not use in dogs or puppies less than two pounds of body weight.

The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females. Studies have been performed with milbemycin oxime alone (see Animal Safety).

Information for Owner or Person Treating Animal:

Echinococcus multilocularis and Echinococcus granulosus are tapeworms found in wild canids and domestic dogs. E. multilocularis and E. granulosus can infect humans and cause serious disease (alveolar hydatid disease and hydatid disease, respectively). Owners of dogs living in areas where E. multilocularis or E. granulosus are endemic should be instructed on how to minimize their risk of exposure to these parasites, as well as their dog's risk of exposure. Although Interceptor Plus was 100% effective in laboratory studies in dogs against E. multilocularis and E. granulosus, no studies have been conducted to show that the use of this product will decrease the incidence of alveolar hydatid disease or hydatid disease in humans. Because the prepatent period for E. multilocularis may be as short as 26 days, dogs treated at the labeled monthly intervals may become reinfected and shed eggs between treatments.

Effectiveness:

Heartworm Prevention:

In a well-controlled laboratory study, Interceptor Plus was 100% effective against induced heartworm infections when administered once monthly for 6 consecutive months. In well-controlled laboratory studies, neither one dose nor two consecutive doses of Interceptor Plus provided 100% effectiveness against induced heartworm infections.

Intestinal Nematodes and Cestodes Treatment and Control:

Elimination of the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxocara canis, Toxascaris leonina), whipworm (Trichuris vulpis) and tapeworm (Echinococcus multilocularis, Echinococcus granulosus, Taenia pisiformis and Dipylidium caninum) infections in dogs was demonstrated in well-controlled laboratory studies.

Palatability:

In a field study of 115 dogs offered Interceptor Plus, 108 dogs (94.0%) accepted the product when offered from the hand as if a treat, 1 dog (0.9%) accepted it from the bowl with food, 2 dogs (1.7%) accepted it when it was placed in the dog's mouth, and 4 dogs (3.5%) refused it.

Animal Safety:

Interceptor Plus:

In a repeated dose safety study, 40 ten-week-old puppies (10 per group) were dosed with either a sham dose (0X) or 1, 3, or 5X the maximum label exposure of Interceptor Plus every 14 days for a total of seven treatments. Ataxia, lethargy, and salivation were seen in the 3X and 5X treated dogs following each of the seven doses. Vomiting was seen in all treatment groups but had a higher incidence in the 3X and 5X treatment groups.

In a repeated dose safety study, 64 six-week-old puppies (16 per group) were dosed with either a sham dose (0X) or 1, 3, or 5X the maximum label exposure of Interceptor Plus every 14 days for a total of four treatments. Lethargy was observed in all groups. Ataxia was observed in the three treated groups, including one dog in the 1X treated group. For both lethargy and ataxia the incidence and duration increased in the 3X and 5X groups. These signs were observed during the first 24 hours following treatment. Salivation and tremors were observed in the 3X and 5X treated dogs beginning immediately after dosing and up to six hours post dose. Vomiting was only observed in the 5X treatment group on most, but not all, treatment days.

For Interceptor Plus the maximum exposure based on product dosing is 2.5 mg/kg for milbemycin oxime and 25.1 mg/kg for praziquantel, which is higher than the minimum effective dose used in the safety studies for milbemycin oxime (see below).

Milbemycin Oxime:

Two studies were conducted in heartworm-infected dogs treated with milbemycin oxime. Mild, transient hypersensitivity reactions were observed in dogs with high microfilariae counts (see Precautions).

Safety studies in pregnant dogs demonstrated that doses of 0.6X the maximum exposure dose of Interceptor Plus, (1.5 mg/kg of milbemycin oxime), administered daily from mating through weaning, resulted in measurable concentrations of milbemycin oxime in milk. Puppies nursing these females demonstrated milbemycin oxime-related effects (depression, decreased activity, diarrhea, dehydration, nasal discharge). A subsequent study, which evaluated the daily administration of 0.6X the maximum exposure dose of Interceptor Plus, from mating until one week before weaning, demonstrated no effects on the pregnant females or their litters. A study, in which pregnant females were dosed once, at 0.6X the maximum exposure dose of Interceptor Plus before, on the day of, or shortly after whelping, resulted in no effects on the puppies.

Some nursing puppies, at 2, 4, and 6 weeks of age, administered oral doses of 9.6 mg/kg milbemycin oxime (3.8X the maximum exposure dose of Interceptor Plus) exhibited tremors, vocalization, and ataxia. These effects were all transient and puppies returned to normal within 24 to 48 hours. No effects were observed in puppies administered 0.5 mg/kg milbemycin oxime (minimum label dose).

A rising-dose safety study conducted in rough-coated Collies resulted in ataxia, pyrexia, and periodic recumbency in one of fourteen dogs administered milbemycin oxime at 12.5 mg/kg (5X the maximum exposure dose of Interceptor Plus). Prior to receiving the 12.5 mg/kg dose on day 56 of the study, all animals had undergone a dosing regimen consisting of 2.5 mg/kg milbemycin oxime on day 0, followed by 5.0 mg/kg on day 14, and 10.0 mg/kg on day 32. No adverse reactions were observed in any of the Collies treated with doses less than 12.5 mg/kg.

Storage:

Store at room temperature, between 59° and 77°F (15-25°C).