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Dormosedan

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Description

Dormosedan for Horses (detomidine hydrochloride) is a nonnarcotic, synthetic equine sedative and analgesic that contains the active ingredient detomidine hydrochloride.

Medical Use

Use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings.

Animals Treated

Horses

Key Benefits

  • Predictable and effect sedation
  • Non-narcotic sedation with a wide margin of safety
  • Simple dosing with 1 or 2 mL per 1,100 lbs horse
  • 80-100x greater potency than xylazine
  • Effects can be maintained for up to 2 hours

Ingredients

Active ingredient

Detomidine Hydrochloride

Directions

View Dormosedan Injection product label.

Dosage and Administration

For Sedation

Administer Dormosedan IV or IM at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Dormosedan per 100 kg or 220 lb), depending on the depth and duration of sedation required. Onset of sedative effects should be reached within 2-4 minutes after IV administration and 3-5 minutes after IM administration. Twenty mcg/kg will provide 30-90 minutes of sedation and 40 mcg/kg will provide appromixately 90 to 2 hours of sedation.

For Analgesia

Administer Dormosedan IV or IM at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Dormosedan per 100 kg or 220 lb), depending on the depth and duration of sedation required. Twenty mcg/kg will usually begin to take effect in 2-4 minutes and provide 30-45 minutes of analgesia. The 40 mcg/kg dose will also begin to take effect 204 minutes and provide 45-75 minutes of analgesia.

For Both Sedation and Analgesia

Administer Dormosedan IV at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Dormosedan IV per 100 kg or 220 lb), depending on the depth and duration of sedation and analgesia required.

Before and after injection, the animal should be allowed to rest quietly.

Storage

Store at controlled room temperature 15=30° C (59-86° F) in the absence of light. Keep away from pets and children.

Overdosage

Detomidine hydrochloride is tolerated in horses at up to 200 mcg/kg of body weight (10 times the low dosage and 5 times the high dosage). In safety studies in horses, detomidine hydrochloride at 400 mcg/kg of body weight administered daily for 3 consecutive days produced microscopic foci of myocardial necrosis in 1 of 8 horses.

Human Safety Information

Buscopan is not recommended for use in horses intended for food. Not for human use. Keep out of reach of children.

Precautions

Before administration, careful consideration should be given to administering Dormosedan to horses approaching or in endotoxic or traumatic shock, to horses with advanced liver or kidney disease, or to horses under stress from extreme heat, cold, fatigue, or high altitude. Protect treated horses from temperature extremes. Some horses, although apparently deeply sedated, may still respond to external stimuli. Routine safety measures should be employed to protect practitioners and handlers. Allowing the horse to stand quietly for 5 minutes before administration and for 10-15 minutes after injection may improve the response to Dormosedan.

Dormosedan is a potent ?2-agonist, and extreme caution should be exercised in its use with other sedative or analgesic drugs for they may produce additive effects.

When using any analgesic to help alleviate abdominal pain, a complete physical examination and diagnostic work-up are necessary to determine the etiology of the pain.

Food and water should be withheld until the sedative effect of Dormosedan has worn off.

Contraindications

Dormosedan should not be used in horses with pre-existing AV or SA block, with severe coronary insufficiency, cerebrovascular disease, respiratory disease, or chronic renal failure. Intravenous potentiated sulfonamides should not be used in anesthetized or sedated horses as potentially fatal dysrhythmias may occur.

Possible Side Effects

Horses treated with Dormosedan exhibit hypertension. Bradycardia routinely occurs 1 minute after injection. The relationship between hypertension and bradycardia is consistent with an adaptive baroreceptor response to the increased pressure and inconsistent with a primary drug-induced bradycardia. Piloerection, sweating, salivation, and slight muscle tremors are frequently seen after administration. Partial transient penis prolapse may be seen. Partial AV and SA blocks may occur with decreased heart and respiratory rates. Urination typically occurs during recovery at about 45-60 minutes posttreatment, depending on dosage. Incoordination or staggering is usually seen only during the first 3-5 minutes after injection, until animals have secured a firm footing.

Because of continued lowering of the head during sedation, mucus discharges from the nose and, occasionally, edema of the head and face may be seen. Holding the head in a slightly elevated position generally prevents these effects.

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