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Percorten-V Injectable Suspension for Dogs

Item# IWM030927
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Recurring Saings in EprxAUTOSHIP & SAVE[Details]
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Percorten-V (desoxycorticosterone pivalate) is the only medication approved by the FDA for treating Canine Addison's Disease (hypoadrenocorticism).

Medical Use

Treatment of Canine Addison's Disease

Animals Treated


Key Benefits

  • FDA-Approved
  • Well tolerated
  • Low incidence of side effects
  • Easy-to-use injectable suspension

How It Works

Canine Addison's Disease is a condition where a dog's adrenal glands don't work properly. Normal adrenal glands produce mineralocorticoids that help regulate many bodily functions such as metabolism, blood pressure, and stress response. Percorten-V is a replacement therapy for the mineralocorticoid deficiency in dogs with Addisons disease.


Do not use any preventative vaccines such as Percorten-V without checking with your veterinarian. Talk to your veterinarian about any side effects that seem unusual or bothersome to your pet. Percorten-V should not be stopped suddenly. Percorten-V should not be given to pregnant dogs, or dogs suffering from congestive heart disease, severe renal disease or edema.


Active Ingredient

Desoxycorticosteron pivalte


25 mg/mL

Other Ingredients

  • Methylcellulose, 10.5 mg/mL
  • Sodium carboxymethlycellulose, 3 mg/mL
  • Polysorbate 80, 1 mg/mL
  • Sodium chloride with 0.002% thimerosal as preservative in water for injection, 8 mg/mL
  • Directions

    View Percorten-V injectable suspension for dogs product insert.

    In treating canine hypoadrenocoricism, Perforten-V replaces the mineralcorticoid hormones only. Glucocorticoid replacement must be supplied by small dail doses of glucocorticoid hormones (e.g., prednisone or prednisolone (0.2 - 0.4 mg/kg/day).

    Dosage requirements are variable and must be individualized on the basis of the response of the patient to therapy. Being treatment with Percorten-V at a dose of 1.0 mg per pound of body weight every 25 days. In some patients the dose may be reduced.

    Serum sodium and potassium levels should be monitured to assure the animal is properly compensated. Most patients are well controlled with a dose range of 0.75 to 1.0 mg per pound of body weight, given every 21 to 30 days.

    The well-controlled patient will have normal electrolytes at 14 days after administration or may exhibit slight hyponatremia and hyperkatemia. This needs no additional therapy as long as the patient is active and eating normally. Watch closely for depression, lethargy, vomiting, or diarrhea which indicate a probable glucocorticoid deficiency.

    At the end of the 25-day dosing interval. the patient should be clinically normal and have normal serum electrolytes. Alternatively, they may have slight hyponatremia, and slight hyperkalemia. This constellation of signs indicate that the dosage and dosage interval should not be altered.

    If the dog is not clinically normal or serum electrolytesare abnormal, then the dosage interval should be decreased 2-3 days.

    Occasionally, dogs on Percorten-V therapy may develop polyuria and polydipsia (PU/PD). This usually indicates excess glucocorticoid, but may also indicate a Percorten-V excess. It is prudent to begin by decreasing the glucocorticoid dose first. If the PU/PD persists, then decrease the dose of Percorten-V without changing the interval between doses.

    • Percorten-V is a prescription medication that is commonly used by veterinarians in dogs for the treatment of Addison’s disease.
    • Percorten-V is a corticosteroid used to treat conditions, such as Addison’s disease, in which the body does not produce enough of its own steroids.
    • Percorten-V is available as a 4 ml multi-dose vial containing 25mg/ml and is administered IM (intramuscularly). Do not administer IV (intravenously).
    • Percorten-V should not be stopped suddenly. Irritation at the injection site may occur.

    Store this product at room temperature, away from moisture and heat. Keep away from children and pets.

    Do not use this drug in pregnant dogs. Do not use in dogs suffering from congestive heart disease, severe renal disease, or edema.

    Keep this and all drugs out of the reach of children. In case of human consumption, contact a physician or Poison Control Center immediately.

    Some dogs are more sensitive to Percorten-V and may exhibit side effects more than others.

    If any of the following serious side effects occur, stop giving Percorten-V and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), increased blood pressure or sudden weight gain. Other less serious side effects may occur. Continue giving Percorten-V and talk to your veterinarian if your pet experiences insomnia, nausea, vomiting or stomach upset, fatigue, muscle weakness or joint pain, problems with diabetes control or increased hunger or thirst. Other side effects that occur rarely, usually with high doses of Percorten-V include thinning of the skin, cataracts, glaucoma, behavior changes. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.


    Give this medication exactly as directed by your veterinarian. Do not give more or less than is prescribed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. The usual dose of Percorten-V in dogs is 1mg/pound given by IM injection every 25 days. Store Percorten-V at room temperature away from moisture and heat. Keep this medication away from children and pets.
    Give the missed dose as soon as you remember. However, if it almost time for the next dose, skip the dose missed and give only the next regularly scheduled dose. Do not give a double dose of this medication.
    Seek emergency veterinary medical treatment. Symptoms of overdose may include swelling or water retention, high blood pressure, weight gain, low levels of potassium in the blood, and Cushing's disease.
    Do not give any other over the counter or prescription medications, including herbal products, during treatment with Percorten-V without first talking to the veterinarian. Tell your veterinarian if your pet is taking Phenobarbital, furosemide, insulin or glipizide, phenytoin, digoxin, warfarin, or aspirin. Drugs other than those listed may interact with Percorten-V resulting in side effects or altered effectiveness.
    Do not give Percorten-V to your pet if the pet has a serious bacterial, viral or fungal infection. Percorten-V weakens the pet's immune response and its ability to fight infections. Tell your veterinarian if your pet has kidney or liver disease, heart disease, stomach ulcers, hypothyroidism, diabetes mellitus or any other medical conditions. Also tell your veterinarian if the pet is pregnant or lactating.


    Review Summary
    1 Reviews
    100% (1)
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    100% Recommend this product (1 of 1 responses)
    By Joanne
    Fremont, California
    Excellent Service
    November 9, 2017
    Entirely Pets was very good about immediately working with the doctor to get permission to fill this prescription. They handled it very well, and I would do business with them again.
    • Great service.
    • none

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