Percorten-V Injectable Suspension for Dogs (25mg/ml) - [Addison Disease Treatment]

In treating canine hypoadrenocoricism, Perforten-V replaces the mineralcorticoid hormones only. Glucocorticoid replacement must be supplied by small dail doses of glucocorticoid hormones (e.g., prednisone or prednisolone (0.2 - 0.4 mg/kg/day).

Dosage requirements are variable and must be individualized on the basis of the response of the patient to therapy. Being treatment with Percorten-V at a dose of 1.0 mg per pound of body weight every 25 days. In some patients the dose may be reduced.

Serum sodium and potassium levels should be monitured to assure the animal is properly compensated. Most patients are well controlled with a dose range of 0.75 to 1.0 mg per pound of body weight, given every 21 to 30 days.

The well-controlled patient will have normal electrolytes at 14 days after administration or may exhibit slight hyponatremia and hyperkatemia. This needs no additional therapy as long as the patient is active and eating normally. Watch closely for depression, lethargy, vomiting, or diarrhea which indicate a probable glucocorticoid deficiency.

At the end of the 25-day dosing interval. the patient should be clinically normal and have normal serum electrolytes. Alternatively, they may have slight hyponatremia, and slight hyperkalemia. This constellation of signs indicate that the dosage and dosage interval should not be altered.

If the dog is not clinically normal or serum electrolytesare abnormal, then the dosage interval should be decreased 2-3 days.

Occasionally, dogs on Percorten-V therapy may develop polyuria and polydipsia (PU/PD). This usually indicates excess glucocorticoid, but may also indicate a Percorten-V excess. It is prudent to begin by decreasing the glucocorticoid dose first. If the PU/PD persists, then decrease the dose of Percorten-V without changing the interval between doses.

• Percorten-V is a prescription medication that is commonly used by veterinarians in dogs for the treatment of Addison’s disease.
• Percorten-V is a corticosteroid used to treat conditions, such as Addison’s disease, in which the body does not produce enough of its own steroids.
• Percorten-V is available as a 4 ml multi-dose vial containing 25mg/ml and is administered IM (intramuscularly). Do not administer IV (intravenously).
• Percorten-V should not be stopped suddenly. Irritation at the injection site may occur.

Store this product at room temperature, away from moisture and heat. Keep away from children and pets.

Do not use this drug in pregnant dogs. Do not use in dogs suffering from congestive heart disease, severe renal disease, or edema.

Keep this and all drugs out of the reach of children. In case of human consumption, contact a physician or Poison Control Center immediately.

Some dogs are more sensitive to Percorten-V and may exhibit side effects more than others.

If any of the following serious side effects occur, stop giving Percorten-V and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), increased blood pressure or sudden weight gain. Other less serious side effects may occur. Continue giving Percorten-V and talk to your veterinarian if your pet experiences insomnia, nausea, vomiting or stomach upset, fatigue, muscle weakness or joint pain, problems with diabetes control or increased hunger or thirst. Other side effects that occur rarely, usually with high doses of Percorten-V include thinning of the skin, cataracts, glaucoma, behavior changes. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.