Palladia is an oral receptor tyrosine kinase (RTK) inhibitor that blocks the activity of multiple receptors on cancer cells and blood vessels. The active ingredient in Palladia is toceranib. It is approved for use in dogs with recurrent, cutaneous mast cell tumors (Patnaik grade II or III) with or without regional lymph node involvement.
Palladia (toceranib phosphate) Tablets for Dogs
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Description
Palladia® (toceranib phosphate) is an FDA-approved antiproliferative and antiangiogenic agent used for the treatment of Patnaik grade II or III cutaneous mast cell tumors in dogs, with or without regional lymph node involvement. This targeted therapy uses toceranib phosphate to inhibit tumor growth and can serve as a non-traditional alternative to chemotherapy for various other types of canine tumors, including thyroid carcinomas and melanomas.
Palladia is available in 10 mg, 15 mg, and 50 mg strengths, making it easier to tailor the dose to your dog’s weight and condition. Each strength is available individually or in bottles of 30 tablets.
Key Features
- Treats Patnaik grade II or III recurrent cutaneous mast cell tumors in dogs
- Can be used as an alternative to traditional chemotherapy for certain other tumor types
- Available in three dosage strengths: 10 mg, 15 mg, and 50 mg
- Sold by individual tablet or in bottles of 30 for flexible treatment planning
How It Works
- Functions as an antiproliferative and antiangiogenic agent
- Helps reduce inflammation associated with malignant tumors
- Inhibits tyrosine kinase—disrupting both tumor cell activity and its supporting blood supply
Conditions Treated
- Primary indication: Mast cell tumors in dogs
- May also be used (off-label) to manage other cancers, including:
- Squamous Cell Carcinoma
- Metastatic Osteosarcoma
- Malignant Melanoma
- Anal Sac Adenocarcinoma
- Vaccine-Associated Fibrosarcoma
- Transitional Cell Carcinoma
- Thyroid Carcinoma
Ingredients
Active Ingredient
Toceranib
Directions
Dosage & Administration
Always provide the Client Information Sheet with the prescription. The recommended starting dose of Palladia is 3.25 mg/kg (1.48 mg/lb) of body weight, administered orally every other day.
If adverse reactions occur, your veterinarian may reduce the dose by 0.5 mg/kg, to a minimum of 2.2 mg/kg (1.0 mg/lb), or pause treatment for up to two weeks. Dose adjustments should be based on veterinary assessments, typically conducted weekly for the first six weeks, and approximately every six weeks thereafter.
Palladia may be given with or without food. Do not split or crush tablets.
Quick Tips
- Consult your veterinarian to determine the correct starting dose for your dog.
- Dose is based on body weight and may require adjustment over time.
- Administer Palladia every other day, as directed.
- Tablet reductions or dose interruptions may be used to manage side effects.
- Veterinary follow-ups are essential to monitor your pet’s response and safety.
Dosage Table
The dosage chart below outlines tablet combinations based on your dog’s weight. Your veterinarian will select the appropriate strength(s) to reach the target dose.
Note: Full dosage table available on product label. The below is for general guidance only.
| Pounds | Kilograms | Dose | 10 mg | 15 mg | 50 mg |
|---|---|---|---|---|---|
| 11.0 - 11.8 | 5.0 - 5.3 | 15 mg | 1 | ||
| 11.9 - 15.2 | 5.4 - 6.9 | 20 mg | 2 | ||
| 15.3 - 18.5 | 7.0 - 8.4 | 25 mg | 1 | 1 | |
| 18.6 - 22.0 | 8.5 - 10.0 | 30 mg | 2 | ||
| 22.1 - 25.4 | 10.1 - 11.5 | 35 mg | 2 | 1 | |
| 25.5 - 28.7 | 11.6 - 13.0 | 40 mg | 1 | 2 | |
| 28.8 - 32.2 | 13.1 - 14.6 | 45 mg | 3 | ||
| 32.3 - 35.5 | 14.7 - 16.1 | 50 mg | 1 |
Storage Directions
Store Palladia at controlled room temperature between 20°C to 25°C (68°F to 77°F). Keep out of reach of children and pets.
Contraindications
Do not use in dogs that are pregnant, lactating, or intended for breeding.
Warnings
Palladia may cause vascular dysfunction, which can lead to edema and thromboembolism, including pulmonary thromboembolism. If these signs occur, discontinue use until clinical symptoms and laboratory values return to normal. To maintain vascular stability, wait at least three days after stopping treatment before performing surgery.
Human Warnings
NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN.
Children should avoid contact with treated dogs, especially their feces, urine, or vomit. Adults should wear gloves and wash hands after handling the medication or waste. Avoid direct contact with broken or moistened tablets. Dispose of gloves and waste in sealed plastic bags.
If accidental eye exposure occurs, rinse thoroughly with water. In case of accidental ingestion, contact a physician immediately. Pregnant women, or those who may become pregnant, should take special care when handling Palladia, as it may interfere with blood vessel formation in the developing fetus and cause birth defects.
Potential Side Effects
In a U.S. clinical study of 151 dogs, the most commonly reported side effects included:
- Diarrhea
- Vomiting
- Anorexia (loss of appetite)
- Lethargy
- Lameness
- Weight loss
- Bloody stool
- Dehydration
- Itching (pruritus)
- Pigmentation changes
- Dermatitis
- Musculoskeletal disorders
FAQ
Palladia is a antineoplastic agent belonging to the receptor tyrosine kinase (RTK) inhibitor class of drugs.
Kinases are enzymes that catalyze the transfer of phosphate groups from ATP. Receptor tyrosine kinases (RTKs) are tyrosine kinases on the cell surface that are activated through binding of growth factors. Receptor tyrosine kinsases play a role in signaling pathways that govern normal cellular processes such as proliferation, migration, metabolism, and differentiation. Examples of RTKs include: platelet-derived growth factor receptor (PDGFR), vascular endothelial growth factor receptor (VEGFR), stem cell factor receptor (Kit). In normal cells, RTK activity is tightly controlled. In some cancerous conditions, abnormalities such as mutations can lead to abnormal activation of RTKs resulting in increased cellular proliferation and growth, prevention of apoptosis (cellular death) as well as increased angiogenesis and metastasis. The result of RTK dysfunction is phosphorylation of the kinase in the absence of an appropriate signal and constitutive signaling and abnormal promotion of cell growth and survival. These conditions promote tumor development, growth and progression.
Toceranib phosphate is a small molecule that has both direct antitumor and antiangiogenic activity. In non-clinical pharmacology studies, toceranib selectively inhibited the tyrosine kinase activity of several members of the split kinase receptor tyrosine kinase (RTK) family, some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. Toceranib inhibited the activity of Flk-1/KDR tyrosine kinase (vascular endothelial growth factor receptor, VEGFR2), platelet-derived growth factor receptor (PDGFR), and stem cell factor receptor (Kit) in both biochemical and cellular assays. Toceranib has been shown to exert an antiproliferative effect on endothelial cells in vitro. Toceranib treatment can induce cell cycle arrest and subsequent apoptosis in tumor cell lines expressing activating mutations in the split kinase RTK, c-Kit. Canine mast cell tumor growth is frequently driven by activating mutations in c-Kit.
Palladia is indicated for the treatment of Patnaik Grade II or III, recurrent, cutaneous mast cell tumors (MCT) with or without regional lymph node involvement in dogs.
Always provide Client Information Sheet with prescription. Administer an initial dosage of 3.25 mg/kg (1.48 mg/lb) body weight, orally every other day. Dose reductions of 0.5 mg/kg (to a minimum dose of 2.2 mg/kg (1.0 mg/lb) every other day) and dose interruptions (cessation of Palladia for up to two weeks) may be utilized, if needed, to manage adverse reactions. Adjust dose based on approximately weekly veterinary assessments for the first 6 weeks and approximately every 6 weeks, thereafter. Palladia may be administered with or without food. Do not split tablets.
During the clinical efficacy study, Palladia was administered concomitantly with other medications such as antimicrobials, H-2 receptor blockers, antihistamines, anti-emetics, non-steroidal anti-inflammatory drugs, locally-acting anti-ulcer medications, opiate gastro-intestinal motility modifiers, opioids, vaccines, anthelmintics, antiparasitics, and topical/ophthalmic/otic corticosteroid preparations. During the open-label phase only, 5 dogs received a brief course of short-acting corticosteroids. Specifically the most common concomitant treatments in the blinded and open label phase: Metronidazole, diphenhydramine, famotidine, metoclopramide, fluids, amoxicillin-clavulanic acid, cephalexin, ampicillin, enrofloxacin, sucralfate, omeprazole, carprofen, cimetidine, dolasetron mesylate, loperamide, ranitidine. A statistically higher number of Palladia treated dogs received metronidazole.
Reviews
Review Summary
5.0
4 Reviews
5
100% (4)
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100% Recommend this product (4 of 4 responses)
By william h.
columbia sc
Great service
April 9, 2015
great service and product availability and price
By Christine C.
Austin, TX
No side effects
November 10, 2023
We haven't had the post surgery ultra sound yet, but the have been no side effects.
By Riley's m.
Florida
Great discount
April 18, 2019
Fast service and price was less than half than they charge at the vets office. For those that are curious she has no side effects and she's happy and energetic.
Merchant Response:Hi, I am very happy to know that we were able to provide you with good service. I am happy to hear that your Dog Riley has no side effects using this product and it working for Riley. I want to thank you and Riley for using our Pharamcy to order from.
Pros
- Price
By Michelle
Ann Arbor, Michigan
Great price an super easy transaction
September 16, 2018
Best price anywhere for this canine cancer medication.
Pros
- Pharmacy will call your vet and obtain a faxed Rx for quick filling of your pets meds.