Palladia (toceranib phosphate)

Palladia is an antiproliferative and antiandiogenic agent used to treat Patnaik grade II or III, cutaneous mast cell tumors in dogs.

This medication uses toceranic phosphate to combat the effects of these recurrent tumors and works on both tumors with and without regional lymph node involvement. Palladia can also be used as an alternative to chemotherapy for other various types of tumors, including melanomas, thyroid carcinomas, and more.

Palladia is available in 10 mg, 15 mg, and 50 mg tabs to ensure that adjusting your dog’s dosage based on their weight is a simple manner. Each dosage is available for purchase by the tab or in a container of 30 tabs.

Key Features:

Treats Patnaik grade II or III recurrent, cutaneous mast cell tumors in dogs

Can be used as alternative to chemotherapy for other types of tumors

Available in three different dosages in singles doses or packs of 30

Product Uses:

Antiproliferative and antiangiogenic agent

Prevents tissue inflammation caused by malignant tumors

Inhibits tyrosine kinase, which kills the tumor cells directly and also interferes with the tumor’s blood supply

Conditions:

• For the treatment of dogs with mast cell tumors
• An alternative to chemotherapy for other types of tumors, including:
• Squamous cell carcinoma
• Metastatic osteosarcoma
• Malignant Melanoma
• Anal sac adrenocarcinoma
• Vaccine Associated Fibrosarcoma
• Transitional Cell Carcinoma
• Thyroid Carcinoma

Dosing:

You should consult a veterinarian to determine the exact dosage that is appropriate for your pet

The appropriate dosage will depend both on the size of your pet

Dosage will be adjusted over time as needed

More information on dosing should be available in the prescription information

Administration:

Administer doses orally every other day

Dose reductions and interruptions can be utilized as advised by your veterinarian

Your veterinarian should make weekly assessments to determine any necessary adjustments to your pet’s dosage

May be administered with or without food- tablets are not to be split and should be administered whole

Side Effects:

Diarrhea

Appetite loss

Lameness

Weight loss

Bloody stool

Dosage & Administration
Always provide Client Information Sheet with prescription. Administer an initial dosage of 3.25 mg/kg (1.48 mg/lb) body weight, orally every other day. Dose reductions of 0.5 mg/kg (to a minimum dose of 2.2 mg/kg (1.0 mg/lb) every other day) and dose interruptions (cessation of PALLADIA for up to two weeks) may be utilized, if needed, to manage adverse reactions. Adjust dose based on approximately weekly veterinary assessments for the first 6 weeks and approximately every 6 weeks, thereafter. PALLADIA may be administered with or without food. Do not split tablets.

Table 1. 3.25 mg/kg Dose Chart Dog Body Weight Number Of Tablets Pounds Kilograms 11.0 - 11.8 5.0 - 5.3 11.9 - 15.2 5.4 - 6.9 15.3 - 18.5 7.0 - 8.4 18.6 - 22.0 8.5 - 10.0 22.1 - 25.4 10.1 - 11.5 25.5 - 28.7 11.6 - 13.0 28.8 - 32.2 13.1 - 14.6 32.3 - 35.5 14.7 - 16.1 35.6 - 38.8 16.2 - 17.6 38.9 - 42.3 17.7 - 19.2 42.4 - 45.6 19.3 - 20.7 45.7 - 50.7 20.8 - 23.0 50.8 - 59.3 23.1 - 26.9 59.4 - 65.9 27.0 - 29.9 66.0 - 71.2 30.0 - 32. 3 71.3 - 76.3 32.4 - 34.6 76.4 - 79.6 34.7 - 36.1 79.7 - 84.7 36.2 - 38.4 84.8 - 94.8 38.5 - 43.0 94.9 -105.0 43.1 - 47.6 105.1 - 110.0 47.7 - 49.9 110.1 - 113.5 50.0 -51.5 113.6 - 118.6 51.6 - 53.8 118.7 - 128.8 53.9 - 58.4 128.9 - 138.9 58.5 - 63.0 139.0 - 144.0 63.1 - 65.3 144.1 - 157.6 65.4 - 71.5 157.7 - 173.1 71.6 - 78.5 173.2 - 177.9 78.6 - 80.7 178.0 - 191.6 80.8 - 86.9 191.7 - 220.5 87.0 - 100.0 Dose 15 mg 20 mg 25 mg 30 mg 35 mg 40 mg 45 mg 50 mg 55 mg 60 mg 65 mg 70 mg 80 mg 95 mg 100 mg 110 mg 115 mg 120 mg 130 mg 150 mg 160 mg 165 mg 170 mg 180 mg 200 mg 210 mg 215 mg 250 mg 260 mg 265 mg 300 mg 10 mg 15 mg 50 mg   1   2     1 1     2   2 1   1 2     3       1 1 3   1   1   1 1 2   1   2 1   3 1     2 1   2   1 2 2   2   2 2     3 1   3   1 3 2   3   2 3   4 1 4   1 4   5 1   5   1 5     6