Palladia (toceranib phosphate)
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Palladia (toceranib phosphate)

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Description

Please Call 1 (800) 738-7209 for availability.

Palladia is an antiproliferative and antiandiogenic agent used to treat Patnaik grade II or III, cutaneous mast cell tumors in dogs.

This medication uses toceranic phosphate to combat the effects of these recurrent tumors and works on both tumors with and without regional lymph node involvement. Palladia can also be used as an alternative to chemotherapy for other various types of tumors, including melanomas, thyroid carcinomas, and more.

Palladia is available in 10 mg, 15 mg, and 50 mg tabs to ensure that adjusting your dog’s dosage based on their weight is a simple manner. Each dosage is available for purchase by the tab or in a container of 30 tabs.

Key Features:
  • Treats Patnaik grade II or III recurrent, cutaneous mast cell tumors in dogs
  • Can be used as alternative to chemotherapy for other types of tumors
  • Available in three different dosages in singles doses or packs of 30


  • Product Uses:
  • Antiproliferative and antiangiogenic agent
  • Prevents tissue inflammation caused by malignant tumors
  • Inhibits tyrosine kinase, which kills the tumor cells directly and also interferes with the tumor’s blood supply

  • Conditions:
    • For the treatment of dogs with mast cell tumors
    • An alternative to chemotherapy for other types of tumors, including:
      • Squamous cell carcinoma
      • Metastatic osteosarcoma
      • Malignant Melanoma
      • Anal sac adrenocarcinoma
      • Vaccine Associated Fibrosarcoma
      • Transitional Cell Carcinoma
      • Thyroid Carcinoma

    Dosing:
  • You should consult a veterinarian to determine the exact dosage that is appropriate for your pet
  • The appropriate dosage will depend both on the size of your pet
  • Dosage will be adjusted over time as needed
  • More information on dosing should be available in the prescription information

  • Administration:
  • Administer doses orally every other day
  • Dose reductions and interruptions can be utilized as advised by your veterinarian
  • Your veterinarian should make weekly assessments to determine any necessary adjustments to your pet’s dosage
  • May be administered with or without food- tablets are not to be split and should be administered whole

  • Side Effects:
  • Diarrhea
  • Appetite loss
  • Lameness
  • Weight loss
  • Bloody stool


  • Prescription Required

    Directions

    Dosage & Administration
    Always provide Client Information Sheet with prescription. Administer an initial dosage of 3.25 mg/kg (1.48 mg/lb) body weight, orally every other day. Dose reductions of 0.5 mg/kg (to a minimum dose of 2.2 mg/kg (1.0 mg/lb) every other day) and dose interruptions (cessation of PALLADIA for up to two weeks) may be utilized, if needed, to manage adverse reactions. Adjust dose based on approximately weekly veterinary assessments for the first 6 weeks and approximately every 6 weeks, thereafter. PALLADIA may be administered with or without food. Do not split tablets.

    Table 1. 3.25 mg/kg Dose Chart
    Dog Body Weight Number Of Tablets
    Pounds Kilograms
    11.0 - 11.8 5.0 - 5.3
    11.9 - 15.2 5.4 - 6.9
    15.3 - 18.5 7.0 - 8.4
    18.6 - 22.0 8.5 - 10.0
    22.1 - 25.4 10.1 - 11.5
    25.5 - 28.7 11.6 - 13.0
    28.8 - 32.2 13.1 - 14.6
    32.3 - 35.5 14.7 - 16.1
    35.6 - 38.8 16.2 - 17.6
    38.9 - 42.3 17.7 - 19.2
    42.4 - 45.6 19.3 - 20.7
    45.7 - 50.7 20.8 - 23.0
    50.8 - 59.3 23.1 - 26.9
    59.4 - 65.9 27.0 - 29.9
    66.0 - 71.2 30.0 - 32. 3
    71.3 - 76.3 32.4 - 34.6
    76.4 - 79.6 34.7 - 36.1
    79.7 - 84.7 36.2 - 38.4
    84.8 - 94.8 38.5 - 43.0
    94.9 -105.0 43.1 - 47.6
    105.1 - 110.0 47.7 - 49.9
    110.1 - 113.5 50.0 -51.5
    113.6 - 118.6 51.6 - 53.8
    118.7 - 128.8 53.9 - 58.4
    128.9 - 138.9 58.5 - 63.0
    139.0 - 144.0 63.1 - 65.3
    144.1 - 157.6 65.4 - 71.5
    157.7 - 173.1 71.6 - 78.5
    173.2 - 177.9 78.6 - 80.7
    178.0 - 191.6 80.8 - 86.9
    191.7 - 220.5 87.0 - 100.0
    Dose
    15 mg
    20 mg
    25 mg
    30 mg
    35 mg
    40 mg
    45 mg
    50 mg
    55 mg
    60 mg
    65 mg
    70 mg
    80 mg
    95 mg
    100 mg
    110 mg
    115 mg
    120 mg
    130 mg
    150 mg
    160 mg
    165 mg
    170 mg
    180 mg
    200 mg
    210 mg
    215 mg
    250 mg
    260 mg
    265 mg
    300 mg
    10 mg 15 mg 50 mg
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