Frontline Plus for Dogs 5-22 lbs (6 Month) | EP Rx
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Frontline Plus for Dogs 5-22 lbs, 6 Month

Item# FPLUS6OR22
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$42.89Reg $54.99
$79.99Reg $102.99
$158.99Reg $205.99
$42.89Reg $54.99
$79.99Reg $102.99
$158.99Reg $205.99
$42.89Reg $54.99
$79.99Reg $102.99
$158.99Reg $205.99
$42.89Reg $54.99
$78.99Reg $101.99
$158.99Reg $205.99
  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


Frontline Plus Orange for Dogs 5-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing 5 - 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes six 0.67 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes six one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing 5 - 22 pounds

Frontline Plus for Dogs is Available In:
(5 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)


How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
5 - 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.


In a study, Frontline Plus began killing fleas 4 hours after application. Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.
No. Frontline Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.
Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.
The fleas you see most likely started as flea eggs that were deposited in the environment before you began using Frontline Plus. Consecutive monthly applications of Frontline Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.
No. As long as you keep it at room temperature and sealed in its original packaging, Frontline Plus will remain ready for battle.
Frontline Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If Frontline Plus is to be applied after a bath, make sure your pet is completely dry before application.
Before using Frontline Plus, ask your vet about possible interactions with any medications your dog is taking.
Don't reapply Frontline Plus before the month is through. It keeps working for a full 30 days.


Review Summary
8 Reviews
88% (7)
0% (0)
0% (0)
0% (0)
13% (1)
88% Recommend this product (7 of 8 responses)
By Holly
Spokane, WA
Used this for years
May 25, 2021
Frontline Plus has been my go to flea and tick treatment for the 7 years I have had my dog. Easy to use, and he has no reactions to it. Never a problem with fleas or ticks. Good price from EntirelyPets Pharmacy.
By Grace
Central Florida
Great service
December 13, 2018
Entirely pets had a great price on this. Their service is outstanding, shipping was immediate and fast. Thanks
By Bill
Meadville, Pa
best protection I have ever had for my dog
March 29, 2018
This product is fantastic have not had fleas since started using this product and at a better price than I could purchase locally
By Gloria
Houston, Texas
Chico & Chica
July 5, 2017
it's been good, so far, thanks.
By Barb
Greensburg, PA
Best flea med
February 15, 2017
I have used this for a long time and it has worked better than others I have tried.
  • Great product
  • cost
By Paul
Rolla, Mo.
The real stuff
April 21, 2016
This is the real McCoy. I ordered this product through a discount provider and it came from Africa and was nothing but water. It had no odor at all and was a waste of money. A valuable lesson learned! Stick with a name you can trust!!!
By Gunhoup
San Leandro, CA
No longer works
April 10, 2016
I switched to Frontline after I got poor results from Advantage. Unfortunately, I got the same poor results from Frontline. These products are no longer effective in the SF Bay Area, California. I take 1-3 fleas off my dog every day, within a few days of having applied the product. Dang!
  • None.
  • No longer works.
By Jane S.
Salem, Ohio
Don't know what this is
February 11, 2016
Fast service
  • Takes care of fleas, eggs, lice & ticks. Easy to admisister.

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