Frontline Plus for Dogs 23-44 lbs (12 Month) | Free Shipping* | EP Rx
EPRX Logo
Licensed U.S. Pet Pharmacy | Verified Pharmacy
Mobile Menu
Search Submit
Live Chat My Account
View Cart 0

Easter Sale!  20% OFF  Use Code EGG20 *

  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image

Frontline Plus for Dogs 23-44 lbs, 12 Month

Item# FPLUS3BL44-12M
FREE SHIPPING Over $79! * Pet Food & Other Exclusions
1. Select dosage:
2. Select weight:
QTY:-+

Price too low to show

Add to cart to see low price
$158.99$205.99
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
$42.89Reg $54.99
$80.99Reg $97.99
$160.99Reg $193.99
$42.89Reg $54.99
$79.99Reg $102.99
$158.99Reg $205.99
$42.89Reg $54.99
$79.99Reg $102.99
$158.99Reg $205.99
$47.99Reg $57.99
$93.99Reg $112.99
$184.99Reg $221.99
  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews

Description

Frontline Plus Orange for Dogs 0-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.


Package Contents

Box includes twelve 1.34 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes twelve one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing less than 22 pounds

Frontline Plus for Dogs is Available In:
Orange
(0 - 22 lbs)
Blue
(23 - 44 lbs)
Purple
(45 - 88 lbs)
Red
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month

Ingredients

Active Ingredients

Fipronil

Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.

Benefits

Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.

(S)-Methoprene

Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.

Benefits

Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Fipronil9.8%
(S)-Methoprene8.8%
Inert Ingredients81.4%
Total100%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Directions

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.

Cautions

To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.


Dosage Table

WeightMonthly Dosage
Up to 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

FAQ

In a study, Frontline Plus began killing fleas 4 hours after application. Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.
No. Frontline Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.
Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.
The fleas you see most likely started as flea eggs that were deposited in the environment before you began using Frontline Plus. Consecutive monthly applications of Frontline Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.
No. As long as you keep it at room temperature and sealed in its original packaging, Frontline Plus will remain ready for battle.
Frontline Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If Frontline Plus is to be applied after a bath, make sure your pet is completely dry before application.
Before using Frontline Plus, ask your vet about possible interactions with any medications your dog is taking.
Don't reapply Frontline Plus before the month is through. It keeps working for a full 30 days.

Reviews

Review Summary
4.6
35 Reviews
5
86% (30)
4
6% (2)
3
0% (0)
2
0% (0)
1
9% (3)
94% Recommend this product (33 of 35 responses)
By D
LONGVIEW, TX
Frontline for my pet
December 2, 2024
really appreciate how easy it is to apply this medication and the fact that it protects our best lil buddy for a full month. We have used Frontline for 9 years, since we first rescued our Beagle and he has had no problems or issues with the med. It gives us assurance that we are doing the absolute best for our lil guy.
Pros
  • Ease of Application
  • Ease of refilling RX
  • No bad odor
  • Best protection for our dog.
By Holly
Spokane, WA
Used this for years
May 25, 2021
Frontline Plus has been my go to flea and tick treatment for the 7 years I have had my dog. Easy to use, and he has no reactions to it. Never a problem with fleas or ticks. Good price from EntirelyPets Pharmacy.
By Edwin
North Carolina
Best product
April 15, 2020
Fast shipping. Will continue to buy from you guys
By Deb
York, PA
Good product, good pricing
August 2, 2019
Works well. We have ticks in our backyard and as long as we apply regularly, our dog stays tick free. Great price, quick shipping. Have been buying Frontline from Entirely Pets Pharmacy for a while and will continue to do so.
By Grace
Central Florida
Great service
December 13, 2018
Entirely pets had a great price on this. Their service is outstanding, shipping was immediate and fast. Thanks
By roy h.
texas
GREAT DELIVERY
July 19, 2018
Quicker delivery and less expensive than the competitor!
By cheryl a.
TX
Great
April 26, 2018
Great price and discount and free shipping too. YAY!!
By Whtebear
Missouri
Works For Us
April 18, 2018
This product does what it is intended to do. It keeps fleas and ticks from infesting or even getting on our dog at all. My only worry is that it may be too powerful and be harmful for dogs. I hope "they" know what they are talking about when they say it is "safe".
Pros
  • Easy to use; effective
Cons
  • WAAAAYYYYYY TOO EXPENSIVE
By Bill
Meadville, Pa
best protection I have ever had for my dog
March 29, 2018
This product is fantastic have not had fleas since started using this product and at a better price than I could purchase locally
By Gloria
Houston, Texas
Chico & Chica
July 5, 2017
it's been good, so far, thanks.
By Teri
Springfield, MO
Awesome service and delivery
June 23, 2017
I have ordered many times from Entirely Pets and the products are quality Very easy to order, customer service is wonderful. I will continue to order all of my pets medications form Entirely Pets. Thank you for the quick ordering and delivery.
By Ted S.
Seattle, Wa
On time at a great price. Thank you!
June 22, 2017
As promised and delivered on time.
By RitaT
Missouri
Fast and Reliable
June 2, 2017
Easy to order on line and fast service. If any issues arise, customer service is always very helpful and resolves any problems quickly.
Pros
  • Always easy to order on line and fast deliver service. Will use service again and recommend to others to use this site.
By Jo-Ellen
Spartanburg, South Carolina
Bulldog may be inside a lot but fleas are out there!
May 10, 2017
My primarily indoor English Bulldog loves to travel with Mom on shopping and outing duties! To be safe, she uses Frontline Plus for -she is 54 lbs- large dogs. Never a whimper or problem. Love this preventive liquid drop for my baby! Easy to use and apply. I see more walks instore for us!
By PEG
ILLINOIS
LOVE THIS PRODUCT
March 26, 2017
THANKS - ON TIME - FAST SERVICE AND PLAN TO ORDER FROM YOU AGAIN, AS YOU GIVE DISCOUNTS ETC., AND TOTALLY APPRECIATE THAT - EVERY LITTLE BIT COUNTS - THANKS FOR YOUR TIME
Pros
  • ALL GOOD
Cons
  • LOVE THIS PRODUCT AND LOVE ORDERING FROM THIS COMPANY - THANKS
By Willie's M.
Portland, OR
Still works best for my guy
March 20, 2017
I've used Frontline Plus most of my 100 lb Lab's 10 + years. Tried Advantage, came back to FP. Last fall I tried chewable Nexguard, which my Vet preferred. I believe my dog reacted poorly to it - his coat got dull, skin flaky and undercoat came out. When I didn't give him the next scheduled dose, his hair grew back, coat glossy, dog happy. Now he's back on Frontline Plus.
Pros
  • reasonable price
  • effective
Cons
  • application's a little messy
By Bob
Middletown, DE
Frontline Plus for Dogs
March 11, 2017
This product provides the protection from ticks and fleas our dog needs. We are very pleased with the product.
By Barb
Greensburg, PA
Best flea med
February 15, 2017
I have used this for a long time and it has worked better than others I have tried.
Pros
  • Great product
Cons
  • cost
By Bill
Meadville, Pennsylvania
Frontline Plus
February 1, 2017
this product has done a fantastic job for the 8 years we have had our dog, not one flea or tick and the price was good,I will continue to purchase this product
By Pat
Hummelstown, Pa.
Love Frontline Plus
November 12, 2016
Ordered from Web Site and was very easy to use. Received product in a very timely mannor.
By PAL
Lakewood, Washington
Good product
October 29, 2016
Easy to apply and works well
By Lisa
Livermore, ca
Fast delivery
October 9, 2016
Great price arrived in days
By Rita
Columbus, OH
Not effective
September 21, 2016
Since purchasing this, I've heard that Fronline no longer works on fleas in Ohio.
By Frankie
South Carolina
Frontline Works
September 5, 2016
I've used Frontline before on my pets. It works immediately.
By john
akron ohio
good price
August 15, 2016
fast service...thanks ...john
By Roseann
Collinsville Illinois
Frontline for Dugan
August 2, 2016
Wouldn't have my pet running around without it. We have deer and my little 12 pounder chases them.
By Joyce
CA
Works quickly once applied.
June 5, 2016
Can tell at once that the Frontline works. My Nala quits scratching and can tell she is more comfortable.
By Natalie
Hamden, CT
Quality Product
May 20, 2016
I have been using Frontline Plus for a long time. I find it to be easy to apply and a very effective way of controlling fleas and ticks. None of my dogs have ever had a problem or adverse reaction to it. I recommend giving it a try
By Tracey
Baraboo, Wisconsin
frontline plus 4 dogs
May 13, 2016
Very satisfied. The product came in a timely fashion and was a good price.
By Paul
Rolla, Mo.
The real stuff
April 21, 2016
This is the real McCoy. I ordered this product through a discount provider and it came from Africa and was nothing but water. It had no odor at all and was a waste of money. A valuable lesson learned! Stick with a name you can trust!!!

Customers Who Bought Also Bought