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Etodolac 400 mg (100 tabs) (Manufacturer may vary)

Item# IWM034591
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Etodolac is available by prescription only. Etodolac is an extra-label medication prescribed for the management of pain and inflammation in dogs with osteoarthritis. Etodolac is a non-steroidal anti-inflammatory drug (NSAID).

Animals Treated

Dogs (over 12 months of age and weighing more than 11 pounds)

Key Benefits

  • Reduces fever
  • Treats pain and inflammation caused by arthritis
  • Relieves joint stiffness

How It Works

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body.


Carefully consider the potential benefits and risks of etodolac, and other treatment options before deciding to use etodolac. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

Etodolac are indicated:

  • For accute and long-term use in the management of signs and symptoms of the following:
    1. Osteoarthritis
    2. Rheumatoid arthritits
  • For the management of acute pain


Etodolac is a non-steroidal anti-inflammatory drug (NSAID) available by prescription used in dogs to treat pain, inflammation, and fever.

Etodolac can increase the risk of serious effects on the stomach and intestines including bleeding or perforation. Call your veterinarian at once if your pet has any symptoms of bleeding in the stomach or intestines such as black, bloody or tarry stools, coughing up blood, or vomit that looks like coffee grounds.

Etodolac is for use in dogs only. Do not give to cats.

Tip: Do not give to dogs that weigh less than 11 lbs. or under 12 months of age. Do not use larger amounts or use for longer than recommended by your veterinarian. Your veterinarian may want to perform blood tests on a regular basis to make sure the medication is not causing harmful effects.

Etodolac Dosage for Dogs/Puppies (over 12 months of age)
Weight Dosage
All weights Usual dose is 4.5-6.8mg per pound of pet's body weight once daily or as directed by veterinarian*
Etodolac Dosage for Cats
Do not use!
Etodolac Dosage for Horses
Do not use!


Store at 20° to 25°C (68° to 77°F)

Store this medication at room temperature away from moisture and heat. * Do not exceed a maximum dose of 6.8mg/lb of pets body weight daily.


Keep out of the reach of children and pets. Do not use in cats. Etodolac may interact with some other medications. Inform your veterinarian of any and all medications your pet may be taking, especially corticosteroids, furosemide, other NSAIDs, or phenobarbital. Do not use in dogs with known hypersensitivity to etodolac. Do not use in puppies less than 12 months old. Use with caution in pregnant or nursing animals.Use with caution in pets suffering from blood disorders, dehydration, GI disorders, heart disorders, or liver disorders. Store at room temperature. Store protected from light and moisture.

Side Effects

Seek emergency veterinary medical attention if your pet experiences any signs of an allergic reaction (hives; difficulty breathing; swelling of the face, lips, tongue, or throat). Stop using the medication and call your veterinarian at once if any of the following serious side effects occur; Black, bloody, or tarry stools; coughing up blood or vomit that looks like coffee grounds; swelling or rapid weight gain; urinating less than usual or not at all; nausea, stomach pain, loss of appetite, dark urine, yellowing of eyes; fever, severe blistering, peeling, and red skin rash; chills, seizure. Keep giving etodolac and talk to your veterinarian if your pet develops any of these less serious side effects; diarrhea, constipation; dizziness; skin itch or rash;. Side effects other than those listed may also occur. Talk to your veterinarian about any side effect that seems unusual or that is especially bothersome to your pet.


Give the missed dose as soon as you remember. However, if it almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.
Seek emergency veterinary medical attention if you think you have used too much of this medication. Symptoms of overdose may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting or coma.
Do not give your pet any over the counter cold, allergy, or pain medications without first asking your veterinarian or pharmacist. Many medicines available over the counter contain aspirin.

Etodolac, like other drugs, may cause some side effects. Serious but rare side effects have been reported in dogs taking NSAIDs, including etodolac. Serious side effects can occur with or without warning and in rare situations result in death.

The most common NSAID-related side effects generally involve the stomach (such as bleeding ulcers), and liver or kidney problems. Look for the following side effects that can indicate your dog may be having a problem with etodolac or may have another medical problem:

  • Decrease or increase in appetite
  • Vomiting
  • Change in bowel movements (such as diarrhea, or black, tarry or bloody stools)
  • Change in behavior (such as decreased or increased activity level, incoordination, seizure or aggression)
  • Yellowing of gums, skin, or whites of the eyes (jaundice)
  • Change in drinking habits (frequency, amount consumed)
  • Change in urination habits (frequency, color, or smell)
  • Change in skin (redness, scabs, or scratching)

It is important to stop therapy and contact your veterinarian immediately if you think your dog has a medical problem or side effect from etodolac therapy. If you have additional questions about possible side effects, talk to your veterinarian.

Tell your veterinarian if your pet is using any of the following medications; Coumadin (warfarin); Lasix (furosemide); prednisone or other steroids; aspirin or other NSAIDs such as Metacam (Meloxicam)Feldene (piroxicam), Rimadyl (Carprofen), Deramaxx (deracoxib); Enacard (enalapril), Lotensin (benazepril), Prinivil (lisinopril). There may be other drugs not listed in this guide that may affect etodolac. Tell your veterinarian about all prescription and non-prescription (OTC) medications, including vitamins, minerals, herbal products, and drugs prescribed by other veterinarians. Do not start using a new medication without telling your veterinarian.
  • Cats (this medication is for dogs only). Call your veterinarian immediately if your cat receives etodolac
  • Has had an allergic reaction to the active ingredient etodolac
  • Has had an allergic reaction to aspirin or other NSAIDs (for example, carprofen or phenylbutazone) such as hives, facial swelling, or red or itchy skin

Talk to your veterinarian about:

  • The signs of OA you have observed (for example, limping, stiffness)
  • The importance of weight control and exercise in the management of OA
  • What tests might be done before etodolac is prescribed
  • How often your dog may need to be examined by your veterinarian
  • The risks and benefits of using etodolac

Tell your veterinarian about:

  • Experienced side effects from etodolac or other NSAIDs, such as aspirin
  • Digestive upset (vomiting and/or diarrhea)
  • Liver and kidney disease
  • A bleeding disorder (for example, Von Willebrand's disease)
  • Any other medical problems or allergies that your dog has now or has had
  • All medicines that you are giving your dog or plan to give your dog, including those you can get without a prescription
  • If your dog is pregnant, nursing or if you plan to breed your dog

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