Entyce Appetite Stimulant for Dogs 30 mg/ml (30 ml)

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Entyce is a flavored oral solution that is used to stimulate appetite in dogs. It is a tasty appetite stimulant that can help treat both chronic and acute conditions in dogs that cause a decrease in appetite. Entyce 30 mg/ml oral solution is available as 10 ml, 15 ml, and 30 ml bottles that come with a convenient dosing syringe for quicker and more accurate administration.

Convenient, once-daily oral solution for treating inappetence
• Easy for pet owners to administer
• Flavored liquid formulation

• ENTYCE (capromorelin oral solution) is the ONLY FDA-approved therapeutic that was developed specifically to stimulate appetite in dogs
• ENTYCE has a targeted mechanism of action that mimics ghrelin (the "hunger hormone") to trigger the feeling of hunger
• ENTYCE is proven to effectively and safely stimulate appetite in dogs
• ENTYCE treats the sympton of inappetence so that you can diagnose the underlying chronic or acute condition

Underlying conditions that can cause inappetence

• Dehydration
• Fever
• Gastroenteritis
• Medications
• Nausea
• Pain
• Psychological
• Aging
• Changes in routine
• Environment changes
• Systemic or chronic disease
• Autoimmune disease
• Cancer
• Endocrine disease
• Gastrointestinal disease
• Heart disease
• Kidney disease
• Neurologic disease
• Respiratory disease

Consequences of inappentence

• When animals do not eat over a period of time, they experience weight loss and muscle wasting
• Pet owners can be distressed by these effects and often perceive them as evidence of suffering or a decreased quality of life
• If pets develop extreme frailty, treatment options may not be as effective

A long-term poor nutritional state may result in:^1,2,3

• Decreased quality of life leading to decreased survival
• Decreased musculoskeletal strength
• Delayed wound healing
• Decreased immune response

Key Benefits

• Stimulates appetite in dogs
• Helps with chronic and acute conditions that cause a lack of appetite
• Comes with dosing syringe
• Easy to administer

How It Works

Entyce contains capromorelin, which mimics the hunger hormone (ghrelin) in the brain that generates the feeling of hunger.

Indications

ENTYCE (capromorelin oral solution) is indicated for appetite stimulation in dogs.

View ENTYCE Drug Facts Sheet.

ENTYCE provides a convenient, once-daily oral solution for treating inappetence. Please reference the chart for recommended dosages.

To administer ENTYCE, the bottle should be shaken gently and then the appropriate amount of solution withdrawn using the provided syringe. The syringe should be rinsed between treatment dose.¹

Field Study The clinical Field Study¹ demonstrated a significantly higher proportion of inappetent dogs that received ENTYCE® (carpromorelin oral solution) had increased appetite as comparerd to dogs that received placebo.

PRIMARY ENDPOINT: Owner Appetite Assessment

• Success Rate on day 4

*A dog was considered a treatment success if the owner answered that their dog's appetite was increased in response to the question,"Do you feel that during the study (over the 4± 1 days of treatment) your dog's appetite was increased, no change or decreased?"

*The following adverse reactions were reported in < 1% of dogs that were administered ENTYCe: hyperractivity, increased fecal volume, increased gut sounds and polyuria.

CONCLUSION This study demonstrates that a ghrelin receptor agonist, ENTYCE, can stimulate appetite and increase body weight in a large population of client-owned dogs with reduced appetite of varying etiologies and was well-tolerated.

Caution:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications:

ENTYCE should not be used in dogs that have a hypersensitivity to capromorelin.

Warnings:

Not for use in humans. Keep this and all medications out of reach of children and pets.Consult a physician in case of accidental ingestion by humans. For use in dogs only

Precautions:

Use with caution in dogs with hepatic dysfunction. ENTYCE is metabolized by CYP3A4 and CYP3A5 enzymes (See Clinical Pharmacology).

Use with caution in dogs with renal insufficiency. ENTYCE is excreted approximately 37% in urine and 62% in feces (See Adverse Reactions and Clinical Pharmacology).

The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches.