Entyce requires a prescription from your veterinarian. It is indicated for appetite stimulation in dogs. Entyce is a flavored oral solution that contains capromorelin. See Entyce product label for complete safety information
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Entyce for Dogs - Appetite Stimulant for Dogs 30 mg/ml (30 ml) - [Flavored Solution]
Item# IWM063641
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Description
Entyce is a flavored oral solution that is used to stimulate appetite in dogs. It is a tasty appetite stimulant that can help treat both chronic and acute conditions in dogs that cause a decrease in appetite. Entyce 30 mg/ml oral solution is available as 10 ml, 15 ml, and 30 ml bottles that come with a convenient dosing syringe for quicker and more accurate administration.
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Convenient, once-daily oral solution for treating inappetence
- Easy for pet owners to administer
- Flavored liquid formulation
- ENTYCE (capromorelin oral solution) is the ONLY FDA-approved therapeutic that was developed specifically to stimulate appetite in dogs
- ENTYCE has a targeted mechanism of action that mimics ghrelin (the "hunger hormone") to trigger the feeling of hunger
- ENTYCE is proven to effectively and safely stimulate appetite in dogs
- ENTYCE treats the sympton of inappetence so that you can diagnose the underlying chronic or acute condition
Underlying conditions that can cause inappetence
- Dehydration
- Fever
- Gastroenteritis
- Medications
- Nausea
- Pain
- Psychological
- Aging
- Changes in routine
- Environment changes
- Systemic or chronic disease
- Autoimmune disease
- Cancer
- Endocrine disease
- Gastrointestinal disease
- Heart disease
- Kidney disease
- Neurologic disease
- Respiratory disease
Consequences of inappentence
- When animals do not eat over a period of time, they experience weight loss and muscle wasting
- Pet owners can be distressed by these effects and often perceive them as evidence of suffering or a decreased quality of life
- If pets develop extreme frailty, treatment options may not be as effective
A long-term poor nutritional state may result in:1,2,3
- Decreased quality of life leading to decreased survival
- Decreased musculoskeletal strength
- Delayed wound healing
- Decreased immune response
Key Benefits
- Stimulates appetite in dogs
- Helps with chronic and acute conditions that cause a lack of appetite
- Comes with dosing syringe
- Easy to administer
How It Works
Entyce contains capromorelin, which mimics the hunger hormone (ghrelin) in the brain that generates the feeling of hunger.
Indications
ENTYCE (capromorelin oral solution) is indicated for appetite stimulation in dogs.
Directions
ENTYCE provides a convenient, once-daily oral solution for treating inappetence. Please reference the chart for recommended dosages.
To administer ENTYCE, the bottle should be shaken gently and then the appropriate amount of solution withdrawn using the provided syringe. The syringe should be rinsed between treatment dose.1
| Weight of Dog | Dose | |
|---|---|---|
| LBS | KG | ML |
| 5 | 2.3 | 0.2 |
| 10 | 4.5 | 0.5 |
| 15 | 6.8 | 0.7 |
| 20 | 9.1 | 0.9 |
| 25 | 11.4 | 1.1 |
| 30 | 13.6 | 1.4 |
| 35 | 15.9 | 1.6 |
| 40 | 18.2 | 1.8 |
| 45 | 20.5 | 2.1 |
| 50 | 22.7 | 2.3 |
| 55 | 25.0 | 2.5 |
| 60 | 27.3 | 2.7 |
| 65 | 29.5 | 3.0 |
| 70 | 31.8 | 3.2 |
| 75 | 34.1 | 3.4 |
| 80 | 36.4 | 3.6 |
| 85 | 38.6 | 3.9 |
| 90 | 40.9 | 4.1 |
Field Study The clinical Field Study1 demonstrated a significantly higher proportion of inappetent dogs that received ENTYCE® (carpromorelin oral solution) had increased appetite as comparerd to dogs that received placebo.
PRIMARY ENDPOINT: Owner Appetite Assessment
- Success Rate on day 4
| Parameter | Capromorelin | Placebo | P-Value |
|---|---|---|---|
| Treatment success-single-question assessment %* | 68.6 | 44.6 | 0.0078 |
| Treatment success-Owner Appetite Assessment, %† | 56.2 | 26.8 | 0.0071 |
| Percent change in body weight, mean (SD) | 1.83(2.8) | 0.11(3.61) | 0.004 |
| Percent change in Owner Appetite Assessment, mean (SD) | 73.4(75.9) | 35.6(53.9) | 0.0125 |
*A dog was considered a treatment success if the owner answered that their dog's appetite was increased in response to the question,"Do you feel that during the study (over the 4± 1 days of treatment) your dog's appetite was increased, no change or decreased?"
†Treatment success was defined as an increase in total score? 5 from day 0 to day 3 ± 1 (scoring scale 5-25)Study Design
Adverse reactions reported in dogs administered ENTYCE oral solution compared with vehicle control.
| Adverse Reactions* | ENTYCE (n=171)* n(%) | Placebo (n=73)* n(%) |
|---|---|---|
| Diarrhea | 12 (7.0%) | 5 (6.8%) |
| Vomiting | 11 (6.4%) | 4 (5.5%) |
| Elevated blood urea nitrogen (BUN) | 7 (4.1%) | 2 (2.7%) |
| Polydipsia | 7 (4.1%) | 1 (1.4%) |
| Elevated phosphorus | 4 (2.3%) | 1 (1.4%) |
| Hypersalivation | 4 (2.3%) | 0 (0.0%) |
| Abdominal discomfort | 2 (1.2%) | 0 (0.0%) |
| Flatulence | 2 (1.2%) | 0 (0.0%) |
| Lethargy/depression | 2 (1.2%) | 0 (0.0%) |
| Nausea | 2 (1.2%) | 0 (0.0%) |
| Elevated creatinine | 1 (0.6%) | 1 (1.4%) |
*The following adverse reactions were reported in < 1% of dogs that were administered ENTYCe: hyperractivity, increased fecal volume, increased gut sounds and polyuria.
CONCLUSION This study demonstrates that a ghrelin receptor agonist, ENTYCE, can stimulate appetite and increase body weight in a large population of client-owned dogs with reduced appetite of varying etiologies and was well-tolerated.
Caution:
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Contraindications:
ENTYCE should not be used in dogs that have a hypersensitivity to capromorelin.
Warnings:
Not for use in humans. Keep this and all medications out of reach of children and pets.Consult a physician in case of accidental ingestion by humans. For use in dogs only
Precautions:
Use with caution in dogs with hepatic dysfunction. ENTYCE is metabolized by CYP3A4 and CYP3A5 enzymes (See Clinical Pharmacology).
Use with caution in dogs with renal insufficiency. ENTYCE is excreted approximately 37% in urine and 62% in feces (See Adverse Reactions and Clinical Pharmacology).
The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches.
FAQ
Talk to your veterinarian about your pet's change or lack of appetite. Tell your veterinarian if your pet is pregnant, breeding, or lactating. Also, let them know if your pet has hepatic dysfunction or renal insufficiency. If your pet has any other medical problems or allergies, let your veterinarian know before giving your pet Entyce.
Administer Entyce directly into the mouth using the provided dosing syringe. Administer one dose of 1.4 mg/lb body weight once daily.
Side effects of Entyce can include diarrhea, vomiting, polydipsia (excessive thirst), and hypersalivation.
If you miss a dose, give the next dose of Entyce as soon as you remember. If it is close to the next dose, skip the missed dose and resume a regular dosing schedule.
If an overdose is suspected, immediately contact your veterinarian.
Before giving your dog other medications, contact your veterinarian.
Reviews
Review Summary
4.6
10 Reviews
5
90% (9)
4
0% (0)
3
0% (0)
2
0% (0)
1
10% (1)
90% Recommend this product (9 of 10 responses)
By CHRISTY D.
Dallas Texas
Dog passed & wanted to cancel since product had not her received.
June 18, 2024
My dog passed before I even received the product. I called & emailed immediately to cancel. I did not hear from anyone so called again the following day, still having not received this. I was told that they do not accept returns but hoped they would make an exception. Especially since my dog had passed & having not received the product until 3 days after I made the initial contact. I was then told,Sean, the supervisor would return my call. It is still unopened in its original box awaiting for a supervisor that would understand my situation & allow me to return this. It’s been two weeks …
Cons
- My dog passed before I even received the product. I called & emailed immediately to cancel. I did not hear from anyone so called again the following day, still having not received this. I was told that they do not accept returns but hoped they would make an exception. Especially since my dog had passed & having not received the product until 3 days after I made the initial contact. I was then told,Sean, the supervisor would return my call. It is still unopened in its original box awaiting for a supervisor that would understand my situation & allow me to return this. It’s been two weeks …
By Carol P.
Wahpeton, ND
Entyce for Pearly
May 29, 2024
Its a lifesaver!! She doesnt need it daily, its about twice a week maybe???
Pros
- It works within 30 minutes.
Cons
- Na
By Carol p.
Wahpeton, North Dakota
Entyce for Pearly
May 7, 2024
Worked miraculously!!
Pros
- Highly recommend it for grieving dogs.
Cons
- None
By Carol M.
Albuquerque, New Mexico
It Works!
April 14, 2022
I have a beautiful German Shepherd. She’s a little high strung, and food simply is not one of her priorities! My Vetinarian prescribed Entyce and we’ve been using it about a year now. She consistently eats all her food when she receives this medicine. But if I choose to not give it to her, she just doesn’t eat much of what I normally prepare for her. Certainly, if you have an animal that is having trouble gaining weight, Entyce will help with everyone walking away winners, and your sweet friend will be nourished and gain the weight needed!
Pros
- - It works.
- - Easy to use large numbered syringe to squirt medication into the mouth.
- - Comes in two sizes depending on the size of your animal and the amount of milligrams it needs.
- - No special handling or storage is needed.
- - It seems to be well tolerated as my pet comes when called and she sees it?s her medicine time.
Cons
- - It?s expensive.
- - It is not easily available through local pharmacies and I have to order it from On-line websites.
- - The bottles are small. 30 millimeters only lasts one week for the weight my pet is.
- - The time from dosage to eating and successful appetite is variable and unpredictable. If I feed too early, my pet may not be interested in eating, and visa versa. If my pet doesn?t eat well, I consider the medicine has failed.
By Jani
SCV CA
Dog Appetite
March 30, 2019
This works to help stimulate my dogs appetite. Entirely Pets was much cheaper than at my Vet office where i initially bought it. Prompt shipping helpful customer service
By Sheryl
Florida
Pharmaceutical
January 16, 2019
Very pleasant to work with. Received order in timely manner.
By Lori
Pasadena, MD
Great stuff
October 28, 2018
My male wouldn’t eat because my female was in heat and started to lose a lot of weight.
Started him on one dose and he eat for me.. I’m a happy doggie mom.
Started him on one dose and he eat for me.. I’m a happy doggie mom.
By Lori
New Port Richey, FL
Great product!
August 26, 2018
Entyce works great! Thanks for such a speedy delivery and a great price.
By Dbbie
Reno, NV
Entice seems to work for our dog
April 20, 2018
Our dog is eating much better since taking Entyce.
By Debbie
Nevada
Entyce appetite stimulant
March 29, 2018
Seems like a good product. Our dog is eating better. The medicine arrived in a timely manner.
I will purchase again.
I will purchase again.
