Entyce for Dogs 30 mg/ml (10 ml) | Free Shipping | EP Rx
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Entyce Appetite Stimulant for Dogs 30 mg/ml (10 ml)

Item# IWM063643
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Description

Entyce is a flavored oral solution that is used to stimulate appetite in dogs. It is a tasty appetite stimulant that can help treat both chronic and acute conditions in dogs that cause a decrease in appetite. Entyce 30 mg/ml oral solution is available as 10 ml, 15 ml, and 30 ml bottles that come with a convenient dosing syringe for quicker and more accurate administration.

    Convenient, once-daily oral solution for treating inappetence
  • Easy for pet owners to administer
  • Flavored liquid formulation
Take control of appetite
  • ENTYCE (capromorelin oral solution) is the ONLY FDA-approved therapeutic that was developed specifically to stimulate appetite in dogs
  • ENTYCE has a targeted mechanism of action that mimics ghrelin (the "hunger hormone") to trigger the feeling of hunger
  • ENTYCE is proven to effectively and safely stimulate appetite in dogs
  • ENTYCE treats the sympton of inappetence so that you can diagnose the underlying chronic or acute condition

Underlying conditions that can cause inappetence

  • Dehydration
  • Fever
  • Gastroenteritis
  • Medications
  • Nausea
  • Pain
  • Psychological
    • Aging
    • Changes in routine
    • Environment changes
  • Systemic or chronic disease
    • Autoimmune disease
    • Cancer
    • Endocrine disease
    • Gastrointestinal disease
    • Heart disease
    • Kidney disease
    • Neurologic disease
    • Respiratory disease

Consequences of inappentence

  • When animals do not eat over a period of time, they experience weight loss and muscle wasting
  • Pet owners can be distressed by these effects and often perceive them as evidence of suffering or a decreased quality of life
  • If pets develop extreme frailty, treatment options may not be as effective

A long-term poor nutritional state may result in:1,2,3

  • Decreased quality of life leading to decreased survival
  • Decreased musculoskeletal strength
  • Delayed wound healing
  • Decreased immune response

Key Benefits

  • Stimulates appetite in dogs
  • Helps with chronic and acute conditions that cause a lack of appetite
  • Comes with dosing syringe
  • Easy to administer

How It Works

Entyce contains capromorelin, which mimics the hunger hormone (ghrelin) in the brain that generates the feeling of hunger.

Indications

ENTYCE (capromorelin oral solution) is indicated for appetite stimulation in dogs.

Directions

View ENTYCE Drug Facts Sheet.

ENTYCE provides a convenient, once-daily oral solution for treating inappetence. Please reference the chart for recommended dosages.

To administer ENTYCE, the bottle should be shaken gently and then the appropriate amount of solution withdrawn using the provided syringe. The syringe should be rinsed between treatment dose.1

Weight of Dog Dose
LBS KG ML
5 2.3 0.2
10 4.5 0.5
15 6.8 0.7
20 9.1 0.9
25 11.4 1.1
30 13.6 1.4
35 15.9 1.6
40 18.2 1.8
45 20.5 2.1
50 22.7 2.3
55 25.0 2.5
60 27.3 2.7
65 29.5 3.0
70 31.8 3.2
75 34.1 3.4
80 36.4 3.6
85 38.6 3.9
90 40.9 4.1

Field Study The clinical Field Study1 demonstrated a significantly higher proportion of inappetent dogs that received ENTYCE® (carpromorelin oral solution) had increased appetite as comparerd to dogs that received placebo.

PRIMARY ENDPOINT: Owner Appetite Assessment

  • Success Rate on day 4
Parameter Capromorelin Placebo P-Value
Treatment success-single-question assessment %* 68.6 44.6 0.0078
Treatment success-Owner Appetite Assessment, %† 56.2 26.8 0.0071
Percent change in body weight, mean (SD) 1.83(2.8) 0.11(3.61) 0.004
Percent change in Owner Appetite Assessment, mean (SD) 73.4(75.9) 35.6(53.9) 0.0125

*A dog was considered a treatment success if the owner answered that their dog's appetite was increased in response to the question,"Do you feel that during the study (over the 4± 1 days of treatment) your dog's appetite was increased, no change or decreased?"

†Treatment success was defined as an increase in total score? 5 from day 0 to day 3 ± 1 (scoring scale 5-25)

Study Design
  • Blinded, placebo-controlled, multi-site study
  • 244 client-owned dogs enrolled, 2:1 randomization
  • Inappentence from a variety of causes
  • 3 mg/kg once daily oral liquid for 4 days
  • All dogs enrolled in the study were evaluated for adverse reactions throughout the course of the study.

  • Adverse reactions reported in dogs administered ENTYCE oral solution compared with vehicle control.
    Adverse Reactions* ENTYCE (n=171)* n(%) Placebo (n=73)* n(%)
    Diarrhea 12 (7.0%) 5 (6.8%)
    Vomiting 11 (6.4%) 4 (5.5%)
    Elevated blood urea nitrogen (BUN) 7 (4.1%) 2 (2.7%)
    Polydipsia 7 (4.1%) 1 (1.4%)
    Elevated phosphorus 4 (2.3%) 1 (1.4%)
    Hypersalivation 4 (2.3%) 0 (0.0%)
    Abdominal discomfort 2 (1.2%) 0 (0.0%)
    Flatulence 2 (1.2%) 0 (0.0%)
    Lethargy/depression 2 (1.2%) 0 (0.0%)
    Nausea 2 (1.2%) 0 (0.0%)
    Elevated creatinine 1 (0.6%) 1 (1.4%)

    *The following adverse reactions were reported in < 1% of dogs that were administered ENTYCe: hyperractivity, increased fecal volume, increased gut sounds and polyuria.

    CONCLUSION This study demonstrates that a ghrelin receptor agonist, ENTYCE, can stimulate appetite and increase body weight in a large population of client-owned dogs with reduced appetite of varying etiologies and was well-tolerated.

    Caution:

    Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

    Contraindications:

    ENTYCE should not be used in dogs that have a hypersensitivity to capromorelin.

    Warnings:

    Not for use in humans. Keep this and all medications out of reach of children and pets.Consult a physician in case of accidental ingestion by humans. For use in dogs only

    Precautions:

    Use with caution in dogs with hepatic dysfunction. ENTYCE is metabolized by CYP3A4 and CYP3A5 enzymes (See Clinical Pharmacology).

    Use with caution in dogs with renal insufficiency. ENTYCE is excreted approximately 37% in urine and 62% in feces (See Adverse Reactions and Clinical Pharmacology).

    The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches.

    FAQ

    Entyce requires a prescription from your veterinarian. It is indicated for appetite stimulation in dogs. Entyce is a flavored oral solution that contains capromorelin. See Entyce product label for complete safety information
    Talk to your veterinarian about your pet's change or lack of appetite. Tell your veterinarian if your pet is pregnant, breeding, or lactating. Also, let them know if your pet has hepatic dysfunction or renal insufficiency. If your pet has any other medical problems or allergies, let your veterinarian know before giving your pet Entyce.
    Administer Entyce directly into the mouth using the provided dosing syringe. Administer one dose of 1.4 mg/lb body weight once daily.
    Side effects of Entyce can include diarrhea, vomiting, polydipsia (excessive thirst), and hypersalivation.
    If you miss a dose, give the next dose of Entyce as soon as you remember. If it is close to the next dose, skip the missed dose and resume a regular dosing schedule.
    If an overdose is suspected, immediately contact your veterinarian.
    Before giving your dog other medications, contact your veterinarian.

    Reviews

    Review Summary
    5.0
    6 Reviews
    5
    100% (6)
    4
    0% (0)
    3
    0% (0)
    2
    0% (0)
    1
    0% (0)
    100% Recommend this product (6 of 6 responses)
    By Jani
    SCV CA
    Dog Appetite
    March 30, 2019
    This works to help stimulate my dogs appetite. Entirely Pets was much cheaper than at my Vet office where i initially bought it. Prompt shipping helpful customer service
    By Sheryl
    Florida
    Pharmaceutical
    January 16, 2019
    Very pleasant to work with. Received order in timely manner.
    By Lori
    Pasadena, MD
    Great stuff
    October 28, 2018
    My male wouldn’t eat because my female was in heat and started to lose a lot of weight.
    Started him on one dose and he eat for me.. I’m a happy doggie mom.
    By Lori
    New Port Richey, FL
    Great product!
    August 26, 2018
    Entyce works great! Thanks for such a speedy delivery and a great price.
    By Dbbie
    Reno, NV
    Entice seems to work for our dog
    April 20, 2018
    Our dog is eating much better since taking Entyce.
    By Debbie
    Nevada
    Entyce appetite stimulant
    March 29, 2018
    Seems like a good product. Our dog is eating better. The medicine arrived in a timely manner.
    I will purchase again.

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