ENTYCE
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ENTYCE

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  • Description
  • Directions
  • Reviews

Description

ENTYCE® is the only FDA-approved veterinary therapeutic labeled for stimulation of appetite in dogs and is an important tool in the medical management of conditions where appetite is reduced.

    Convenient, once-daily oral solution for treating inappetence
  • Easy for pet owners to administer
  • Flavored liquid formulation

Take control of appetite
  • ENTYCE® (capromorelin oral solution) is the ONLY FDA-approved therapeutic that was developed specifically to stimulate appetite in dogs
  • ENTYCE has a targeted mechanism of action that mimics ghrelin (the "hunger hormone") to trigger the feeling of hunger
  • ENTYCE is proven to effectively and safely stimulate appetite in dogs
  • ENTYCE treats the sympton of inappetence so that you can diagnose the underlying chronic or acute condition

    • Underlying conditions that can cause inappetence
    • Dehydration
    • Fever
    • Gastroenteritis
    • Medications
    • Nausea
    • Pain

    • Psychological
      • Aging
        Changes in routine
        Environment changes

    • Systemic or chronic disease
      • Autoimmune disease
        Cancer
        Endocrine disease
        Gastrointestinal disease
        Heart disease
        Kidney disease
        Neurologic disease
        Respiratory disease

      Consequences of inappentence
    • When animals do not eat over a period of time, they experience weight loss and muscle wasting
    • Pet owners can be distressed by these effects and often perceive them as evidence of suffering or a decreased quality of life
    • If pets develop extreme frailty, treatment options may not be as effective

    • A long-term poor nutritional state may result in:1,2,3
      • Decreased quality of life leading to decreased survival
        Decreased musculoskeletal strength
        Delayed wound healing
        Decreased immune response


    Prescription Required

    Directions

    ENTYCE provides a convenient, once-daily oral solution for treating inappetence. Please reference the chart for recommended dosages.

    To administer ENTYCE, the bottle should be shaken gently and then the appropriate amount of solution withdrawn using the provided syringe. The syringe should be rinsed between treatment dose.1

    Weight of Dog Dose
    LBS KG ML
    5 2.3 0.2
    10 4.5 0.5
    15 6.8 0.7
    20 9.1 0.9
    25 11.4 1.1
    30 13.6 1.4
    35 15.9 1.6
    40 18.2 1.8
    45 20.5 2.1
    50 22.7 2.3
    55 25.0 2.5
    60 27.3 2.7
    65 29.5 3.0
    70 31.8 3.2
    75 34.1 3.4
    80 36.4 3.6
    85 38.6 3.9
    90 40.9 4.1

    Field Study The clinical Field Study1 demonstrated a significantly higher proportion of inappetent dogs that received ENTYCE® (carpromorelin oral solution) had increased appetite as comparerd to dogs that received placebo.

    PRIMARY ENDPOINT: Owner Appetite Assessment
  • Success Rate on day 4
  • Parameter Capromorelin Placebo P-Value
    Treatment success-single-question assessment %* 68.6 44.6 0.0078
    Treatment success-Owner Appetite Assessment, %† 56.2 26.8 0.0071
    Percent change in body weight, mean (SD) 1.83(2.8) 0.11(3.61) 0.004
    Percent change in Owner Appetite Assessment, mean (SD) 73.4(75.9) 35.6(53.9) 0.0125
    *A dog was considered a treatment success if the owner answered that their dog's appetite was increased in response to the question,"Do you feel that during the study (over the 4± 1 days of treatment) your dog's appetite was increased, no change or decreased?"
    †Treatment success was defined as an increase in total score? 5 from day 0 to day 3 ± 1 (scoring scale 5-25)

    Study Design
  • Blinded, placebo-controlled, multi-site study
  • 244 client-owned dogs enrolled, 2:1 randomization
  • Inappentence from a variety of causes
  • 3 mg/kg once daily oral liquid for 4 days
  • All dogs enrolled in the study were evaluated for adverse reactions throughout the course of the study.

  • Adverse reactions reported in dogs administered ENTYCE oral solution compared with vehicle control.
    Adverse Reactions* ENTYCE (n=171)* n(%) Placebo (n=73)* n(%)
    Diarrhea 12 (7.0%) 5 (6.8%)
    Vomiting 11 (6.4%) 4 (5.5%)
    Elevated blood urea nitrogen (BUN) 7 (4.1%) 2 (2.7%)
    Polydipsia 7 (4.1%) 1 (1.4%)
    Elevated phosphorus 4 (2.3%) 1 (1.4%)
    Hypersalivation 4 (2.3%) 0 (0.0%)
    Abdominal discomfort 2 (1.2%) 0 (0.0%)
    Flatulence 2 (1.2%) 0 (0.0%)
    Lethargy/depression 2 (1.2%) 0 (0.0%)
    Nausea 2 (1.2%) 0 (0.0%)
    Elevated creatinine 1 (0.6%) 1 (1.4%)
    *The following adverse reactions were reported in < 1% of dogs that were administered ENTYCe: hyperractivity, increased fecal volume, increased gut sounds and polyuria.

    CONCLUSION This study demonstrates that a ghrelin receptor agonist, ENTYCE, can stimulate appetite and increase body weight in a large population of client-owned dogs with reduced appetite of varying etiologies and was well-tolerated.

    Reviews

    Review Summary
    5.0
    5 Reviews
    5
    100% (5)
    4
    0% (0)
    3
    0% (0)
    2
    0% (0)
    1
    0% (0)
    100% Recommend this product (5 of 5 responses)
    By Sheryl
    Florida
    Pharmaceutical
    January 16, 2019
    Very pleasant to work with. Received order in timely manner.
    By Lori
    Pasadena, MD
    Great stuff
    October 28, 2018
    My male wouldn’t eat because my female was in heat and started to lose a lot of weight.
    Started him on one dose and he eat for me.. I’m a happy doggie mom.
    By Lori
    New Port Richey, FL
    Great product!
    August 26, 2018
    Entyce works great! Thanks for such a speedy delivery and a great price.
    By Dbbie
    Reno, NV
    Entice seems to work for our dog
    April 20, 2018
    Our dog is eating much better since taking Entyce.
    By Debbie
    Nevada
    Entyce appetite stimulant
    March 29, 2018
    Seems like a good product. Our dog is eating better. The medicine arrived in a timely manner.
    I will purchase again.