Entyce Appetite Stimulant for Dogs | FDA Approved | EntirelyPets Rx
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Entyce Appetite Stimulant for Dogs

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Entyce® is the only FDA-approved veterinary therapeutic labeled for stimulation of appetite in dogs and is an important tool in the medical management of conditions where appetite is reduced.

    Convenient, once-daily oral solution for treating inappetence
  • Easy for pet owners to administer
  • Flavored liquid formulation

Take control of appetite
  • ENTYCE® (capromorelin oral solution) is the ONLY FDA-approved therapeutic that was developed specifically to stimulate appetite in dogs
  • ENTYCE has a targeted mechanism of action that mimics ghrelin (the "hunger hormone") to trigger the feeling of hunger
  • ENTYCE is proven to effectively and safely stimulate appetite in dogs
  • ENTYCE treats the sympton of inappetence so that you can diagnose the underlying chronic or acute condition

    • Underlying conditions that can cause inappetence
    • Dehydration
    • Fever
    • Gastroenteritis
    • Medications
    • Nausea
    • Pain

    • Psychological
      • Aging
        Changes in routine
        Environment changes

    • Systemic or chronic disease
      • Autoimmune disease
        Endocrine disease
        Gastrointestinal disease
        Heart disease
        Kidney disease
        Neurologic disease
        Respiratory disease

      Consequences of inappentence
    • When animals do not eat over a period of time, they experience weight loss and muscle wasting
    • Pet owners can be distressed by these effects and often perceive them as evidence of suffering or a decreased quality of life
    • If pets develop extreme frailty, treatment options may not be as effective

    • A long-term poor nutritional state may result in:1,2,3
      • Decreased quality of life leading to decreased survival
        Decreased musculoskeletal strength
        Delayed wound healing
        Decreased immune response


    ENTYCE provides a convenient, once-daily oral solution for treating inappetence. Please reference the chart for recommended dosages.

    To administer ENTYCE, the bottle should be shaken gently and then the appropriate amount of solution withdrawn using the provided syringe. The syringe should be rinsed between treatment dose.1

    Weight of Dog Dose
    5 2.3 0.2
    10 4.5 0.5
    15 6.8 0.7
    20 9.1 0.9
    25 11.4 1.1
    30 13.6 1.4
    35 15.9 1.6
    40 18.2 1.8
    45 20.5 2.1
    50 22.7 2.3
    55 25.0 2.5
    60 27.3 2.7
    65 29.5 3.0
    70 31.8 3.2
    75 34.1 3.4
    80 36.4 3.6
    85 38.6 3.9
    90 40.9 4.1

    Field Study The clinical Field Study1 demonstrated a significantly higher proportion of inappetent dogs that received ENTYCE® (carpromorelin oral solution) had increased appetite as comparerd to dogs that received placebo.

    PRIMARY ENDPOINT: Owner Appetite Assessment
  • Success Rate on day 4
  • Parameter Capromorelin Placebo P-Value
    Treatment success-single-question assessment %* 68.6 44.6 0.0078
    Treatment success-Owner Appetite Assessment, %† 56.2 26.8 0.0071
    Percent change in body weight, mean (SD) 1.83(2.8) 0.11(3.61) 0.004
    Percent change in Owner Appetite Assessment, mean (SD) 73.4(75.9) 35.6(53.9) 0.0125
    *A dog was considered a treatment success if the owner answered that their dog's appetite was increased in response to the question,"Do you feel that during the study (over the 4± 1 days of treatment) your dog's appetite was increased, no change or decreased?"
    †Treatment success was defined as an increase in total score? 5 from day 0 to day 3 ± 1 (scoring scale 5-25)

    Study Design
  • Blinded, placebo-controlled, multi-site study
  • 244 client-owned dogs enrolled, 2:1 randomization
  • Inappentence from a variety of causes
  • 3 mg/kg once daily oral liquid for 4 days
  • All dogs enrolled in the study were evaluated for adverse reactions throughout the course of the study.

  • Adverse reactions reported in dogs administered ENTYCE oral solution compared with vehicle control.
    Adverse Reactions* ENTYCE (n=171)* n(%) Placebo (n=73)* n(%)
    Diarrhea 12 (7.0%) 5 (6.8%)
    Vomiting 11 (6.4%) 4 (5.5%)
    Elevated blood urea nitrogen (BUN) 7 (4.1%) 2 (2.7%)
    Polydipsia 7 (4.1%) 1 (1.4%)
    Elevated phosphorus 4 (2.3%) 1 (1.4%)
    Hypersalivation 4 (2.3%) 0 (0.0%)
    Abdominal discomfort 2 (1.2%) 0 (0.0%)
    Flatulence 2 (1.2%) 0 (0.0%)
    Lethargy/depression 2 (1.2%) 0 (0.0%)
    Nausea 2 (1.2%) 0 (0.0%)
    Elevated creatinine 1 (0.6%) 1 (1.4%)
    *The following adverse reactions were reported in < 1% of dogs that were administered ENTYCe: hyperractivity, increased fecal volume, increased gut sounds and polyuria.

    CONCLUSION This study demonstrates that a ghrelin receptor agonist, ENTYCE, can stimulate appetite and increase body weight in a large population of client-owned dogs with reduced appetite of varying etiologies and was well-tolerated.


    Review Summary
    7 Reviews
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    100% Recommend this product (7 of 7 responses)
    By Carol M.
    Albuquerque, New Mexico
    It Works!
    April 14, 2022
    I have a beautiful German Shepherd. She’s a little high strung, and food simply is not one of her priorities! My Vetinarian prescribed Entyce and we’ve been using it about a year now. She consistently eats all her food when she receives this medicine. But if I choose to not give it to her, she just doesn’t eat much of what I normally prepare for her. Certainly, if you have an animal that is having trouble gaining weight, Entyce will help with everyone walking away winners, and your sweet friend will be nourished and gain the weight needed!
    • - It works.
    • - Easy to use large numbered syringe to squirt medication into the mouth.
    • - Comes in two sizes depending on the size of your animal and the amount of milligrams it needs.
    • - No special handling or storage is needed.
    • - It seems to be well tolerated as my pet comes when called and she sees it?s her medicine time.
    • - It?s expensive.
    • - It is not easily available through local pharmacies and I have to order it from On-line websites.
    • - The bottles are small. 30 millimeters only lasts one week for the weight my pet is.
    • - The time from dosage to eating and successful appetite is variable and unpredictable. If I feed too early, my pet may not be interested in eating, and visa versa. If my pet doesn?t eat well, I consider the medicine has failed.
    By Jani
    SCV CA
    Dog Appetite
    March 30, 2019
    This works to help stimulate my dogs appetite. Entirely Pets was much cheaper than at my Vet office where i initially bought it. Prompt shipping helpful customer service
    By Sheryl
    January 16, 2019
    Very pleasant to work with. Received order in timely manner.
    By Lori
    Pasadena, MD
    Great stuff
    October 28, 2018
    My male wouldn’t eat because my female was in heat and started to lose a lot of weight.
    Started him on one dose and he eat for me.. I’m a happy doggie mom.
    By Lori
    New Port Richey, FL
    Great product!
    August 26, 2018
    Entyce works great! Thanks for such a speedy delivery and a great price.
    By Dbbie
    Reno, NV
    Entice seems to work for our dog
    April 20, 2018
    Our dog is eating much better since taking Entyce.
    By Debbie
    Entyce appetite stimulant
    March 29, 2018
    Seems like a good product. Our dog is eating better. The medicine arrived in a timely manner.
    I will purchase again.

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