Bexacat for Cats - Bexagliflozin - 15-mg (90 tablets) - [Diabetes]

Bexacat (Bexagliflozin) Flavored Tablets for Cats are a veterinary medication used for the management of diabetes mellitus in cats. Each tablet contains bexagliflozin, which helps to lower blood sugar levels by inhibiting glucose reabsorption in the kidneys. These flavored tablets are easy to administer orally, with a taste that cats find palatable. Bexacat tablets help manage diabetes in cats by controlling blood sugar levels. Please note that Bexacat tablets are available only with a prescription from a licensed veterinarian, and the dosage should be determined by your veterinarian based on your cat's individual needs.

Key Features

• Bexagliflozin: Active ingredient that helps lower blood sugar levels in cats with diabetes mellitus.
• Flavored Tablets: Easy to administer orally, with a taste that cats find palatable.
• Management of Diabetes Mellitus: Helps manage diabetes in cats by controlling blood sugar levels.
• Veterinary Prescription Required: Available only with a prescription from a licensed veterinarian.
• Dosage: The dosage of Bexacat tablets should be determined by your veterinarian based on your cat's individual needs.

Indications:

Baxacat is indicvated to improve glymic control in otherwise healthy cats with diabetes mellitus not previously treated with insulin.

How it works:

Bexacat (Bexagliflozin) works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys of cats. This mechanism of action helps the kidneys remove excess glucose from the bloodstream and excrete it through the urine. By promoting the excretion of glucose, Bexacat helps lower blood sugar levels in cats with diabetes mellitus. This can lead to improved blood sugar control and reduced reliance on insulin injections in some cases. Additionally, by removing excess glucose from the body, Bexacat may also help manage weight and improve kidney function in diabetic cats.

Specifications:

• Brand: Bexacat
• Active Ingredient: Bexagliflozin
• Type: Oral Liquid
• Indicated For: Diabetes mellitus in cats
• Dosage Form: Liquid
• Strength: Various strengths available

Bexagliflozin

Always provide the Client Information Sheet with the prescription.

Administer one tablet by mouth to cats weighing 6.6 lbs (3.0 kg) or greater once daily, at approximately the same time each day, with or without food, and regardless of blood glucose level.

Monitoring:

• Sudden onset of hyporexia/anorexia, lethargy, dehydration, or weight loss in cats receiving Bexacat should prompt immediate discontinuation of Bexacat and assessment for diabetic ketoacidosis, regardless of blood glucose level.
• During treatment with Bexacat, blood glucose, fructosamine, serum β-hydroxybutyrate (BHBA), serum feline pancreas-specific lipase (fPL), liver parameters, serum cholesterol and triglycerides; and body weight and clinical signs should be routinely monitored.
• Increasing or persistently elevated feline pancreas-specific lipase or liver parameters should prompt further evaluation for pancreatitis and/or hepatic disease and consideration for discontinuing Bexacat.
• BHBA is the predominate ketoacid in diabetic ketoacidosis. Bexacat should be discontinued if a notable reduction in BHBA is not observed after initiation of Bexacat, or if BHBA persistently rises after an initial reduction.
• Cats with increasing or persistently elevated cholesterol and triglyceride levels may be at an increased risk for developing diabetic ketoacidosis or euglycemic diabetic ketoacidosis.
• Bexacat should be discontinued if poor glycemic control, as described below, develops.
• During the first 8 weeks after initiation of Bexacat, assessment of glycemic control and clinical improvement should be evaluated.
• A physical examination, an 8-hour blood glucose curve, serum fructosamine and body weight improvement should be evaluated.
• Cats demonstrating poor glycemic control, including weight loss, an average blood glucose concentration from an 8-hour blood glucose curve ≥ 250 mg/dL, and/or a fructosamine indicating poor glycemic control, as described above, at 8 weeks.
• Bexacat should be discontinued, and initiation of insulin considered in cats demonstrating poor glycemic control, as described above, at 8 weeks.
• Cats may present with diabetic ketoacidosis and a normal blood glucose concentration (euglycemic diabetic letoacidosis). Delay in recognition and treatment of diabetic ketoacidosis and euglycemic diabetic ketoacidosis may result in increased morbidity and mortality.
• Development of diabetic ketoacidosis and euglycemic diabetic ketoacidosis requires the following actions:
• Discontinuation of Bexacat
• Prompt Initiation of insulin therapy
• Administration of dextrose or other carbohydrate source, regardless of blood glucose concentration
• Appropriate nutritional support should be promptly initiated to prevent or treat hepatic lipidosis.

Contraindications:

• Do not use Bexacat in cats with diabetes mellitus who have previously been treated with insulin, who are receiving insulin, or in cats with insulin-dependent diabetes mellitus. The use of Bexacat in cats with insulin-dependent diabetes mellitus, or the withdrawal of insulin and initiation of Bexacat, is associated with an increased risk of diabetic ketoacidosis or euglycemic diabetic ketoacidosis and death.
• Due to risk of severe adverse reactions, do not use Bexacat in cats with evidence of hepatic disease of reduce renal function.

Warnings:

User Safety Warnings:

Not for use in humans, Keep our of reach of children. Consult a physician in case of accidental ingestion by humans.

Animal Safety Warnings

• Bexacat should not be initiated in cats with:
• Anorexia, dehydration, or lethargy at the time of diagnosis of diabetes mellitus, as it may indicate the presence of other concurrent disease and increase the risk of diabetic ketoacidosis.
• An fPL level › 5.3 mcg/L, diagnostic imaging consitent with pancreatitis, a history of pancreatitis, or current clinical signs suggestive of pancreatitis.
• Laboratory values consistent with diabetic ketoacidosis, including elevated urine or serum ketones, and metabolic acidosis (high anion gap, or decreased bicarbonate, pH or partial pressure carbon diocide [PaCO2] levels).
• A BHBA › 37 mg/dL, or if BhBA is › 25 mg/dL and the cat has a history of renal disease or metabolic acidosis.
• Persistent plasma bexagliflozin concentrations and reduce clearance of Bexacat, represented as the presence of plasma half-lives in excess of 24 hours, may result in prolonged clinical effects such as glucosuria and/or euglycemia despite discontinuation of Bexacat in some cats with hepatic disease and/or reduced renal function, including cats with clinically undetectable disease at the time of Bexacat initiation. Reduce clearance of Bexacat may contribute to persistent glucosuria, resulting in an osmotic diuresis and dehydration that requires appropriate hydration support. These cats may require hospitalization, which may be protracted, for sequalae such as diabetic ketoacidosis, euglycemic diabetic ketoacidosis, or hepatic lipidosis.
• Cats should be screened for urinary tract infections and treated, if indicated, when initiating Bexacat. Treatment with Bexacat may increase the risk for urinary tract infections (see Adverse Reactions). Cats treated with Bexacat should be monitored for urinary tract infections and treated promptly. Consider discontinuation of Bexacat in cats with recurrent urinary tract infections.
• Bexacat may cause increased serum calcium concentrations. Bexacat should be discontinued in cats with persistent increases in serum total calcium or ionized calcium because of increased risk of forming calcium containing uroliths (see Adverse Reactions).
• Long term use of Bexacat may increase the risk of urothelial carcinoma (see Adverse Reactions).
• Keep Bexacat in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.

Precautions:

• Bexacat should be discontinued in cats who develop diarrhea unresponsive to conventional therapy
• Consider temporary discontinuation of Bexacat in cats during times of decreased caloric intake, such as surgery or decreased appetite, as administration of Bexacat in these cats may increase the risk of diabetic ketoacidosis or hepatic lipidosis.
• The osmotic diuretic effect of Bexacat may contribute to inappropriate urination in some cats (see Adverse Reactions)
• Polyphagia as a compensatory response to caloric wasting from glucosuria may persist in up the 80% of cats, despite evidence of adequate glycemic control, and may lead to progressive weight gain.
• Approximately 20-30% of cats may have persistent polyuria and/or polydipsia secondary to Bexacat-induced osmotic diuresis and may be a risk factor for dehydration-associated diabetic ketoacidosis.
• The safety of Bexacat in breeding, pregnant, and lactating cats has not been evaluated.

Storage:

Bexacat should be stored at tum temperature 68 too 77 °F (20 to 25 C°).