Voriconazole for Injection USP 200 mg SDV

Voriconazole is an antifungal medication that is a derivative of the drug fluconazole. The main difference between the two is that voriconazole is shown to be more effective against a wider number of fungal organisms.

Voriconazole is often used by veterinarians to treat pets that are infected by fungal organisms that have developed a resistance to fluconazole and other antifungal drugs like itraconazole and amphotericin-B. Due to the broadness of its fungicidal activity, voriconazole is most commonly used to treat aspergillus infections as well as candida, fusarium, and Cryptococcus.

Indications

Voriconazole for Injection is an azole antifungal indicated for use in the treatment of:

• Invasive aspergillosis
• Candidemia (nonneutropenics) and disseminated candidiasis in skin, abdomen, kidney, bladder wall, and wounds
• Esophageal candidiasis
• Serious infections caused by Scedosporium apiospermum and Fusarium species including Fusarium solani, in patients intolerant of, or refractory to, other therapy

Use this medication as directed by your veterinarian.

• Hypersensitivity to voriconazole or its excipients.
• Coadministration with terfenadine, astemizole, cisapride, pimozide or quinidine, sirolimus due to risk of serious adverse reactions
• Coadministration with rifampin, carbamazepine, long-acting barbiturates, efavirenz ritonavir, rifabutin, ergot alkaloids, and St. John's Wort due to risk of loss of efficacy

Warnings & Precautions

Clinically Significant Drug Interactions: Review patient's concomitant medications.

• Hepatic Toxicity: Serious hepatic reactions reported. Evaluate liver function tests at start of and during voriconazole therapy
• Visual Disturbances (including optic neuritis and papilledema): Monitor visual function if treatment continues beyond 28 days
• Embryo-Fetal Toxicity: Do not administer to pregnant women unless the benefit to the mother outweighs the risk to the fetus. Inform pregnant patient of hazard
• Arrhythmias and QT Prolongation: Correct potassium, magnesium and calcium prior to use; caution patients with proarrhythmic conditions
Infusion Related Reactions (including anaphylaxis): Stop the infusion Dermatological Reactions: Discontinue for exfoliative cutaneous reactions or phototoxicity. Avoid sunlight due to risk of photosensitivity Skeletal Events: Fluorosis and periostitis with long-term voriconazole therapy. Discontinue if these events occur