What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
Revolution Plus is a safe and effective monthly topical medication that provides 6-in-1 protection for cats. Revolution Plus kills fleas before they lay eggs, and kills ticks for a full month. In comparison to Revolution for cats, Revolution Plus kills 3 types of ticks (black-legged tick, Gulf Coast tick, and American dog tick) for a full month. It also prevents heartworm disease and treats and controls ear mites, roundworms, and hookworms. Revolution Plus is easy to apply and is a quick-drying solution for a mess-free administration. Revolution Plus requires a prescription from your veterinarian.
Revolution Plus is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. Revolution Plus kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Ixodes scapularis (black-legged tick or deer tick), Amblyomma maculatum (Gulf Coast tick) and Dermacentor variabilis (American dog tick), the treatment and control of ear mite (Otodectes cynotis) infestations, and the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.
Revolution Plus contains two active ingredients, selamectin and sarolaner, which absorbs into the skin and enter the bloodstream. Combined, these ingredients start killing fleas within 6 hours of administration, begin to kill ticks within 24 hours of administration, prevent the development of heartworm, and eliminate and control ear mites and other worms.
The recommended minimum dosage is 2.7 mg selamactin per pound (6 mg/kg) of body weight and 0.45 mg sarolaner per pond (1 mg/kg) of body weight.
Administer the entire contents of a single tube (or two tubes in combination for cats weighing over 22 pounds) of Revolution Plus topically in accordance with the following table.
|Body Weight (lb)||Tube Cap Color||Tube Volume (mL)||Tube Contents|
|Selamectin (mg/tube)||Sarolaner (mg/tube)|
*Cats over 22 lbs should be treated with the appropriate combination of tubes. Recommended for use in cats and kittens 8 weeks of age or older.
A veterinarian r veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolution Plus topically to cats and kittens prior to first use.
Firmly press the cap down to puncture the seal on the Revolution Plus tube; a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly on the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty.
Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the hair coat is wet. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some cats. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in yor ordinary household refuse.
The effectiveness of Revolution Plus against D. immitis after bathing has not been evaluated. Bathing or shampooing the cat 24 hours after treatment does not reduce the effectiveness of topical selamectin, one f the ingredients of Revolution Plus, against D. immitis.
For the treatment and prevention of flea infestations, Revolution Plus may begin at anytime of year. Revolution Plus shold be administered year-round at monthly intervals or begin at least one month before fleas become active. If a cat is already infested with fleas when the first dose of Revolution Plus is administered, adult fleas on the animal are killed before they can lay eggs. However, an environmental infestation may persist for a short time after beginning treatment with Revolution Plus because of the development of adult fleas from eggs that were laid prior to the initiation of treatment.
For the treatment and control of infestations with Ixodes scapularis, Amblyomma maculatum and Dermacentor variabilus, Revolution Plus may begin at any time of year. Revolution Plus should be administered year-round at monthly intervals or begin at least one month befor ethe ticks become active.
For the prevention of heartworm disease, Revolution Plus must be administered on a monthly basis. Revolution Plus should be administered year-round or at least within one month after the animal's first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose missed and a monthly interval between dosing is exceeded then immediate administration of Revolution Plus and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another monthly heartworm preventive product in a heartworm disease prevention program, the first dose of Revolution Plus must be given within a month of the last dose of the former medication.
Selamectin, one of the active ingredients in Revolution Plus, is a macrocryclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. This product effectively eliminates the tissue stage of heartworm larvae for a month after infection. Cats with unknown heartworm history that test negative prior to the initiation of Revolution Plus may be harboring pre-patent infections at the time Revolution Plus was started. Testing such animals 3-4 months after initiation of Revolution Plus would be necessary to confirm their negative heartworm status.
At the discretion of the veterinarian, cats > 6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with Revolution Plus. Cats already infected with adult heartworms can be given Revolution Plus monthly to prevent further infections.
For the treatment of ear mite (Otodectes cynotis) infestations, Revolution Plus should be administered once as a single topical dose. Do not administer into the ear canal. Monthly use of Revolution Plus will control any subsequent ear mite infestations. Cleansing of the infested ears is recommended to remove debris.
For the treatment of roundworm (Toxocara cati) and intestinal hookworm (ancylostoma tubaeforme) infections, Revolution Plus should be applied once as a single topical dose. Monthly use of Revolution Plus will control any subsequent roundworm and intestinal hookworm infections.
Store at or below 30°C (86°F). Keep out of reach of children and pets.
Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Use with caution in cats with a history of neurologic disorders.
The safe use of Revolution Plus has not been evaluated in kittens less than 8 weeks of age. The safe use of Revolution Plus has not been evaluated in breeding, pregnant, or lactating cats.
Lethargy, skin lesions, anorexia, pruritus, conjunctivitis, sneezing, administration site hair changed (alopecia), administration site lesions (scabbing).
The most commonly reported side effects in clinical trials were temporary loss of appetite and drowsiness. No side effects were noted when Revolution Plus was used along with commonly prescribed veterinary products.
While there was a low incidence of side effects in clinical trials, it's important to report to your veterinarian any unusual signs or activity in your cat or kitten after applying the product.
Revolution Plus is proven safe for cats and kittens as young as 8 weeks of age, weighing 2.8 lbs or greater. The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or breeding, pregnant, or lactating cats.
Since one of the active ingredients (sarolaner) in Revolution Plus is a member of the isoxazoline class, use with caution in cats with a history of neurologic disorders such as seizures. Revolution Plus has been administered in conjunction with numerous cat medications and may be given to cats with adult heartworm infection.