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PRN Firocoxib Tablets for Horses is a veterinary prescription nonsteroidal anti-inflammatory drug (NSAID) of the coxib class used to control pain and inflammation associated with osteoarthritis in horses. Osteoarthritis (OA) is a painful condition caused by progressive "wear and tear" of cartilage and other parts of the joints that may result in the following changes or signs in your horse:
Firocoxib Tablets for Horses are administered once daily for up to 14 days for the control of pain and inflammation associated with osteoarthritis in horses.
Always provide the Client Information Sheet with the prescription. The recommended dosage of Firocoxib Tablets for Horses is one 57 mg tablet administered orally to horses weighing 800 - 1300 lbs, once daily for up to 14 days. For ease of administration, Tablets for Horses may be given with food.
The overall duration of treatment with any firocoxib formulation in horses, including tablets, injection or oral paste should not exceed 14 days. Please see the package insert for firocoxib injection or oral paste for appropriate prescribing information for those fonnulations.
Horses with a hypersensitivity to firocoxib should not receive Firocoxib Tablets for Horses.
For use in horses only. Do not use in horses intended for human consumption. Store Firocoxib Tablets for Horses out of the reach of dogs and other pets in a secured location in order to prevent ingestion or overdose.
Not for use in humans. Keep this and all medications out of the reach of chil- dren. Consult a physician in case of accidental ingestion by humans.
Horses should undergo a thorough history and examination before initiation of NSAID therapy. Appropriate laboratory tests should be conducted to establish hematological and serum biochemical baseline data before and periodically during administration of any NSAID. Clients should be advised to observe for signs of potential drug toxicity and be given a Client Information Sheet with each prescription. See Information for Owner or Person Treating Horse section of this package insert.
Treatment with Firocoxib Tablets for Horses should be terminated if signs such as inappetence, colic, abnonnal feces, or lethargy are observed.
As a class, cyclooxygenase inhibitory NSAIDs may be associated with gastrointestinal, renal, and hepatic toxicity. Sensitivity to drug-associated adverse events varies with the individual patient. Horses that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. Patients at greatest risk for adverse events are those that are dehydrated, on diuretic therapy, or those with existing renal, cardiovascular, and/or hepatic dysfunction. Concurrent administration of potentially nephrotoxic drugs should be carefully approached or avoided. NSAIDs may inhibit the prostaglandins that maintain normal homeostatic function. Such anti-prostaglandin effects may result in clinically significant disease in patients with underlying or pre-existing disease that has not been previously diagnosed. Since many NSAIDs possess the to produce gastrointestinal ulcerations and/ or gastrointestinal perforation, concomitant use of Firocoxib Tablets for Horses with other inflammatory drugs, such as NSAIDs or should be avoided.
The concomitant use of protein bound drugs with Firocoxib Tablets for Horses has not been studied in horses. The influence of concomitant drugs that may inhibit the metabolism of Firocoxib Tablets for Horses has not been evaluated. Drug compatibility should be monitored in patients requiring adjunctive therapy.
The safe use of Firocoxib Tablets for Horses in horses less than one year in age, horses used for breeding, or in pregnant or lactating mares has not been evaluated.
Consider appropriate washout times when switching from one NSAID to another NSAID or corticosteroid.
Firocoxib Tablets for Horses should be given according to your veterinarian's instructions. Do not change the way you give Firocoxib Tablets for Horses to your horse without first speaking with your veterinarian. Do not exceed 14 days of treatment.
Firocoxib Tablets for Horses may be given with or without food. Do not give firocoxib chewable tablets for dogs to horses, as overdoses may occur and result in serious side effects.
Your horse should not be given Firocoxib Tablets for Horses if he/she:
Talk to your veterinarian about:
Tell your veterinarian if your horse has ever had the following medical problems:
Tell your veterinarian about:
Tell your veterinarian if you plan to breed your horse, or if your mare is pregnant or nursing a foal.
Firocoxib Tablets for Horses, like other NSAIDS, may cause some side effects. Serious side effects associated with NSAID therapy in horses can occur with or without warning. The most common side effects associated with Firocoxib Tablets for Horses therapy involve the tongue, lips and skin of the mouth and face (erosions and ulcers of the mucosa and skin) and the kidney. Gastrointestinal, kidney and liver problems have also been reported with other NSAIDs. Look for the following side effects that may indicate your horse is having a problem with Firocoxib Tablets for Horses or may have another medical problem:
It is important to stop therapy and contact your veterinarian if you think your horse has a medical problem or side effect while taking Firocoxib Tablets for Horses. If you have additional questions about possible side effects, talk with your veterinarian or call 1-800-874-9764.
Firocoxib Tablets for Horses should not be given with other NSAIDs (for example, aspirin, phenylbutazone, diclofenac, ketoprofen or flunixin) or systemic corticosteroids (for example, prednisone, cortisone, dexamethasone, or triamcinolone).
Tell your veterinarian about all medications that you have given your horse in the past, and any medications you are planning to give with Firocoxib Tablets for Horses. This should include other medicines that you can get without a prescription or any dietary supplements. Your veterinarian may want to check that all of your horse’s medicines can be given together.