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Optimmune Ophthalmic Ointment

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Notices

Optimmune is excluded from free shipping.

Description

Optimmune ophthalmic ointment is a veterinary medication used for the treatment of chronic keratoconjunctivitis sicca (dry eye) in dogs. It contains 0.2% cyclosporine, which helps to increase tear production and reduce inflammation in the eye. Optimmune is formulated as an ophthalmic ointment for easy application to the eye. This medication is available only with a prescription from a licensed veterinarian and is typically administered twice daily as directed. Optimmune is a trusted choice for managing dry eye in dogs, providing relief from symptoms and promoting eye health.

Key Features

  • Cyclosporine: Active ingredient that helps increase tear production and reduce inflammation.
  • Ophthalmic Ointment: Formulated for easy application to the eye.
  • Treatment for Dry Eye: Used to treat chronic keratoconjunctivitis sicca (dry eye) in dogs.
  • Veterinary Prescription Required: Available only with a prescription from a licensed veterinarian.
  • Twice-Daily Dosage: Typically administered twice daily, as directed by a veterinarian.

How It Works

Optimmune Ophthalmic Ointment contains cyclosporine, which has broad anti-inflammatory effects that help to reduce damage to the tear glands while also stimulating tear production. Optimmune Ophthalmic Ointment also reduces eye inflammation.

Indications

Optimmune Ophthalmic Ointment is indicated for management of chronic keratoconjunctivitis sicca(KCS) and chronic superficial keratitis (CSK) in dogs.

Optimmune Ophthalmic Ointment is a registered trademark of Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck ∓ Co. Inc.

Ingredients

Active Ingredient: Cyclosporine 2 Mg, USP.

Inactive Ingredients: Petrolatum, USP; Corn Oil, NF; Petrolatum and Lanolin Alcohol.

Directions

View Optimmune Drug Facts Sheet.

  • Remove debris with suitable nonirritating solutions. Apply a 1/4 inch strip of ointment to the affected eye every 12 hours. The ointment may be placed directly on the cornea or into the conjunctival sac.
  • It is recommended that dogs exhibiting chronic recurring conjunctivitis be tested for adequate tear production to determine if they are suffering from early stages of chronic KCS.
  • For best results in treating KCS, cyclosporine ophthalmic ointment should be administered early in the course of the disease before irreversible damage to the lacrimal tissue, or dense corneal scarring or pigmentation occurs.
  • Dogs afflicted with KCS or CSK will most likely require lifelong consistent therapy (see Efficacy section above). For CSK, because environmental factors such as ultraviolet (UV) radiation are implicated in the pathogenesis, clinical signs may subside in the winter months when light intensity is reduced or if the dog is moved to a lower altitude, or indoors, and thus exposed to less UV radiation.
  • In cases refractory to cyclosporine, the diagnosis should be reevaluated and a different course oftherapy considered. Periodic reassessment of the need for Optimmune Ophthalmic Ointmenttherapy is recommended.

Caution

US Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Precautions

The clinical effects of Optimmune Ophthalmic Ointment have not been determined in dogs with KCS due to the following conditions: congenital alacrima, sulfonamide usage, canine distemper virus, metabolic disease, surgical removal of the third eyelid gland, and facial nerve paralysis with loss of the palpebral reflex. Some of the underlying conditions which may lead to KCS can be either transient (eg,facial nerve trauma) or correctable with appropriate treatment. Consequently, recovery from clinical signs attributed to KCS may be observed and treatment options may need reconsideration.

When switching to cyclosporine from another therapeutic agent (eg, frequent application of an artificialtear preparation) for KCS or CSK, it should be kept in mind that clinical efficacy is not necessarily apparent immediately after initiation of Optimmune Ophthalmic Ointment therapy. Several days to afew weeks may be required before the clinical effects of Optimmune Ophthalmic Ointment are of sufficient magnitude such that previously initiated therapy can be safely withdrawn. Abrupt cessation of a therapeutic agent immediately upon initiation of Optimmune Ophthalmic Ointment therapy can result in rapid clinical relapse which may be erroneously interpreted as an adverse reaction to Optimmune Ophthalmic Ointment.

The safety of Optimmune Ophthalmic Ointment has not been determined in cases of preexisting viral or fungal ocular infections. It is recommended that in such cases, Optimmune Ophthalmic Ointment therapy be delayed until the fungal/viral ocular infection has been successfully treated.

The safety of Optimmune Ophthalmic Ointment in puppies, pregnant bitches, or dogs used for breeding has not been determined.

Safety

A target animal safety study and clinical field studies with Optimmune Ophthalmic Ointment showed a wide safety margin in adult dogs. In the 6-month target animal safety study, dogs weresubjected twice daily to up to 10 times the approved concentration of Optimmune Ophthalmic Ointment. No apparent toxicity or adverse reactions were observed. Dogs in this study were vaccinated with commercially available vaccines. No effect on antibody titer response was noted. Epiphora was noted in all groups, including the placebo group, and was not associated with any inflammatory change,nor was there any correlation to gross and histopathological changes.

Adverse Reactions

In the KCS clinical field trial, there were 20 adverse reactions reported out of 132 cases enrolled. This corresponds to an adverse reaction rate of 12.9% (13 of 101 cases) for Optimmune Ophthalmic Ointment treated dogs and 22.6% (7 of 31) for placebo treated dogs. The reactions described were primarily ocular and periocular inflammatory reactions. These were likely a function of therapy being unable to fully control the keratoconjunctivitis, rather than a true "adverse reaction." Similarly, in the CSK trial, of 36 cases evaluated for safety, adverse reactions were noted in 2 animals (5.6%). One involved transient hyperemia, epiphora, and mild discomfort of the eye. The other involved periocular/palpebral inflammation and mild alopecia.

On rare occasion, instillation of Optimmune Ophthalmic Ointment may be associated with local irritation as manifested by periocular redness, lid spasm, and excessive rubbing. As the eyes of dogs with KCS often demonstrate considerable inflammation, it will be difficult to determine whether this local irritation constitutes a hyper sensitivity to Optimmune Ophthalmic Ointment. If this ocular irritation persists beyond 7 days, hyper sensitivity to a component of Optimmune Ophthalmic Ointment should be suspected and therapeutic options reassessed.

Storage

Store between 2° and 25° C (36° and 77° F).

FAQ

Optimmune Ophthalmic Ointment is an immunosuppressive agent used to reduce inflammation in the eye(s). It is used to treat chronic dry eye (KCS, keratoconjunctivitis sicca) that may be caused by inflammation. Optimmune Ophthalmic Ointment may also be used for purposes other than those listed. Optimmune Ophthalmic Ointment is FDA approved for veterinary use in dogs only. Optimmune Ophthalmic Ointment is a prescription medication available as a sterile eye ointment. The sterile ointment is usually applied as a ¼ inch strip to the eye(s) every 12 hours. Do not touch the tube opening to any surface, including eyes and hands. The tube opening is sterile. If it becomes contaminated, it could cause an infection in the eye.
Do not use Optimmune Ophthalmic Ointment if your pet has any type of infection in the eye(s). Tell your veterinarian if your pet is pregnant or lactating.
Use this medication exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Wash your hands prior to using the eye ointment. Apply a ¼ inch strip of the ointment into the lower eyelid. Store Optimmune Ophthalmic Ointment at room temperature, away from moisture and heat. Keep the tube properly capped.
Serious side effects are not expected. Some burning, redness, tearing, discharge, pain, itching, stinging, or blurring of the vision may occur. Continue the medication and talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not give a double dose of the medication.
An overdose of this medication is unlikely. If an overdose is suspected, wash the eye with water and seek emergency veterinary medical treatment.
Do not touch the tube opening to any surface including eyes or hands. This medication may cause blurred vision. Avoid using other eye medications unless approved by your veterinarian.
Before using Optimmune Ophthalmic Ointment, tell your veterinarian if your pet is using other eye ointment or eye medications. Drugs other than those listed may also interact with Optimmune Ophthalmic Ointment. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.

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