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Optimmune ophthalmic ointment is a veterinary medication used for the treatment of chronic keratoconjunctivitis sicca (dry eye) in dogs. It contains 0.2% cyclosporine, which helps to increase tear production and reduce inflammation in the eye. Optimmune is formulated as an ophthalmic ointment for easy application to the eye. This medication is available only with a prescription from a licensed veterinarian and is typically administered twice daily as directed. Optimmune is a trusted choice for managing dry eye in dogs, providing relief from symptoms and promoting eye health.
Optimmune Ophthalmic Ointment contains cyclosporine, which has broad anti-inflammatory effects that help to reduce damage to the tear glands while also stimulating tear production. Optimmune Ophthalmic Ointment also reduces eye inflammation.
Optimmune Ophthalmic Ointment is indicated for management of chronic keratoconjunctivitis sicca(KCS) and chronic superficial keratitis (CSK) in dogs.
Optimmune Ophthalmic Ointment is a registered trademark of Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck ∓ Co. Inc.
Active Ingredient: Cyclosporine 2 Mg, USP.
Inactive Ingredients: Petrolatum, USP; Corn Oil, NF; Petrolatum and Lanolin Alcohol.
View Optimmune Drug Facts Sheet.
US Federal law restricts this drug to use by or on the order of a licensed veterinarian.
The clinical effects of Optimmune Ophthalmic Ointment have not been determined in dogs with KCS due to the following conditions: congenital alacrima, sulfonamide usage, canine distemper virus, metabolic disease, surgical removal of the third eyelid gland, and facial nerve paralysis with loss of the palpebral reflex. Some of the underlying conditions which may lead to KCS can be either transient (eg,facial nerve trauma) or correctable with appropriate treatment. Consequently, recovery from clinical signs attributed to KCS may be observed and treatment options may need reconsideration.
When switching to cyclosporine from another therapeutic agent (eg, frequent application of an artificialtear preparation) for KCS or CSK, it should be kept in mind that clinical efficacy is not necessarily apparent immediately after initiation of Optimmune Ophthalmic Ointment therapy. Several days to afew weeks may be required before the clinical effects of Optimmune Ophthalmic Ointment are of sufficient magnitude such that previously initiated therapy can be safely withdrawn. Abrupt cessation of a therapeutic agent immediately upon initiation of Optimmune Ophthalmic Ointment therapy can result in rapid clinical relapse which may be erroneously interpreted as an adverse reaction to Optimmune Ophthalmic Ointment.
The safety of Optimmune Ophthalmic Ointment has not been determined in cases of preexisting viral or fungal ocular infections. It is recommended that in such cases, Optimmune Ophthalmic Ointment therapy be delayed until the fungal/viral ocular infection has been successfully treated.
The safety of Optimmune Ophthalmic Ointment in puppies, pregnant bitches, or dogs used for breeding has not been determined.
A target animal safety study and clinical field studies with Optimmune Ophthalmic Ointment showed a wide safety margin in adult dogs. In the 6-month target animal safety study, dogs weresubjected twice daily to up to 10 times the approved concentration of Optimmune Ophthalmic Ointment. No apparent toxicity or adverse reactions were observed. Dogs in this study were vaccinated with commercially available vaccines. No effect on antibody titer response was noted. Epiphora was noted in all groups, including the placebo group, and was not associated with any inflammatory change,nor was there any correlation to gross and histopathological changes.
In the KCS clinical field trial, there were 20 adverse reactions reported out of 132 cases enrolled. This corresponds to an adverse reaction rate of 12.9% (13 of 101 cases) for Optimmune Ophthalmic Ointment treated dogs and 22.6% (7 of 31) for placebo treated dogs. The reactions described were primarily ocular and periocular inflammatory reactions. These were likely a function of therapy being unable to fully control the keratoconjunctivitis, rather than a true "adverse reaction." Similarly, in the CSK trial, of 36 cases evaluated for safety, adverse reactions were noted in 2 animals (5.6%). One involved transient hyperemia, epiphora, and mild discomfort of the eye. The other involved periocular/palpebral inflammation and mild alopecia.
On rare occasion, instillation of Optimmune Ophthalmic Ointment may be associated with local irritation as manifested by periocular redness, lid spasm, and excessive rubbing. As the eyes of dogs with KCS often demonstrate considerable inflammation, it will be difficult to determine whether this local irritation constitutes a hyper sensitivity to Optimmune Ophthalmic Ointment. If this ocular irritation persists beyond 7 days, hyper sensitivity to a component of Optimmune Ophthalmic Ointment should be suspected and therapeutic options reassessed.
Store between 2° and 25° C (36° and 77° F).