Novox for Dogs - 100 mg, 30 Chewable Tablets - [Joint Pain & Inflammation Relief] | On Sale | EntirelyPets Rx
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Novox for Dogs - 100 mg, 30 Chewable Tablets - [Joint Pain & Inflammation Relief]

Item# VINV-CHEW-1003
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  • Reviews


Novox is a generic equivalent for Rimadyl (carprofen). It's a non-steroidal anti-inflammatory (NSAID) used to treat pain and inflammation due to arthritis and other joint diseases, including hip dysplasia. It's also used to reduce fever and to help control postoperative pain associated with soft tissue and orthopedic surgery in dogs. Novox is available as caplets (non-chewable) and liver-flavored chewable tablets. Both are scored for easy dosing and administration. Novox requires a prescription from your veterinarian.

For: Dogs (over 6 weeks of age)

Key Benefits

  • Effective
  • Easy to administer
  • Available as a liver-flavored chewable tablet or caplet
  • Same ingredient as: Norocarp, Vetprofen, Carpaquin and Putney's Carprofen

How It Works

Novox works by reducing hormones that cause pain and inflammation in your dog's body.


Novox is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.


Novox Carprofen 25 mg
Active Ingredient Amount
Carprofen 25 mg
Novox Carprofen 75 mg
Active Ingredient Amount
Carprofen 75 mg
Novox Carprofen 100 mg
Active Ingredient Amount
Carprofen 100 mg


View Novox Drug Facts Sheet

Always provide Client Information Sheet with prescription. Carefully consider the potential benefits and risk of Novox and other treatment options before deciding to use Novox. Use the lowest effective dose for the shortest duration consistent with individual response. The recommended dosage for oral administration to dogs is 2 mg/lb of body weight daily. The total daily dose may be administered as 1 mg/lb twice daily. For the control of postoperative pain, administer approximately 2 hours before the procedure. Novox chewable tablets are scored and dosage should be calculated in half-tablet increments. Tablets can be halved by placing the tablet increments. Tablets can be halved by placing the tablet on hard surface and pressing down on both sides of the score. These liver flavored Novox chewable tablets may be offered to the dog by hand or placed on food. If the dog does not willingly consume the tablets, they may be hand-administered (pilled) as with other oral tablet medications. Care should be taken to ensure that the dog consumes the complete dose.


Confirmation of the effectiveness of carprofen for the relief of pain and inflammation associated with osteoarthritis, and for the control of postoperative pain associated with soft tissue and orthopedic surgeries, was demonstrated in 5 placebo-controlled, masked studies examining the anti-inflammatory and analgesic effectiveness of carprofen caplets in various breeds of dogs.

Separate placebo-controlled, masked, multicenter field studies confirmed the anti-inflammatory and analgesic effectiveness of carprofen caplets when dosed at 2 mg/lb once daily or when divided and administered at 1 mg/lb twice daily. In these 2 field studies, dogs diagnosed with osteoarthritis showed statistically significant overall improvement based on lameness evaluations by the veterinarian and owner observations when administered carporfen at labeled doses.

Separate placebo-controlled, masked, multicenter-field studies confirmed the effectiveness of carprofen caplets for the control of postoperative pain when dosed at 2 mg/lb once daily in various breeds of dogs. In these studies, dogs presented for ovariohysterectomy, cruciate repair and aural surgeries were administered carprofen preoperatively and for a maximum of 3 days (soft tissue) or 4 days (orthopedic) postoperatively. In general, dogs administered carprofen showed statistically significant reduction in pain scores compared to controls.


Federal law restricts this drug to use by or on the order of a licensed veterinarian.


Novox should not be used in dogs exhibiting previous hypersensitivity to carprofen.


Keep out of reach of children. Not for human use. Consult a physician in cases of accidental ingestion by humans. For use in dogs only. Do not use in cats.

All dogs should undergo a thorough history of NSAID therapy. Appropriate laboratory tests to establish hematological and serum biochemical baseline data prior to, and periodically during, administration of any NSAID should be considered. Owners should be advised to observe for signs of potential drug toxicity (see Information for Dog Owners, Adverse Reactions, Animal Safety and Post-Approval Experience).


As a class, cyclooxygenase inhibitory NSAIDs may be associated with gastrointestinal, renal, and hepatic toxicity. Effects may result from decreased prostaglandin production and inhibition of the enzyme cyclooxygenase which is responsible for the formation of prostaglandins from arachidonic acid.11-14 When NSAIDs inhibit protaglandins that cause inflammation they may also inhibit those prostaglandins which maintain normal homeostatic function. These anti-prostaglandin effects may result in clinically significant disease in patients with underlying or pre-existing disease more often that in healthy patients.12,14 NSAID therapy could unmask occult disease which has previously been undiagnosed due to the absence of apparent clinical signs. Patients with underlying renal disease for example, may experience exacerbation or decompensation of their renal disease while on NSAID therapy.11-14 The use of parenteral fluids during surgery should be considered to reduce the potential risk of renal complications when using NSAIDs perioperatively.

Carprofen is an NSAID, and as with others in that class, adverse reactions may occur with its use. The most frequently reported effects have been gastrointestinal signs. Events involving suspected renal, hematologic, neurologic, dermatologic, and hepatic effects have also been reported.

Patients at greatest risk for renal toxicity are those that are dehydrate, on concomitant diuretic therapy, or those with renal, cardiovascular, and/or hepatic dysfunction. Concurrent administration of potentially nephrotoxic drugs should be approached cautiously, with appropriate monitoring. Concomitant use of carprofen with other anti-inflammatory drugs, such as other NSAIDs or corticosteroids, should be avoided because of the potential increase of adverse reactions, including gastrointestinal ulcerations and/or perforations. Sensitivity to drug-associated adverse reactions varies with the individual patient. Dogs that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. Carprofen treatment was not associated with renal toxicity or gastrointestinal ulceration in well-controlled safety studies of up to ten times the dose in healthy dogs.

Novox is not recommended for use in dogs with bleeding disorders (e.g., Von Willebrand's disease), as safety has not been established in dogs with these disorders. The safe use of Novox in animals less than 6 weeks of age, pregnant dogs, dogs used for breeding purposes, or in lactating bitches has not been established. Studies to determine the activity of Novox when administered concomitantly with other protein-bound or similarly metabolized drugs have not been conducted. Drug compatibility should be monitored closely in patients requiring additional therapy. Such drugs commonly used include cardiac, anticonvulsant and behavioral medications. It has been suggested that treatment with carprofen may reduce the level of inhalant anesthetics needed.15

If additional pain medication is warranted after administration of the total daily dose of Novox, alternative analgesia should be considered. The use of another NSAID is not recommended. Consider appropriate washout times when switching from one NSAID to another or when switching from corticosteroids use to NSAID use.

Due to the liver flavoring contained in Novox chewable tablets, store out of the reach of dogs and in a secured area. Severe adverse reactions may occur if large quantities of tablets are ingested. If you suspect your dog has consumed Novox chewable tablets above the labeled dose, please call your veterinarian for immediate assistance and notify Vedco (1-888-708-3326).

Information for Dog Owners:

Novox, like other drugs of its class, is not free from adverse reactions. Owners should be advised of the potential for adverse reactions and be informed of the clinical signs associated with drug intolerance. Adverse reactions may include decreased appetite, vomiting, diarrhea, dark or tarry stools, increased water consumption, increased urination, pale gums due to anemia, yellowing of gums, skin or white of the eye due to jaundice, lethargy, incoordination, seizure, or behavioral changes. Serious adverse reactions associated with this drug class can occur without warning and in rare situations result in death (see Adverse Reactions). Owners should be advised to discontinue Novox therapy and contact their veterinarian immediately if signs of intolerance are observed. The vast majority of patients with drug related adverse reactions have recovered when the signs are recognized, the drug is withdrawn, and veterinary care, if appropriate, is initiated. Owners should be advised of the importance of periodic follow up for all dogs during administration of any NSAID.

Animal Safety:

Laboratory studies in unanesthetized dogs and clinical field studies have demonstrated that carprofen is well tolerated in dogs after oral administration. In target animal safety studies, carprofen was administered orally to health Beagle dogs at 1, 3, and 5 mg/lb twice daily (1, 3, and 5 times the recommended total daily dose) for 42 consecutive days with no significant adverse reactions.

Serum albumin for a single female dog receiving 5 mg/lb twice daily decreased to 2.1 g/dL after 2 weeks of treatment, returned to the pre-treatment value (2.6 g/dL) after 4 weeks of treatment, and was 2.3 g/dL at the final 6-week evaluation.

Over the 6-week treatment period, black or bloody stools were observed in 1 dog (1 incident) treated with 1 mg/lb twice daily and 1 dog (2 incidents) treated with 3 mg/lb twice daily. Redness of the colonic mucosa was observed in 1 male that received 3 mg/lb twice daily.

Two of 8 dogs receiving 10 mg/lb orally twice daily (10 times the recommended total daily dose) for 14 days exhibited hypoalbuminemia. The mean albumin level in the dogs receiving this dose was lower (2.38 g/dL) than each of two placebo control groups (2.88 and 2.93 g/dL), respectively). Three incidents of black or bloody stool were observed in 1 dog. Five of 8 dogs exhibited reddened areas of duodenal mucosa on gross pathologic examination. Histologic exam of these areas revealed no evidence of ulceration, but did show minimal congestion of the lamina propria in 2 of the 5 dogs.

In separate safety studies lasting 13 and 52 weeks, respectively, dogs were administered orally up to 11.4 mg/lb/day (5.7 times the recommended total daily dose of 2 mg/lb) of carprofen. In both studies, the drug was well tolerated clinically by all of the animals. No gross or histologic changes were seen in any of the treated animals. In both studies, dogs receiving the highest doses had average increases in serum L-alanine aminotransferase (ALT) of approximately 20 IU.

In the 52-week study, minor dermatologic changes occurred in dogs in each of the treatment groups but not in the control dogs. The changes were described as slight redness or rash and were diagnosed as non-specific dermatitis, The possibility exists that these mild lesions were treatment related, but no dose relationship was observed.

Clinical field studies were conducted with 549 dogs of different breeds at the recommended oral doses for 14 days (297 dogs were included in a study evaluating 1 mg/lb twice daily and 252 dogs were included in a separate study evaluating 2 mg/lb once daily). In both studies the drug was clinically well tolerated and the incidence of clinical adverse reactions for carprofen-treated animals was no higher than placebo-treated animals (placebo contained inactive ingredients found in carprofen caplets). For animals receiving 1 mg/lb twice daily, the mean post-treatment serum ALT values were 11 IU greater and 9 IU less than pre0treatment values for dogs receiving carprofen and placebo, respectively. Differences were not statistically significant. For animal receiving 2 mg/lb once daily, the mean post-treatment serum ALT values were 4.5 IU greater and 0.9 IU less than pre-treatment values for dogs receiving carprofen and placebo, respectively. In the latter study, 3 carprofen-treated dogs developed a 3-fold or greater increase in (ALT) and/or (AST) during the course of therapy. Once placebo-treated dog has a greater than 2-fold increase in ALT. Non of these animals showed clinical signs associated with laboratory value changes. Changes in the clinical laboratory values (hematology and clinical chemistry( were not considered clinically significant. The 1 mg/lb twice daily course of therapy was repeated as needed at 2-week intervals in 244 dogs, some for as long as 5 years.

Clinical field studies were conducted in 297 dogs of different breeds undergoing orthopedic or soft tissue surgery. Dogs were administered 2 mg/lb of carprofen two hours prior to surgery then once daily, as needed for 2 days (soft tissue surgery) or 3 days orthopedic surgery). Carprofen was well tolerated when used in conjunction with a variety of anesthetic-related drugs. The type and severity of abnormal health observation in carprofen and placebo treated animals were approximately equal and few in number see Adverse Reactions). The most frequent abnormal health observation was vomiting and was observed at approximately the same frequency in carprofen and placebo treated animals. Changes in clinicopathologic indices of hematopoietic, renal, hepatic, and clotting function were not clinically significant.

The mean post treatment serum ALT values were 7.3 IU and 2.5 IU less than pre-treatment values for dogs receiving carprofen and placebo respectively. The mean post treatment AST values were 3.1 IU less for dogs receiving carprofen and 0.2 IU greater for dogs receiving placebo.


Give the missed dose as soon as you remember. However, it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
Seek emergency veterinary medical treatment. Symptoms of Novox overdose include nausea, vomiting, stomach pain, drowsiness, headache, blurred vision, seizures, panting, little or no urine production, and slow breathing.
Novox is a prescription medication that is FDA approved for use in dogs. Novox is available as 25mg, 75mg and 100mg capsule shaped scored non-chewable tablets (Caplets). The usual total daily dose in dogs is 2mg per pound given as a single daily dose or divided and administered as 1mg per pound twice a day. Contact the veterinarian if the pet has bloody, black or tarry stools as these symptoms could indicate damage to the stomach or intestines, which could be dangerous. Before giving your pet, any prescription or over the counter medications check with your veterinarian or pharmacist.
Tell your veterinarian if your pet has an allergy to aspirin or any other NSAID; an ulcer or bleeding in the stomach; has liver, or kidney disease; congestive heart failure; fluid retention; bleeding disorders; heart disease or high blood pressure. Tell your veterinarian if your pet is pregnant or lactating.
Many over a counter cough, cold, allergy and pain medicines contain aspirin or other NSAID's similar to Novox. Before taking any prescription or over the counter medications talk to the veterinarian or pharmacist.
Adverse reactions may include decreased appetite, vomiting, diarrhea, dark or tarry stools, increased water consumption, increased urination, pale gums due to anemia, yellowing of gums, skin or white of the eye due to jaundice, lethargy, incoordination, seizure, or behavioral changes. Serious adverse reactions associated with this drug class can occur without warning and in rare situations result in death. Pet parents should be advised to discontinue Novox Carprofen therapy and contact their veterinarian immediately if signs of intolerance are observed. The vast majority of patients with drug-related adverse reactions have recovered when the signs are recognized, the drug is withdrawn, and veterinary care, if appropriate, is initiated. Talk to your veterinarian about any side effect that seems unusual or bothersome to your dog.
Tell your veterinarian if your pet is being given aspirin; another NSAID such as etodolac, carprofen or piroxicam; an over the counter cough, cold, allergy or pain medication; warfarin; furosemide; a steroid such as prednisone, insulin; or probenecid. Novox Carprofen should not be given with other NSAIDs (for example, aspirin, deracoxib, etodolac, firocoxib, meloxicam, tepoxalin) or steroids (for example, cortisone, dexamethasone, prednisone, triamcinolone). Drugs other than those listed may also interact with Novox Carprofen. Talk to your veterinarian before giving your pet any prescription or over the counter medicines.


Review Summary
27 Reviews
81% (22)
11% (3)
4% (1)
0% (0)
4% (1)
96% Recommend this product (26 of 27 responses)
By Marge
Kurtistown, Hawaii
July 3, 2024
As in the past, my recent order of Novox for my dog, Heinz, arrived on time and was reasonably priced. It is so convenient to have medication delivered by mail. Thank you for the great service.
By Pam
Huntersville, NC
Changed color
July 1, 2024
It would have been better to label the bottle to explain that the medicine has changed from the orange pill seen in the picture here to a white pill maybe from a different manufacturer, but I think it is the same medicine that my dog has been using for awhile now.
By Marge B.
Kurtistown, Hawaii
Novox Pain Medication
February 28, 2024
I have used Novox for pain control for my 80 pound Labrador in the past so I was concerned when my regular supplier was out of stock and no expectation date was given as to when a new shipment would arrive. I contacted Entirely Pets and a partial order was sent to me right away. I was kept updated as to the arrival date of the remainder of my order and it too was soon in my post office box. Thank you!
St. Louis
Awesome service and super quick response!
May 1, 2022
Thanks again for shipping my Salley’s meds quickly. Much appreciated.
  • Easy and knowledgeable staff!
By Mollie S.
Lenexa, KS
Excellent Service
September 4, 2021
First of all, somehow I couldn’t complete my order online so I had to phone customer service. The lady was super nice and helpful. My discount code came up with a price cheaper than it should have, but the company honored it. On top of that, I have never received my pet’s medication so fast. Incredible service!!
By Norma
January 2, 2021
My dog is 10 years and has arthritic hips, Since he has been taking this he is able to get around without a lot of pain
By Sandra D.
Novox for pain and arthritis
December 20, 2020
So far the Novox seems to be helping my elderly dog who has severe pain and arthritis in his back legs and hips. He has only used it for two and a half weeks however so it will likely take longer to see the full effects. In fact, the veterinarian wants to check his kidney and liver functions after one month of use to make sure there is not any negative impact before allowing him to continue on this drug.
After two weeks longer we will know more about how it is affecting him.
The product was shipped quickly and the price was the best I found offered for this RX.
By David
Anchorage, AK
Extremely low priced
October 18, 2020
This product seems to work as well as the more expensive pills I bought from my veterinarian. My dog has a limp at her left front shoulder and this product helps the swelling go down. I will be buying more of this from here from now on.
By Jennifer J.
Midlothian Texas
October 4, 2020
My 11 year old lab is like a puppy again He has JUMPED in the car and able to go on longer walks Amazing
By larry s.
littletom, co
novox100 mg
July 24, 2020
again, most satisied with the product and your prompt service
By larry s.
l[ttleton, co
novox 75 mg
July 24, 2020
glad vet prescribed it and entirely pets supplied it
By Juliann S.
Houston Texas
Difficult to administer due to being powdered and broken in pieces
June 30, 2020
We have to piece together little broken pieces to equate to an entire pill because this order came 30% broken and powdered. We will have to do this for a month.
We do not recommend buying this product online. Just go to your vet to buy.
Helps my dog with pain
May 14, 2020
My dog has many aches and pains and this medication helps keep it under control!! Recommend
  • Works and is affordable
  • None
By L A.
Atlanta, GA
Best price on Carprofen!
January 4, 2020
My mastiff is on the 100 mg pills for arthritis and it is working well. I order the unflavored pills (not chewables) as I have smaller dogs too and don't want to worry about a smaller dog scarfing up a dropped chewable pill (a carprofen overdose is a serious matter).
  • Great price.
By Margie
Happy Customer
November 21, 2019
I am so glad I found entirely pets pharmacy. They are priced so good, they are speedy and my order was perfect. Thank you for amazing service. I will definitely return and spread the good news of your site. Hope you continue to provide impeccable service.

Merchant Response:Hi Margie, we are so glad to here that you had a good experience with us!!!
By Snow d.
Upstare NY
Great Service and product choices
November 17, 2019
So happy to buy my dogs medicine in large supply with great price. Will definitely be purchasing more items!
Happy to support a company that recognizems we all just love our pets like family! So hard for many folks to properly care for beloved pets on overpriced vet meds.
By Jennifer
Great Product
September 12, 2019
I've had my dog, Syd, on this for a few years now. He is a 14yo border collie mix. This helps him live his best life while aging gracefully.

By Mark
Novox is a much less expensive anti inflammatory than Rimadyl
March 20, 2019
Same as above
  • It's much easier to get my dog to take a chewable than take a pill.
  • None
By donna j.
hilton head, sc
Very pleased that it has become possible to order our dog's prescriptions thorough your company.
October 20, 2018
Great service, great prices.
By Joan
Sun City, AZ
Just as good as the name brand
August 5, 2018
I'm always trying to save money especially on medications for my dogs, and this one does the trick.

Merchant Response:Hi Joan, Glad we're able to save you some money while still providing the vital medicine for your Dog! We are always here to help!
By Lucy
Cottonwood Heights, Utah
Prompt service
July 2, 2018
They contacted the vet for the prescription. I asked for easy open containers; however, the container hasn't been opened yet (I forgot to check the right box, so called the representative. He said that he would add that instruction to the order.)
By Kenneth C.
Great price!
June 22, 2018
Cheapest price to be found...:~)

Merchant Response:Dear Kenneth, Thank you for your business. We hope everything is to your satisfaction with our website and the Novox (Carprofen). Have a great day!
By Diane
Great generic to Rimadyl
February 2, 2018
Very happy with the prices & availability of the products. Staff are very knowledgeable and helpful if a problem arises. I will continue to order in the future.
By Linda A.
Tucson, AZ
Works Great
September 3, 2017
Our 10 year old male bulldog Scooby is on them and when he does not take them he has a very difficult time walking they help a great deal

Merchant Response:Thank you for your feedback Linda and we're happy the Novox keeps Scooby comfortable and helps him move around better!
By Lori
Las Vegas, NV
Excellent Value
April 28, 2016
This medication really does the trick for my dog's arthritis/knee pain
By Lizzie
Pasadena, TX
Wonderful website, great product!
January 21, 2016
Ordering and receiving were both a snap with EntirelyPets. The medication itself is fairly effective for arthritis pain.
  • Easy order,fast shipping,easy to read and understand label
  • Medication not as long acting as the vet had hoped
By Cynthia
los angeles
January 15, 2016
got exactly what I expected. I just put the caplet in my dog's food before mixing in the wet food, and he eats it just like it was kibble.

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