Fertagyl Sterile Solution for Cattle - (GnRH) (20 ml) - [Cystic Ovaries Treatment]

Fertagyl (Gonadorelin) injectable is indicated for the treatment of cystic ovaries in dairy cattle and can also can be used to synchronize estrous cycles to allow for fixed time artificial insemination in lactating dairy cows.

Key Benefits

• Safe and effective treatment of follicular and luteal cysts since the product is identical to the hormone produced naturally by the cow.
• When given during estrus cycle or at breeding can improve fertility.
• No withholding times.

How It Works

Endogenous gonadorelin is synthesized by and/or released from the hypothalamus during various stages of the bovine estrous cycle following appropriate neurogenic stimuli. It passes via the hypophyseal portal vessels, to the anterior pituitary to effect the release of gonadotropins (e.g. LH, FSH). Synthetic gonadorelin administered intramuscularly or intravenously also causes the release of endogenous LH and FSH from the anterior pituitary.

Indications

Cystic Ovaries

Fertagyl is indicated for the treatment of ovarian follicular cysts in dairy cattle. Ovarian cysts are nonovulated follicles with incomplete luteinization which result in nymphomania or irregular estrus.

Historically, cystic ovaries have responded to an exogenous source of LH such as human chorionic gonadotropin.

Fertagyl initiates release of endogenous LH to cause ovulation and luteinization.

Reproductive Synchrony

Fertagyl is indicated for use with Estrumate (cloprostenol injection) to synchronize estrous cycles to allow for fixed time artificial insemination (FTAI) in lactating dairy cows.

Fertagyl is indicated for use with cloprostenol sodium to synchronize estrous cycles to allow for FTAI in beef cows.

Cystic Ovaries

The intravenous or intramuscular dosage of Fertagyl is 86 mcg gonadorelin (2 mL) per cow.

Reproductive Synchrony

For lactating dairy cows, the intramuscular dosage of Fertagyl is 86 mcg gonadorelin (2 mL) per cow, used in reproductive synchrony programs similar to the following:

• Administer the first Fertagyl injection (2 mL) on Day 0.
• Administer 2 mL of Estrumate (500 mcg cloprostenol, as cloprostenol sodium) by intramuscular injection 6 to 8 days after the first Fertagyl injection.
• Administer the second Fertagyl injection (2 mL) 30 to 72 hours after the Estrumate injection.
• Perform FTAI 8 to 24 hours after the second Fertagyl injection, or inseminate cows on detected estrus using standard herd practices.

For beef cows, the intramuscular dosage of Fertagyl is 86 mcg gonadorelin (2 mL) per cow, used in reproductive synchrony programs similar to the following:

• Administer the first Fertagyl injection (2 mL) on Day 0.
• Administer 500 mcg cloprostenol (as cloprostenol sodium) by intramuscular injection 6 to 8 days after the first Fertagyl injection.
• Administer the second Fertagyl injection (2 mL) 30 to 72 hours after the cloprostenol sodium injection.
• Perform FTAI 0 to 24 hours after the second Fertagyl injection, or inseminate cows on detected estrus using standard herd practices.

WARNINGS AND PRECAUTIONS:

Not for use in humans. Keep out of reach of children.

WITHDRAWAL PERIODS:

No withdrawal period or milk discard time is required when used according to the labeling.

Caution:

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Storage:

Keep refrigerated: 2°-8°C (36°-46°F).

20 mL vial: Use within 28 days of first puncture.

100 mL vial: Use within 28 days of first puncture and puncture a maximum of 10 times when using an 18 gauge needle. When using a draw-off spike or needle with bore diameter larger than 18 gauge, discard any product remaining in the vial immediately after use.