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Fertagyl (Gonadorelin) injectable is indicated for the treatment of cystic ovaries in dairy cattle and can also can be used to synchronize estrous cycles to allow for fixed time artificial insemination in lactating dairy cows.
Endogenous gonadorelin is synthesized by and/or released from the hypothalamus during various stages of the bovine estrous cycle following appropriate neurogenic stimuli. It passes via the hypophyseal portal vessels, to the anterior pituitary to effect the release of gonadotropins (e.g. LH, FSH). Synthetic gonadorelin administered intramuscularly or intravenously also causes the release of endogenous LH and FSH from the anterior pituitary.
Fertagyl is indicated for the treatment of ovarian follicular cysts in dairy cattle. Ovarian cysts are nonovulated follicles with incomplete luteinization which result in nymphomania or irregular estrus.
Historically, cystic ovaries have responded to an exogenous source of LH such as human chorionic gonadotropin.
Fertagyl initiates release of endogenous LH to cause ovulation and luteinization.
Fertagyl is indicated for use with Estrumate (cloprostenol injection) to synchronize estrous cycles to allow for fixed time artificial insemination (FTAI) in lactating dairy cows.
Fertagyl is indicated for use with cloprostenol sodium to synchronize estrous cycles to allow for FTAI in beef cows.
The intravenous or intramuscular dosage of Fertagyl is 86 mcg gonadorelin (2 mL) per cow.
For lactating dairy cows, the intramuscular dosage of Fertagyl is 86 mcg gonadorelin (2 mL) per cow, used in reproductive synchrony programs similar to the following:
For beef cows, the intramuscular dosage of Fertagyl is 86 mcg gonadorelin (2 mL) per cow, used in reproductive synchrony programs similar to the following:
Not for use in humans. Keep out of reach of children.
No withdrawal period or milk discard time is required when used according to the labeling.
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Keep refrigerated: 2°-8°C (36°-46°F).
20 mL vial: Use within 28 days of first puncture.
100 mL vial: Use within 28 days of first puncture and puncture a maximum of 10 times when using an 18 gauge needle. When using a draw-off spike or needle with bore diameter larger than 18 gauge, discard any product remaining in the vial immediately after use.