Cystorelin Sterile Solution (GnRH), 50 mcg/mL (30 cc)

Cystorelin (gonadorelin diacetate tetrahydrate) is a GnRH product approved by the FDA for treatment of cystic ovaries in cattle, and helps your herd conceive and calve on schedule. Historically, cystic ovaries have responded to an exogenous source of luteinizing hormone (LH) such as human chorionic gonadotropin. Cystorelin® (gonadorelin diacetate tetrahydrate) stimulates the release of normal physiological levels of endogenous LH to cause ovulation and luteinization.

Key Benefits

Injection for the treatment of ovarian follicular cysts in dairy cattle to help maintain herd productivity

• Gonadorelin diacetate tetrahydrate injection
• For the treatment of cystic ovaries in dairy cattle
• Initiates release of LH to cause ovulation and luteinization
• No meat withdrawal or milk withholding period
• Sterile solution, no mixing required

How It Works

Cystorelin treats dairy cattle for ovarian follicular cysts. Ovarian cysts are follicles that have failed to ovulate and have not completely luteinized, resulting in irregular estrus or nymphomania. This medication initiates the release of endogenous luteinizing hormone, causing luteinization and ovulation.

Indications

Cystic Ovaries

CYSTORELIN is indicated for the treatment of ovarian follicular cysts in dairy cattle. Ovarian cysts are non-ovulated follicles with incomplete luteinization which result in nymphomania or irregular estrus. Historically, cystic ovaries have responded to an exogenous source of LH such as human chorionic gonadotrophin. CYSTORELIN initiates release of endogenous LH to cause ovulation and luteinization.

Reproductive Synchrony

CYSTORELIN is indicated for use with cloprostenol sodium to synchronize estrous cycles to allow for fixed time artificial insemination (FTAI) in lactating dairy cows and beef cows.

Cystic Ovaries

The intravenous or intramuscular dosage of CYSTORELIN is 100 mcg gonadorelin diacetate tetrahydrate (2 mL) per cow.

Reproductive Synchrony

The intramuscular dosage of CYSTORELIN is 100 mcg gonadorelin diacetate tetrahydrate (2 mL) per cow, used in reproductive synchrony programs similar to the following:

1. Administer the first CYSTORELIN injection (2 mL) at Time 0.
2. Administer 500 mcg cloprostenol (as cloprostenol sodium) by intramuscular injection 6 to 8 days after the first CYSTORELIN injection.
3. Administer the second CYSTORELIN injection (2 mL) 30 to 72 hours after the cloprostenol sodium injection.
4. Perform FTAI 0 to 24 hours after the second CYSTORELIN injection, or inseminate cows on detected estrus using standard herd practices.

Caution:

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

Warnings and Precautions:

Not for use in humans.

Keep this and all drugs out of reach of children.

Withdrawal Periods:

No withdrawal period or milk discard time is required when used according to the labeling.

The Safety Data Sheet (SDS) contains more detailed occupational safety information. To obtain a SDS or for technical assistance, contact Merial at 1-888-637-4251. To report suspected adverse drug experiences, contact Merial at 1-888-637-4251. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or http://www.fda.gov/AnimalVeterinary.

Storage:

Store at or below 77°F (25°C). Brief excursions to 86°F (30°C) are permitted. Use within 6 months of first puncture.