What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
Clomipramine Hydrochloride, Some furry friends have a very hard time being separated from their pet parents, but thankfully there are ways to help. Clomipramine Hydrochloride (Generic) Tablets is a prescriptions medication formulated to help reduce clinical signs of separation anxiety. It works by affecting serotonergic and noradrenergic neuronal transmission into your pet’s central nervous system. And for easy oral administration, this medication comes in a convenient uncoated tablet form.
Separation anxiety in dogs six months and older.
Possible Side Effects
Possible side effects are emesis, letargy, and anorexia
The recommended daily dose of Clomipramine Hydrochloride Tablets is 2 to 4 mg/kg/day (0.9 -1.8 mg/lb/day) (see dosing table below). It can be administered as a single daily dose or divided twice daily based on patient response and/or tolerance of the side effects. It may be prudent to initiate treatment in divided doses to minimize side effects by permitting tolerance to side effects to develop or allowing the patient time to adapt if tolerance does not develop. To reduce the incidence of vomiting that may be experienced by some dogs, Clomipramine Hydrochloride Tablets may be given with a small amount of food.
|Dog Weight (lbs)||No. Tablets per Day||Tablet Strength|
Clomipramine Hydrochloride Tablets are not recommended for other behavior problems, such as aggression. (see Adverse Reactions). Studies to establish the safety and efficacy of clomipramine hydrochloride tablets in dogs less than 6 months of age have not been conducted. Not for use in humans. Keep out of reach of children. In case of accidental ingestion seek medical attention immediately. In children, accidental ingestion should be regarded as serious. There is no specific antidote for clomipramine. Overdose in humans causes anticholinergic effects including effects on the central nervous (e.g., convulsions) and cardiovascular (e.g., arrhythmia, tachycardia) systems. People hypersensitive to clomipramine should administer the product with caution.
Clomipramine Hydrochloride Tablets are contraindicated in dogs with known hypersensitivity to clomipramine or other tricyclic antidepressants.
Clomipramine Hydrochloride Tablets should not be used in male breeding dogs. Testicular hypoplasia was seen in dogs treated for 1 year at 12.5 times the maximum daily dose.
Clomipramine Hydrochloride Tablets should not be given in combination, or within 14 days before or after treatment with a monoamine oxidase inhibitor [e.g. selegiline hydrochloride (L-deprenyl), amitraz].
Clomipramine Hydrochloride Tablets are contraindicated for use in dogs with a history of seizures or concomitantly with drugs which lower the seizure threshold.
Not for use in humans. Keep out of reach of children. In case of accidental ingestion seek medical attention immediately. In children, accidental ingestion should be regarded as serious. There is no specific antidote for clomipramine. Overdose in humans causes anticholinergic effects including effects on the central nervous (e.g., convulsions) and cardiovascular (e.g., arrhythmia, tachycardia) systems. People with known hypersensitivity to clomipramine should administer the product with caution.
General: Clomipramine Hydrochloride Tablets are not recommended for other behavior problems, such as aggression (see Adverse Reactions). Studies to establish the safety and efficacy of clomipramine hydrochloride tablets in dogs less than 6 months of age have not been conducted.
Diagnosis: It is critical to conduct a comprehensive physical examination, including appropriate laboratory tests, and to obtain a thorough history and assessment of the patient's household environment, to rule-out causes of inappropriate behavior unrelated to separation anxiety before prescribing Clomipramine Hydrochloride Tablets. Periodic reassessment of hematological and serum biochemical data during the administration of this medication is advised. Veterinarians should be familiar with the risks and benefits of the treatment of behavioral disorders in dogs before initiating therapy. Inappropriate use of Clomipramine Hydrochloride Tablets, i.e., in the absence of a diagnosis or without concurrent behavioral modification, may expose the animal to unnecessary adverse effects and may not provide any lasting benefit of therapy.
Recommendations on the interaction between clomipramine and other medications are extrapolated from data generated in humans. Plasma levels of tricyclic antidepressants have been reported to be decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin); therefore plasma concentrations of clomipramine may be decreased by the concomitant administration of phenobarbital. Plasma levels of closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine). Tricyclic antidepressants themselves may exhibit hepatic enzyme inhibition and possibly increase plasma levels of barbiturates (phenobarbital). Caution is advised in using clomipramine with anticholinergic or sympathomimetic drugs or with other CNS-active drugs, including general anesthetics and neuroleptics.
Prior to elective surgery with general anesthetics, clomipramine should be discontinued for as long as clinically feasible.
Use with caution in dogs with cardiovascular disease. At 20 mg/kg/day (5X the maximum recommended dose), bradycardia and arrhythmias (atrioventricular node block and ventricular extrasystole) were observed in dogs. Because of its anticholinergic properties, clomipramine should be used with caution in patients with increased intraocular pressure, a history of narrow angle glaucoma, urinary retention or reduced gastrointestinal motility. Because clomipramine is principally metabolized in the liver, caution is advised in using this medication in the presence of preexisting liver disease.
Safety studies to determine the effects of clomipramine hydrochloride tablets in pregnant or lactating female dogs have not been conducted. Clomipramine Hydrochloride Tablets should not be used in breeding males.
Behavior training is a necessary component of therapy with Clomipramine Hydrochloride Tablets. In clinical trials, specific behavior training techniques were used at the following times:
Since the methods used for behavior training can vary according to patient needs, it is important that you follow the instructions provided by your veterinarian regarding the specific techniques recommended for modifying your dog's behavior.