Advantage Multi for Dogs 55.1-88 lbs.|6-in-1 Heartworm Prevention|Kills Fleas & More|1-Month Supply

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Advantage Multi for Dogs is a popular veterinary product that provides comprehensive protection against fleas, heartworms, intestinal parasites, and some species of ticks. It is a topical treatment that is applied to the skin on the back of your dog's neck once a month.

Key Benefits:

• Flea Control: Advantage Multi kills fleas on your dog within 12 hours of application and prevents re-infestations for up to 4 weeks. It also controls flea infestations in the dog's environment by killing flea larvae in the surroundings.
• Heartworm Prevention: This product is highly effective in preventing heartworm disease in dogs. It kills heartworm larvae (Dirofilaria immitis) before they develop into adult worms, thus protecting your dog from potentially life-threatening heartworm infestations.
• Intestinal Parasite Control: Advantage Multi also provides protection against various intestinal parasites such as roundworms, hookworms, and whipworms. It kills these parasites and helps prevent the re-infestation of your dog.
• Some Tick Protection: Advantage Multi has some efficacy against certain tick species, including the American dog tick and the black-legged tick (deer tick). While it may kill ticks present on the dog at the time of application, it may not provide complete protection against all tick species. If tick control is a primary concern, it is recommended to use a product specifically designed for that purpose.
• Convenient Application: The product comes in pre-measured, single-dose tubes, making it easy to apply. You simply part your dog's fur at the base of the neck and apply the liquid directly onto the skin.

Indications:

• Treatment and prevention of flea infestations: Advantage Multi kills fleas on dogs and prevents re-infestations for up to 4 weeks.
• Prevention of heartworm disease: Advantage Multi is effective in preventing heartworm disease caused by the parasitic worm Dirofilaria immitis. It kills heartworm larvae (microfilariae) before they develop into adult worms.
• Treatment and control of intestinal parasites: This product controls and treats certain intestinal parasites in dogs, including roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), and whipworms (Trichuris vulpis).
• Treatment and control of sarcoptic mange: Advantage Multi is indicated for the treatment and control of sarcoptic mange (caused by Sarcoptes scabiei var. canis) in dogs.

It's important to note that Advantage Multi for Dogs is available in different formulations based on the weight of your dog, so it's essential to use the appropriate product for your dog's size. Additionally, always follow the dosage instructions provided by your veterinarian and read the product label carefully for proper application and safety precautions.

How it works:

Advantage Multi for Dogs contains two active ingredients: imidacloprid and moxidectin. These ingredients work together to provide multiple modes of action against different parasites. Here's how each ingredient works:

1. Imidacloprid: Imidacloprid is an insecticide that belongs to the neonicotinoid class. It acts by targeting the nervous system of fleas and other insects. When applied to the dog's skin, imidacloprid is absorbed into the bloodstream and distributed throughout the body. When fleas come into contact with the treated dog, imidacloprid binds to specific receptors in the flea's nervous system, causing paralysis and ultimately leading to the death of the fleas.
2. Moxidectin: Moxidectin is an antiparasitic agent that belongs to the class of drugs called macrocyclic lactones. It has a broad spectrum of activity against various parasites, including heartworms and certain intestinal parasites. Moxidectin works by targeting the nervous system of these parasites, interfering with their neurotransmission and causing paralysis and death.

When Advantage Multi for Dogs is applied to the dog's skin, both imidacloprid and moxidectin are absorbed into the bloodstream and provide systemic protection. Imidacloprid primarily targets fleas, killing them upon contact, while moxidectin targets internal parasites like heartworms and intestinal worms, preventing their growth and reproduction.

It's important to note that Advantage Multi for Dogs is a topical treatment, meaning it is applied externally to the skin. The active ingredients are then absorbed into the bloodstream, providing continuous protection against fleas, heartworms, and intestinal parasites for up to a month. It's essential to follow the specific application instructions provided by your veterinarian to ensure proper absorption and efficacy of the product.

Active Ingredients:
Package	Imidacloprid	Moxidectin
Advantage Multi 9	40 mg	10 mg
Advantage Multi 20	100 mg	25 mg
Advantage Multi 55	250 mg	62.5 mg
Advantage Multi 88	400 mg	100 mg
Advantage Multi 110	500 mg	125 mg

View Advantage Multi Dogs Drug Facts Sheet.

The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.

Do not apply to irritated skin

1. Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the Advantage Multi for Dogs tube that correctly corresponds with the body weight of the dog.

Dog (lb.)	Advantage Multi For Dogs	Volume (mL)	Imidacloprid (mg)	Moxidectin (mg)
3-9	Advantage Multi 9	0.4	40	10
9.1-20	Advantage Multi 20	1.0	100	25
20.1-55	Advantage Multi 55	2.5	250	62.5
55.1-88	Advantage Multi 88	4.0	400	100
88.1-110*	Advantage Multi 110	5.0	500	125

*Dogs over 110 lbs. should be treated with the appropriate combination of Advantage Multi for Dogs tubes.

2. While holding the tube in an upright position, remove the cap from the tube.
3. Turn the cap over and push the other end of cap onto the tip of the tube.
4. Twist the cap to break the seal and then remove cap from the tube.



5. The dog should be standing for application. Part the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Do not apply an amount of solution at any one location that could run off the side of the dog.

Do not let this product get in our dog's mouth or eyes. Do not allow the dog to lick any of the application sites for 30 minutes. In households with multiple pets, keep reach treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the applications sites. (See Warnings.)

Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. This is temporary and does not affect the safety and effectiveness of the product.

Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease.

Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas.

Protect your dog with a broad-spectrum solution.

With just one treatment, once a month, Advantage Multi® for Dogs not only provides heartworm disease prevention, but kills fleas through contact so they don't have to bite your dog to die.

Advantage Multi® for Dogs works to:

• Prevent heartworm disease
• Treat circulating microfilariae in heartworm-positive dogs
• Kill adult fleas and treat flea infestations
• Treat and control common intestinal parasites: roundworms, hookworms and whipworms
• Treat and control sarcoptic mange

Heartworm Prevention:

For prevention of heartworm disease, Advantage Multi Dogs should be administered at one-month intervals. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Dogs immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi Dogs should be given within one month of the last dose of the former medication.

Treatment of Circulating Microfilariae:

For the treatment of circulating D.immitis microfilariae in heartworm-positive dogs, Advantage Multi for Dogs should be administered at one-month intervals. Treatment with an approved adulticide therapy is recommended because Advantage Multi for Dogs is not effective for the treatment of adult D.immitis. (See Precautions.)

Flea Treatment:

For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Dogs treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the dog.

Treatment and Control of Intestinal Nematode Infections:

For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinaria stenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults an fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), Advantage Multi for Dogs should be administered once as a single topical dose.

Treatment and Control of Sarcoptic Mange:

For the treatment and control of sarcoptic mange cause by Sarcoptes scabieivar, canis, Advantage Multi for Dogs should be administered as a single topical dose. A second monthly dose may be administered if necessary.

Animal Safety:

Heartworm-Negative Dogs

Field Study:

In a controlled, double-masked, field safety study, Advantage Multi for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 t0 157 pounds. Advantage Multi for Dogs was used sagely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, opthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. Owners reported the following signs in their dogs after application of Advantage Multi for Dogs: pruritus, flaky/greasy residue at the treatment site, medicinal odor, lethargy, inappetence, and hyperactivity. (See Adverse Reactions.)

Safety Study in Puppies:

Advantage Multi for Dogs was applied topically at 1, 3 and 5x the recommended dose to 7-week-old Beagle puppies once ever 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. Vomiting was seen in one puppy from the 1x treatment (day 57), in to puppies from the 3x treatment group (days 1 and 79), and in one puppy from the 5x treatment group (day 1). Two puppies each in the 1x, 3x, and 5x groups had decreased appetites within 24 hours post-dosing. One puppy in the 1x treatment group had pruritus for one hour following the fifth treatment. A puppy from the 5x treatment group displayed rapid, difficult breathing from 4 to hours following the second treatment.

Dermal Dose Tolerance Study:

Advantage Multi for Dogs was administered topically to 8-month-old Beagle dogs at 10x the recommended dose once. One dog showed signs of treatment site irritation after application. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. Dogs in the treated group did not gain as much weight as the control group.

Oral Safety Study in Beagles:

Advantage Multi for Dogs was administered once orally at the recommended topical dose to 12 dogs. Six dogs vomited within 1 hour of receiving the test article, 2 of these dogs vomited again at 2 hours, and 1 dog vomited again up to 18 hours post-dosing. One dog exhibited shaking (nervousness) 1 hour post-dosing. Another dog exhibited abnormal neurological signs (circling, ataxia, generalized muscle tremors, and dilated pupils with a slow pupillary light response) starting at 4 hours post-dosing through 18 hours post-dosing. Without treatment, this dog was neurologically normal at 24 hours and had a normal appetite by 48 hours post-dosing. (See Contraindications.)

Dermal Safety Study in Ivermectin-Sensitive Collies:

Advantage Multi for Dogs was administered topically at 3 and 5x the recommended dose every 8 days for 3 treatments to Collies which had been-screened for avermectin sensitivity. No clinical abnormalities were observed.

Oral Safety Study in Ivermectin-Sensitive Collies:

Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. The Collies were asymp-tomatic after ingesting 10% of the minimum labeled dose. At 40% of the minimum recommended topical dose, 4 of the dogs experienced neurological signs indicative of avermectin toxicity including depression, ataxia, mydriasis, salivation, muscle fasciculation, and coma, and were euthanized.

Heartworm-Positive Dogs

Laboratory Safety Study in Heartworm-Positive Dogs:

Advantage Multi for Dogs was administered topically at 1 and 5x the recommended dose every 14 days for 3 treatments to dogs with adult heartworm infections and circulating microfilatiae. At 5x, one dog was observed vomiting three hours after the second treatment. Hypersensitivity reactions were not seen in the 5x treatment group. Microfilariae counts decreased with treatment.

Contraindications:

Do not administer this product orally. (See Warnings)

Do not use this product (containing 2.5% moxidectin) on cats.

Warnings

For the first 30 minutes after application:

Ensure that dogs cannot lick the product from application sites on themselves or other treated dogs, and separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. Ingestion of this product by dogs may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors.

In avermectin sensitive dogs, ^a the signs may be more severe and may include coma and death.^b

^a Some dogs are more sensitive to avermectins due to a mutation in the MDR1 gene, Dogs with this mutation may develop signs of severe avermectin toxicity if they ingest this product. The most common breeds associated with this mutation include Collies and Collie crosses.

^b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care.

Human Warnings:

Not for human use. Keep out of the reach of children.

Children should not come in contact with application sites for two (2) hours after application.

Causes eye irritation. Harmful if swallowed, Do not get in eyes or on clothing. Avoid contact with skin. Exposure to the product has been reported to cause headache; dizziness; and redness, burning, tingling, or numbness of the skin. Wash hands thoroughly with soap and warm water after handling.

If contact with eyes occurs, hold eyelids open and flush with copious amounts of water for 15 minutes. If eye irritation develops or persists, contact a physician. If swallowed, call poison control center or physician immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or physician. People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin should administer the product with caution. In case of allergic reaction, contact a physician. If contact with skin or clothing occurs, take off contaminate clothing. Wash skin immediately with plenty of soap and water. Call a poison control center or physician for treatment advice.

The Safety Data Sheet (SDS) provides additional occupational safety information. For a copy of the Safety Data Sheet (SDS) or to report adverse reactions call Bayer Veterinary Services at 1-800-422-9874. For consumer question call 1-800-255-6826.

Precautions:

Do not dispense dose applicator tubes without complete safety and administration information.

Use with caution in sick, debilitated, or underweight animals. The safety of Advantage Multi for Dogs has not been established in breeding, pregnant, or lactating dogs. The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. body weight.

Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. The safety of Advantage Multi for Dogs has not been evaluated when administered on the same day as an adulticide. Advantage Multi for Dogs is not effective against adult D. immitis. Although the number of circulating microfilariae is substantially reduced in most dogs following treatment with Advantage Multi for Dogs, the microfilaria count in some heartworm-positive dogs may increase or remain unchanged following treatment with Advantage Multi for Dogs or in a dosing regimen with melarsomine dihydrochloride. (See Adverse Reactions and Animal Safety - Safety Study in Heartworm-Positive Dogs.)

Advantage Multi for Dogs has not been evaluated in heartworm-positive dogs with class 4 heartworm disease.

Adverse Reactions:

Heartworm-Negative Dogs

Field Studies: Following treatment with Advantage Multi for Dogs or an active control, dog owners reported the following post-treatment reactions:

Observation	Advantage Multi n=128	Active Control n=68
Pruritus	19 dogs (14.8%)	7 dogs (10.3%)
Residue	9 dogs (7.0%)	5 dogs (7.4%)
Medicinal Odor	5 dogs (3.9%)	None observed
Lethargy	1 dog (0.8%	1 dog (1.5%
Inappetence	1 dog (0.8%)	1 dog (1.5%)
Hyperactivity	1 dog (0.8%)	None observed

During a field study using 61 dogs with pre-existing flea allergy dermatitis, one (1.6%) dog experienced localized pruritus immediately after imidacloprid application, and one investigator noted hyperkeratosis at the application site of one dog (1.6%).

In a field safety and effectiveness study, Advantage Multi for Dogs was administered to 92 client-owned dogs with sarcoptic mange. The dogs ranged in age from 2 months to 12.5 years and ranged in weight from 3 to 231.5 pounds. Adverse reaction in dogs treated with Advantage Multi for Dogs included hematochezia, diarrhea, vomiting, lethargy, inappetence, and pyoderma.

Laboratory Effectiveness Studies:

One dog in laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application of Advantage Multi for Dogs. The signs resolved without intervention by day 10 post-application. The signs in this dog may have been related to peak serum levels of moxidectin, which vary between dogs, and occur between 1 and 21 days after application of Advantage Multi for Dogs.

The following clinical observations also occurred in laboratory effectiveness studies following application with Advantage Multi for Dogs and may be directly attributed to the drug or may be secondary to the intestinal parasite burden or other underlying conditions in the dogs: diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge and nasal discharge. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours.

Heartworm-Postive Dogs

Field Study: A 56-day field safety study was conducted in 214 D.immitis heartworm and microfilariae positive dogs with Class 1, 2 or 3 heartworm disease. All dogs received Advantage Multi for Dogs on Study Days 0 and 28; 108 dogs also received melarsomine dihydrochloride on Study Days - 14, 14 and 15. All dogs were hospitalized for a minimum of 12 hours following each treatment. Effectiveness against circulating D.immitis microfilariae was > 90% at five of sic sites; however, one site had an effectiveness of 73.3%. The microfilariae count in some heartworm-positive dogs increased or remained unchanged following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride. Following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride, the following adverse reactions were observed:

Adverse Reaction	Dogs Treated with Advantage Multi for Dogs Only n=106	Dogs Treated with Advantage Multi for Dogs + Melarsomine n=108
Cough	24 (22.6%)	25 (23.1%)
Lethargy	14 (13.2%)	42 (38.9%)
Vomiting	11 (10.4%)	18 (16.7%)
Diarrhea, including hemorrhagic	10 (9.4%)	22 (20.4%)
Inappetence	7 (6.6%)	19 (17.6%)
Dyspnea	6 (5.7%)	10 (9.3%)
Tachypnea	1 (< 1%)	7 (6.5%)
Pulmonary hemorrhage	0	1 (<1 %)
Death	0	3 (2.8%)

Three dogs treated with Advantage Multi for Dogs in a dosing regimen with melarsomine dihydrochloride died of pulmonary embolism from dead and dying heartworms. One dog, treated with Advantage Multi for Dogs and melarsomine dihydrochloride, experienced pulmonary hemorrhage and responded to supportive medical treatment. Following the first treatment with Advantage Multi for Dogs alone, two dogs experienced adverse reactions (coughing, vomiting, and dyspnea) that required hospitalization. In both groups, there were more adverse reactions to Advantage Multi for Dogs following the first treatment than the second treatment.

To report a suspected adverse reactions, call 1-800-422-9874.

Post-Approval Experience

The following adverse events are based on post-approval drug experience reporting. Not all adverse reaction s are reported to FDA CVM. It is not always possible to reliably estimate the adverse even frequency or establish a causal relationship to product exposure using this data. The following adverse events in dogs are listed in decreasing order of reporting frequency: depression/lethargy, vomiting, pruritus, diarrhea, anorexiz, hyperactivity, ataxia, trembling, hypersalivation, application site reactions ( alopecia, pruritusm lesions, and erythema), seizures, and anaphylaxis/anaphylactic reactions (hives, urticaria, facial swelling, edema of the head).

Serious reactions, including neurologic signs and death have been reported when cats have been exposed (orally and topically) to this product.

In humans, nausea, numbness or tingling of the mouth/lips and throat, ocular and dermal irritation, pruritus, headache, vomiting, diarrhea, depression and dyspnea have been reported following exposure to this product. To report suspected adverse events and/or obtain a copy of the SDS or for technical assistance, call Bayer Animal Health at 1-800-422-9874. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth.