View Viceton product label.
Dogs - 25 mg/lb. body weight every 6 hours for oral administration.
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Store at or below 25°C (77°F) in a dry place.
Chloramphenicol Tablets are recommended for oral treatment of the following conditions in dogs:
- Bacterial pulmonary infections caused by susceptible microorganisms such as: Staphylococcus aureus, Streptococcus pyogenes and Brucella bronchiseptica.
- Imfections of the urinary tract caused by susceptible microorganisms such as: Escherchia coli, Proteus vulgaris, Corynebacterium renale, Streptococcus spp., and hemolytic Staphylococcus.
- Enteritis caused by susceptible microorganisms such as: E. coli, Proteus spp., Salmonella spp., and Pseudomonas spp.
- Infections associated with canine distemper caused by susceptible microorganism such as: B. bronchiseptica, E. coli, P. aeruginosa, Proteus spp., Shigella spp. and Neisseria catarrhalis.
Additional adjunctive therapy should be used when indicated. Most susceptible infectious disease organisms will respond to chloramphenicol therapy in three to five days when the recommended dosage regimen is followed. If no response to chloramphenicol therapy is obtained in three to five days, discontinue its use and review the diagnosis. Also, a change of therapy should be considered.
Laboratory tests should be conducted including in vitro culturing and susceptibility tests on samples collected prior to treatment.
Because of potential antagonism, chloramphenicol should not be administered simultaneously with penicillin or streptomycin.
Not for use in animals which are raised for food production.
- Chloramphenicol products should not be administered in conjunction with or two hours prior to the induction of general anesthesia with pentobarbital because of prolonged recovery time.
- Chloramphenicol products should not be administered to dogs maintained for breeding purposes. Some experiments indicate that chlorampenicol causes, in experimental animals particularly females, significant disorders in morphology as well as in function of the gonads.
Certain individual dogs may exhibit transient vomiting or diarrhea after an oral dose of 25 mg/lb. body weight.
- This antibiotic contains a chemical structure (nitrobenzene group) that is characteristic of a group of drugs long known to depress hematopoietic activity of the bone marrow.
- In Vitro tissue culture studies using canine bone marrow cells have demonstrated that extremely high concentrations of chloramphenicol inhibit both uptake of iron by the nucleated red cells and incorporation of iron into heme.