Uniprim for Horses - 37.5 g (SINGLE packet) - [Bacterial Infections Treatment]

Uniprim Powder is an oral antibiotic powder for horses. It's indicated for use against systematic bacterial infections during the treatment of respiratory tract infections, wounds and abscesses, acute urogenital infections (urinary tract infections), and acute strangles (upper respiratory tract infection).

Key Benefits

• Equine antibiotic powder
• Treats a variety of bacterial infections
• Contains trimethoprim and sulfadiazine
• Administer orally in the horse's feed

How It Works

Uniprim Powder contains the active ingredients trimethoprim and sulfadiazine. When combined, these ingredients provide effective antibacterial activity against a wide range of bacterial infections in horses.

Indications

Trimethoprim/sulfadiazine is indicated in horses where potent systemic antibacterial action against sensitive organisms is required. Trimethoprim/sulfadiazine is indicated where control of bacterial infections is required during treatment of:

• Acute Strangles
• Acute Urogenital Infections
• Respiratory Tract Infections
• Wound Infections and Abscesses

The recommended dosage is 3.75 g UNIPRIM Powder per 110 lbs (50 kg) body weight per day. Administer UNIPRIM Powder orally once a day in a small amount of palatable feed.

Dose Instructions:

One 37.5 g packet is sufficient to treat 1100 lbs (500 kg) of body weight. For the 1125 g packets and 12 kg boxes, a level, loose-filled, 67 cc scoop contains 37.5 g, sufficient to treat 1100 lbs (500 kg) of body weight. For the 200 g, 400 g, and 1200 g jars, and 2000 g pail, two level, loose-filled, 32 cc scoops contain 37.5 g, sufficient to treat 1100 lbs (500 kg) of body weight. Since product contents may settle, gentle agitation during scooping is recommended.

The usual course of treatment is a single, daily dose for 5 to 7 days.

Continue acute infection therapy for 2 or 3 days after clinical signs have subsided.

If no improvement of acute infections is seen in 3 to 5 days, reevaluate the diagnosis.

UNIPRIM Powder may be used alone or in conjunction with intravenous dosing. Following treatment with trimethoprim/ sulfadiazine 48% injection, therapy can be maintained using oral UNIPRIM Powder.

A complete blood count should be done periodically in patients receiving UNIPRIM Powder for prolonged periods. If significant reduction in the count of any formed blood element is noted, treatment with UNIPRIM Powder should be discontinued.

Caution:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications:

Trimethoprim/sulfadiazine should not be used in horses showing marked liver parenchymal damage, blood dyscrasias, or in those with a history of sulfonamide sensitivity.

Warning:

Do not use in horses intended for human consumption.

Adverse Reactions:

During clinical trials, one case of anorexia and one case of loose feces following treatment with the drug were reported.

Individual animal hypersensitivity may result in local or generalized reactions, sometimes fatal. Anaphylactoid reactions, although rare, may also occur.

Antidote: Epinephrine.

Post Approval Experience: Horses have developed diarrhea during trimethoprim/sulfadiazine treatment, which could be fatal. If fecal consistency changes during trimethoprim/sulfadiazine therapy, discontinue treatment immediately and contact your veterinarian.

Precaution:

Water should be readily available to horses receiving sulfonamide therapy.

Animal Safety:

Toxicity is low. The acute toxicity (LD50) of trimethoprim/sulfadiazine is more than 5 g/kg orally in rats and mice. No significant changes were recorded in rats given doses of 600 mg/kg per day for 90 days.

Horses treated intravenously with trimethoprim/sulfadiazine 48% injection have tolerated up to five times the recommended daily dose for 7 days or on the recommended daily dose for 21 consecutive days without clinical effects or histopathological changes.

Lengthening of clotting time was seen in some of the horses on high or prolonged dosing in one of two trials. The effect, which may have been related to a resolving infection, was not seen in a second similar trial.

Slight to moderate reductions in hematopoietic activity following high, prolonged dosage in several species have been recorded. This is usually reversible by folinic acid (leucovorin) administration or by stopping the drug. During long-term treatment of horses, periodic platelet counts and white and red blood cell counts are advisable.

Storage:

Store at or below 25°C (77°F)