Tildren 500mg (30 ml) | On Sale | EntirelyPets Rx
Licensed U.S. Pet Pharmacy | Verified Pharmacy
Mobile Menu
Search Submit
Live Chat My Account
View Cart 0

Sitewide SALE!  GET 15% Off!  Use Code EPX15 *

  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
Tildren 500mg (30 ml) Video

Tildren 500mg (30 ml)

Item# IWM054089
FREE SHIPPING Over $79! * Pet Food & Other Exclusions

Price too low to show

Add to cart to see low price
  1. We'll ask for your vet's info during check out.
  2. We'll verify your prescription and ship your order! Learn more >>
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
  • Description
  • Directions
  • FAQ
  • Reviews


Tildren (tiludronate disodium) is an effective new tool to help veterinarians control clinical signs associated with navicular syndrome. Best results are achieved when Tildren is used early in the disease process. In addition, it is important that corrective shoeing is part of the overall treatment protocol for success.

Key Benefits

  • Restores balance to the process of bone remodeling
  • Decreases mineral loss and slows the rate of bone turnover
  • Alleviates pain induced by abnormal osteolysis

How It Works

The active ingredient in Tildren is tiludronate disodium, a bisphosphate that achieves its effect by regulating osteoclasts in areas of excessive activity. Following IV infusion, Tildren travels through the blood stream and binds to the mineral matrix of the bone. The acidity of the remodeling environment causes the release of Tildren from the bone matrix to the resorption space. This leads to improved bone remodeling, decreased mineral loss and alleviation of pain induced by abnormal osteolysis.


Tildren is indicated for the control of clinical signs associated with navicular syndrome in horses.


View Tildren Drug Facts Sheet.

A single dose of Tildren should be administered as an intravenous infusion at a dose of 1 mg/kg (0.45 mg/lb). The infusion should be administered slowly and evenly over 90 minutes to minimize the risk of adverse reactions.Maximum effect may not occur until 2 months post-treatment.

Directions for Adminsitration:

Do not reconstitute or mix Tildren with calcium containing solutions or other solutions containing divalent cations such as Lactated Ringers as it may form complexes with these ions.

  1. Preparation of the reconstituted solution (20 mg/mL). Tildren should be reconstituted using strict aseptic technique. Remove 25 mL of solution from a 1 liter bag of sterile 0.9% Sodium Chloride Injection, USP and add it to one vial of Tildren. Shake gently until the powder is completely dissolved. This reconstituted solution contains 20 mg of tiludronate disodium per mL. After reconstitution further dilution is required before administration.
  2. Preparation of the solution for infusion. Using strict aseptic technique, withdraw the appropriate volume of the reconstituted solution based on the horse's body weight. Inject that volume back into the 1 liter bag of sterile 0.9% Sodium Chloride Injection, USP. Horses greater than 1,210 lbs. will require a second vial of reconstituted Tildren solution. Invert the infusion bag to mix the solution before infusion. Label the infusion bag to ensure proper use.
  3. After preparation, the infusion should be administered either within 2 hours of preparation, or it can be stored for up to 24 hours under refrigeration at 36°F-46°F(2°C-8°C) and protected from light.
Dosing Table
Weight Range (lbs) Volume of Reconstituted Tildren Solution (20 mg/mL) to be added to the infusion bag
550-770 15 mL
771-990 20 mL
991-1210 25 mL
1211-1430 30 mL (25 mL + 5 mL from additional vial)
1431-1650 35 mL (25 mL + 10 mL from additional vial)
1651-1875 40 mL (25 mL + 15 mL from additional vial)
*1 vial = 25mL


Federal law restricts this drug to use by or on the order of a licensed veterinarian.


Do not use in horses with known hypersensitivity to tiludronate disodium or to mannitol.

Do not use in horses with impaired renal function or with a history of renal disease. Bisphosphonates are excreted by the kidney; therefore, conditions causing renal impairment may increase plasma bisphosphonate concentrations resulting in an increased risk for adverse reactions.


Do not use in horses intended for human consumption.

NSAIDs should not be used concurrently with Tildren. Concurrent use of NSAIDs with Tildren may increase the risk of renal toxicity and acute renal failure.Acute renal failure has been reported in horses concurrently administered NSAIDs and Tildren within a 48 hour period. Additionally, horses concurrently administered Tildren and NSAIDs in field studies demonstrated a statistically significant increase in serum blood urea nitrogen (BUN) and creatinine concentrations. These elevations were not always associated with clinical signs of renal dysfunction. Therefore, appropriate wash-out periods should be observed between NSAID and Tildren administration, and BUN and creatinine should be monitored. If treatment for discomfort is required after Tildren administration, a non-NSAID treatment should be used.

Human Warnings:

Not for human use. Keep this and all drugs out of the reach of children. Consult a physician in case of accidental human exposure.


Approximately 30-45% of horses administered Tildren will demonstrate transient signs consistent with abdominal pain (colic). Clinical signs usually occur shortly after Tildren administration and may be associated with alterations in intestinal motility. Horses should be observed closely for 4 hours post-infusion for the development of clinical signs consistent with colic or other adverse reactions. Colic signs can last approximately 90 minutes and may be intermittent in nature. Hand-walking the horse may improve or resolve the colic signs in many cases. If a horse requires medical therapy, non-NSAID treatments should be administered due to the risk for renal toxicity. Avoid NSAID use.

Tildren should be administered slowly and evenly over 90 minutes to minimize the risk of adverse reactions. Field studies demonstrated a higher incidence of adverse reactions when the infusion was administered over shorter periods of time.

Horses should be well hydrated prior to administration of Tildren due to the potential nephrotoxic effects of Tildren.

Concurrent administration of other potentially nephrotoxic drugs should be approached with caution, and if administered, renal function should be monitored.Tildren affects plasma concentrations of certain minerals and electrolytes, including calcium, magnesium and potassium, immediately post-treatment, with effects lasting up to several hours. Caution should be used when administering Tildren to horses with conditions affecting mineral or electrolyte homeostasis (e.g. hyperkalemic periodic paralysis (HYPP), hypocalcemia, etc.) and conditions which may be exacerbated by hypocalcemia (e.g. cardiac disease). Tildren should be used with caution in horses receiving concurrent administration of other drugs that may reduce serum calcium (such as tetracyclines) or whose toxicity may exacerbate a reduction in serum calcium (such as aminoglycosides).

Horses with HYPP (heterozygous or homozygous) may be at an increased risk for adverse reactions, including colic signs, hyperkalemic episodes, and death. In one field study, one horse that was an unknown carrier (heterozygous) for HYPP died after receiving Tildren. In a study evaluating the safety of Tildren in horses with HYPP, an increased percentage of horses showed colic signs following the second Tildren infusion (See Animal Safety). Genetic testing for HYPP in horses with possible or known Impressive bloodlines should be considered prior to the administration of Tildren.

The safe use of Tildren has not been evaluated in horses less than 4 years of age. The effect of bisphosphonates on the skeleton of growing horses has not been studied; however, bisphosphonates inhibit osteoclast activity which impacts bone turnover and may affect bone growth.

Bisphosphonates should not be used in pregnant or lactating mares, or mares intended for breeding. The safe use of Tildren has not been evaluated in pregnant or lactating mares, or in breeding horses; however, bisphosphonates are incorporated into the bone matrix, from where they are gradually released over periods of months to years. The extent of bisphosphonate incorporation into adult bone, and hence, the amount available for release back into the systemic circulation, is directly related to the total dose and duration of bisphosphonate use. Bisphosphonates have been shown to cause fetal developmental abnormalities in laboratory animals. The uptake of bisphosphonates into fetal bone may be greater than into maternal bone creating a possible risk for skeletal or other abnormalities in the fetus. Many drugs, including bisphosphonates, may be excreted in milk and may be absorbed by nursing animals.

Increased bone fragility has been observed in laboratory animals treated with bisphosphonates at high doses or for long periods of time. Bisphosphonates in-hibit bone resorption and decrease bone turnover which may lead to an inability to repair microdamage within the bone. In humans, atypical femur fractures have been reported in patients on long term bisphosphonate therapy; however, a causal relationship has not been established.


Sterile powder (not reconstituted): Store at controlled room temperature 68 °F-77 °F (20 °C-25 °C).After preparation, the infusion should be administered either within 2 hours of preparation, or it can be stored for up to 24 hours under refrigeration at 36 °F-46 °F (2 °C-8 °C) and protected from light.

Information for Owners:

Prior to Tildren administration, owners should be advised of the potential for adverse reactions in the hours or days following treatment. Adverse reactions within 4 hours post dosing may include signs of colic (manifested as pawing, stretching, getting up and down, sweating, rolling, looking at flanks, kicking at belly, frequent gas, and pacing). Owners should be instructed to contact their veterinarian immediately if any adverse reactions are observed. Owners should be advised to consult with their veterinarian prior to the administration of an NSAID following Tildren administration.


Tildren is indicated for the control of clinical signs associated with navicular syndrome in horses.
Tildren is useful for horses suffering from navicular syndrome.
This intravenously-infused bisphosphonate medication comes in a 30mL vial of sterile powder. Each vial contains 250mg of mannitol USP and 500mg of tiludronic acid (tiludronate disodium). It contains tiludronic acid sodium salt, a bisphosphonate known as tiludronate disodium. This is the hydrated hemihydrate form of tuludronic acid disodium salt.

Potential side effects include:

  • Large colon impaction
  • Gastric ulcers
  • Fever
  • Anorexia
  • Inappetence
  • Polydipsia
  • Polyuria
  • Muscle fasciculations
  • Frequent urination
  • Hematoma or injection site swelling
  • Colic
  • Death
  • Do not use with NSAIDs. These can cause renal toxicity. If your horse requires medical therapies, use a non-NSAID treatment. Observe an appropriate washout period between Tildren administration and NSAID withdrawal.
  • Observe your horse for four hours after infusion to rule out clinical signs of any adverse reaction, including colic. Signs of colic may last about 90 minutes, and are typically intermittent. Hand-walking your horse can resolve or improve the signs.
  • About 30-45% of horses will experience transient symptoms of colic (abdominal pain). Clinical signs are typically seen just after administration and may be related to intestinal motility alterations.
  • Not for use in breeding, lactating, or pregnant animals.
  • Not for use in horses intended for food slaughter.
  • Not for use in humans.
  • Keep this and all other medications away from children.
  • Conditions causing renal impairment can lead to an increased risk of an adverse reaction due to the fact that bisphosphonates are excreted by the kidneys.
  • Not for use in horses with a history of renal disease or impaired renal function.
  • Do not administer to horses with known mannitol or tiludronate sodium hypersensitivity.
Contact your closest emergency pet hospital.

Customers Who Bought Also Bought